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Wednesday, June 13, 2012

The Fasrha


The Fasrha (Sanskrit:फरसा) is an Indian battle-axe. It is generally wielded with two hands but could also be used with only one.

Construction

The Fasrha could be double edged or bladed or single-bladed with a spike on the non cutting edge. It usually measures between 3 – 5 feet though some are as long as 7 feet. The Fasrha is usually made of iron or wootz steel. The cutting edge is broader than the edge which is attached to the haft. The haft is often tied with a leather sheet to provide a good grip.

In Hinduism

The Fasrha was the choice weapon of Parashurama, sixth Avatar of Vishnu, whose name means "Rama with the axe". He was one of the few Brahmin guru who were also masters of hand to hand combat. Parashurama was the guru of Dronacharya, the guru who instructed the Pandavas in the epic of the Mahabharata. Bhishma and Karna, half brother of Pandava also took instruction in weaponry from Parashurama, a disciple of lord Shiva, and was known to have terrible temper having lost his father to the evil Asura. In his anger, Parashurama used the Fasrha to get rid of the all the Earth's kshatriya (warrior class) twenty one times over. Parashurama's weapon had supernatural powers. It had four cutting edges, one on each end of the blade head and one on each end of the shaft.

The Fasrha was known as the most lethal close combat weapons of the epics. It is also one of the weapons of the goddess Durga and is still depicted on her idols throughout India.

Tuesday, June 12, 2012

SUCCESS OF MARRIAGE

Once upon a time a married couple celebrated their 25th marriage
anniversary.
They had become famous in the city for not having a single conflict in
their period of 25 years.
Local newspaper editors had gathered at the occasion to find out the
secret
of their well known "happy going marriage".
Editor: "Sir. It's amazingly unbelievable. How did you make this
possible?"
Husband recalling his old honeymoon days said:
"We had been to Shimla for honeymoon after marriage.
Having selected the horse riding finally, we both started the ride on
different horses.
My horse was pretty okay but the horse on which my wife was riding
seemed to be a crazy one.
On the way ahead, that horse jumped suddenly, making my wife topple
over.
Recovering her position from the ground, she patted the horse's back
and said "This is your first time".
She again climbed the horse and continued with the ride. After a
while, it happened again.
This time she again kept calm and said "This is your second time" and
continued.
When the horse dropped her third time, she silently took out the
revolver from the purse and shot the horse dead !!
I shouted at my wife: "What did you do you psycho. You killed the poor
animal. Are you  crazy?" ..

She gave a silent look and said: "This is your first time!!!"."

Husband:"That's it. We are happy ever after."



THANKS & REGARDS
VIPIN KUCHHAL

Sanyasi Yoga




1) If Ketu aspects either Shani or Guru then the person will have spiritual thoughts.

2) If Guru, Surya and Ketu are located in the same sign, or in the same direction or
in the successive sign then the person will practice RAJAYOGA.

3) If Guru, Chandra and Ketu are located in the same sign, or in the same direction
or in the successive sign then the person will practice BHAKTIYOGA.

4) If Guru, Mangal and Ketu are located in the same sign, or in the same direction or in
the successive sign then the person will practice HATTAYOGA.

5) If Guru, Budha and Ketu are located in the same sign, or in the same direction or
in the successive sign then the person will practice GYANAYOGA.

6) If Guru, Shukra and Ketu are located in the same sign, or in the same direction or
in the successive sign then the person will practice KUNDALINIYOGA/SAHAJA
YOGA.

7) If Guru, Shani and Ketu are located in the same sign, or in the same direction or in
If Ketu aspects either Shani or Guru then the person will have spiritual thoughts.

8) If Shani, Surya and Ketu are located in the same sign, or in the same direction or
in the successive sign then the person will practice RAJAYOGA.

9) If Shani, Chandra and Ketu are located in the same sign, or in the same direction
or in the successive sign then the person will practice BHAKTIYOGA.

10) If Shani, Mangal and Ketu are located in the same sign, or in the same direction or in
the successive sign then the person will practice HATTAYOGA.

11) If Shani, Budha and Ketu are located in the same sign, or in the same direction or
in the successive sign then the person will practice GNANAYOGA.

12) If Shani, Sukra and Ketu are located in the same sign, or in the same direction or
in the successive sign then the person will practice KUNDALINIYOGA/SAHAJA
YOGA.

இந்திய மருத்துவத்துறையின் லட்சணத்தை தோலுரித்த அமீர்கான்





“மக்களை ஏமாற்றும் மருத்துவர்களின் லைசென்ஸ் ரத்து செய்யப்பட வேண்டும்” இது சத்யமேவ ஜெயதே நிகழ்ச்சியில் விவாதம் செய்த இந்திய மருத்துவக் கவுன்சில் தலைவரிடம் நிகழ்ச்சி ஒருங்கிணைப்பாளர் அமீர்கான் வைத்த கோரிக்கை.ஸ்டார் ப்ளஸ், டிடி, விஜய் டிவி என மூன்று சேனல்களிலும் ஞாயிறு காலை 11 மணிக்கு சத்யமேவ ஜெயதே நிகழ்ச்சி ஒளிபரப்பாகிறது. அமீர்கான் நடத்தும் இந்த நிகழ்ச்சியில் ஒவ்வொரு வாராமும் முக்கியமான பிரச்சினைகளை எடுத்துக்கொண்டு விவாதம் நடைபெறுகிறது. முதல் வாரத்தில் பெண்கருக்கொலையை மையமாக வைத்து விவாதம் நடைபெற்றது. கருவில் இருக்கும் குழந்தையை ஆணா, பெண்ணா என்று கண்டறிந்து கூறுவதோடு பெண் குழந்தை என்றால் அவற்றை கருவிலேயே அழிக்கும் கொடுமை பற்றி விவாதம் நடைபெற்றது. இந்த நிகழ்ச்சி நாடுமுழுவதும் அதிர்ச்சி அலைகளை ஏற்படுத்தியுள்ளது. இதன் எதிரொலியாக ராஜஸ்தான் மத்திய பிரதேசம் ஆகிய மாநிலங்களில் பெண் கருக்கொலைக்கு காரணமான ஸ்கேன் சென்டர்களின் லைசென்ஸ் ரத்து செய்யப்பட்டுள்ளது.இந்த வாரம் விஜய் டிவியில் ஒளிபரப்பான நிகழ்ச்சியில் இந்திய மருத்துவத்துறையில் என்ன நடந்து கொண்டு இருக்கிறது என்பது பற்றியும் இந்திய மருத்துவத்துறையின் லட்சணம் பற்றியும் புட்டு புட்டு வைத்தார் அமீர்கான். இந்த நிகழ்ச்சியில் பங்கேற்று பேசிய பாதிக்கப்பட்டவர்களின் கருத்து அதிர்ச்சியளிக்கும் படியாக இருந்தது. ஆபரேசன் என்று கூறி பல லட்சம் ரூபாயை கறந்து விட்டு உயிரைக்கூட காப்பாற்ற முடியாத கையாலாகாத மருத்துவர்களைப் பற்றியும், மருத்துவமனைகளைப் பற்றியும் கூறியது நெஞ்சத்தை பதை பதைக்கச் செய்தது. இந்த நிகழ்ச்சியில் இந்திய மருத்துவ கவுன்சிலின் சேர்மன் பேசிய போது அவரிடம் மருத்துவர்களுக்கான கொள்ளை கோட்பாடு பற்றி அமீர்கான் கூறினார். மருத்துவம் என்பது தொழில் அல்ல எனவே மருத்துவர்கள் இதை தொழிலாக பார்க்க கூடாது. சேவையாகத்தான் செய்யவேண்டும். எந்த ஒரு மருத்துவரும் நோயாளியிடம் அவருடைய நோயைக் பற்றி பயமுறுத்தும் வகையில் கூறக்கூடாது. அதேசமயம் அவருக்கு உள்ள நோயைப் பற்றி கண்டிப்பாக தெரிவிக்க வேண்டும். மருத்துவர்கள் பிற மருத்துவமனைக்கு நோயாளியை அனுப்பும் போது அதற்கு கமிசனோ வேறு எந்த அன்பளிப்போ பெறக்கூடாது என்பது கொள்கை.இந்த கொள்கையில் ஒன்றைக்கூட தற்போது மருத்துவர்கள் பின்பற்றுவதில்லை. நோயாளிகளுக்கு நோயினால் ஏற்படும் வேதனையையும், வலியையும் விட மருத்துவமனை நிர்வாகத்தினர் வழங்கும் பில் தொகையே அதிக வேதனை தருவதாக இருக்கிறது என்ற கருத்தை முன் வைத்தார். இதையேதான் ரமணா படத்தில் விஜயகாந்த், “ கடவுளுக்கு அடுத்தபடியாக மக்கள் கையெடுத்துக் கும்பிடுவது டாக்டர்களைத்தான். உங்களை நம்பி வந்த நோயாளிகளை பணத்துக்காக இப்படி ஏமாத்துறீங்களே” என்று கேட்பார். இன்றைக்கு பெரும்பாலான கார்ப்பரேட் மருத்துவமனைகள் நோயாளிகளின் கழுத்தில் கத்திவைக்கும் வேலையைத்தான் செய்கின்றன. வசூல்ராஜாக்களாக செயல்படும் மருத்துவர்களும், மருத்துவமனைகளும் இன்றைக்கு பெருகி வருகின்றன.அரசு மருத்துவமனைகளின் மீது ஏற்படும் நம்பிக்கையின்மையினாலேயே நடுத்தர வர்க்கத்தினர்கள் கார்ப்பரேட் மருத்துவமனைகளை நாடுகின்றனர். அவர்களின் நிலையை அறிந்த பின்னரும் நோய்க்கு ஏற்ற சிகிச்சையை மட்டுமே அளிக்காமல் மருத்துவமனையில் இருக்கும் மெஷினுக்கும் சேர்த்து மருத்துவமனை நிர்வாகங்கள் பில் போடுகின்றன. இப்படி நோயாளிகளை ஏமாற்றும் மருத்துவர்களின் லைசென்ஸ்களை ரத்து செய்ய வேண்டும் என்று இந்திய மருத்துவ கவுன்சிலின் தலைவரிடம் கேட்டுக்கொண்டார் அமீர்கான். மருத்துவர்கள்தான் இப்படி என்றால் மருந்துகளின் விலையோ யானை விலை குதிரை விலையாக இருக்கிறது. ராஜஸ்தான் மாநிலத்தில் ஏழை மக்களுக்கு சகாயவிலையில் மருந்துகள் கிடைக்கும் வகையில் அரசே மருந்தகங்களை செயல்படுத்தி வருகிறது. ஒரு மருந்தை தனியார் மருந்தகங்களில் வாங்குவதற்கும் அரசு மருந்தகங்களில் வாங்குவதற்கும் ஆயிரக்கணக்கான ரூபாய் வித்தியாசம் இருக்கிறது. மருத்துவர்களின் கொள்ளை ஒருபக்கம் மருந்தகங்களின் கொள்ளை ஒருபக்கம் என இரண்டு பக்கமும் மாட்டிக்கொண்டு விழி பிதுங்கி நிற்கின்றனர் ஏழை மற்றும் நடுத்தர வர்க்கத்து நோயாளிகள்இன்றைக்கும் கிராமப்புறங்களில் உள்ள மக்களுக்காக சேவை மனப்பான்மையோடு மருத்துவமனைகளை நடத்திவரும் மருத்துவர்கள் இருக்கத்தான் செய்கின்றனர். எவ்வளவு பெரிய நோய் என்றாலும் அதனை எளிதாக குணப்படுத்தும் மருத்துவர்களை கடவுளுக்கு சமமாக மதிக்கும் மக்கள் இருக்கின்றனர். நாற்பது வருடங்களுக்கு மேலாக கிராமப்புற மக்களுக்காக மருத்துவ சேவை செய்து வரும் டாக்டர் ஆர். முத்துகிருஷ்ணன் எம்.எஸ்., அவர்களிடம் சத்யமேவ ஜெயதே நிகழ்சியில் அமீர்கான் முன்வைத்த குற்றச்சாட்டுகள் குறித்து கேட்டோம். அதற்கு பதிலளித்த அவர் வருத்தத்துடன் இந்த கருத்தை ஒத்துக்கொள்வதாக கூறினார்.
கார்ப்பரேட் மருத்துவமனைகள் இன்றைக்கு நோயாளிகளின் கழுத்தில் கத்தியை வைத்துதான் பணத்தை வசூல் செய்கின்றன என்பதை அவர் ஒத்துக்கொண்டார். மருத்துவத்தொழில் செய்யும் தன்னுடைய அனுபவத்திலேயே தனது சொந்தக்காரர்களுக்கே இதுபோன்ற நிலை ஏற்பட்டதாகவும் உதாரணத்துடன் தெரிவித்தார்.நடுத்த குடும்பத்தைச் சேர்ந்த ஆசாரி தொழில் செய்யும் ஒருவரின் மகள் அபாயமான சூழ்நிலையில் மதுரை அப்பல்லோ மருத்துவமனையில் அனுமதிக்கப்பட்டபோது அவர்களிடம் லட்சக்கணக்கான ரூபாயை வசூல் செய்த பின்பே மருத்துவமனை நிர்வாகம் அவர்களை டிஸ்சார்ஜ் செய்த்தாகவும் அவர் கூறினார். கார்ப்பரேட் மருத்துமனைகள் எதுவும் மருத்துவத்துறைக்கான கொள்கை, கோட்பாடுகளை பின்பற்றுவதில்லை என்றும் அவர் கூறினார். எனவே சத்யமேவ ஜெயதே நிகழ்ச்சியில் கூறியதைப்போல நோயாளிகளை ஏமாற்றும் மருத்துவர்களின் லைசென்ஸ்களை ரத்து செய்வதில் தவறு எதுவும் என்றும் டாக்டர் முத்துகிருஷ்ணன் தெரிவித்துள்ளார்.


முரளி

Scientists identify brain area that determines distance from which sound originates




Brain area identified that determines distance from which sound originatesThis is an image of human cerebral cortex, digitally "inflated" to smooth out normal folds and ridges, showing in red the portion of auditory cortex that responds to the distance from which sounds arrive. Credit: Jyrki Ahveninen, Ph.D., Martinos Center for Biomedical Imaging, Massachusetts General Hospital
Researchers at the Martinos Center for Biomedical Imaging at Massachusetts General Hospital have identified a portion of the brain responsible for determining how far away a sound originates, a process that does not rely solely on how loud the sound is. The investigators' report, which will appear in the early edition of Proceeding of the National Academy of Sciences, is receiving early online release this week.
"Although sounds get louder when the source approaches us, humans are able to discriminate between loud sounds that come from far away and softer sound from a closer source, suggesting that our brains use distance cues independent of loudness," says Jyrki Ahveninen, PhD, of the Martinos Center, senior author of the PNAS report. "Using functional MRI we found a group of neurons in the auditory cortex sensitive to the distance of sound sources and different from those that process changes in loudness. In addition to providing basic scientific information, our results could help future studies of hearing disorders."
The human brain has distinct areas for processing sensory information – signals responsible for vision, hearing, taste etc. Studies of the visual cortex, located at the back of the brain, have produced detailed maps of areas handling particular portions of the visual field. But understanding of the auditory cortex, located on the side of the head above and behind the ear, is quite limited. While it is known that the portion of the auditory cortex extending toward the back of the head determines where a sound comes from, exactly how the brain translates complex auditory signals to determine both the location and distance from which a sound originates is not yet known.
In their search for auditory neurons that process sound distance, the research team faced some particular challenges. In research laboratories that study hearing, sounds must be delivered to study participants through headphones, which means the acoustical "space" in which a sound is generated must be simulated. This must be done with exquisite accuracy, since environmental aspects causing sound to reverberate probably contribute to distance perception. Since the MRI equipment itself generates a loud noise, the researchers scanned participants' brains once every 12 seconds to measure responses to sounds presented during intervening quiet periods.
In the first experiment, study participants – 12 adults with normal hearing – listened to a series of paired sounds of varying degrees of loudness and at simulated distances ranging from 15 to 100 cm and were asked to indicate whether the second sound was closer or farther away than the first. Although the differences in loudness varied randomly, participants were quite accurate in distinguishing the simulated distances of the sounds. Acoustical analysis of the particular sound cues presented indicated that the reverberations produced by a sound, which are more pronounced in a closed environment and for sounds traveling farther, may be more important distance cues than are the differences between sounds perceived by a participant's two ears.
After the first experiment confirmed the accuracy of the simulated acoustical environment, functional MR images taken while participants listened to another series of paired sounds recorded how activity in the auditory cortex changed in response to sounds of varying loudness and direction as well as during sound of constant levels and silence. The images produced identified a small area that appears to be sensitive to cues indicating distance but not loudness. As far as the investigators know, this is the first time neurons sensitive to sound-source distances have been discovered.
"The identified area is located near other auditory cortical areas that process spatial information," says corresponding author Norbert Kopco, PhD. "This is consistent with a general model of perceptual processing in the brain, suggesting that in hearing, as in vision and other senses, spatial information is processed separately from information about the object's identity or characteristics such as the musical pitch of sound. Our study also illustrates how important it is to combine expertise from different fields – in our case imaging/physiology, psychology, and computational neuroscience – to advance our understanding of such a complex system as the human brain."
Provided by Massachusetts General Hospital
"Scientists identify brain area that determines distance from which sound originates." June 11th, 2012. http://medicalxpress.com/news/2012-06-scientists-brain-area-distance.html
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New stroke treatment could prevent and reduce brain damage




New stroke treatment could prevent and reduce brain damageZezong Gu, M.D., Ph.D., right, and Jiankun Cui, M.D., both assistant professors of pathology and anatomical sciences, are studying a new compound designed to stop the spread of brain bleeds and protect brain cells from further damage in the crucial hours after a stroke. Stroke is a leading cause of death in the US with more than 800,000 deaths occurring each year from stroke and other cardiac events. Credit: University of Missouri School of Medicine
Researchers at the University of Missouri have demonstrated the effectiveness of a potential new therapy for stroke patients in an article published in the journal Molecular Neurodegeneration. Created to target a specific enzyme known to affect important brain functions, the new compound being studied at MU is designed to stop the spread of brain bleeds and protect brain cells from further damage in the crucial hours after a stroke.
Stroke is a leading cause of death in the U.S. with more than 800,000 deaths occurring each year from stroke and other cardiac events. Other than surgery, existing emergency treatments for stroke victims such as the use of a tissue plasminogen activator (tPA) must be administered within hours of the stroke onset because of the risk for brain hemorrhaging. The injectable medication can only be used to treat the most common type of stroke that occurs when blood clots block blood flow to the brain, called ischemic stroke.
"For a stroke victim, time is a matter of life and death. While we are still in the research phase for this type of compound, we believe it could be combined with tPA in the future to buy ischemic stroke patients a longer window of time to receive emergency treatment," said Zezong Gu, MD, PhD, the article's corresponding author and assistant professor of pathology and anatomical sciences at the MU School of Medicine. The new compound being studied also has potential for use in patients experiencing hemorrhagic stroke, which is a less common type of stroke caused by bleeding within the brain, Gu said.
MU researchers collaborated with a team at the University of Notre Dame to study the effects of the new compound, a thiirane class of gelatinase selective inhibitors, on the function of a type of matrix metalloproteinase (MMP) enzyme, particularly MMP-9. MMP-9 is part of a group of more than 20 enzymes or MMPs that are known to contribute to many key pathological events in the brain after stroke, traumatic brain injury and other neurodegenerative events.
In 2005, Gu served as a lead author on a research paper published in the Journal of Neuroscience that identified MMP-9 as a promising target for development of therapeutic drugs for stroke patients. Since then, his lab at MU medical school's Center for Translational Neuroscience has been studying the function of MMP enzymes and how to inhibit the harmful effects of MMP-9.
"MMPs play a role in the structure of blood vessels in the brain and are also needed in the interactions between cells during development and tissue remodeling," Gu said. "Unregulated, the activity of these enzymes contributes to neurological disorders and stroke. With this compound, we've now confirmed a potential method to rescue the blood vessels from the damaging effects of MMP-9 and protect neurons at the same time."
MU researchers successfully used a model of ischemic stroke in mice and studied the effects of the MMP-9 inhibitor compound on brain activity after a stroke.
"Our lab at the Center for Translational Neuroscience is one of only a few in the United States that has successfully induced a blood clot in the brains of mice," said Jiankun Cui, MD, the article's lead author and assistant professor of pathology and anatomical sciences at the MU School of Medicine. "To be able to study the effectiveness of this potential new treatment under these conditions provides us with a highly unique set of data showing this compound can disrupt key harmful pathological events that occur after a stroke."
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Treating childhood anxiety with computers, not drugs




According to the Anxiety and Depression Association of America, one in eight children suffers from an anxiety disorder. And because many anxious children turn into severely anxious adults, early intervention can have a major impact on a patient's life trajectory. The understandable reluctance to use psychiatric medications when it comes to children means child psychologists are always searching for viable therapeutic alternatives.
Now Prof. Yair Bar-Haim of Tel Aviv University's School of Psychological Sciences and his fellow researchers are pursuing a new method to address childhood anxiety. Based on a computer program, the treatment uses a technique called Attention Bias Modification (ABM) to reduce anxiety by drawing children away from their tendency to dwell on potential threats, ultimately changing their thought patterns. In its initial clinical trial, the program was as effective as medication and cognitive therapy for children — with several distinct advantages.
The results of the trial were reported in the American Journal of Psychiatry.
Computers instead of capsules
Children are comfortable with computers, explains Prof. Bar-Haim. And because of the potential side effects of medications or the difficulty in obtaining cognitive behavioral therapy, such as the need for highly trained professionals, it is good to have an alternative treatment method. ABM treatments can be disseminated over the Internet or administered by personnel who don't have to be Ph.D.s. "This could be a game-changer for providing treatment," he says.
Anxious individuals have a heightened sensitivity towards threats that the average person would ignore, a sensitivity which creates and maintains anxiety, says Prof. Bar-Haim. One of the ways to measure a patient's threat-related attention patterns is called the dot-probe test. The patient is presented with two pictures or words, one threatening and one neutral. These words then disappear and a dot appears where one of the pictures or words had been, and the patient is asked to press a button to indicate the dot's location. A fast response time to a dot that appears in the place of the threatening picture or word indicates a bias towards threat.
To turn this test into a therapy, the location of the dot target is manipulated to appear more frequently beneath the neutral word or picture. Gradually, the patient begins to focus on that stimulus instead, predicting that this is where the dot will appear — helping to normalize the attention bias pattern and reduce anxiety.
Prof. Bar-Haim and his colleagues enlisted the participation of 40 pediatric patients with ongoing anxiety disorders and divided them into three groups. The first received the new ABM treatment; the second served as a placebo group where the dot appeared equally behind threatening and neutral images; and the third group was shown only neutral stimuli. Patients participated in one session a week for four weeks, completing 480 dot probe trials each session.
The children's anxiety levels were measured before and after the training sessions using interviews and questionnaires. In both the placebo group and neutral images group, researchers found no significant change in the patients' bias towards threatening stimuli. However, in the ABM group, there were marked differences in the participants' threat bias. By the end of the trial, approximately 33 percent of the patients in this group no longer met the diagnostic criteria for anxiety disorder.
New methods for personalized treatment
These indications of the method's success in treating children warrant further investigation, says Prof. Bar-Haim. In collaboration with the National Institute of Mental Health in the US, a large international trial involving his computer program is now being carried out at more than 20 sites across five continents.
The more options that exist for patients, the better that clinicians can tailor treatment for their patient's individual needs, Prof. Bar-Haim observes. There are always patients for whom medication or cognitive therapy is not a viable option, he explains. "Psychological disorders are complex, and not every patient will respond well to every treatment. It's great to have new methods that have a basis in neuroscience and clinical evidence."
Provided by Tel Aviv University
"Treating childhood anxiety with computers, not drugs." June 11th, 2012. http://medicalxpress.com/news/2012-06-childhood-anxiety-drugs.html
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Dealing with depression




Dealing with depression(Medical Xpress) -- A technique which helps people control activity in a specific part of their brain could be used to help ease depression, University research has found.
Published in the journal, PLoS ONE, Professor David Linden, School of Psychology, from Cardiff University’s Brain Research Imaging Centre (CUBRIC) and his team found that a technique known as Neurofeedback helped ease depression symptoms.
Neurofeedback involves patients going into an MRI scanner where their brain activity is continuously measured with functional magnetic resonance imaging (fMRI) and fed back to them.
The same research group has already applied this technique to Parkinson’s disease.
In the present study, eight patients with depression were shown positive, negative and neutral pictures to help identify areas in their brain that were engaged in the processing of positive emotions.
The patients were then asked to increase the activity in this area by engaging in positive emotional imagery. During this task patients received feedback via a thermometer display on how well they were doing so they could test the effectiveness of different mental strategies.
"This was the first time this Neurofeedback procedure has been used in depression," according to Professor Linden, who led the research.
Using this technique, the researchers found that all patients were able to control the activity in the targeted emotion networks. Their depression improved significantly after the interventions. Their medication dose was not changed during the study.
Another eight patients that had been assigned to the control group performed exactly the same positive emotion imagery task outside the scanner, but this group did not show any clinical improvements.
Professor Linden added: "The findings of the initial pilot study are preliminary and further research is required to assess the possible clinical benefits to patients. We do not expect this to become a stand-alone treatment tool, but rather a potential part of comprehensive treatment packages."
The team has already started a larger randomised controlled trial, funded by the Medical Research Council (MRC), to evaluate the potential therapeutic effects on depression.
"One of the interesting aspects of this technique is that it gives patients the experience of controlling aspects of their own brain activity. Many of them were very interested in this new way of engaging with their brain," Professor Linden added.
Provided by Cardiff University
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Keeping pace: Walking speed may signal thinking problems ahead




A new study shows that changes in walking speed in late life may signal the early stages of dementia known as mild cognitive impairment (MCI). The research is published in the June 12, 2012, print issue of Neurology, the medical journal of the American Academy of Neurology.
"In our study, we used a new technique that included installing infrared sensors in the ceilings of homes, a system designed to detect walking movement in hallways," said study author Hiroko Dodge, PhD, with Oregon Health and Science University in Portland and a member of the American Academy of Neurology. "By using this new monitoring method, we were able to get a better idea of how even subtle changes in walking speed may correlate with the development of MCI."
The study involved 93 people age 70 or older who lived alone. Of those, 54 participants had no cognitive impairment, 31 had non-memory related MCI and eight had memory-related MCI. Participants were given memory and thinking tests and had their walking speed monitored at their homes unobtrusively over a three-year period. Participants were placed in groups of slow, moderate or fast based on their average weekly walking speed and how much their walking speed fluctuated at home.
The study found that people with non-memory related MCI were nine times more likely to be slow walkers than moderate or fast walkers and the amount of the fluctuation in walking speed was also associated with MCI.
"Further studies need to be done using larger groups of participants to determine whether walking speed and its fluctuations could be a predictor of future memory and thinking problems in the elderly," said Dodge. "If we can detect dementia at its earliest phases, then we can work to maintain people's independence, provide treatments and ultimately develop ways to prevent the disease from developing. Our in-home monitoring approach has a lot of potential to be used for sustaining independence of the elderly."
Provided by American Academy of Neurology
"Keeping pace: Walking speed may signal thinking problems ahead." June 11th, 2012. http://medicalxpress.com/news/2012-06-pace-problems.html
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Chinese mindfulness meditation prompts double positive punch in brain white matter



Scientists studying the Chinese mindfulness meditation known as integrative body-mind training (IBMT) say they've confirmed and expanded their findings on changes in structural efficiency of white matter in the brain that can be related to positive behavioral changes in subjects practicing the technique regularly for a month.
In a paper appearing this week in the online Early Edition of the Proceedings of the National Academy of Sciences, scientists Yi-Yuan Tang and Michael Posner report improved mood changes coincided with increased axonal density -- more brain-signaling connections -- and an expansion of myelin, the protective fatty tissue that surrounds the axons, in the brain's anterior cingulate region.
Deficits in activation of the anterior cingulate cortex have been associated with attention deficit disorder, dementia, depression, schizophrenia and many other disorders.
IBMT was adapted from traditional Chinese medicine in the 1990s in China, where it is practiced by thousands of people. It differs from other forms of meditation because it depends heavily on the inducement of a high degree of awareness and balance of the body, mind and environment. The meditative state is facilitated through training and trainer-group dynamics, harmony and resonance.
In 2010, research led by Tang, a visiting research professor at the University of Oregon, and Michael I. Posner, professor of psychology at the UO, first reported positive structural changes in brain connectivity, based on functional magnetic resonance imaging, that correlated to behavioral regulation. The study was done in the UO's Robert and Beverly Lewis Center for Neuroimaging with 45 participating UO undergraduate students.
The new findings came from additional scrutiny of the 2010 study and another that involved 68 undergraduate students at China's Dalian University of Technology. The researchers revisited data obtained from using an MRI technique known as diffusion tensor imaging. The research team found improved density of the axons involved in brain connections but no change in myelin formation after two weeks. After a month, or about 11 hours of IBMT, both increases in axon density and myelin formation were found as measured by fractional anisotropy, axial diffusivity and radial diffusivity -- the important indexes for measuring the integrity of white matter fibers.
"This dynamic pattern of white matter change involving the anterior cingulate cortex, a part of the brain network related to self-regulation, could provide a means for intervention to improve or prevent mental disorders," the authors concluded.
"When we got the results, we all got very excited because all of the other training exercises, like working-memory training or computer-based training, only have been shown to change myelination," Tang said. "We believe these changes may be reflective of the time of training involved in IBMT. We found a different pattern of neural plasticity induced by the training."
"This study gives us a much more detailed picture of what it is that is actually changing," Posner said. "We did confirm the exact locations of the white-matter changes that we had found previously. And now we show that both myelination and axon density are improving. The order of changes we found may be similar to changes found during brain development in early childhood, allowing a new way to reveal how such changes might influence emotional and cognitive development."
The improved mood changes noted in this and earlier studies are based on self-ratings of subjects based on a standard six-dimensional mood-state measure, said Tang, who is now the director of Texas Tech University's Neuroimaging Institute and holder of the Presidential Endowed Chair in Neuroscience in TTU's psychology department.
Tang and Posner first reported findings related to IBMT in 2007, also in PNAS. They found that doing IBMT for five days prior to a mental math test led to low levels of the stress hormone cortisol among Chinese students. The experimental group also showed lower levels of anxiety, depression, anger and fatigue than students in a relaxation control group.
In 2009 in PNAS, Tang and his Chinese colleagues, with assistance from Posner and UO psychology professor Mary K. Rothbart, found that IBMT subjects in China had increased blood flow in the right anterior cingulate cortex after receiving training for 20 minutes a day over five days. Compared with the relaxation group, IBMT subjects also had lower heart rates and skin conductance responses, increased belly breathing amplitude and decreased chest respiration rates.
"These new findings provide fundamental new insights on how the brain responds in positive ways to new inputs and reflect the excellence in cognitive neuroscience research that has defined Michael Posner's work at the University of Oregon," said Kimberly Andrews Espy, vice president for research and innovation. "The research by professors Posner and Tang also reflects the university's long-running commitment to collaborate with institutions in Pacific Rim countries."
More information: “Mechanisms of white matter changes induced by meditation,” by Yi-Yuan Tang et al., PNAS, 2012.
Provided by University of Oregon
"Chinese mindfulness meditation prompts double positive punch in brain white matter." June 11th, 2012. http://medicalxpress.com/news/2012-06-chinese-meditation-ibmt-prompts-positive.html
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First Nations and low-income children visit emergency departments more often for mental health care




First Nations children and those from families receiving government subsidies had more return visits to emergency departments for mental health crises than other socioeconomic groups, found a study published in CMAJ (Canadian Medical Association Journal).
"We found that more First Nations children presented to emergency departments for disorders secondary to substance abuse and intentional self-harm than other children, and that, compared with other children, First Nations children returned more quickly to the emergency department and had a longer time before visiting a physician in the post-crisis period," writes Dr. Amanda Newton, Departments of Pediatrics and Psychiatry, University of Alberta, with coauthors.
Emergency departments are often the first access point for children with mental health issues who have not received care previously or are in crisis. Although some US research has shown a relationship between race, ethnic background and socioeconomic status and more emergency department visits, there is little Canadian information on the topic.
To determine whether sociodemographic factors influence emergency department visits for mental health care, researchers conducted a population-based cohort analysis of 30 656 visits by 20 956 children under 18 years of age to 104 emergency departments in Alberta between Apr. 1, 2002 and Mar. 31, 2008.
During the six-year study period, First nations children represented 6% of the province's pediatric population; children from families receiving welfare made up 3% and children from families receiving government subsidies made up 14%. However, children in these groups had significantly more visits for emergency mental health care than families with no health care subsidy: 13.8% of visits (4230/30 656) were from First Nations children, 6.4% (1972/30 656) from children in families receiving welfare, and 18.7% (5739/30 656) from children in families receiving government subsidies compared with children in whose families did not receive government subsidies.
"Visits to the emergency department for mental health care should be considered a 'stop gap' solution in the full suite of mental health services," write the authors. "For many children, these visits reflect a need for earlier intervention to prevent illness destabilization into crisis."
Across all socioeconomic groups, more girls and youth aged 15 to 17 years sought emergency mental health care compared with boys and other age groups. Anxiety- or stress-related disorders and emotional or behavioural issues from substance abuse were the most common diagnoses.
In addition, children from First Nations families and those receiving government subsidies returned earlier to the emergency department than other demographic groups. Increasing age and an unspecific diagnosis were also factors associated with earlier returns.
"These findings suggest that investments in culturally based, community- and school-based resources targeting the high-risk behaviours seen in the emergency department may help to reduce crisis events and foster the use of mental health resources," write the authors.
Provided by Canadian Medical Association Journal
"First Nations and low-income children visit emergency departments more often for mental health care." June 11th, 2012.http://medicalxpress.com/news/2012-06-nations-low-income-children-emergency-departments.html
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The complexities of cognitive comparisons




The complexities of cognitive comparisons
Are the red dots bigger than the blue dots? New research about the way people answer this question may shed light on our cognitive processes. Image courtesy Noah Goodman, Peter Graff and Gregory Scontras
Which mountain range is bigger, the Rockies or the Alps?
The answer depends on how you compare them. The Alps reach a greater height, and the 10 highest peaks in the Alps are taller in sum than the 10 highest peaks in the Rockies. Then again, the Rockies have three times as many peaks over 4,000 meters, or 13,000 feet, and the main spine of the Rockies runs about five times as far as that of the Alps — meaning the Rockies surely contain a greater volume of mountains.
In short, comparing groups of objects can be tricky, especially when we are evaluating their characteristics, and not just the number of members in each group. So how does the mind process these kinds of comparisons and turn them into linguistic statements?
In the past, linguists exploring this issue have asserted that “plural comparison follows from comparing every individual in one set with every individual in another set,” says Peter Graff, a doctoral student in MIT’s Department of Linguistics and Philosophy. Suppose we ranked every high peak in the Alps and Rockies, put the lists side by side, and found that at each point in the rankings, the Alpine peak was taller. Then we would have a straightforward method for stating that the Alps are bigger, or at least taller, based on a series of individual comparisons.
But in research recently published in the journal Cognition, Graff and two co-authors dig into the nature of comparison, and find something different. When we compare groups of this sort, our minds don’t construct a series of individual comparisons. Instead, “plural entities are represented as entities with their own properties,” as their paper states. Our minds choose some line of comparison — average size, or sum of the sizes, for instance — and then compare groups, as groups, on that basis.
“You can ascribe a property to a plurality, namely an average statistic, which may not necessarily be true of any of its members,” says Gregory Scontras, a doctoral student in linguistics at Harvard University and another co-author of the paper.
Probably right
To arrive at this conclusion, the researchers — Graff, Scontras, and Noah Goodman, an assistant professor of cognitive psychology at Stanford University and a former research scientist in MIT’s Department of Brain and Cognitive Sciences — conducted a series of experiments in which 43 respondents compared groups of five blue dots and five red dots, and were asked if the red dots were bigger than the blue dots. The subjects saw 32 iterations of the comparison, in which the sizes of all the dots varied; the largest dot size was seven times bigger than the smallest. But in very few iterations was there a rule of thumb that could be used, such as all blue dots being bigger than the biggest red dot.
The result? Respondents scored highest, over the 32 rounds of comparisons, when intuitively averaging the mean size of the dots, rather than looking at any attribute of any particular dot.
In a follow-up experiment, the researchers had 40 respondents look at 32 iterations of the dots again to see if people were judging size according to the mean size or the sum of the sizes. When the mean size of the dots conflicted with the sum size, respondents would render their verdict largely based on the mean size.
For the researchers, two conclusions follow: First, Scontras says, the point of the research “wasn’t that in all cases you’re going to find an average statistic from each plurality and compare that.” Rather, he points out, groups “can have aggregate statistics attributed to them that might not be true of any individual member,” something that “has not yet been shown in the linguistics literature.”
Second, as Graff notes, “The underlying process that underlies those judgments is probabilistic in nature.” That is, respondents do not have a deterministic method for deriving the results, and they do not always judge the same evidence the same way. That creates a little statistical noise around the results; for any given comparison, answers will take the form of a probability distribution. However, the respondents erred most frequently when the mean sizes of the red and blue dots were, in fact, very close to each other. Thus, Graff adds, “This work shows that the noise in these judgments is not random. So it becomes harder to maintain the hypothesis that the underlying process is categorical,” or rule-based.
That, in turn, may have implications for the way linguists analyze how we create and express truth statements. “The goal of formal semantics is to come up with the algorithm we use to determine if something is true or false,” Scontras says. “We want something deterministic. And what we’re finding here is that … the processes that determine the meanings we are using in language are themselves probabilistic.”
Other scholars have found the research promising. “This work is important because it shows that very abstract conceptual principles guide how we organize and store basic perceptual information,” says David Barner, a professor of psychology at the University of California at San Diego, who has read the paper. He adds: “Logical models of reasoning and language since Aristotle have treated individuals as fundamental, and so you might think that all sentence meanings could be described building up from statements about individuals. … This work suggests that language may be more clever than this, and may allow us to create complex things, or ‘plural objects.’”
Barner, who specializes in language acquisition among children, notes that the paper also relates to the issue of whether “infants could acquire abstract logical representations like those we find in language, and whether some of these capacities are present before infants begin to use and comprehend language. … Getting an idea of how these [capacities] work in adults, using a simple method like this, lays out a very clear path forward for understanding how language emerges in humans.”
The researchers are now conducting additional experiments about the ways people compare pluralities. By creating a variety of scenarios and changing the particular measure being compared — such as weight, height and size — they are looking at how the linguistic context can influence the way people compare these complex groups.
Provided by Massachusetts Institute of Technology
This story is republished courtesy of MIT News (http://web.mit.edu/newsoffice/), a popular site that covers news about MIT research, innovation and teaching.
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Molecular imaging finds link between low dopamine levels and aggression



Out of control competitive aggression could be a result of a lagging neurotransmitter called dopamine, say researchers presenting a study at the Society of Nuclear Medicine's 2012 Annual Meeting. During a computer game against a putative cheating adversary, participants who had a lower capacity to synthesize this neurotransmitter in the brain were more distracted from their basic motivation to earn moneyand were more likely to act out with aggression.
For many people, anger is an almost automatic response to life's challenges. In clinical psychiatry, scientists look at not only the impact of aggressive behavior on the individual, their loved ones and the community but also the triggers in the brain that lead to aggressive response. The neurobiology of aggression is not well understood, but scientists are aware of a relationship between the neurotransmitter serotonin and certain aggressive behaviors. The objective of this study was to explore whether higher levels of another brain chemical called dopamine, involved in pleasure and reward, increased aggressive response in its subjects. To scientists' surprise, it was not as they first theorized.
"The results of this study were astonishingly opposite of what was previously hypothesized," says Ingo Vernaleken, M.D., lead author of the study and research scientist for the department of psychiatry at RWTH Aachen University in Aachen, Germany. "Subjects with more functional dopaminergic reward-systems were not more aggressive in competitive situations and could concentrate even more on the game. Subjects with lower dopaminergic capacity were more likely to be distracted by the cheating behavior."
In this study, 18 healthy adults in their twenties were tested for aggression using the psychological behavioral task known as the point subtraction aggression paradigm (PSAP). Participants were asked to play a computer game that required them to press a bar multiple times with the incentive of winning money, but they were also told that an adversary in the next room who is able to cheat may steal some of their winnings. What the paranoid participants did not know was that there was no adversary. The computer program is designed to perform randomized deductions of the subjects' monetary reward to simulate the cheating competitor.The participant had three choices to react: punish the cheater, shield against the adversary by repeatedly pressing a defense button, or continue playing the game in order to maximize their ability to win cash, which indicated resilience.
"The PSAP focuses on aggressive reaction within a competitive situation," says Vernaleken. "Aggression and its neurobiological mechanisms in humans have been only moderately investigated in the past. Furthermore, most of the previous studies mainly covered the more reactive part of aggression, which merely reflects impulsive behavior and appears to be associated merely with the serotonin system. This investigation focuses on the association with the dopaminergic reward-system, which reflects goal-directed aggression."
Subjects' brains were imaged using positron emission tomography, which provides a range of information about physiological functions inside the body, depending on the imaging probe used. In this investigation, F-18 FDOPA, a biomarker that lights up enzymes' ability to synthesize this transmitter, was used and the uptake of this drug in the brain was analyzed to gauge the correlation between the participants' dopamine synthesis capacity and aggressive behavior.
Results of the study showed a significant impact on aggressive response in areas in the brain where dopamine synthesis was present, especially in the basal ganglia, which among other functions include the motivation center. Minimized aggression was associated with higher dopamine levels in both the midbrain and the striatum, which plays a role in planning and executive function. People with greater capacity for dopamine synthesis were more invested in the monetary reward aspect of the PSAP, instead of acting in defense or with aggression against their perceived adversary, whereas subjects with lower capacities had a higher vulnerability to act either aggressive, defensive or both.
"Thus, we think that a well-functioning reward system causes more resilience against provocation," says Vernaleken. "However, we cannot exclude that in a situation where the subject would directly profit from aggressive behavior, in absence of alternatives, the correlation might be the other way around."
Further research is required to explore the link between dopamine and a range of aggressive behavior. More insight into these relationships could potentially lead to new psychological therapies and drug treatments to moderate or prevent aggressive response.
Provided by Society of Nuclear Medicine
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