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Tuesday, February 21, 2012

Free Medicine for Blood Cancer (Leukemia) available at Adyar - Cancer Institute Chennai !!!!




  
  Dear All,

Medicine for Blood Cancer (Lukemia)!!!!

Please don't delete this without forwarding.
I am forwarding it to the maximum I can. 
 
'Imitinef Mercilet' is a medicine which cures blood cancer. Its available free of cost at "Adyar Cancer Institute in Chennai".
Create Awareness. It might help someone.

Forward to as many as u can, kindness costs nothing.
Cancer Institute in Adyar, Chennai

Category: 
           Cancer
Address: 
             East Canal Bank Road , Gandhi Nagar 
                              Adyar 
                               Chennai -600020 
                               Landmark: Near Michael School 
                               Phone: 044-24910754 044-24910754 , 044-24911526 044-24911526 , 044-22350241 044-22350241



 

Right choice, but not the intuitive one




When faced with a tough choice, we already have the cognitive tools we need to make the right decision, Daniel Gilbert, a professor of psychology at Harvard, told his Law School audience. Credit: Jon Chase/Harvard Staff Photographer
To take a gratifying, low-paying job or a well-paid corporate position, to get married or play the field, to move across the country or stay put: The fact that most people face such choices at some point in their lives doesn’t make them any easier. No one knows the dilemma better than law students, who are poised to enter a competitive job market after staking years of study on their chosen field.
When faced with a tough choice, we already have the cognitive tools we need to make the right decision, Daniel Gilbert, professor of psychology at Harvard and host of the PBS series “This Emotional Life,” told a Harvard Law School (HLS) audience on Feb. 16. The hard part is overcoming the tricks our minds play on us that render rational decision-making nearly impossible.
Gilbert’s talk, titled “How To Do Precisely the Right Thing at All Possible Times,” was part of Living Well in the Law, a new program sponsored by the HLS Dean of Students Office that aims to help law students consider their personal and professional development beyond the fast track of summer associate positions and big-law job offers.
There is a relatively simple equation for figuring out the best course of action in any situation, Gilbert explained: What are the odds of a particular action getting you what you want, and how much do you value getting what you want? If you really want something, and you identify an action that will make it likely, then taking that action is a good move.
Unfortunately, Gilbert said, “these are also the two ways human beings screw up.”
First, he said, humans have a hard time estimating how likely we are to get what we want. “We know how to calculate odds [mathematically], but it’s not how we actually calculate odds,” he said.
We buy lottery tickets, because we “never see interviews with lottery losers.” If every one of the 170 million losing ticket holders were interviewed on television for 10 seconds apiece, we’d be having the image of losing drilled into our brains for 65 straight years, he said.
“When something’s easy to imagine, you think it’s more likely to happen,” he said.
For example, if asked to guess the number of annual deaths in the United States by firework accidents and storms versus asthma and drowning, most people will vastly overestimate the former and underestimate the latter. That’s because we don’t see headlines when someone dies of an asthma attack or drowns, Gilbert said. “It’s less available in your memory, but it is in fact more frequent.”
Then there’s the fact that we’re prone to irrational levels of optimism, a pattern that has been documented across all areas of life. Sports fans in every city believe their team has better-than-average odds of winning; the vast majority of people believe they’ll live to be 100.
A study of Harvard seniors, Gilbert gleefully reported, showed they on average believed they’d finish their theses within 28 to 48 days, but most likely within 33 — “a number virtually indistinguishable from their best-case scenario.” In reality, they complete their theses within 56 days on average.
Still, he said, calculating our odds of success is actually the easy part. “What’s really hard in life is knowing how much you’re going to value the thing you’re striving so hard to get,” he said.
When we consider buying a $2 cup of coffee at Starbucks, for example, we don’t compare the satisfaction of a morning caffeine jolt against the millions of other things we could purchase for $2. Rather, we compare the value of that cup of coffee against our own past experiences. If the same coffee only cost $1.50 yesterday, we might balk at paying $2 for it today.
“One of the problems with this bias, this tendency to pay attention to change, is that it’s hard to know if things really did change,” he said. “Whether things changed is often in the eye of the beholder.
“It turns out that every form of judgment works by comparison,” he said. “People shop by comparison.” Unfortunately, our comparisons are easily manipulated, and comparing one option with all other possible options is an impossible task.
Real estate companies, for example, show potential buyers “set-up properties,” rundown fixer-uppers that they actually own, to lower their clients’ expectations for houses that are actually for sale.
In his own lab, Gilbert’s research team had two groups of college students predict how much they would enjoy eating a bag of potato chips. The group that sat in a room with chocolates on display predicted they’d enjoy the chips less, while the second group — stuck in a room with the chips and a variety of canned meats — predicted much higher enjoyment of the salty snack.
But when the students rated their enjoyment of the chips while they were eating them, those differences disappeared. While their previous visual judgment was tainted by comparison, their judgment of the actual taste was not.
“The comparisons you make when you’re shopping are not the ones you’ll make after you’ve bought,” Gilbert said.
The human mind evolved to deal with different dilemmas than the ones we face today, Gilbert explained. Our ancestors weighed short-term consequences to ensure their survival, evolving a snap-judgment process that often serves us poorly when making long-term decisions such as buying a home, investing in the stock market, or making a cross-country move.
The brain “thinks like the old machine it is,” Gilbert said. “We are in some sense on a very ancient vessel, and we are sailing a very ancient sea.”
Still, he told his audience, we have the ability to overcome these evolutionary roadblocks to self-aware, smart decision-making, as long as we acknowledge our biases.
“We’ve been given that gift,” Gilbert said. “The question is, will we use it?”
Provided by Harvard University
This story is published courtesy of the Harvard Gazette, Harvard University's official newspaper. For additional university news, visitHarvard.edu.
"Right choice, but not the intuitive one." February 20th, 2012. http://medicalxpress.com/news/2012-02-choice-intuitive.html
Posted by
Robert Karl Stonjek

New transistor has one atom



THE UNIVERSITY OF NEW SOUTH WALES   



In a remarkable feat of micro-engineering, UNSW physicists have created a working transistor consisting of a single atom placed precisely in a silicon crystal.
The tiny electronic device, described today in a paper published in the journal Nature Nanotechnology, uses as its active component an individual phosphorus atom patterned between atomic-scale electrodes and electrostatic control gates.
This unprecedented atomic accuracy may yield the elementary building block for a future quantum computer with unparalleled computational efficiency.
Until now, single-atom transistors have been realised only by chance, where researchers either have had to search through many devices or tune multi-atom devices to isolate one that works.
“But this device is perfect”, says Professor Michelle Simmons, group leader and director of the ARC Centre for Quantum Computation and Communication Technology at UNSW. “This is the first time anyone has shown control of a single atom in a substrate with this level of precise accuracy.”
The microscopic device even has tiny visible markers etched onto its surface so researchers can connect metal contacts and apply a voltage, says research fellow and lead author Dr Martin Fuechsle from UNSW.
“Our group has proved that it is really possible to position one phosphorus atom in a silicon environment - exactly as we need it - with near-atomic precision, and at the same time register gates,” he says. 
The device is also remarkable, says Dr Fuechsle, because its electronic characteristics exactly match theoretical predictions undertaken with Professor Gerhard Klimeck’s group at Purdue University in the US and Professor Hollenberg’s group at the University of Melbourne, the joint authors on the paper.
The UNSW team used a scanning tunnelling microscope (STM) to see and manipulate atoms at the surface of the crystal inside an ultra-high vacuum chamber. Using a lithographic process, they patterned phosphorus atoms into functional devices on the crystal then covered them with a non-reactive layer of hydrogen.
Hydrogen atoms were removed selectively in precisely defined regions with the super-fine metal tip of the STM. A controlled chemical reaction then incorporated phosphorus atoms into the silicon surface.
Finally, the structure was encapsulated with a silicon layer and the device contacted electrically using an intricate system of alignment markers on the silicon chip to align metallic connects. The electronic properties of the device were in excellent agreement with theoretical predictions for a single phosphorus atom transistor.  
It is predicted that transistors will reach the single-atom level by about 2020 to keep pace with Moore’s Law, which describes an ongoing trend in computer hardware that sees the number of chip components double every 18 months.
This major advance has developed the technology to make this possible well ahead of schedule and gives valuable insights to manufacturers into how devices will behave once they reach the atomic limit, says Professor Simmons.
Watch the video here.
Editor's Note: Original news release can be found here.

‘Infertile’ women need more time



THE UNIVERSITY OF QUEENSLAND   



One-in-four women with a history of infertility can still end up having a baby without treatment, a new study from The University of Queensland (UQ) shows.

The study led by Dr Danielle Herbert, from the School of Population Health and Centre for Clinical Research, reveals that women who have been clinically diagnosed as infertile after 12 months of unsuccessfully trying for a baby may actually just need longer to conceive.

"Many women aged up to 36 years with a history of infertility, especially those who have already had a baby, can achieve spontaneous conception and live birth without using fertility treatment indicating they are sub-fertile rather than infertile," Dr Herbert said.

The study shows one-in-four Australian women aged 28-36 years who reported a history of infertilityhad a baby without using fertility treatment, and a further one-in-four had a baby after undergoing fertility treatment, which included IVF or fertility hormones, such as Clomid.

Half of those women who had not used treatment had already had a baby prior to reporting infertility.

Dr Herbert said the national study, which appears in the journal Fertility and Sterility, offers a more complete picture of infertility in Australia compared to previous clinic-based studies.

“The strength of this study is the inclusion of all women with a self-reported history of infertility,” she said.

“That means that women who have experienced difficulty falling pregnant but not sought treatment are included, as well as women who do seek treatment but do not become pregnant.”

The research is part of the Australian Longitudinal Study on Women's Health which has followed more than 8,000 women since 1996. This latest data comes from surveys conducted in 2006 and 2009.

For women who did have a baby, there was no difference in pregnancy complications - including stillbirths or premature births - between those who did and those who didn't use fertility treatment. Women who received fertility treatment were more likely to have twins.

Dr Herbert said that while the study has its limitations – researchers do not know if women changed male partners during the study period – it provides important evidence that can help doctors decide when best to start patients on fertility treatment.

“These findings are particularly encouraging for women aged up to 36 years who have previously had a baby, or been diagnosed with unexplained infertility – that is the woman is ovulating regularly and their partner is making good quality sperm - to persevere to conceive without treatment.”
Editor's Note: Original news release can be found here.

Exercise still ‘valuable’: study



THE UNIVERSITY OF WESTERN AUSTRALIA   


In spite of recent media reports suggesting that exercise may not be useful in obesity management, overweight and obese people should not be discouraged from taking it up, according to a paper published today in theMedical Journal of Australia.

Winthrop Professor Daniel Green from UWA's School of Sports Science, Exercise and Health said although treatments such as bariatric (weight loss) surgery were being promoted in some quarters, exercise was still a valuable part of the health equation for overweight and obese people.

"Bariatric surgery has an important and evidence-based role in the treatment of severe obesity.  However, lack of attention to prevention, especially exercise, effectively condemns a large proportion of the 20 per cent of Australians who are already obese to disease progression and, ultimately, surgery," Professor Green said.

"Exercise is good for you whether you lose weight or not, because it can help increase muscle mass, improve artery function and decrease the risks of heart attack, stroke and diabetes.

"Recent studies suggest that obese people who develop some level of fitness have a lower cardiovascular disease and death risk than those who are lean but unfit.  Exercise is especially good at preventing diabetes in obese people, who are at higher risk of developing this disease."

Professor Green said experts recommended comprehensive weight management programs should be available for obese patients and those with Type 2 diabetes, and that non-surgical options should be attempted first.
Editor's Note: Original news release can be found here.

Vitamin C boosts tumour death



UNIVERSITY OF OTAGO   

syolacan_-_vitamin_C
Giving brain cancer cells high dose vitamin C makes them much more susceptible to radiation therapy.
Image: syolacan/iStockphoto
Recent research by the University of Otago, Wellington has shown that giving brain cancer cells high dose vitamin C makes them much more susceptible to radiation therapy.

The study, carried out in association with Wellington’s Malaghan Institute was recently published in Free Radical Biology and Medicine.

Lead author Dr Patries Herst together with Dr Melanie McConnell investigated how combining high dose vitamin C with radiation affected survival of cancer cells isolated from glioblastoma multiforme (GBM) brain tumours, and compared this with the survival of normal cells.

They found that high dose vitamin C by itself caused DNA damage and cell death which was much more pronounced when high dose vitamin C was given just prior to radiation.

Herst says GBM patients have a poor prognosis because the aggressive GBM tumours are very resistant to radiation therapy. “We found that high dose vitamin C makes it easier to kill these GBM cells by radiation therapy”.

She says there has long been debate about the use of high dose vitamin C in the treatment of cancer. High dose vitamin C specifically kills a range of cancer cells in the laboratory and in animal models. It produces aggressive free radicals in the tumour environment but not in the environment of healthy cells. The free radicals damage DNA, which kills the cells, but the high concentration necessary to kill cancer cells can only be achieved by intravenous injection.

However, these promising findings have so far not been validated in clinical studies. “If carefully designed clinical trials show that combining high dose vitamin C with radiation therapy improves patient survival, there may be merit in combining both treatments for radiation-resistant cancers, such as glioblastoma multiforme,” says Dr Herst.
Editor's Note: Original news release can be found here.

How cholesterol gets shipped



THE UNIVERSITY OF NEW SOUTH WALES   

dlerick_-_cholesterol
Hrs plays a specific role in directing how and where low-density lipoproteins are deposited.
Image: dlerick/iStockphoto
A protein that directs traffic within human cells has been identified as playing a key role in the accumulation of so-called “bad” cholesterol, according to a new study.

Little is known about how this bad cholesterol is transported inside a cell, notes Associate Professor Rob Yang, a member of a UNSW research team writing in the journal Cell Reports.

“Cholesterol is carried around our bloodstream, packaged in particles called lipoproteins,

Cholesterol from the low-density lipoproteins - also known as ‘bad’ cholesterol - enters our cells and deposits at different locations through a poorly-understood maze of transport routes,” says Professor Yang, and ARC Future Fellow in the UNSW School of Biotechnology and Biomolecular Sciences.

The lead author on the paper was Postdoctoral Research Fellow Robin Du. Other authors were Abdulla Kazim and Associate Professor Andrew Brown.

The team found that the protein – known as Hrs - plays a specific role in directing how and where low-density lipoproteins are deposited. The researchers showed in experiments that reducing the amount of Hrs causes cholesterol to accumulate in endosomes, a cellular compartment usually containing little cholesterol.

“This discovery provides a better understanding of how cells handle cholesterol,” he says. “Misdirection of cholesterol will cause it to accumulate in the wrong places in a cell, resulting in disturbed cholesterol metabolism and eventual cell death.

“This will in turn contribute to the development of heart disease, and a number of neurological disorders including Alzheimer’s disease and Parkinson’s disease.”

The team is now trying to identify other factors that may co-operate with Hrs to help direct cholesterol traffic, and in turn may point towards new therapeutic strategies against heart and neurodegenerative diseases.
Editor's Note: Original news release can be found here.

How mitochondrial DNA defects cause inherited deafness



 
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Yale scientists have discovered the molecular pathway by which maternally inherited deafness appears to occur: Mitochondrial DNA mutations trigger a signaling cascade, resulting in programmed cell death. 
Mitochondria are cellular structures that function as “cellular power plants” because they generate most of the cell’s supply of energy. They contain DNA inherited from one’s mother. Mitochondria determine whether a cell lives or dies via the process of programmed cell death, or apoptosis.
The Yale scientists focused on a specific mitochondrial DNA mutation that causes maternally inherited deafness. The mutation occurs in a gene that codes for RNA in mitochondrial ribosomes, which generate proteins required for cellular respiration. The team found that cell lines containing this mutation are prone to cell death not directly due to the mutation, but rather because it enhanced a normal chemical modification of the RNA called methylation, which regulates ribosome assembly.



How mitochondrial DNA defect causes inherited hearing loss.
“Our lab had previously discovered that overexpression of the enzyme responsible for this methylation could cause cell death, even in cells without the deafness mutation,” said corresponding author Gerald S. Shadel, professor of pathology and genetics at Yale School of Medicine. “But when the researchers overexpressed the enzyme in mice to mimic the effects of the mutation,” he said, “we were astonished to discover that the animals progressively lost their hearing, reflecting how such disease would develop due to a known pathogenic human mitochondrial DNA mutation. This new mouse model will be instrumental in understanding genetic and environmental factors known to impact mitochondrial disease pathology.
The researchers found that reactive oxygen molecules produced by diseased mitochondria are what trigger events leading to a cell death-inducing gene expression program. By genetically depleting the protein ultimately responsible for activating this programmed cell death response, they were able to restore normal hearing to the mice.
The study not only sheds light on inherited deafness in humans, but possibly also age-related hearing loss and other human diseases. First author Nuno Raimundo, a postdoctoral associate in pathology, said, “Mitochondrial diseases are complicated because different tissues are affected in often unpredictable ways. Defining the molecular mechanism underlying death of only a specific subset of cells in the inner ear is a major step toward unraveling this complexity.”

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Other authors are Sharen E. McCay, Lei Song, Timothy E. Shutt, Justin Cotney, Thomas C. Gilliland, David Hohuan and Joseph Santos-Sacchi of Yale; and Min-Xin Guan of Zhejiang University.
This study was supported by grants from the National Institutes of Health, and in the Feb. 17 issue of Cell. 
Courtesy Yale University

Tongue drive system goes inside the mouth to improve performance and user comfort



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The Tongue Drive System is getting less conspicuous and more capable. Tongue Drive is a wireless device that enables people with high-level spinal cord injuries to operate a computer and maneuver an electrically powered wheelchair simply by moving their tongues.

The circuitry for the new intraoral Tongue Drive System developed at Georgia Tech is embedded in this dental retainer worn in the mouth (right). The system interprets commands from seven different tongue movements to operate a computer (left) or maneuver an electrically powered wheelchair. Credit: Georgia Tech/Maysam Ghovanloo
The newest prototype of the system allows users to wear an inconspicuous dental retainer embedded with sensors to control the system. The sensors track the location of a tiny magnet attached to the tongues of users. In earlier versions of the Tongue Drive System, the sensors that track the movement of the magnet on the tongue were mounted on a headset worn by the user.
“By moving the sensors inside the mouth, we have created a Tongue Drive System with increased mechanical stability and comfort that is nearly unnoticeable,” said Maysam Ghovanloo, an associate professor in the School of Electrical and Computer Engineering at the Georgia Institute of Technology.

The new intraoral Tongue Drive System was presented and demonstrated on Feb. 20, 2012 at the IEEE International Solid-State Circuits Conference in San Francisco. Development of the system is supported by the National Institutes of Health, National Science Foundation, and Christopher and Dana Reeve Foundation.
The new dental appliance contains magnetic field sensors mounted on its four corners that detect movement of a tiny magnet attached to the tongue. It also includes a rechargeable lithium-ion battery and an induction coil to charge the battery. The circuitry fits in the space available on the retainer, which sits against the roof of the mouth and is covered with an insulating, water-resistant material and vacuum-molded inside standard dental acrylic.
“One of the problems we encountered with the earlier headset was that it could shift on a user’s head and the system would need to be recalibrated,” explained Ghovanloo. “Because the dental appliance is worn inside the mouth and molded from dental impressions to fit tightly around an individual’s teeth with clasps, it is protected from these types of disturbances.”
When in use, the output signals from the sensors are wirelessly transmitted to an iPod or iPhone. Software installed on the iPod interprets the user’s tongue commands by determining the relative position of the magnet with respect to the array of sensors in real-time. This information is used to control the movements of a cursor on the computer screen or to substitute for the joystick function in a powered wheelchair.
Ghovanloo and his team have also created a universal interface for the intraoral Tongue Drive System that attaches directly to a standard electric wheelchair. The interface boasts multiple functions: it not only holds the iPod, but also wirelessly receives the sensor data and delivers it to the iPod, connects the iPod to the wheelchair, charges the iPod, and includes a container where the dental retainer can be placed at night for charging.
In preliminary tests, the intraoral device exhibited an increased signal-to-noise ratio, even when a smaller magnet was placed on the tongue. That improved sensitivity could allow additional commands to be programmed into the system. The existing Tongue Drive System that uses a headset interprets commands from seven different tongue movements.

The dental appliance for the new intraoral Tongue Drive System contains magnetic field sensors mounted on its four corners that detect movement of a tiny magnet attached to the tongue. It also includes a rechargeable lithium-ion battery and an induction coil to charge the battery. The circuitry fits in the space available on the retainer, which sits against the roof of the mouth and is covered with an insulating, water-resistant material and vacuum-molded inside standard dental acrylic. Credit: Georgia Tech/Maysam Ghovanloo
The ability to train the system with additional commands – as many commands as an individual can comfortably remember – and having all of the commands available to the user at the same time are significant advantages over the common sip-n-puff device that acts as a simple switch controlled by sucking or blowing through a straw.
The researchers plan to begin testing the usability of the intraoral Tongue Drive System by able-bodied individuals soon and then move onto clinical trials to test its usability by people with high-level spinal cord injuries.
In recent months, Ghovanloo and his team have recruited 11 individuals with high-level spinal cord injuries to test the headset version of the system at the Atlanta-based Shepherd Center and the Rehabilitation Institute of Chicago. Trial participants received a clinical tongue piercing and tongue stud that contained a tiny magnet embedded in the upper ball. They repeated two test sessions per week during a six-week period that assessed their ability to use the Tongue Drive System to operate a computer and navigate an electric wheelchair through an obstacle course.
“During the trials, users have been able to learn to use the system, move the computer cursor quicker and with more accuracy, and maneuver through the obstacle course faster and with fewer collisions,” said Ghovanloo. “We expect even better results in the future when trial participants begin to use the intraoral Tongue Drive System on a daily basis.”
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Georgia Tech graduate students Abner Ayala-Acevedo, Xueliang Huo, Jeonghee Kim, Hangue Park and Xueli Xiao, and former postdoctoral fellow Benoit Gosselin also contributed to this work. 
Source: Georgia Institute of Technology