Changing The Subject Matter

 

“No one can check the thinking activities of a living being, nor the feeling, willing or working processes. But if one wants actual happiness, one must change the subject matter only. Instead of talking of the politics of a dying man, one might discuss the politics administered by the Lord Himself.” (Shrila Prabhupada, Shrimad Bhagavatam, 1.6.34 Purport)

This whole world is a product of God’s energy after all, so a blanket rejection of everything within it as being detrimental towards one’s spiritual aspirations is not a very wise policy. Though the human being has so many tendencies towards behavior that proves to be harmful in the end, the inclination to act needn’t be unnaturally checked. Rather, the same interests can be directed towards the inexhaustibly brilliant Vedic literature, which is full of enough variety to satisfy the inquisitive mind for many lifetimes. The hero in these documented accounts, the person who is the central focus of the pious behavior followed and the anger and rage of those who defy the established law codes, is none other than the Supreme Lord, whose spiritual form allows for an attachment that proves to be the most auspicious.

Can attachment be detrimental? What is wrong with having affection for something? Is not the human spirit meant to love? If you have attachment to something that will cause you harm in the end, then obviously the emotional fixation is not warranted. For instance, having a few drinks at home after work may cause a slight relaxed sensation, but should the person indulge in even more adult beverages due to that feeling, in the process developing an attachment so strong that they can’t go a single day without intoxication

 

, will they be benefitted by that behavior?

What about an attachment to a relationship, such as one involving romance or friendship? Fidelity to the relationship is certainly honorable, but basing attachment solely on bodily designations is flawed from the beginning, for the forms identified with must be renounced at some point in the future. Death is guaranteed for whoever takes birth, and whoever dies is guaranteed to take birth. The spirit soul, the essence of identity, is transcendental to these changes, but unless one knows how to identify with the self, the attachments they form will be based on temporary objects that must be parted with eventually. The stronger the attachment, the more painful the emotional fall at the time of separation.

In day-to-day affairs, there is a desire to hear about famous people. The news media profits from this desire. And the sentiments don’t necessarily have to be positive. Should there be a lascivious scandal on the campus of a university famous for its football program, the same figures previously adored and hailed as legends will be dragged down to the point that the newsmakers won’t settle until everyone hates the involved parties. Politics is arguably followed by the most number of people, for what a politician says and how they say it form the subject matter for the endless debates that take place both in print and television news media.

Should we not follow world events? If things are going on around us, why would we want to close our ears to them? The Vedas declare that the human form of body is the most auspicious, but not for its ability to form attachments to bodily relationships or famous figures described in the news. These tendencies indeed exist because of the properties of spirit, which from its constitution has a propensity to love. Love results in service, the kind which operates without motivation and interruption.

“The supreme occupation [dharma] for all humanity is that by which men can attain to loving devotional service unto the transcendent Lord. Such devotional service must be unmotivated [ahaituki] and uninterrupted [apratihata] to completely satisfy the self.” (Shrimad Bhagavatam

 

, 1.2.6)

Service to worldly entities always involves motivation, and interruption is guaranteed. The attraction to the dealings of worldly figures carries the motivation for some type of personal enjoyment, either the ability to praise and honor someone or the inverse of harboring hatred and resentment. A famous athlete is praised for being so good at what they do, but should they fall from grace through illicit relations with many women, they will be hated by the same fans.

Shrila Bhaktivinoda Thakura, a famous acharya on the Vedic teachings of Lord Chaitanya

 

, remarks that hatred is borne of the same loving spirit found within the soul. Indeed, every emotion is derived from the soul’s desire to love in a transcendental way. This cogent fact uncovers the secret to finding lasting happiness, felicity which continues beyond the current lifetime. As the human being is the only species capable of rationally reaching this conclusion through following instruction and thinking it over before fully accepting it within the mind, it is the most advanced species. A precious human birth thus should not go to waste.

How do we break the tendency for harboring attachment to the temporary, or asat? When reviewing the disciplines of spirituality to potentially take up, it is natural to look at the restrictions first. To follow a discipline means that one currently does not have discipline. This only makes sense after all. We attend school to get educated because we are initially uneducated. We get trained in a particular field if we lack the training. Similarly, we start to follow religious principles because we currently don’t follow them at all.

The more restrictions you impose, the less appealing your system will be to potential followers. In the ultimate system of religion

 

 known as bhakti-yoga, or devotional service

 

, the bona fide acharyas, when deciding to accept disciples, will impose a restriction on meat eating, gambling

 

, intoxication and illicit sex

 

. It should be noted that these prohibitions are not necessary for practicing bhakti, as the chanting

 

 of the holy names, “Hare Krishna Hare Krishna, Krishna Krishna, Hare Hare, Hare Rama Hare Rama, Rama Rama, Hare Hare

 

”, can be taken up by anyone at any stage in life. The famous brahmana Ajamila inadvertently recited the name of Narayana, which is another word for God, at the time of death and was rescued from punishment for his past sinful behavior. During the latter half of his life Ajamila did not follow the regulative principles, so he would not have been accepted as a disciple of a bona fide spiritual master

 

. Nevertheless, through past accumulated spiritual merits, he was fortunate enough to say the holy name while quitting the body, which thus guaranteed his salvation.

This incident reveals the end-goal of the human birth: to think of God at the time of death. The restrictions are put into place to make that happen. Obviously for someone who grew up eating meat it will be difficult to give up the practice at every meal. The same goes for abandoning intoxication for someone who enjoys it so much, but the focus on the positives in bhakti is more important. With enough immersion in transcendental service, the restrictions will take care of themselves, though they are still explicitly stressed and monitored to show what is required in a spiritual leader. If a preacher speaks on the superiority of being attached to God and no one else, if they have attachments to sinful behavior, how will their message resonate? Example is better than precept, so one who actually follows the principles they preach will be a more effective leader.

Lord Chaitanya

 

, the famous preacher incarnation of Godhead, took to the renounced order of life at a very young age precisely for this purpose. Imagine a twenty-four year old coming up to you and speaking about detachment, the endless existence of the spirit soul, and how one should abandon attachment to anything not directly related to Krishna, or God. Will we take such a youngster seriously? What could they possibly know anyway? But if the same person lives in the renounced order of life, they immediately become superior to others in terms of authority. After all, the person being preached to likely isn’t asannyasi, and even if they are, they probably didn’t take to the order at such a young age. Thus through following the regulative principles, one earns respect from others and gets their attention when speaking on the glories of bhakti.

If the restrictions are imposed and followed, the tendency towards hearing about famous figures will be there anyway. If we don’t watch the news, we’ll still want to hear about someone else. Luckily for us, the Supreme Lord, the object of sacrifice and penance, comes to earth every so often along with His closest associates. As a respectful guest of the land He owns, Lord Krishna

 

 takes part in activities which mimic those of the ordinary living entities. The difference is that Krishna’s tejas, or splendor, is impossible to fully cover up. His activities, which include His instructing others, are the most splendid, so marvelous that they are still talked about to this day.

Pick up a gossip paper that is more than a week old and it likely won’t be useful to you. The twitter feed from a month ago doesn’t have any relevant information because the news reported was meant to only pique the curiosity of someone looking for higher enjoyment, not to satisfy them. With Krishna’s activities, the enjoyment derived from hearing lasts for as long as the Supreme Lord’s stories continue to be told. If you’re interested in hearing about politics, how people lie to get ahead, and how the pious counteract the influence of the sinful, just immerse yourself in the Mahabharata

 

, which describes Krishna’s involvement in the famous feud between the Kauravas and Pandavas. If you like hearing about love stories, men and women getting together, condition yourself to learn about Shri Krishna and His eternal consort Shrimati Radharani

 

. Then hear about their dealings from a bona fide source. These pastimes, though very intimate and thus off limits to the neophyte, are documented in the Shrimad Bhagavatam for a reason. They give tremendous joy to those who have an anxious desire to hear about God and His activities.

If you like hearing about weddings, focus your mind on the famous ceremony held in Janaka’s kingdom, where Krishna in His form of Lord Rama

 

 lifted an extremely heavy bow belonging to Lord Shiva

 

 to win Janaka’s daughter’s hand in marriage. If you want to hear about the struggle for existence, the successful triumph over both physical and mental obstacles, travel back in time to when Shri Hanuman

 

, Rama’s most faithful servant, infiltrated the enemy territory of Lanka all by himself to find Rama’s missing wife, Sita Devi

 

.

These mental trips will be so worth it that you’ll eventually abandon your attachment to the temporary. The natural yearning towards service and stimulation of the mind doesn’t have to be artificially renounced. Rather, just by changing the subject matter, one can go from living a material existence to enjoying a spiritual life which is full of knowledge, bliss and eternality. The human being’s birthright is to love God, and by following the methods laid down by Krishna Himself, that destiny can become a reality.

In Closing:

Stories of celebrities in papers you’ll find,

Piques the curiosity of your mind.

From hearing about scorn, love and deceit,

Some pleasure in your mind you receive.

These tendencies don’t outwardly reject,

Focus on Krishna instead, change the subject.

With proper training hear of highest love,

Radha and Krishna always think of.

For bravery Hanuman, and Mahabharata politics,

This way guarantee of salvation when body you quit.

Extended synaptic development may explain our cognitive edge over other primates

Over the first few years of life, human cognition continues to develop, soaking up information and experiences from the environment and far surpassing the abilities of even our nearest primate relatives. In a study published online today in Genome Research, researchers have identified extended synaptic development in the human brain relative to other primates, a finding that sheds new light on the biology and evolution of human cognition.

"Why can we absorb environmental information during infancy and childhood and develop intellectual skills that chimpanzees cannot?" asks Dr. Philipp Khaitovich of the Chinese Academy of Sciences and the Max Planck Institute for Evolutionary Anthropology, senior author of the report. "What makes the human brain so special?"

Chimps diverged from the human lineage about 4-6 million years ago, a relatively short period of time by evolutionary standards. Yet the differences in specialized social and cultural cognitive skills between humans and chimps are striking, and much remains unknown about the biological basis.

To answer his questions, Khaitovich and an international team of researchers used microarray and RNA-sequencing technology to investigate changes in how genes are read, or expressed, during development of the postnatal brain in humans, chimps, and macaques, a more distantly related primate. And the timing of these changes may set human cognitive development apart from other primates. The group sampled the prefrontal cortex, a more recently evolved brain region associated with cognition, and the cerebellum, an ancient brain region related to motor control.

Khaitovich explained that evolutionary studies of the human brain often produce murky results, however this approach performed even better than expected, pointing them to a specific postnatal developmental process. "Among all developmental changes specific to the human brain, one process – synaptogenesis – clearly stood out." Khaitovich explained that synaptogenesis, the foundation of learning and memory in the developing brain, is characterized by the formation of synaptic connections, strengthening useful connections, and also elimination of useless connections.

The authors found that in humans, peak expression of synaptic genes in the prefrontal cortex is delayed until about age five, in contrast to chimps and macaques where this occurs in the first year of life. The authors noted that this human-specific change was only observed in the prefrontal cortex, and not in the cerebellum

"Our findings suggest that the human brain remains extremely plastic and susceptible to environmental input during the first five years of life," said Khaitovich. "Our study uncovers one of the important mechanisms potentially involved in evolution of human cognition."

More information: Liu X, Somel M,Tang L, Yan Z, Jiang X, Guo S, Yuan Y, He L, Oleksiak A, Zhang Y, Li N, Hu Y, Chen W, Qiu Z, Pääbo S, Khaitovich P. Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res doi: 10.1101/gr.127324.111

 

Provided by Cold Spring Harbor Laboratory

"Extended synaptic development may explain our cognitive edge over other primates." February 1st, 2012. http://medicalxpress.com/news/2012-02-synaptic-cognitive-edge-primates.html

 

Posted by
Robert Karl Stonjek

Cancer sequencing initiative discovers mutations tied to aggressive childhood brain tumors

 by Biomechanism 

St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project provides first evidence linking cancer to mutations in genes involved in DNA organization

Brain tumor

Researchers studying a rare, lethal childhood tumor of the brainstem discovered that nearly 80 percent of the tumors have mutations in genes not previously tied to cancer. Early evidence suggests the alterations play a unique role in other aggressive pediatric brain tumors as well.

The findings from the St. Jude Children’s Research Hospital – Washington University Pediatric Cancer Genome Project (PCGP) offer important insight into a poorly understood tumor that kills more than 90 percent of patients within two years. The tumor, diffuse intrinsic pontine glioma (DIPG), is found almost exclusively in children and accounts for 10 to 15 percent of pediatric tumors of the brain and central nervous system.

“We are hopeful that identifying these mutations will lead us to new selective therapeutic targets, which are particularly important since this tumor cannot be treated surgically and still lacks effective therapies,” said Suzanne Baker, Ph.D., co-leader of the St. Jude Neurobiology and Brain Tumor Program and a member of the St. Jude Department of Developmental Neurobiology. She is a corresponding author of the study published in the January 29 online edition of the scientific journal Nature Genetics.

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DIPG is an extremely invasive tumor that occurs in the brainstem, which is at the base of the skull and controls such vital functions as breathing and heart rate. DIPG cannot be cured by surgery and is accurately diagnosed by non-invasive imaging. As a result, DIPG is rarely biopsied in the U.S. and little is known about it.

Cancer occurs when normal gene activity is disrupted, allowing for the unchecked cell growth and spread that makes cancer so lethal. In this study, investigators found 78 percent of the DIPG tumors had alterations in one of two genes that carry instructions for making proteins that play similar roles in packaging DNA inside cells. Both belong to the histone H3 family of proteins. DNA must be wrapped around histones so that it is compact enough to fit into the nucleus. The packaging of DNA by histones influences which genes are switched on or off, as well as the repair of mutations in DNA and the stability of DNA. Disruption of any of these processes can contribute to cancer.

Researchers said that the mutations seem unique to aggressive childhood brain tumors.

“It is amazing to see that this particular tumor type appears to be characterized by a molecular ‘smoking gun’ and that these mutations are unique to fast-growing pediatric cancers in the brain,” said Richard K. Wilson, Ph.D., director of The Genome Institute at Washington University School of Medicine in St. Louis and one of the study’s corresponding authors. “This is exactly the type of result one hopes to find when studying the genomes of cancer patients.”

The results are the latest from the PCGP, an ambitious three-year effort to sequence the complete normal and cancer genomes of 600 children with some of the most poorly understood and aggressive pediatric cancers. The human genome includes the complete set of instructions needed to assemble and sustain human life. The goal is to identify differences that explain why cancer develops, spreads and kills. Researchers believe the findings will provide the foundation for new tools to diagnose, treat or prevent the disease.

For this study, researchers sequenced the complete normal and cancer genomes of seven patients with DIPG. “The mutations were found at such high frequency in the cancer genomes of those seven patients that we immediately checked for the same alterations in a larger group of DIPGs,” Baker said. When researchers sequenced all 16 of the related genes that make closely related variants of histone H3 proteins in an additional 43 DIPGs, they found many of the tumors contained the same mistakes in only two of these genes.

Of the 50 DIPG tumors included in this study, 60 percent had a single alteration in the makeup of the H3F3A gene. When the mutated gene was translated into a protein, the point mutation led to the substitution of methionine for lysine as the 27th amino acid in this variant of histone H3 protein. Another 18 percent of the DIPG patients carried the same mistake in a different gene, HIST1H3B.

Researchers are now working to understand how mutations in H3F3A and HIST1H3B impact cell function and contribute to cancer. Earlier research provides some clues. The lysine that is mutated is normally targeted by enzymes that attach other molecules to histone H3, influencing how it interacts with other proteins that regulate gene expression, Baker said. Mutations in the enzymes that target histone H3 have been identified in other cancers, but this is the first report showing a specific alteration of histones in cancer.

H3F3A and HIST1H3B were also mutated in other aggressive childhood brain tumors, glioblastoma, that develop outside the brain stem. Of 36 such tumors included in this study, 36 percent carried one of three distinct point mutations in the genes. The alterations included another single change in the makeup of H3F3A not found in DIPGs.

The histone H3 genes, however, were not mutated in any of the 252 other childhood tumors researchers checked for this study. The list included the brain tumors known as low-grade gliomas, medulloblastomas and ependymomas plus other cancers outside the brain and nervous system. The H3 changes have not been reported in any other cancers, including adult glioblastoma. “This suggests these particular mutations give a very important selective advantage, particularly in the developing brainstem and to a lesser degree in the developing brain, which leads to a terribly aggressive brain tumor in children, but not in adults,” Baker said.

“This discovery would not have been possible without the unbiased approach taken by the Pediatric Cancer Genome Project,” Baker said. “The mutations had not been reported in any other tumor, so we would not have searched for them in DIPGs. Yet the alterations clearly play an important role in generating this particular tumor.”

__________

Courtesy St. Jude Children’s Research Hospital 

childhood brain tumors

cancer sequencing 

DNA organization

A mutant protein linked to pancreatic cancer growth, new study finds

 by Biomechanism 

A mutant protein found in nearly all pancreatic cancers plays a role not only in the cancer’s development but in its continued growth, according to a new study from University of Michigan Comprehensive Cancer Center researchers. The finding suggests a possible target for developing new ways to treat this deadly disease.

Researchers have known that mutations in the Kras gene are what cause pancreatic cancer to develop. These mutations are frequently seen in common precancerous lesions, suggesting it has an early role in pancreatic cancer.

The new study, published in the February Journal of Clinical Investigation, finds that in mice, mutant Kras also keeps the tumor growing and helps precancerous tumors grow into invasive cancer. When the researchers turned off Kras, the tumors disappeared and showed no signs of recurring.

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The researchers were able to manipulate Kras in a mouse model that they designed to look at Kras at various points in pancreatic cancer development. In the precancerous lesions, turning off Kras eliminated the tumors in mice and the pancreas tissue returned to normal, with no signs of the cancer returning. With invasive cancer, inactivating Kras killed off the cancer but left the pancreas with fibrous areas similar to scar tissue. Tumors did not recur.

Researchers hope this finding provides the basis for future drug development.

“Right now no drugs specifically target Kras, but there are drugs that target the cellular processes downstream of Kras. We next need to figure out which of these downstream effectors of Kras are important in pancreatic cancer,” says study author Marina Pasca di Magliano, Ph.D., assistant professor of surgery and of cell and developmental biology at the U-M Medical School.

Kras is also known to play a role in lung and colon cancer. But it is likely the biggest player in pancreatic cancer, where more than 90% of all tumors have mutated Kras. Pancreatic cancer is one of the most deadly types of cancer: about 4% of patients are alive five years after their diagnosis. The disease is often diagnosed when surgery is not an option and it tends to be resistant to available chemotherapies.

“There is a dire need for new therapies for pancreas cancer based on a better understanding of the biology of this disease. My lab is now looking at the downstream inhibitors of Kras to try to find the best target,” Pasca di Magliano says.

What is Kras? 

Kras are activating mutations that result in continual signal transduction, stimulating downstream signaling pathways involved in cell growth, proliferation, invasion, and metastasis. They have been observed in a variety of cancers.

Note to patients:

This research was based in mice and needs further testing before any possible treatments are available for clinical trials. For information about current pancreatic cancer treatments, call the U-M Cancer AnswerLine at 800-865-1125.

Pancreatic cancer statistics:

43,140 Americans will be diagnosed with pancreatic cancer this year and 36,800 will die from the disease, according to the American Cancer Society.

Additional authors: Meredith A. Collins, Filip Bednar, Yaqing Zhang, Jean-christophe Brisset, Stefanie Galban, Craig J. Galban, Sabita Rakshit, and Karen S. Flannagan, all from U-M; and N. Volkan Adsay from Emory University.

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Courtesy University of Michigan Cancer Center

New target for cancer therapy identified, preclinical study shows

 by Biomechanism 

An enzyme called tryptophan 2,3-dioxygenase or TDO enables tumors to avoid detection and rejection by the immune system 

Scientists from the Ludwig Institute for Cancer Research (LICR) in Brussels identified a new target for cancer therapy, an enzyme which prevents the immune system from recognizing and destroying certain types of tumors. Called tryptophan 2,3-dioxygenase or TDO, the enzyme works by depriving immune cells of tryptophan, an amino acid essential to their activity. TDO is produced by a significant number of human tumors.

Scientists also show that blocking TDO activity with a novel TDO inhibitor promotes tumor rejection in mice. The study findings were published online today in the January 30 issue of the Proceedings of the National Academy of Sciences (PNAS).

Cancer immunotherapy — leveraging the body’s own immune system to attack and destroy tumors — is emerging as a promising method for cancer treatment. Clinical testing of several immunotherapeutic approaches has shown variable success. Tumors often develop survival mechanisms to prevent the attack from the immune system. Researchers are now looking to evaluate the mechanisms that enable these tumors to escape detection by the immune system.

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Previously, Brussels scientists from LICR and the de Duve Institute at the Université catholique de Louvain (UCL) studied one enzyme that proved to do just that. It is known as indoleamine 2,3 dioxygenase or IDO1 for short. IDO1 is expressed in many cancers, including prostate, colon, pancreas and cervical tumors. IDO1 blocks the immune system’s ability to reject those tumors, by depriving immune cells of tryptophan.

In the PNAS study released today, the same Belgian researchers have shown that TDO is also expressed in various human tumors and degrades tryptophan in a similar manner. Tumors expressing TDO include bladder and liver cancers, as well as melanomas.

“Little is known about the TDO enzyme and its ability to trick the immune system and prevent it from destroying deadly tumors. Our research is the first to explore this relationship,” said study lead investigator, Benoit J. Van den Eynde, M.D., Ph.D., Brussels Branch Director at LICR.

The group studied a series of 104 human tumor lines of different types to confirm the activity of TDO in tumor cells. They learned that 20 tumors expressed TDO only, 17 others expressed IDO1 only and 16 expressed both. The findings suggest that TDO and IDO1 enzymes represent complementary cancer immunotherapy targets, which if blocked could potentially impact 51% of all tumors.

Demonstrating TDO Expression and Its Role in Thwarting Immune Attack

Knowledge: The colon is shaped like a tube, and is made up of several layers starting with the innermost layer, the mucosa (which is made up of epithelium), and then the lamina propria and muscularis mucosa. This is surrounded by the submucosa, which is surrounded by two layers of muscle (or muscularis), and finally, the serosa layer, which is the outside layer of the tube. The outside of the colon is covered with a layer of fat, also called adipose tissue, which contains lymph nodes and blood vessels which feed the colon tissue.

Using a validated mouse tumor model, researchers established that TDO expression caused tumor cells to resist immune rejection. They first vaccinated the mice with an antigen that caused them to reject the tumor. Then they injected TDO-expressing tumor cells into the immunized mice. Researchers found that immunized mice no longer rejected the TDO-expressing tumors. This demonstrated that the presence of TDO prevented the immune system from attacking tumors.

In collaboration with scientists from the University of Namur (Belgium), the team then developed an active compound to inhibit TDO enzymatic activity. “Our study showed quite beautifully that the TDO inhibitor restored the ability of mice to reject tumors despite the presence of TDO in tumor cells,” said Dr. Van den Eynde.

Research recently published in the October 6, 2011 issue of Nature (Opitz, C.A. et al.) validates today’s study results by showing that TDO expression in human glioblastomas promotes tumor progression.

Toward Clinical Development of a TDO-inhibitor

The research team is moving forward to validate TDO inhibition in other preclinical models. Working closely with LICR colleagues in San Diego, the team will also conduct high-throughput screening to find a more stable TDO-inhibitor compound that can be advanced in clinical testing.

LICR plans, conducts, administers, and sponsors its own clinical trials as part of its technology development process. This process allows basic investigations to continue into early stage clinical evaluation of a new therapy, and makes the clinic an essential arm of the research enterprise.

“We will continue to search for inhibitors of TDO, an important new clinical target,” confirmed Jonathan Skipper, Ph.D., Executive Director, Technology Development at LICR. “LICR intends to license its discovery to a new commercial enterprise in the near future.”

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NOTE: For further information on this study, please contact Rachel Steinhardt, rsteinhardt@licr.org or 212-450-1582. 

From mice to elephants

MONASH UNIVERSITY

"It takes 24 million generations for a mouse-sized animal to evolve to the size of an elephant." Image: Kerrick/iStockphoto Scientists have for the first time measured how fast large-scale evolution can occur in mammals, showing it takes 24 million generations for a mouse-sized animal to evolve to the size of an elephant. Research published today in the Proceedings of the National Academy of Sciences USA (PNAS) describes increases and decreases in mammal size following the extinction of the dinosaurs 65 million years ago. Led by Dr Alistair Evans of Monash University's School of Biological Sciences a team of 20 biologists and palaeontologists discovered that rates of size decrease are much faster than growth rates. It takes only 100,000 generations for very large decreases, leading to dwarfism, to occur. Dr Evans, an evolutionary biologist and Australian Research Fellow, said the study was unique because most previous work had focused on microevolution, the small changes that occur within a species. “Instead we concentrated on large-scale changes in body size. We can now show that it took at least 24 million generations to make the proverbial mouse-to-elephant size change – a massive change, but also a very long time,” Dr Evans said. "A less dramatic change, such as rabbit-sized to elephant-sized, takes 10 million generations." The paper looked at 28 different groups of mammals, including elephants, primates and whales, from various continents and ocean basins over the past 70 million years. Size change was tracked in generations rather than years to allow meaningful comparison between species with differing life spans.  Dr Erich Fitzgerald, Senior Curator of Vertebrate Palaeontology at Museum Victoria and a co-author, said changes in whale size occurred at twice the rate of land mammals. “This is probably because it’s easier to be big in the water – it helps support your weight,” Dr Fitzgerald said. Dr Evans said he was surprised to find that decreases in body size occurred more than ten times faster than the increases. “The huge difference in rates for getting smaller and getting bigger is really astounding – we certainly never expected it could happen so fast!” Dr Evans said. Many miniature animals, such as the pygmy mammoth, dwarf hippo and ‘hobbit’ hominids lived on islands, helping to explain the size reduction. “When you do get smaller, you need less food and can reproduce faster, which are real advantages on small islands,” Dr Evans said. The research furthers understanding of conditions that allow certain mammals to thrive and grow bigger and circumstances that slow the pace of increase and potentially contribute to extinction. Editor's Note: Original news release can be found here

Minds can affect illness: study

THE UNIVERSITY OF AUCKLAND

Illness perceptions can be associated with emotional distress, recovery, disability and more.  Image: MarsBars/iStockphoto What you think about your illness matters just as much, if not more, in determining your health according to a new report by researchers from The University of Auckland and King’s College London. The paper “Patients’ perceptions of their illness: The dynamo of volition in health care” which reviews many studies examining the impact of perception on health was published in the Association in Psychological Science journalCurrent Directions in Psychological Science this week. Findings show that people’s perceptions about their illness bear a direct relationship to several important health outcomes, including how well they are able to function, their use of health care, adherence to treatment plans, the duration of the illness and even mortality. Moreover, some research suggests that how a person views their illness may play a bigger role in determining their health outcomes than the actual severity of the disease. The review shows that illness perceptions change rapidly in response to diagnostic results and can be associated with emotional distress, recovery, and disability, as well as with treatment-related behaviour such as adherence. Lead author Professor Keith Petrie from The University of Auckland’s Department of Psychological Medicine says: “In general, our illness perceptions emerge out of our beliefs about illness and what illness means in the context of our lives. We might have beliefs about how an illness is caused, how long it will last, how it will impact us or our family, and how we can control or cure it. The bottom line is that patients’ perceptions of their illness guide their decisions about health. “This suggests that effective treatment is about much more than having a competent physician. A doctor can make accurate diagnoses and have excellent treatments but if the therapy doesn’t fit with the patient’s view of their illness, they are unlikely to keep taking it.” The authors suggest that simple interventions such as conversations between health professionals and patients which elicit what people really think about their illness might identify patients at risk of coping poorly with the demands of their illness, allow erroneous beliefs to be corrected and improve treatment regimes. “Examining patients’ perceptions opens up a new approach in modern medicine. Ultimately it could lead to more effective treatment.” Editor's Note: Original news release can be found here.