JOHN HRYNIUK
Adrian Owen still gets animated when he talks about patient 23. The patient was only 24 years old when his life was devastated by a car accident. Alive but unresponsive, he had been languishing in what neurologists refer to as a vegetative state for five years, when Owen, a neuro-scientist then at the University of Cambridge, UK, and his colleagues at the University of Liège in Belgium, put him into a functional magnetic resonance imaging (fMRI) machine and started asking him questions.
Incredibly, he provided answers. A change in blood flow to certain parts of the man's injured brain convinced Owen that patient 23 was conscious and able to communicate. It was the first time that anyone had exchanged information with someone in a vegetative state.
Patients in these states have emerged from a coma and seem awake. Some parts of their brains function, and they may be able to grind their teeth, grimace or make random eye movements. They also have sleep–wake cycles. But they show no awareness of their surroundings, and doctors have assumed that the parts of the brain needed for cognition, perception, memory and intention are fundamentally damaged. They are usually written off as lost.
Owen's discovery1, reported in 2010, caused a media furore. Medical ethicist Joseph Fins and neurologist Nicholas Schiff, both at Weill Cornell Medical College in New York, called it a “potential game changer for clinical practice”2. The University of Western Ontario in London, Canada, soon lured Owen away from Cambridge with Can$20 million (US$19.5 million) in funding to make the techniques more reliable, cheaper, more accurate and more portable — all of which Owen considers essential if he is to help some of the hundreds of thousands of people worldwide in vegetative states. “It's hard to open up a channel of communication with a patient and then not be able to follow up immediately with a tool for them and their families to be able to do this routinely,” he says.
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Communicating with vegetative patients.
Many researchers disagree with Owen's contention that these individuals are conscious. But Owen takes a practical approach to applying the technology, hoping that it will identify patients who might respond to rehabilitation, direct the dosing of analgesics and even explore some patients' feelings and desires. “Eventually we will be able to provide something that will be beneficial to patients and their families,” he says.
Still, he shies away from asking patients the toughest question of all — whether they wish life support to be ended — saying that it is too early to think about such applications. “The consequences of asking are very complicated, and we need to be absolutely sure that we know what to do with the answers before we go down this road,” he warns.
Lost and found
With short, reddish hair and beard, Owen is a polished speaker who is not afraid of publicity. His home page is a billboard of links to his television and radio appearances. He lectures to scientific and lay audiences with confidence and a touch of defensiveness.
Owen traces the roots of his experiments to the late 1990s, when he was asked to write a review of clinical applications for technologies such as fMRI. He says that he had a “weird crisis of confidence”. Neuroimaging had confirmed a lot of what was known from brain mapping studies, he says, but it was not doing anything new. “We would just tweak a psych test and see what happens,” says Owen. As for real clinical applications: “I realized there weren't any. We all realized that.”
Owen wanted to find one. He and his colleagues got their chance in 1997, with a 26-year-old patient named Kate Bainbridge. A viral infection had put her in a coma — a condition that generally persists for two to four weeks, after which patients die, recover fully or, in rare cases, slip into a vegetative or a minimally conscious state — a more recently defined category characterized by intermittent hints of conscious activity.
Months after her infection cleared, Bainbridge was diagnosed as being in a vegetative state. Owen had been using positron-emission tomography in healthy people to show that a part of the brain called the fusiform face area (FFA) is activated when people see a familiar face. When the team showed Bainbridge familiar faces and scanned her brain, “it lit up like a Christmas tree, especially the FFA”, says Owen. “That was the beginning of everything.” Bainbridge was found to have significant brain function and responded well to rehabilitation3. In 2010, still in a wheelchair but otherwise active, she wrote to thank Owen for the brain scan. “It scares me to think of what might have happened to me if I had not had mine,” she wrote. “It was like magic, it found me.”
Owen moved from visual to auditory tests — “up the cognition ladder, from basic sound perception, to speech perception and then to speech comprehension”. For example, he presented people in a vegetative state with phrases containing words that sound the same but have two meanings, such as “The dates and pears are in the bowl”. The ambiguity forces the brain to work harder and shows up in characteristic fMRI patterns in healthy people — if, that is, they are comprehending the words. One of Owen's patients, a 30-year-old man who had been incapacitated by a stroke, showed the same pattern4. But not everyone was convinced that these signs pointed to comprehension. “Every time I would go to a neurologist or anaesthesiologist and say, 'he's perceiving speech', they'd ask 'but is he conscious?'.” Owen realized that he needed a different experiment to persuade the sceptics.
Anyone for tennis?
It was June 2006. Wimbledon was on, and in a headline-stealing study, Owen took fMRI scans of a 23-year-old woman in a vegetative state while he asked her to imagine playing tennis and walking through the rooms of her house. When healthy, conscious adults imagine playing tennis, they consistently show activation in a region of the motor cortex called the supplementary motor area, and when they think about navigating through a house, they generate activity in the parahippocampal gyrus, right in the centre of the brain. The woman, who had been unresponsive for five months after a traffic accident, had strikingly similar brain activation patterns to healthy volunteers who were imagining these activities, proving, in Owen's mind, that she was conscious. The result, published in a one-page article in Science5, evoked wonder and disbelief. “I got two types of e-mail. People either said 'this is great' or 'how could you possibly say this woman is conscious?',” Owen says.
Other researchers contended that the response was not a sign of consciousness, but something involuntary, like a knee-jerk reflex. Daniel Greenberg, a psychologist at the University of California, Los Angeles, suggested in a letter to Science that “the brain activity was unconsciously triggered by the last word of the instructions, which always referred to the item to be imagined”6.
But Owen went on to bolster his case. Working with neurologist and neuroscientist Steven Laureys from the University of Liège, Owen showed that of 54 patients in a vegetative or minimally conscious state, five responded in the same way as the first woman1. Four of them were in a vegetative state. After refining their methods, the researchers asked patient 23 to use that capability to answer yes-or-no questions: imagine playing tennis for yes, navigating the house for no. They then asked about things that the technicians scoring the brain scans couldn't possibly know.
Is your father's name Thomas? No. Is your father's name Alexander? Yes. Do you have any brothers? Yes. Do you have any sisters? No. The experiment is no easy feat for the patient. Owen's protocol demands patients maintain focus for 30 seconds then rest for 30 seconds, with lots of repetition.
In front of a computer screen showing the fMRI data, Owen traces a blue line indicating activity in the supplementary motor area — a 'yes' — as it rises during the 'answer' period. It dives during the rest periods. A red line — indicating activity in the parahippocampal gyrus — represents the 'no'. The lines are sharp and clear, and Owen, who has a taste for puns, calls the implication “a no-brainer”. “You don't need to be a functional-imaging expert to appreciate what this person is telling you,” he says. The patient answered five of six questions correctly1. There was no discernible signal for the sixth.
Russell Poldrack, a neuroimaging expert at the University of Texas at Austin, calls Owen's methods ingenious. “When I want to give someone examples in which fMRI has told us something we really didn't know before, I use these,” he says.
But Parashkev Nachev, a clinical neuroscientist at Imperial College London, criticizes the work for “assuming that consciousness is a binary phenomenon”. Many patients, such as those having certain types of epileptic seizures, exhibit limited responsiveness without being conscious. Nachev says that more data are needed to indicate where in the continuum of cognitive abilities people in vegetative states fall.
Owen agrees that consciousness is not an “on-or-off thing”. He sees it as an “emergent property” of many “modules” of the brain working together. Enough of these modules are at work in his exercise, he says, for responsive patients to qualify as being conscious. A person needs long-term memory to know what tennis is, short-term memory to remember the question or command and intention to give an answer. Ultimately, Owen is not concerned with pinpointing a threshold of consciousness or with providing a comprehensive definition for it. He takes a “know it if you see it” approach. Responding to commands and questions — communication — is an undeniably conscious activity, in his view. “In the end if they say they have no reason to believe the patient is conscious, I say 'fine, but I have no reason to believe you are either',” he says.
To the clinic
Currently, there are tens of thousands of people in a vegetative state in the United States alone. Owen reckons that up to 20% of them are capable of communicating; they just don't have a way to do so. “What we're seeing here is a population of totally locked-in patients,” Owen says.
Owen now wants to put his technique into the hands of clinicians and family members. So far, the technology has done little. The first woman in the tennis study died last year, and patient 23, for logistic and financial reasons, was assessed only once. Even if a person in a vegetative state is 'found', there is no guarantee that he or she will later be able to return a normal life. Owen nevertheless insists that “clarifying” a patient's state of consciousness helps families to deal with the tragedy. “They want to know what the diagnosis really is so that they can move on and deal with that. Doubt and uncertainty are always bad things.”
Two years ago, Owen was awarded a 7-year Can$10-million Canada Excellence Research Chair and another $10 million from the University of Western Ontario. He is pressing forward with the help of three new faculty members and a troop of postdocs and graduate students.
An early goal of the programme was to repeat the fMRI findings using an electroencephalogram (EEG)7. An EEG lacks fMRI's precision, and it cannot look as deeply into the brain, so the regions active in the tennis study were “off the menu”, says Owen. But other tasks — imagining wiggling a finger or toe — produce signals that, through repetition, become clear. An EEG is also cheap, relatively portable and fast (with milliseconds of lag compared with 8 seconds for fMRI), meaning that the research team can ask up to 200 questions in 30 minutes. “From a single trial you're not going to say, 'that person is saying yes', but if they get 175 of 190 right when tested, it's pretty clear.”
Now, using an EEG, Owen is planning to study 25 people in a vegetative state every year. He will have the help of a new 'EEGeep', a jeep equipped with experimental equipment that will allow the researchers to travel around to test patients who cannot be transported to Western Ontario.
One goal is to identify other brain systems, such as smell or taste, that might be intact and usable for communication. Imagining sucking a lemon, for example, can produce a pH-level change in the mouth and a recognizable brain signal8. Owen has shown that registering jokes provokes a characteristic response in healthy people9 and plans to try it on patients in a vegetative state. He hopes that he can use these tests to find some level of responsiveness in patients who cannot produce the tennis and navigation patterns of activity because of their level of brain damage.
The studies will also explore whether these patients have the capacity for greater intellectual depth. Owen thinks that some people in a vegetative state will eventually be able to express hopes and desires, perhaps like French magazine editor Jean-Dominique Bauby, who dictated his memoirs by repeatedly winking one eye. “I don't see a reason why they could not have a similar richness of thought, although undoubtedly some will not,” Owen says.
His techniques could also radically change treatment. Owen is already asking patients whether they feel pain. The answers will be useful in dosing pain killers, and similar tests could even be used in intensive-care units to guide rehabilitation resources, says Loretta Norton, a graduate student who is undertaking a study for this purpose. But she recognizes that this will be controversial.
Decision time
Owen's methods raise more difficult dilemmas. One is whether they should influence a family's or clinician's decision to end a life. If a patient answers questions and demonstrates some form of consciousness, he or she moves from the 'possibly allowed to die' category to the 'not generally allowed to die' category, says Owens. Nachev says that claiming consciousness for these patients puts families in an awkward position. Some will be given hope and solace that their relative is still 'in there somewhere'. Others will be burdened by the prospect of keeping them alive on the basis of what might be ambiguous signs of communication.
Even more ethically fraught is whether the question should be put to the patients themselves. Fins and Schiff question whether patients would ever be able to show that they can understand the complexities of that question in the way that is normally demanded of, for example, patients giving informed consent.
Owen hopes one day to ask patients that most difficult of questions, but says that new ethical and legal frameworks will be needed. And it will be many years, he says, “before one could be sure that the patient retained the necessary cognitive and emotional capacity to make such a complex decision”. So far, he has stayed away from the issue. “It might be a little reassuring if the answer was 'no' but you can't presuppose that.” A 'yes' would be upsetting, confusing and controversial.
For now, Owen is hoping to use the technology to find other responders like Kate Bainbridge — who Owen now describes as a “motivational force”. “Otherwise,” he says, “what's the point?”
Nature 486, 178–180 ( 14 June 2012 ) doi :10.1038/486178a
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