Lesser Known But Great Horror Films Of The 21st Century

Pulse (2001)

Toho Company / Via wordpress.com

Ring might have started the whole J-Horror fad but Pulse is where it’s at. Genuinely creepy, unnerving and just opaque enough to leave you constantly intrigued, this is what an art house director’s most accessible horror effort looks like.

A Tale of Two Sisters (2003)

B.O.M. Film Productions Co. / Via tumblr.com

Remade in the U.S. as The Uninvited in 2009, as per usual, the original is the one to stick to. A wicked stepmother, an eerie kid under the sink and a bloody sack which contents are twitching all make this a genuinely unsettling experience and twisted fairy tale.

Shutter (2004)

Phenomena Motion Pictures / Via tumblr.com

Japan might have taken all the credit for the Asian horror wave which swept the globe around the millennium but this Thai shocker ranks among the very best in the genre. Who knew the ghosts of the dead could be sitting right there on your shoulders?

Inside (2007)

La Fabrique de Films / Via wordpress.com

One of two entries of the New French Extremity on this list, Inside deals with a woman whose partner has recently died but who still carrying his child. If that wasn’t bad enough, someone is stalking her and is hell bent on getting her baby. Before it’s born the regular way that is. Go French Extremity.

The Signal (2007)

Magnolia Pictures / Via i44.photobucket.com

Three different directors direct the three different acts of the one story, resulting in one hardcore opening, one darkly funny second act and one utterly weird finale. If you want to see something different, The Signal will do the trick.

Splinter (2008)

Magnolia Pictures / Via media.giphy.com

A parasite transforms its hosts into some serious nasty creatures. Whilst the limited budget does show at times, the enthusiasm of the filmmakers jumps off the screen and makes Splinter a horror flick which deserves a lot more exposure and appreciation. It’s fresh.

Pontypool (2008)

Ponty Up Pictures Shadow Shows / Via tumblr.com

Maybe not for everyone, Pontypool is one hell of a different take on the zombie genre. Moody and funny, it’s certainly not the goriest entry on this list but it might be the most original one. For those who like their horror more cerebral.

Let The Right One In (2008)

Magnet Releasing / Via media.giphy.com

Whilst the American 2010 remake Let Me In certainly did a decent job, the Swedish original takes home the cake. As melancholic as bizarre, this is a very fresh take on the vampire film and a beautifully made film. A must for all serious lovers of the genre.

The Broken (2008)

Versus Entertainment / Via tumblr.com

Under seen and under appreciated, The Broken is a stylish British doppelgänger mystery which presents a story line which is as fractured as its main characters. Cold, unsettling and with a nightmare logic, this movie is ripe for re-evaluation.

Lake Mungo (2008)

Arclight Films / Via wordpress.com

A faux documentary done right, Lake Mungo is partly a ghost story, partly an examination of grief and partly a comment on the medium of film itself. Never going for big scares, this Australian chiller maintains its sense of mystery and dread throughout whilst simultaneously exploring some serious themes often lacking in these types of films.

Martyrs (2008)

Wild Bunch / Via tumblr.com

Relentless, unforgiving, utterly disturbing and definitely not for the faint of heart, Martyrs is the second New French Extremity entry on this list and it certainly fits the bill. Those who can handle the truly extreme and confronting will be in for a treat although others might want to give this one a miss as it doesn’t get more intense than this. A true modern classic.

Triangle (2009)

UK Film Council / Via tumblr.com

A true mind-bender, Triangle is a psychological horror thriller which keeps you guessing till the end and also delivers in its satisfying finale. A Twilight Zone episode successfully drawn out to feature length, here’s another little gem more people need to see.

The Loved Ones (2009)

Ambience Entertainment / Via tumblr.com

Wonderfully twisted and subverting some genre tropes, The Loved Ones is a sick little Australian film that goes for the jugular and never lets go. Not since Carrie has a prom been so messed up.

The Crazies (2010)

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A remake of a lesser known film by horror maestro George A. Romero, The Crazies doesn’t waste any time getting into its story of an outbreak of zombie-like creatures and has more memorable scenes than a few of your average zombie shockers combined. Fast paced and entertaining, this one is highly accessible and the definition of a successful update.

Kill List (2011)

Rook Films / Via tumblr.com

A wildly original mix between British kitchen sink drama, a small time crime movie and pagan horror, Kill List doesn’t show its true nature until the very end but for those who stick with it, it’s a ride well worth taking. This is what would happen if Mike Leigh directed The Wicker Man.

Maniac (2012)

IFC Midnight / Via wordpress.com

A remake of the infamous 1980 slasher, shot entirely from the killer’s point of view and thereby making the viewer complicit in the murderer’s horrendous deeds, Maniac is a stylish, nasty and distressing little movie starring Elijah Wood, who clearly set out to shed his hobbit image. Job well done.

We Are What We Are (2013)

Entertainment One / Via cdn.bloody-disgusting.com

The rare remake that actually improves upon its original, We Are What We Are is a very slow burn with a very big pay-off. This is American Gothic at its best and it has cannibalism to boot. What’s not to like?

Starry Eyes (2014)

Snowfort Pictures / Via wordpress.com

Best described as the twisted little love child of David Cronenberg and David Lynch, Starry Eyes explores what we are willing to do for fame and how it transforms us…literally. Dark and disturbing, this one keeps building tension until it explodes in a gory finale.

Spring (2014)

XYZ Films / Via joblo.com

Highly original, this mix between love story and Lovecraftian nightmare blends genres effortlessly and comes out as something truly innovative. Beautifully shot, well acted and with some impressive effects, Spring is a remarkable low-budget treat.

It Follows (2014)

Dimension Films / Via imagesmtv-a.akamaihd.net

Proving that blood and guts aren’t necessary to bring on the chills, It Follows takes an original concept and runs with it. Maintaining a sense of dread throughout its entire run time, this movie looks stunning and feels like something John Carpenter would have done in his prime. And that tall guy is seriously creepy.

Why is it absolutely critical that you take a small nap middle of the day?

Taking a nap, we’ve seen time and again, is like rebooting your brain. Here's when to nap and how long to nap and its respective benefits.

Rapid, sensitive test for HIV mutations

Tests that can distinguish whether HIV-positive people are infected with a drug-resistant strain or a non-resistant strain allow patients to get the most effective treatment as quickly as possible.

Published in the Journal of Molecular Diagnostics, researchers describes a new method that works faster and more sensitively in lab testing than the current standard technologies.

The main advance enabling that improved performance is that the system operates directly on the virus' more readily available RNA rather than requiring extra, potentially error-prone steps to examine DNA derived from RNA. In a single tube, the system can first combine two engineered probes (ligation) if a mutation is present and then make many copies of those combined probes (amplification) for detection.

The experiments reported in the paper show that the LRA (ligation on RNA amplification) test was sensitive enough to find a commonly sought K103N mutation in concentrations as low as one mutant per 10,000 strands of "normal" viral RNA. The LRA detection worked within two hours, while alternative technologies such as ASPCR or pyrosequencing, can take as long as eight.

LRA works by sending in many copies of a pair of short engineered probes of genetic material to complement the RNA in the HIV sample. Under optimized conditions, those pairs that perfectly match the target HIV RNA containing a mutation that causes drug resistance can rapidly become fused together, or ligated, by an enzyme. If there is a single nucleotide difference, the pair won't fuse

http://sciencemission.com/site/index.php…

An artistic Photo

சினிமா கதாநாயகன் அல்ல உண்மையான கதாநாயகன் மருத்துவர் ,செந்தில்வேலன் ஐ.பி.எஸ்

இளம் வயதிலையே சிக்கல்கள் பல கடந்து சிகரம் தொட்ட செந்தில்வேலன் , நம்பிக்கை .மிடுக்கான தோற்றம் துடிப்பான வேகத்தோடு ரவுடிசத்தை களை எடுத்து வருகிறார். இவர் பொறுப்பேற்றுக்கொண்ட பிறகு அந்த மாவட்டங்களில் உள்ள காவல் நிலையங்களில் உரிய மரியாதையுடன் உடனடியாக முதல் தகவல் அறிக்கை (FIR) வழங்கப்படுகிறது மேலும் அதன் மீது உடனடி நடவடிக்கையும் எடுக்கப்படுகிறது மருத்துவம் படித்தவர் என்பதால் அடுத்த நிலை அதிகாரிகளின் மனநிலை உடல்நிலை அறிந்து அதற்கு ஏற்பக் கட்டளை பிறப்பிக்கிறார்.அரசியல்வாதிகளுக்கு கார் கதவை திறந்துவிடும் அதிகாரிகளுக்கு மத்தியில், இவரை கண்டால் அரசியல்வாதிகளும் பயப்படும் நிலையை உருவாக்கியவர்

இவருக்கு சொந்த ஊர் மதுரை .இவர் தந்தை ஒரு தனியார் நிறுவனத்தில் மக்கள் தொடர்பு அதிகாரியாக இருந்தார் . அம்மா ஆசிரியை, மூன்று அக்கா.இவர்தான் கடைசி பையன் இவர் தாத்தாவோட அப்பா ஆங்கிலேய இந்தியா காலத்தில் போலீஸ் -இல் இருந்தவர். இவர் தாத்தாவும் போலீஸ்தான் . அதனால் சின்ன வயசில் இருந்துதே போலிஸா ஆகணும்னு ஆசையோடு வளர்ந்தவர், ஆனால் இவர் தந்தை இவர் டாக்டர் ஆகணும்னு ஆசைப்பட்டார் .சின்னதாக் குழப்பம் .முதல்ல அப்பா ஆசையை நிறைவேத்துவோம் . அப்புறம் போலீஸ் ஆகலாம்னு முடிவு செய்தார், . அப்பாவுக்காக மருத்துவ படிப்பை தொடர்ந்தார், மூன்றாவது வருடம் படிச்சுட்டு இருக்கும் போதே இவர் தந்தை மறைந்துவிட்டார், பின்னர் மருத்துவ படிப்பை படித்துவிட்டு அரசு மருத்துவராக வேலைக்குச் சேர்ந்தார்....

ஆனால் இவருக்குள் இருந்த போலீஸ் கனவோடு எப்பவும் இவர் சமரசம் செஞ்சுக்கவே இல்லை. வேலை பார்த்துகிட்டே படிக்க ஆரம்பித்தார், நம்பிக்கையோடு சிவில் சர்வீஸ் தேர்வு எழுதினார் எதிர்பார்க்காத ஆச்சர்யம் இந்திய அளவில் 86 ஆவது ரேங்க் ஐ.ஏ.எஸ். ஆகவே வாய்ப்பு கிடைத்தது. ஆனால் ஐ.பி.எஸ்தான் இவர் சாய்ஸ்னு உறுதியாக இருந்தார், ஐ.பி.எஸ் அதிகாரி ஆனார்...
முதல் முறையா ராமநாதபுரம் மாவட்டம்,கமுதியில் ஏ.எஸ்.பி பொறுப்பு.ரொம்ப சென்சிட்டிவ் ஏரியா. எப்பவும் சாதிக்கலவரம் பத்தியெரியாக் கூடிய அசாதாரணச் சூழல். நெருக்கடிமிக்க சூழல்தான் அதிக அனுபவத்தையும்,அதிக அறிவையும் பெற்றுகொள்ளும்
காலம்னு சொல்லுவாங்க.அதுஉண்மை.அடுத்ததா சிதம்பரத்தில் ஒரு வருஷம் ஏ.எஸ்.பியா இருந்தார்,
மக்களுக்கு எதிரா,சட்டத்துக்கு விரோதமா உள்ள எல்லா விசயங்களையும் முடக்கணும். நல்லவங்க மட்டும்தான் ரோட்டில் தைரியமா நடமாடணும்.அப்படி ஒரு சூழல் வர்ற வரைக்கும் எனக்கு நிம்மதியானl உறக்கம் இல்லை! என்கிறார் செந்தில்வேலன்

நெஞ்சை நிமிர்ந்து சொல்கிறேன், சல்யூட் செந்தில்வேலன் சார்....

Writing an Editorial

CHARACTERISTICS OF EDITORIAL WRITING

An editorial is an article that presents the newspaper's opinion on an issue. It reflects the majority vote of the editorial board, the governing body of the newspaper made up of editors and business managers. It is usually unsigned. Much in the same manner of a lawyer, editorial writers build on an argument and try to persuade readers to think the same way they do. Editorials are meant to influence public opinion, promote critical thinking, and sometimes cause people to take action on an issue. In essence, an editorial is an opinionated news story.

Editorials have:

1. Introduction, body and conclusion like other news stories
2. An objective explanation of the issue, especially complex issues
3. A timely news angle
4. Opinions from the opposing viewpoint that refute directly the same issues the writer addresses
5. The opinions of the writer delivered in a professional manner. Good editorials engage issues, not personalities and refrain from name-calling or other petty tactics of persuasion.
6. Alternative solutions to the problem or issue being criticized. Anyone can gripe about a problem, but a good editorial should take a pro-active approach to making the situation better by using constructive criticism and giving solutions.
7. A solid and concise conclusion that powerfully summarizes the writer's opinion. Give it some punch.

Four Types of Editorials Will:

1. Explain or interpret: Editors often use these editorials to explain the way the newspaper covered a sensitive or controversial subject. School newspapers may explain new school rules or a particular student-body effort like a food drive.
2. Criticize: These editorials constructively criticize actions, decisions or situations while providing solutions to the problem identified. Immediate purpose is to get readers to see the problem, not the solution.
3. Persuade: Editorials of persuasion aim to immediately see the solution, not the problem. From the first paragraph, readers will be encouraged to take a specific, positive action. Political endorsements are good examples of editorials of persuasion.
4. Praise: These editorials commend people and organizations for something done well. They are not as common as the other three.

Writing an Editorial

1. Pick a significant topic that has a current news angle and would interest readers.
2. Collect information and facts; include objective reporting; do research
3. State your opinion briefly in the fashion of a thesis statement
4. Explain the issue objectively as a reporter would and tell why this situation is important
5. Give opposing viewpoint first with its quotations and facts
6. Refute (reject) the other side and develop your case using facts, details, figures, quotations. Pick apart the other side's logic.
7. Concede a point of the opposition — they must have some good points you can acknowledge that would make you look rational.
8. Repeat key phrases to reinforce an idea into the reader's minds.
9. Give a realistic solution(s) to the problem that goes beyond common knowledge. Encourage critical thinking and pro-active reaction.
10. Wrap it up in a concluding punch that restates your opening remark (thesis statement).
11. Keep it to 500 words; make every work count; never use "I"

A Sample Structure

I. Lead with an Objective Explanation of the Issue/Controversy.

Include the five W's and the H. (Members of Congress, in effort to reduce the budget, are looking to cut funding from public television. Hearings were held …)

• Pull in facts and quotations from the sources which are relevant.
• Additional research may be necessary.

II. Present Your Opposition First. 

As the writer you disagree with these viewpoints. Identify the people (specifically who oppose you. (Republicans feel that these cuts are necessary; other cable stations can pick them; only the rich watch public television.)

• Use facts and quotations to state objectively their opinions.
• Give a strong position of the opposition. You gain nothing in refuting a weak position.

III. Directly Refute The Opposition's Beliefs.

You can begin your article with transition. (Republicans believe public televison is a "sandbox for the rich." However, statistics show most people who watch public television make less than $40,000 per year.)

• Pull in other facts and quotations from people who support your position.
• Concede a valid point of the opposition which will make you appear rational, one who has considered all the options (fiscal times are tough, and we can cut some of the funding for the arts; however, …).

IV. Give Other, Original Reasons/Analogies

In defense of your position, give reasons from strong to strongest order. (Taking money away from public television is robbing children of their education …)

• Use a literary or cultural allusion that lends to your credibility and perceived intelligence (We should render unto Caesar that which belongs to him …)

V. Conclude With Some Punch.

Give solutions to the problem or challenge the reader to be informed. (Congress should look to where real wastes exist — perhaps in defense and entitlements — to find ways to save money. Digging into public television's pocket hurts us all.)

• A quotation can be effective, especially if from a respected source
• A rhetorical question can be an effective concluder as well (If the government doesn't defend the interests of children, who will?)

Go to the library or any computer lab and complete the “webquest” located at

http://library.thinkquest.org/50084/index.shtml

http://library.thinkquest.org/50084/editorials/index.html

Another Tutorial by:Alan Weintraut
Annandale High School
Annandale, VA 22312
Atraut@aol.com

Aggressive music related to depression in men

"Emotion regulation is an essential component to mental health. Poor emotion regulation is associated with psychiatric mood disorders such as depression. Clinical music therapists know the power music can have over emotions, and are able to use music to help their clients to better mood states and even to help relieve symptoms of psychiatric mood disorders like depression. But many people also listen to music on their own as a means of emotion regulation, and not much is known about how this kind of music listening affects mental health. Researchers at the Centre for Interdisciplinary Music Research at the University of Jyväskylä, Aalto University in Finland and Aarhus University in Denmark decided to investigate the relationship between mental health, music listening habits and neural responses to music emotions by looking at a combination of behavioural and neuroimaging data. The study was published in August in the journal Frontiers in Human Neuroscience."

Simulated brain cells give robot instinctive navigation skills

One robot has been given a simulated version of the brain cells that let animals build a mental map of their surroundings.

The behavior and interplay of two types of neurons in the brain helps give humans and other animals an uncanny ability to navigate by building a mental map of their surroundings. Now one robot has been given a similar cluster of virtual cells to help it find its own way around.

Researchers in Singapore simulated two types of cells known to be used for navigation in the brain—so-called “place” and “grid” cells—and showed they could enable a small-wheeled robot to find its way around. Rather than simulate the cells physically, they created a simple two-dimensional model of the cells in software. The work was led by Haizhou Li, a professor at the Agency for Science, Technology and Research (A*STAR).

“Artificial grid cells could provide an adaptive and robust mapping and navigation system,” Li wrote in an e-mail coauthored with Huajin Tang and Yuan Miaolong, two research scientists at A*STAR who coauthored a paper about the work. “Humans and animals have an instinctual ability to navigate freely and deliberately in an environment rather effortlessly.”

The work is significant because it shows the potential for having machines mimic more complex activity in the brain. Roboticists increasingly use artificial neural networks to train robots to perform tasks such as object recognition and grasping, but these networks do not faithfully reflect the complexity and subtlety of a real biological brain.

Dan Pink: The puzzle of motivation

Why anti-cancer antibody, cixutumumab, does not work in patients

Drug resistance is a major impediment in medical oncology. Recent studies have emphasized the importance of the tumor microenvironment (TME) to innate resistance, to molecularly targeted therapies.

In this study, authors investigate the role of TME in resistance to cixutumumab, an anti-IGF-1R monoclonal antibody that has shown limited clinical efficacy. They show that treatment with cixutumumab accelerates tumor infiltration of stromal cells and metastatic tumor growth, and decreases overall survival of mice.

Cixutumumab treatment stimulates STAT3-dependent transcriptional upregulation of IGF-2 in cancer cells and recruitment of macrophages and fibroblasts via paracrine IGF-2/IGF-2R activation, resulting in the stroma-derived CXCL8 production, and thus angiogenic and metastatic environment.

Silencing IGF-2 or STAT3 expression in cancer cells or IGF-2R or CXCL8 expression in stromal cells significantly inhibits the cancer–stroma communication and vascular endothelial cells’ angiogenic activities.

These findings suggest that blocking the STAT3/IGF-2/IGF-2R intercellular signalling loop may overcome the adverse consequences of anti-IGF-1R monoclonal antibody-based therapies.

http://sciencemission.com/site/index.php…