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Tuesday, August 2, 2011

The World Bank as Convener First, Lender Second?

"Are you sure we should do this in the World Bank atrium?"

"Yes, sir," I said.  "Why not?"
I tried to act confident, but I was terrified.  It was February 1998, and on the phone was a managing director, second only in power to the president of the World Bank.  He was known for asking questions that were actually orders. Arguing rather than obeying was considered ill-advised.
"Well," he said, "we may have outside visitors that day.   Do you think they should see some of those crazy ideas that staff may come up with?  What if we relocated the event to the basement, out of the way?"
A small innovation team, with encouragement from Jim Wolfensohn, the Bank's president, had decided to launch the first-ever Innovation Marketplace, a one-day event when any Bank staff member (regardless of title or seniority) could propose an idea for helping the Bank better fight poverty.  We would award $5 million to help fund the start-up of the most promising ideas. We had decided to hold the event in the atrium of the Bank, a beautiful space that soars thirteen stories.
The only problem was that the atrium was almost never used for public events; it was always eerily quiet and deserted, even sterile.  You never wanted to linger there - you always hurried through. The culture of the Bank at that time was such that everyone worked behind closed doors, beavering away on in-depth country or sector studies designed to find out the right answers to various development challenges.  Staff emerged only for the occasional review meetings, or to go on mission to the countries they worked on.
My, oh, my how the world - and the World Bank - have changed since then.  A couple of months ago, I went back to my old stomping grounds to witness an Apps for Development competition. Not only was the Bank's atrium a beehive of activity, but there was even techno music pumping up the mood of the crowd before the announcement of the event's winners.
Stephanie Strom recently wrote a nice article in the NY Times about how the Bank is opening its "treasure chest of data" for researchers and others around the world to use.  The articles has good insights into the benefits of making data public; and the fact that the World Bank (previously among the most secretive of aid institutions) is now making such huge strides is sure to encourage other agencies to do the same.  (The UNDP also created a very impressive open data portal for some of its projects here.)
Sharing data is a big leap, but there is now a window of opportunity for the Bank to do something much, much bigger.  Back in 1998, with my heart pounding, I stood my ground with the Managing Director, and the Innovation Marketplace was a huge success; by cutting through the usual layers of bureaucracy and giving everyone an equal voice, the event allowed all sorts of good ideas to bubble up, any many of them soon became major strategic.  In some sense, we were democratizing the World Bank, even if for only one day.
Building on that success, in early 2000 we went on to launch the Development Marketplace, which allowed anyone in the world (not just the Bank) to propose an idea for funding.  The planning of this event also generated a lot of controversy (and not only from senior managers this time), but it was a big success, too.  And though I left the World Bank shortly afterwards to co-found GlobalGiving, the Bank went on to replicate the Development Marketplace many times, including in some seventy countries around the world over the past decade.  Country directors would sometime report that it was the first time they had been able to get civil society groups and government officials in one room together talking about ideas and solutions rather than just arguing.
Nonetheless, despite their success, these marketplaces have remained peripheral to World Bank's main business.  In the decade since my departure, many former colleagues complained to me that the Bank was failing to innovate in ways that would keep it relevant for a changing world.
That may be about to change.  Bob Zoellick, the Bank's current president, recently talked in a speech about the "democratization" of development, where the Bank and other aid agencies no longer pretend to have a monopoly on understanding problems and devising solutions. Bank experts would still have a great deal of technical expertise, but the role of Bank staff would shift.  Instead of trying to find and hire the elusive "best expert in the world on subject X," the Bank would hire very good experts who are capable of leading a conversation among other experts, government officials, and regular citizens about the most pressing problems and the most viable potential solutions.  Bank staff would in a sense become "hosts" of conversations about what to do, and then would have the ability to financially support the initiatives and approaches that arise from these conversations.
Hosting effective conversations is hard, and it may be the most in-demand skill at the Bank in the decade ahead.  If the Bank can make progress in this area, however, the payoff for the institution could be large.  In addition, by modeling openness and an ability to listen, the Bank would be putting indirect pressure on governments around the world to do the same.  If regular people are able to comment on and even contribute to the design of World Bank projects, they are surely going to begin demanding the same treatment from their own governments.  The resulting increase in citizen voice and government responsiveness could end up having a far more important impact than any particular Bank project(s).
Zoellick has assembled a solid team to help the Bank remake itself.  Sanjay Pradhan, Randi Ryterman, Aleem Walji, and others are helping lead a conversation within the Bank on ways to cultivate new thinking and approaches. As the NY Times article notes, significant culture change is going to be required, and that is  always tough.  And change will also demand hard thinking about the World Bank's business model, which currently relies on generating a spread on its loans and other financial instruments.  Incentives within the institution remain tied to the ability of staff to make loans and help the institution generate the income that it needs to operate.
The good news is that the best staff at the World Bank are leading the way.  A while back, some of my former colleagues hosted an informal all-day Saturday session for health officials in a Latin American country.  No ties were allowed, and there was no rigid agenda.  When I told one of the Bank conveners that I was sorry he had to work on a Saturday, he told me that it was one of the most productive days of his career. "For once, we did not give them a long lecture," he told me.  "We just served them pizza and kept the conversation headed in the right direction, injecting bits of information but not pressing my own views too hard."
As a result, the health officials swapped stories about what was working and what wasn't in their country.  They were able to be candid about their failures as well as their successes.  The conversation was not about What is the RIGHT ANSWER? Rather, it was about What are some reasonable things to try in our country, and how can we best evaluate the results? The participants liked the experience so much that one of the officials present hosted a similar session, with Bank help, for other countries in the region. The effort led to a great deal of social capital that allowed successes and failures to be honestly shared, thereby speeding experimentation and improving feedback loops.
My friend told me he felt he had helped advance reform more on that single day than in months of formal meetings and expert presentations.  Instead of being a Bank expert pushing for the RIGHT policy, he was helping a country's own experts iterate toward an approach that would work in their context. Furthermore, the trust and social capital that emanated from these meetings led the countries involved to seek several hundred million dollars of funding from the Bank to support their reform agendas.  The revenue from these loans in turn enable the Bank staff to provide additional intellectual support, including hosting more conversations.
 

Hebrew University student turns paper mill waste into 'green' material for industrial applications


by Biomechanics 

A method to use paper mill waste to produce ecologically friendly, industrial foams from renewable resources has been developed by a graduate student in agriculture at the Hebrew University of Jerusalem. 


Caption: Shaul Lapidot is a Ph.D. student in agriculture at the Hebrew University of Jerusalem. 

Foams are used for numerous day-to-day uses, including in the manufacture of furniture and car interiors. In many composite material applications, they are used as core material in "sandwich" panels to achieve high strength, weight reduction, energy dissipation and insulation. Conventional foams are produced from polymers such as polyurethane, polystyrene, polyvinyl chloride (PVC) and polyethylene terephthalate (PET). Since all of these current foams rely on fossil oil, they present a clear environmental disadvantage. 

Shaul Lapidot, a Ph.D. student of Prof. Oded Shoseyov, along with his laboratory colleagues at the Robert H. Smith Faculty of Agriculture, Food and Environment of the Hebrew University in Rehovot, has formulated a procedure for production of nano-crystalline cellulose (NCC) from paper mill waste. NCC is further processed into composite foams for applications in the composite materials industry as bio-based replacement for synthetic foams. 

The process of paper production involves loss of all fibers with dimensions lower than the forming fabric mesh. Consequently around 50% of the total fibers initially produced are washed away as sludge. In Europe alone, 11 million tons of waste are produced annually by this industry, creating an incentive for finding alternative uses and different applications for the wastes. 

Lapidot has found that fibers from paper mill sludge are a perfect source for NCC production due to their small dimensions which require relatively low energy and chemical input in order to process them into NCC. He also developed the application of NCC into nano-structured foams. This is further processed into composite foams for applications in the composite materials industry to be used as bio-based replacement for synthetic foams. 

NCC foams that Lapidot and his colleagues have recently developed are highly porous and lightweight. Additional strengthening of the foams was enabled by infiltration of furan resin, a hemicellulose-based resin produced from raw crop waste, such as that remaining from sugar cane processing, as well as oat hulls, corn cobs and rice hulls. 

The new NCC reinforced foams display technical performance which matches current high-end synthetic foams. The technology was recently licensed from Yissum, the technology transfer company of the Hebrew University, by Melodea Ltd., an Israeli-Swedish start-up company which aims to develop it for industrial scale production. 

Lapidot's development has led to his being awarded one of the Barenholz Prizes that were presented on June 21 at the Hebrew University Board of Governors meeting. The award is named for its donor, Prof. Yehezkel Barenholz of the Hebrew University-Hadassah Medical School.

Solar cells get a boost from bouncing light

Engineering:  
A new twist on an old solar cell design sends light ricocheting through layers of microscopic spheres, increasing its electricity-generating potential by 26 percent. 

By engineering alternating layers of nanometer and micrometer particles, a team of engineers from the University of Minnesota has improved the efficiency of a type of solar cell by as much as 26 percent. These cells, known as dye-sensitized solar cells (DSSC), are made of titanium dioxide (TiO2), a photosensitive material that is less expensive than the more traditional silicon solar cells, which are rapidly approaching the theoretical limit of their efficiency.

Current DSSC designs, however, are only about 10 percent efficient. One reason for this low efficiency is that light from the infrared portion of the spectrum is not easily absorbed in the solar cell. The new layered design, as described in the AIP's Journal of Renewable and Sustainable Energy, increases the path of the light through the solar cell and converts more of the electromagnetic spectrum into electricity.

The cells consist of micrometer-scale spheres with nanometer pores sandwiched between layers of nanoscale particles. The spheres, which are made of TiO2, act like tightly packed bumpers on a pinball machine, causing photons to bounce around before eventually making their way through the cell. Each time the photon interacts with one of the spheres, a small charge is produced. The interfaces between the layers also help enhance the efficiency by acting like mirrors and keeping the light inside the solar cell where it can be converted to electricity.

This strategy to increase light-harvesting efficiency can be easily integrated into current commercial DSSCs.
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Article: "Layered mesoporous nanostructures for enhanced light harvesting in dye-sensitized solar cells" is accepted for publication in the Journal of Renewable and Sustainable Energy.

Authors: Bin Liu and Eray S. Aydil, University of Minnesota

India: Biotechnology Research and Development



(“Biomechanism.com“) — Biotechnology has transformed many parts of the chemical industry, agriculture, and medicine. This area of science has little demarcation between basic and applied research, and new discoveries and innovations, in most cases, can find direct application.
Innovations, techniques, and tools that have emerged and revolutionized modern biotechnology include genetic engineering, cell fusion technology, bioprocess technologies, and structure-based molecular designs including drug development, drug targeting, and drug delivery systems.
In the 1980s the Government of India considered the need for creating a separate institutional framework to strengthen biology and biotechnology research in the country. Scientific agencies supporting research in modern biology included:
  • Council of Scientific and Industrial Research (CSIR),
  • Indian Council of Agricultural Research (ICAR),
  • Indian Council of Medical Research (ICMR),
  • Department of Science and Technology, and
  • University Grants Commission.
Biotechnology was given an important boost in 1982 with the establishment of the National Biotechnology Board. Its priorities were human resource development, creation of infrastructure facilities, and supporting research and development (R&D) in specific areas. The success and impact of the National Biotechnology Board prompted the Government to establish a separate Department of Biotechnology (DBT) in February 1986.
There have been major accomplishments in areas of basic research in agriculture, health, environment, human resource development, industry, safety, and ethical issues.
Author: Manju Sharma
View the full paper here: India: Biotechnology Research and Development (PDF)
References
French, C.E., S.J. Rosser, G.J. Davies, S. Nicklin, and N.C. Bruce. 1999. Biodegradation of explosives by transgenic plants expressing pentaerythritol tetranitrate reductase. Nature Biotechnology 17(5) May, 491-4.
James, C. 1998. Global Review of Transgenic Crops: 1998. ISAAA Brief No. 8. Ithaca, N.Y.: International Service for the Acquisition of Agri-biotech Applications.

Antioxidants of Interest To Address Infertility, Erectile Dysfunction



A growing body of evidence suggests that antioxidants may have significant value in addressing infertility issues in both women and men, including erectile dysfunction, and researchers say that large, specific clinical studies are merited to determine how much they could help.
A new analysis, published online in the journal Pharmacological Research, noted that previous studies on the potential for antioxidants to help address this serious and growing problem have been inconclusive, but that other data indicates nutritional therapies may have significant potential.

Fruits and vegetables provide the body with an added source of antioxidants that is needed to properly wage war against free radicals. -Biomechanism.com
The researchers also observed that infertility problems are often an early indicator of other degenerative disease issues such as atherosclerosis, high blood pressure and congestive heart failure. The same approaches that may help treat infertility could also be of value to head off those problems, they said.
The findings were made by Tory Hagen, in the Linus Pauling Institute at Oregon State University, and Francesco Visioli, lead author of the study at the Madrid Institute for Advanced Studies in Spain.
“If oxidative stress is an underlying factor causing infertility, which we think the evidence points to, we should be able to do something about it,” said Hagen, the Jamieson Chair of Healthspan Research in the Linus Pauling Institute. “This might help prevent other critical health problems as well, at an early stage when nutritional therapies often work best.”
The results from early research have been equivocal, Hagen said, but that may be because they were too small or did not focus on antioxidants. Laboratory and in-vitro studies have been very promising, especially with some newer antioxidants such as lipoic acid that have received much less attention.
“The jury is still out on this,” Hagen said. “But the problem is huge, and the data from laboratory studies is very robust, it all fits. There is evidence this might work, and the potential benefits could be enormous.”
The researchers from Oregon and Spain point, in particular, to inadequate production of nitric oxide, an agent that relaxes and dilates blood vessels. This is often caused, in turn, by free radicals that destroy nitric oxide and reduce its function. Antioxidants can help control free radicals. Some existing medical treatments for erectile dysfunction work, in part, by increasing production of nitric oxide.
Aging, which is often associated with erectile dysfunction problems, is also a time when nitric oxide synthesis begins to falter. And infertility problems in general are increasing, scientists say, as more people delay having children until older ages.
“Infertility is multifactorial and we still don’t know the precise nature of this phenomenon,” Visioli said.
If new approaches were developed successfully, the researchers said, they might help treat erectile dysfunction in men, egg implantation and endometriosis in women, and reduce the often serious and sometimes fatal condition of pre-eclampsia in pregnancy. The quality and health of semen and eggs might be improved.
As many as 50 percent of conceptions fail and about 20 percent of clinical pregnancies end in miscarriage, the researchers noted in their report. Both male and female reproductive dysfunction is believed to contribute to this high level of reproductive failure, they said, but few real causes have been identified.
“Some people and physicians are already using antioxidants to help with fertility problems, but we don’t have the real scientific evidence yet to prove its efficacy,” Hagen said. “It’s time to change that.”
Some commonly used antioxidants, such as vitamins C and E, could help, Hagen said. But others, such as lipoic acid, are a little more cutting-edge and set up a biological chain reaction that has a more sustained impact on vasomotor function and health.
Polyphenols, the phytochemicals that often give vegetables their intense color and are also found in chocolate and tea, are also of considerable interest. But many claims are being made and products marketed, the researchers said, before the appropriate science is completed – actions that have actually delayed doing the proper studies.
“There’s a large market of plant-based supplements that requires hard data,” Visioli said. “Most claims are not backed by scientific evidence and human trials. We still need to obtain proof of efficacy before people invest money and hope in preparations of doubtful efficacy.”

Grapes protect against ultraviolet radiation



Some compounds found in grapes help to protect skin cells from the sun’s ultraviolet radiation, according to a study by researchers from the University of Barcelona and the CSIC (Spanish National Research Council). The study supports the use of grapes or grape derivatives in sun protection products.
It's important to note that the seed and the skin of grapes contain the richest concentration of antioxidants. -Biomechanism
Ultraviolet (UV) rays emitted by the sun are the leading environmental cause of skin complaints, causing skin cancer, sunburn and solar erythema, as well as premature ageing of the dermis and epidermis. Now, a Spanish study has proven that some substances in grapes can reduce the amount of cell damage caused in skin exposed to this radiation.
UV rays act on the skin by activating ‘reactive oxygen species’ (ROS). These compounds in turn oxidise macromolecules such as lipids and DNA, stimulating certain reactions and enzymes (JNK and p38MAPK) which cause cell death.
A group of scientists from the University of Barcelona and the CSIC have shown that some polyphenolic substances extracted from grapes (flavonoids) can reduce the formation of ROSs in human epidermis cells that have been exposed to long-wave (UVA) and medium-wave (UVB) ultraviolet radiation. The study, carried out in vitro in the laboratory, has been published in the Journal of Agricultural and Food Chemistry.
Grape-based Sun Protection
“These polyphenolic fractions inhibit the generation of the ROSs and, as a result, the subsequent activation of the JNK and p38 enzymes, meaning they have a protective effect against ultraviolet radiation emitted by the sun”, Marta Cascante, a biochemist at the University of Barcelona (Spain) and director of the research project, tells SINC.
The researchers found that the higher the degree of the flavonoids’ polymerisation and formation of compounds containing gallic acid, the greater their photoprotective capacity.
The study suggests that these “encouraging results should be taken into consideration in clinical pharmacology using plant-based polyphenolic extracts to develop new photoprotection skin products.
Cosmetics and drugs containing grape compounds are already available, but the way they act on cells has not been well understood until now. “This study supports the idea of using these products to protect the skin from cell damage and death caused by solar radiation, as well as increasing our understanding of the mechanism by which they act”, concludes Cascante.
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References:
Cecilia Matito, Neus Agell, Susana Sanchez-Tena, Josep L. Torres, Marta Cascante. “Protective Effect of Structurally Diverse Grape Procyanidin Fractions against UV-Induced Cell Damage and Death”. Journal of Agricultural and Food Chemistry 59 (9): 4489-4495, May 2011. DOI: 10.1021/jf103692a.