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Monday, October 17, 2011

Beware of inflation coming from expansionary fiscal policy





The Nobel Prize in Economics in 2011 was jointly awarded to two leading economists, Thomas Sargent of the New York University and Christopher Sims of Princeton University, last week by the Royal Swedish Academy of Sciences on the advice of Economics Sciences Prize Committee.
Unlike the other Nobel Prizes which are announced by the Oslo-based Nobel Foundation, the Nobel Prize in Economics is announced in Stockholm, capital of Sweden, since it is a prize established by Sveriges Riksbank, the Central Bank of Sweden, to mark its 300th anniversary that fell in 1968.
The Economics Sciences Prize Committee has justified the selection of Sargent and Sims for this high accolade on the ground of their ‘contribution to developing relationship between macroeconomic policy making and macroeconomic variables’.
In laymen’s language, what it means is that the two economists have studied the impact of budget deficits run by governments by resorting to borrowing from people and abroad and printing money through central banks and the central banks’ own policies of changing interest rates to fight inflation (representing macroeconomic policy) on creating jobs, increasing production and prosperity of people, lowering cost of living and contributing to strengthening of exchange rates (macroeconomic variables) and have left the policy makers with a set of policy guidelines to follow.
Though it appears to be a simple exercise, the underlying reasoning and the theoretical underpinning of their research, done separately and independently, are complex and, therefore, not easy to comprehend.
There are some strange coincidences relating to the two Nobel Laureates. Both are 68 years old when they were selected for this high accolade, had done their PhDs at Harvard University in 1968 and are reported to have been taking a joint lecture in macroeconomic policy at Princeton University when they were reached by the Nobel Prize Awarding Committee to give them the happy news.
Freshwater economics versus saltwater economics
Both Sargent and Sims belong to an economics school known as ‘the freshwater or sweetwater economics school,’ a term coined by economist Robert E Hall in 1976 to describe the body of economics that sprang up near and around the Great Lakes of the US and constituted principally the academics attached to Carnegie Mellon University and the Universities of Chicago, Rochester, Minnesota and Pittsburgh.
As against this school, a saltwater economics school too has been framed to describe the body of economics that was developed in association with universities located in both the East and the West coasts of USA such as Harvard, Massachusetts Institute of Technology, University of California, Berkley, Yale, Princeton, Columbia, Pennsylvania and Stanford.
Nobel Prizes had moved from saltwater to freshwater from time to time depending on the importance of the particular school’s ideology and prescriptions to sort out existing economic issues in the world, but this year’s recognition of the freshwater came after the lapse of some 16 years since its leading figure, Robert Lucas of the University of Chicago, was awarded the Nobel Prize in economics in 1995. Prior to that leading saltwater economists like Joseph Stiglitz and Paul Krugman had been recognised for awarding the Nobel Prize in economics.
Freshwater economists believe that markets are efficient
The freshwater school differs from the saltwater school in a number of ways they approach issues in macroeconomics, the branch of economics that studies an economy as a whole.
The freshwater school is principally a market based school and believes in markets’ self correcting ability to spring back to normalcy after suffering from a temporary setback or temporary displacement. Along with these self correcting markets, the economies concerned too would spring back to normalcy.
This is because they believe in the existence of efficient markets supported by rational decision makers who acquire all the information necessary for them to make decisions and those decisions are informed decisions based on carefully processed facts and not on emotions.
How does an economy spring back to normalcy without an outside push? Suppose that an economy faces a recession and it is necessary to bring it back to the normal growth path. The traditional prescription found in the popular body of economics knows as Keynesianism in such an event is for the government to step in and stimulate the economy to such a level so that it would reach its growth path once again.
But the freshwater economists believe that people who are bent on attaining the maximum for them, a notion known as maximisation objective of people and firms, will reallocate their resources to overcome the deficiencies and gradually take the economy back to its growth path. Thus, there is no necessity for them to wait for outside support.
Accordingly, they subscribe to ‘laissez faire type’ no government intervention economic policies. If the government intervenes, it not only causes a permanent damage to the economy by distorting its incentive structure but also prolongs the recovery process because of the new impediments such as regulations, laws etc it would create in the system.
The saltwater economists, on the other hand, believe that people are not rational, markets are not inherently efficient and people do not have all the information which they need to make decisions. Hence, there is a necessity for governments to intervene in the economies and such interventions are effective in speeding up the recovery of a sick – economy. So, they belong to the Keynesian school of economics.
And people form rational expectations
They also differ with respect to the way in which people make expectations about future events. The freshwater economists believe in people making rational expectations about the future, an expectation formation process which was first put into theoretical form by Carnegie Mellon University academic John Muth in 1961 and then further developed by Robert Lucas, Thomas Sargent and Neil Wallace among others.
Adaptive expectations: people can be fooled continuously
Prior to Muth, the belief was that people made expectations based on their past experience and therefore if they had made mistakes in the past, some components of those mistakes were reflected in the expectations they had made about the future. The expectations are made on a trial and error basis and the mistakes made most recently which are still fresh on their mind would play a significant role in the new expectations they have formed.
People are aware of the mistakes they have made in the past but do not learn fully from those mistakes. Thus, when new expectations are formed, they do not fully eliminate the past mistake making only a partial adjustment on that account to the new expectations. These types of expectations were known as ‘adaptive expectations,’ so called because expectations are modified only to suit one’s requirements.
Since mistakes are a part of the expectations, those making adaptive expectations are supposed to make mistakes continuously. From a practical point of view, they do not learn fully from their past mistakes and therefore, can be fooled by others continuously.
Rational expectations: want to fool people? Forget it
But when one makes rational expectations, he learns from past mistakes and therefore does not make the same mistake twice. This type of behaviour perfectly conforms to the popular sayings ‘once bitten twice shy’ or ‘if one has fallen in to a pit in the dark, he should not fall in to the same pit in broad daylight’.
It is an explicit recognition that people make choices wisely; it is, therefore, recognition of the true nature of the Homo sapiens, the wise man. Hence, the freshwater economists believe that people cannot be fooled continuously and that behavioural trait places them in a position superior to governments and central banks.
The implication of this on macroeconomic policy is far reaching: if a government offers a stimulus package to speed up the recovery of a sick economy and if the funds for that stimulus package have come from either borrowing from the market or printing money, people immediately take account of its impact on their future.
Today’s borrowings make them pay more taxes in the future, while today’s printing of money will generate inflation in the future. Thus, in either case, they end up poorer than before. Once this factor is taken into their decision making, they find themselves indifferent to the stimulus package and therefore it does not serve as an incentive for them to work harder, the only way to speed up the recovery of a sick economy.
Consider also the plight of central banks under rational expectations. Suppose a central bank announces that in order to accelerate economic growth, it plans to double credit to private sector. The rational people would immediately infer that it will lead to an increase in money supply and inflation in the future.
High inflation would make them poorer if they do not take measures to protect them from the ill effects of inflation. Thus, they make higher expectations of inflation and incorporate that higher inflation into all new contracts they would sign, workers for wages and firms for outputs they deliver to customers. They also would invest in unproductive assets like land, real estates and gold to keep their wealth in a safer form.
This last action will create a bubble in the respective property markets and that bubble in no way contributes to an accelerated economic growth. Thus, the central would have doubled credit to private sector, but since it cannot fool people under rational expectations, it will not have a commensurate economic growth.
What it means is that since people are rational and form expectations rationally, neither authority can attain their policy targets by misleading them.
Sims and his Vector Autoregression
Since the freshwater economists base their analysis entirely on rational people making rational expectations, they are also called ‘rational expectations theorists’. While Sargent played a leading role in forming the rational expectations theory of macroeconomics with its other doyens like Robert Lucas and Neil Wallace, Sims concentrated in developing econometric and statistical techniques to assess policies and came up with the same conclusions which the rational expectations theorists had theorised.
His contribution was to use a new statistical technique called Vector Autoregression or simply VAR in short form, to assess policy impact without assuming any particular economic theory as the basis of the analysis. Thus even the opponents of the freshwater economics school or in other words who did not subscribe to the rational expectations theory of macroeconomics, could use Sims’ VAR technique in order to assess the impact of the policies of their choice on the major macroeconomic variables.
The Fiscal Theory of the Price Level
Another major contribution of Sims is the radical theory he formulated in 1994 on the impact of government’s spending on inflation, called the Fiscal Theory of the Price level. Though there are scathing critics of this theory like Narayana Kocherlakota, Bennet McCallum and William Buiter, it has by far stood the test of time and deserves careful attention of policy makers.
The main proposition of the fiscal theory of the price level is as follows.
Government spending made to accelerate economic growth, irrespective of whether such spending is on day to day consumption or building up the economy’s capital stock, has to be financed re resorting to two ways: the government has to either borrow money or print money. If it borrows, it has to repay the same with interest on a future date. When it comes to repaying, it has three options to consider.
First, it can reissue the maturing Treasury bills and Treasury bonds and pay both the principal and interest. This is called refinancing or rolling over of public debt and its implication is that it increases the total borrowings of a government.
Second, it can generate a surplus in the revenue by keeping its consumption expenditure below the revenue and use that surplus to repay the principal and pay interest. This is called amortising of the public debt.
The third option is to create inflation in the economy by getting the central bank to print new money and reduce the real value of its debt. Then, though the government pays the same amount in nominal terms to those who hold governments’ Treasury bills and Treasury bonds, the real value of their savings become very much lower.
The historical experience is that almost all governments have resorted to the first and the third options in the past and it is very rarely they have resorted to the second option. So, the rational people, according to the freshwater economists, make a series of rational choices like the following: “Oh, the government has increased its expenditure and its implication is to raise further credit in the future to repay its loans. But it cannot borrow continuously and increase its total public debt.So, sooner or later, it has to print new money to repay the existing loans. It raises inflation in the future. That inflation makes us poorer by eating away our wealth. So, let’s get ready for this eventuality by consuming more today and thinking of only today and not of tomorrow. If we think of tomorrow, let’s think in terms of how we can make our wealth safer by converting it into forms that cannot be eaten away by inflation like real estates and gold.”
So, the government’s expenditure leads to an immediate increase in the demand for consumer goods creating an excess demand in the market. Though the government had expected people to produce more and fill that excess demand that does not happen because people, instead of investing in productive forms that would supply more goods to the market, put their moneys into unproductive forms of investments.
The result is obvious: an acceleration of the inflation rate. So, the governments have tried to fool the people by raising its expenditure levels by borrowing or printing money, but in the long run, it is the government which finds itself fooled by people. That is because, instead of attaining its objective of accelerated growth, it has now planted the seeds of permanent inflation in the economy.
Sims’ proposition is a revelation because up to that time, the belief was that it is only the money supply increases generated by central banks that would contribute to inflation. But now it is apparent that even without the central bank’s increasing its money supply, governments’ enhanced expenditures would lead to increases in the price level, because people would form higher inflation expectations assuming that the future inflation would be higher due to governments’ high expenditure in the current period. Economists have called this ‘policy ineffectiveness proposition’ which is true only if people are rational and make expectations on a rational basis.
Economists like Herbert Simon, Daniel Kahneman and Amos Tversky have come up with alternative forms of behaviour by the so-called Homo sapiens. That alternative form of behaviour has placed boundaries on their rational thinking and rational behaviour. Yet it is a proven fact that people cannot be fooled continuously and that particular behavioural trait is the one which necessary to prove Sargent and Sims correct.
So, if the two Nobel Laureates, Thomas Sargent and Christopher Sims, are taken seriously, governments should be beware of announcing bigger and bigger expenditure programmes to accelerate growth in their respective economies.
(Wijewardena can be reached at waw1949@gmail.com)

Human Rights

"All human beings are born free and equal in dignity and rights." This is what it says in the very first Article of the Universal Declaration of Human Rights. The idea of Human Rights is one of the most important fundaments of human co-existence. At the same time human rights are subject to fierce debates and Human Rights violations are common all over the world.

But what exactly are Human Rights? Who is responsible for protecting them? And do they really apply to all people? These are the question the newest animated Video clip in the WissensWerte series deals with.

Click "CC" in the navigation bar for chinese subtitles.

WissensWerte is a project of the german non-profit organisation /e-politik.de/ e.V. (http://www.e-politik.de). It is realized by Jörn Barkemeyer and Jan Künzl
(edeos- digital education http://www.edeos.org )

Scientific Curiosities's videos (SOLAR BULBS )


Infrastructure: Do all Roads Lead to Green Investments?



I am sitting in a conference room in Panama and the room is so cold it just might start snowing. I can barely write, my fingers are so stiff, and this makes me wonder about the psychology of being cold in a hot climate…about the excessive use of energy while oil hovers around US$86 per barrel and the Earth’s temperature creeps higher.

Since it is often beyond a question of comfort, is it a statement about our rights to consume, about our control over our environment, about wealth? Whatever the cause, the citizens of Mexico City and Managua share the habit with those of Manila and Miami.


The use of power expresses itself as a sign of power. ....And so, too, the use of the automobile. One hundred and fifty years ago, in “Song of the Open Road,” Walt Whitman wrote

“O public road …
You express me better than I can express myself.
From this hour, freedom!
Pausing, searching, receiving, contemplating
Gently, but with undeniable will,
divesting myself of the holds that would hold me.”

This poem remains a celebration of the opportunity that the highway provides. Across the Americas, the relationship between personal freedom and physical movement—especially the kind provided by a car on an open road—has become part of our DNA.

Latin America and the Caribbean has the highest rates of motorization of any region in the world—about the same as China at nearly 4.5 percent per year. Unlike China, however, the majority of our population already lives in cities.

Since 78 percent of LAC’s population is urban, this means that the region’s municipalities are clogged, polluted and getting worse. So too are the arteries that connect the cities. In energy generation, Latin America runs the risk of losing its green mantel from its baseload of hydropower and natural gas. With demand for the region’s energy growing historically about 1.5 times faster than economic growth, big investments in generation are on the horizon.

We estimate that the region will need the equivalent of 5 Itaipu’s over the next 8 years… and there are only so many large rivers to dam in Latin America. Greater energy efficiency, as well as scale economies from regional markets, may abate that growth, but growing (i.e, with power) green (i.e, with renewables and low emitting technologies) will require a re-thinking of the region’s common practice of subsidizing fuel prices upstream and electricity prices downstream.

In the absence of a carbon tax, it may also mean more regulatory incentives and feed-in tariffs that reflect the full benefits of cleaner generation. In our last two discussions, we looked at the relationships between infrastructure and growth and between infrastructure and social inclusiveness—and we found the relationships to be positively correlated in both cases.

But what about infrastructure and the environment? Can we “grow green” with the help of infrastructure or does infrastructure investment always mean more power, more cars, more emissions, more environmental degradation?

In fact, infrastructure investments that balance economic, social and environmental needs do happen—and they are happening with increasing frequency in Latin America and the Caribbean—in urban transport, in energy production and in freight transport.

Better Transport Systems

Bus Rapid Transit systems are springing up across the region like grass in the cracks of pavement—not only in Bogota, Santiago, Mexico City and Lima, but in the secondary cities of Colombia, Brazil and Mexico. Costa Rica may be next.

Upcoming research from the World Resources Institute on urban transport in Mexico City illustrates how expansion of “Metro-Bus”—the dedicated bus lanes and services of the Metropolitan Area—has helped reverse a 15-year trend of increased dependence on polluting micro-buses, stemming the growth in emissions.

People and the environment benefit from better mass transit, and when cities become healthier, safer and less congested, investment and economic growth are likely to respond.

What has been missing so far is the integration of these mass transit projects into land use planning—planning that would densify cities, curb peri-urban sprawl and bring scale to basic urban service provision. To be truly transformative, the next generation of these investments will require greater forethought and integration into the urban landscape.

In freight transport, the greenness of the investment follows the incentives and options that shippers have when moving cargo. When they are faced with the true cost of fuel, including the costs of pollution, firms often decide on their own to seek more efficient modes. Cargo moves from small trucks to large trucks, and from large trucks to railroads and waterways.

The expansion of the Hidrovia system along the Parana-Paraguay Rivers will allow more ships and barges to move grains hundreds of kilometers. It takes hundreds of trucks off the roads of the Southern Cone--and carbon out of the air.

Realistically, the vast majority of the region’s freight will continue to move by truck, so greening the freight haulage industry itself will be a necessary step in the process of green growth. This means enforcement of tailpipe regulations, incentives for upgrading truck technologies, and training for drivers. The World Bank is now helping the Government of Brazil to build a strategy for greening the trucking industry… a regional example that will spread in the years ahead.

Phew.

In three blogs, we raced through the Triple Win, finding that investments in infrastructure can potentially (1) spur Growth that is (2) Inclusive and (3) Green. But, as I’ve learned from your posts and comments, we also have to admit that there is no easy recipe, that investments that are inclusive and green include costs—typically, the loss of a subsidy—that consumers and/or taxpayers may have to bear in the short-run.

I also read in your posts an observation that Walt Whitman would have appreciated: It is the human component—planning, coordinating, educating, changing behavior—that remains our greatest challenge.

The Worst Kind of Poverty: Energy Poverty



Click here to find out more!
Vendors in a market in Abidjan, Ivory Coast, use candles during a power outage. Over 95% of those without electricity are either in sub-Saharan Africa or developing Asia
Issouf Sanogo / AFP / Getty Images
  • COMMENTI want you to try to imagine what it's like to live without electricity. It's boring, for one thing — no television, no MP3 player, no video games. And it's lonely and disconnected as well — no computer, no Internet, no mobile phone. You can read books, of course — but at night you won't have light, other than the flicker of firewood. And about that firewood — you or someone in your family had to gather it during the day, taking you away from more productive work or schooling, and in some parts of the world, exposing you to danger. That same firewood is used to cook dinner, throwing off smoke that can turn the air inside your home far more toxic than that breathed in an industrial city. You may lack access to vaccines and modern drugs because the nearest hospital doesn't have regular power to keep the medicine refrigerated. You're desperately poor — and the lack of electricity helps to ensure that you'll stay that way.
That's life for the 1.3 billion people around the planet who lack access to the grid. It's overwhelmingly a problem of the developing world and the countryside — more than 95% of those without electricity are either in sub-Saharan Africa or developing Asia, and 84% live in rural areas. Though it hasn't gotten the attention that global problems like HIV/AIDS and malaria have received in recent years, lack of power remains a major obstacle to any progress in global development.(See photos of new ways to boost energy efficiency.)
"Lacking access to electricity affects health, well-being and income," says Fatih Birol, the chief economist of the International Energy Agency (IEA). "It's a problem the world has to pay attention to."
Fortunately that attention is finally forthcoming. The U.N. has already declared 2012 the International Year of Sustainable Energy for All, and on Oct. 10 the IEA released a special report that details the problem of energy access and outlines how a universal power grid might be financed. The need for clean cooking stoves — 2.7 billion people lack them, an offshoot of the energy-access problem — is rising up the development agenda as well. The experts' analyses about how solvable these problems are is surprisingly sunny: according to the IEA's analysis, it would be possible to achieve universal energy access for the world by 2030 with around $48 billion a year in global investment. "We very much have the capacity to make a difference in this field," says Birol, who has worked for years to call attention to electricity access. No one needs to stay in the dark.
At a time when even developed countries are feeling poor — or at least poorer than they once were — $48 billion a year sounds like a fair chunk of change, but it actually only amounts to about 3% of yearly global energy investment, which should give you a sense of just how vast the worldwide energy industry is. But right now the world is falling well short of that necessary target — perhaps $9 billion a year is currently invested in shrinking the energy gap, with much of it coming from foreign aid and other public sources that are unlikely to grow in a straitened global economy. Nearly all of that investment goes toward improving grid access in urban areas, which leaves those in rural villages out of luck. Even if investment rises to $14 billion a year, the IEA expects that 1 billion people will still be without power in 2030. "What's being done now clearly isn't enough," says Birol.(See photos of power in cities.)
And the problem will get worse rapidly thanks to rising oil prices, which could put a crimp in development. It's worth noting that when rich nations were at roughly the same economic stage as developing countries are today, oil cost an average of around $22 per barrel. Though the price has fluctuated recently, the $100-a-barrel threshold is increasingly being crossed. For developing countries that are net oil importers, those high prices can quickly eat up a national budget; oil-import bills in sub-Saharan Africa, for example, went up by $2.2 billion in 2010, more than one-third higher than the increase in official development aid. Environmentalists sometimes welcome higher energy prices as a spur to conservation and efficiency, but that's true mostly in rich countries; in developing, energy-starved ones, high prices can be economically crippling.
Beyond ensuring that there's more overall investment in closing the energy gap, there's the question of how the money should be spent. The tendency has been toward big projects — major fossil-fuel plants and electrical transmission lines. That sort of infrastructure can serve cities well, but it's not going to reach the rural villagers that are the most energy-starved — not to mention the fact that it's not the best idea to lock in carbon-heavy power sources in a warming world. That's where renewables might have a practical advantage, as well as an environmental one. Solar power can be installed quickly and cheaply far off the grid, providing enough power for light and basic services — and it's not as if sub-Saharan Africa is lacking for sunlight. With smart and green investment, the IEA believes that achieving universal energy access would increase global carbon emissions by only 0.7% by 2030 — a drop in the climate bucket. "Solar is going to play a huge role in improving energy access," says Birol. "It's one of the best ways to meet challenges off the grid."
Energy poverty is, of course, only a piece of larger economic poverty, but it's one of the best ways out of it too. If you need one more reminder of that fact — and of how radical the difference is between the world's haves and have-nots — take a look at a satellite photograph of earth at night, with large swathes of the planet radiating light and other stretches cloaked in darkness, an electric map of wealth and poverty. The very least we can do is wake up to the fact that everyone deserves a light.


Read more: http://www.time.com/time/health/article/0,8599,2096602,00.html#ixzz1b0OqrSXP

Rising Food Prices - Nearly One Billion Go to Bed Hungry


Put Food First - Every day nearly 1 billion people go to bed hungry. Rising and volatile food prices are causing pain and suffering for poor people around the world, driving 44 million people into extreme poverty in recent months. We need to find solutions to ensure everyone has enough nutritious food now and in the years to come.

Researchers invent tiny artificial muscles with the strength, flexibility of elephant trunk







An international team of researchers has invented new artificial muscles strong enough to rotate objects a thousand times their own weight, but with the same flexibility of an elephant’s trunk or octopus limbs.
In a paper published online today on Science Express, the scientists and engineers from the University of British Columbia, the University of Wollongong in Australia, the University of Texas at Dallas and Hanyang University in Korea detail their innovation. The study elaborates on a discovery made by research fellow Javad Foroughi at the University of Wollongong.
Using yarns of carbon nanotubes that are enormously strong, tough and highly flexible, the researchers developed artificial muscles that can rotate 250 degrees per millimetre of muscle length. This is more than a thousand times that of available artificial muscles composed of shape memory alloys, conducting organic polymers or ferroelectrics, a class of materials that can hold both positive and negative electric charges, even in the absence of voltage.

“What’s amazing is that these barely visible yarns composed of fibres 10,000 times thinner than a human hair can move and rapidly rotate objects two thousand times their own weight,” says  Assoc. Prof. John Madden, UBC Dept. of Electrical and Computer Engineering.
Madden says, “While not large enough to drive an arm or power a car, this new generation of artificial muscles – which are simple and inexpensive to make – could be used to make tiny valves, positioners, pumps, stirrers and flagella for use in drug discovery, precision assembly and perhaps even to propel tiny objects inside the bloodstream.”
Central to the team’s success are nanotubes that are spun into helical yarns, which means that they have left and right handed versions, which allows the yearn to be controlled by applying an electrochemical charge, and to twist and untwist.
The new material was devised at the University of Texas at Dallas and then tested as an artificial muscle in Madden’s lab at UBC. A chance discovery by collaborators from Wollongong showed the enormous twist developed by the device. Guided by theory at UBC and further experiments in Wollongong and Texas, the team was able to extract considerable torsion and power from the yarns.
The torsional rotation of helically wound muscles, such as those in the flagella of bacteria, has existed in nature for hundreds of millions of years.  Many other natural appendages – from the trunk of an elephant to octopus’s powerful and limber tentacles – also show how helically wound muscle fibers cause rotation by contracting against a boneless core.
The nanotube yarns are activated by charging them in a salt solution, much as a battery is charged. A breakthrough discovery came from former UBC PhD student Tissaphern Mirfakhrai – now at Stanford – who found that the deformation of the yarns is proportional to the size and number of ions inserted. A similar effect is seen in lithium ion battery electrodes used in portable electronic devices, but in yarns it is put to good use.  The helical structure of the yarns makes them unwind as they accept charge and swell. They twist back up again when discharged.
“The discovery, characterization, and understanding of these high performance torsional motors show the power of international collaborations,” says corresponding author Ray Baughman, Robert A. Welch Professor of Chemistry and director of the University of Texas at Dallas Alan G. MacDiarmid NanoTech Institute.
___________

Understanding the beginnings of embryonic stem cells helps predict the future






Ordinarily, embryonic stem cells exist only a day or two as they begin the formation of the embryo itself. Then they are gone.
In the laboratory dish, however, they act more like perpetual stem cells – renewing themselves and exhibiting the ability to form cells of almost any type, a status called totipotency.
Dr. Thomas Zwaka, associate professor in the Stem Cell and Regenerative Medicine Center at Baylor College of Medicine, and his colleagues here and abroad showed that laboratory-grown cells express a protein called Blimp1, which represses differentiation to somatic or regular tissue cells during germ cell development. Studies of these cells show that they also express other genes associated with early germ cell specification. A report on their work published online today in the journal Current Biology. It will appear in the October 25 print edition of the journal.
“What are embryonic stem cells?” said Zwaka, who is also part of the Center for Cell and Gene Therapy at BCM, Texas Children’s Hospital and The Methodist Hospital. “It is quite a surprise that we have them. In the embryo, there is a mass of cells that eventually form the embryo, but they do not persist. They do not have a program built in that allows them to persist.”
To study this, he examined mice. If you put the mass of cells in a Petri dish in the laboratory, they act as thought they are stem cells with the ability for self renewal and totipotency – the ability to become almost any kind of cell.
Understanding what happens early in development of embryonic stem cells in the laboratory might help make the process of growing them and another, new kind of stem cell called induced pluripotent stem cells – cells with the potential of becoming many different kinds of tissues that are derived from somatic or adult cells.
“These induced pluripotent stem cells are poorly understood,” said Zwaka. “If we know what is happening when we derive embryonic stem cells in the laboratory, it will inform us when we make induced pluripotent stem cells. The end product is similar.”
The process of making the induced pluripotent stem cells is noisy and random, he said.
“Every time, the clones look different and emerge at different time points,” said Zwaka. By contrast, embryonic development is like clockwork, with events occurring at the same point with each embryo. However, development of embryonic stem cells in the laboratory becomes more disorganized as time goes on.
In the laboratory dish, the mouse embryo continues to develop at a fairly organized rate for two or three days, but when the single cells are separated and grown singly, the embryonic stem cells begin to emerge. Only a tiny subset – roughly 1 percent – of the cells become an embryonic stem cell in the laboratory.”
“We found that these cells (from the embryonic stem cells come) resemble in almost every feature an early germ cell (primordial germ cell),” he said. (Primordial germ cells are the source of gametes – eggs and sperm.)
“It seems that these seeming germ cells are the cells that make the embryonic stem cells in culture,” he said.
“Germ cells in the embryo are unique and pluripotent (able to become many different kinds of cells) and have a very sophisticated program in them that protects the from becoming somatic cells (specific tissue cells),” he said. “They retain their primitive state.” Blimp1 is a master regulator of germ cells.
In the future, he said, he hopes that investigators in both fields can collaborate and learn from one another.

FIVE SURPRISING FACTS ABOUT MILLIONAIRES IN THE NEXT TEN YEARS




Do you know what country plays host to the most millionaires? How about what country is predicted to create the most millionaires in the next ten years? This information and more is revealed in the following article!
Deloitte Center for Financial Services conducted research on the millionaires in the world for next 10 years. Both their homes and investment trends that will be their choice. What is the research like?
25 countries that examined in this study covers 15 developed countries, like Australia, Canada, France, Germany, China, Italy, Japan, Netherlands, Norway, Singapore, Spain, Sweden, Switzerland, USA and UK. Then the 10 developing countries such as Brazil, China, India, Malaysia, Mexico, Poland, Russia, South Korea, Taiwan and Turkey.
The total wealth of the millionaires in the world for the next 10 years would grow 119% from U.S. $ 92 trillion to U.S. $ 202 trillion. For the developing countries, growth in 2020 is quite impressive, which is bolted 260%, from U.S. $ 7 to $ 25, significantly with the growth in developed countries amounted to 107%, from U.S. $ 85 to $ 177.
U.S. will remain as a country with the largest number of millionaires in the world for 2020, followed by Japan, Germany and Britain. Global ranking of the total number of millionaires in the world of developing countries will experience an increase rankings, with some economies grow significantly, such as South Korea and Mexico. While some of that is decreasing, like Taiwan and Turkey.
China is still going to hold its position as the country with second highest economy, after the U.S., with a fortune of over U.S. $ 30 million. While Brazil and India ranked fifth in sixth position.
Singapore will have the largest population of millionaires in the world. The proportion of total relevant super rich millionaire in 2020 became the highest in Singapore, with a percentage of 1.82%. While the Swiss will become number two on the percentage population of 0.61% and Hong Kong on third position with a percentage of 0.52%.
However, Swiss millionaires will be the richest millionaires in the world. According to the study, for millionaires in Switzerland will have an average wealth of U.S. $ 4.2 million, the highest among 25 countries in this study. The second position is Singapore with U.S. $ 4 million, then the U.S. with $ 3.9 million. China may have an average final wealth separately millionaire, ni yak U.S. $ 1.3 million per household.
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NAAM LAB PE RAHEGA SADA SAI KA........

Sunday, October 16, 2011

Eating green veggies improves immune defenses






Researchers reporting online in the journal Cell, a Cell Press publication, have found another good reason to eat your green vegetables, although it may or may not win any arguments with kids at the dinner table.
It turns out that green vegetables — from bok choy to broccoli — are the source of a chemical signal that is important to a fully functioning immune system. They do this by ensuring that immune cells in the gut and the skin known as intra-epithelial lymphocytes (IELs) function properly.
“It is still surprising to me,” said Marc Veldhoen of The Babraham Institute in Cambridge. “I would have expected cells at the surface would play some role in the interaction with the outside world, but such a clear cut interaction with the diet was unexpected. After feeding otherwise healthy mice a vegetable-poor diet for two to three weeks, I was amazed to see 70 to 80 percent of these protective cells disappeared.”
Those protective IELs exist as a network beneath the barrier of epithelial cells covering inner and outer body surfaces, where they are important as a first line of defense and in wound repair. Veldhoen’s team now finds that the numbers of IELs depend on levels of a cell-surface protein called the aryl hydrocarbon receptor (AhR), which can be regulated by dietary ingredients found primarily in cruciferous vegetables. Mice lacking this receptor lose control over the microbes living on the intestinal surface, both in terms of their numbers and composition.
Earlier studies suggested that breakdown of cruciferous vegetables can yield a compound that can be converted into a molecule that triggers AhRs. The new work finds that mice fed a synthetic diet lacking this key compound experience a significant reduction in AhR activity and lose IELs. With reduced numbers of these key immune cells, animals showed lower levels of antimicrobial proteins, heightened immune activation and greater susceptibility to injury. When the researchers intentionally damaged the intestinal surface in animals that didn’t have normal AhR activity, the mice were not as “quick to repair” that damage.
As an immunologist, Veldhoen says he hopes the findings will generate interest in the medical community, noting that some of the characteristics observed in the mice are consistent with those seen in patients with inflammatory bowel disease.
“It’s tempting to extrapolate to humans,” he said. “But there are many other factors that might play a role.”
For the rest of us, he says, “it’s already a good idea to eat your greens.” Still, the results offer a molecular basis for the importance of cruciferous vegetable-derived phyto-nutrients as part of a healthy diet.
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