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Monday, October 10, 2011

Three women's rights activists share Nobel Peace Prize



By Laura Smith-Spark, CNN

(L-R) Yemen's Arab Spring activist Tawakkul Karman, Liberian President Ellen Johnson Sirleaf and activist Leymah Gbowee
(L-R) Yemen's Arab Spring activist Tawakkul Karman, Liberian President Ellen Johnson Sirleaf and activist Leymah Gbowee
STORY HIGHLIGHTS
  • NEW: Tawakkul Karman is the first Arab woman to win the peace prize
  • The prize is divided between three women; two in Liberia and one in Yemen
  • Johnson Sirleaf says she accepts the prize on behalf of all Liberians
  • Rights group Amnesty International welcomes the award
(CNN) -- Liberian President Ellen Johnson Sirleaf, activist Leymah Gbowee of Liberia and rights activist Tawakkul Karman of Yemen share this year's Nobel Peace Prize, the Norwegian Nobel Committee announced Friday.
They were chosen "for their nonviolent struggle for the safety of women and for women's rights to full participation in peace-building work," the committee said in Oslo, Norway.
"We cannot achieve democracy and lasting peace in the world unless women obtain the same opportunities as men to influence developments at all levels of society."
In an interview with CNN, Karman -- the first Arab woman to win the Nobel Peace Prize and one of the youngest recipients -- said she heard the news while demonstrating in the Yemeni capital, Sanaa.
Three share Nobel Peace Prize
Where is 2010's Peace Prize winner?
Gbowee talks about empowering women
"Congratulations to all the Yemeni people. I am so happy for the award. I believe this award is for all Yemenis, for all the Yemeni people, and for all Arab women," she said.
"This is a victory for peace in the Arab world, a victory for the peaceful revolution in Yemen."
Johnson Sirleaf, Liberia's 72-year-old president and Africa's first elected female head of state, told CNN she was excited about the prize, which she said was shared by all her country's people.
"I'm accepting this on behalf of the Liberian people, so credit goes to them," she said. "For the past eight years, we have had peace and each and every one of them has contributed to this peace."
She said the peace that had ended 14 years of civil war should be attributed to the country's women.
They were "women from all walks of life who challenged the dictatorship of former President Charles Taylor and who stayed out in the sun and the rain working for peace in our country," she said.
Johnson Sirleaf, whose political resilience and tough reputation have earned her the nickname "Iron Lady," is campaigning for re-election.
The Harvard graduate's commencement address in high school in 1972 sharply criticized the government, a rare defiance in Africa, especially at the time. She has also worked at the World Bank and the United Nations.
Her historic 2006 election win was a major milestone for Africa, a continent dominated by male dictators who are referred to as strongmen. The mother of four sons published a book, "This Child Will Be Great" in 2008.
Liberian Information Minister Cletus Sieh told CNN that Johnson Sirleaf is a role model for many women in Africa.
Gbowee, a founder and executive director of Women Peace and Security Network-Africa, was also a recipient in 2009 of the John F. Kennedy Profile in Courage Award.
She was the focus of the documentary "Pray the Devil Back to Hell," which shows how women confronted Taylor with a demand for peace to end the bloody 14-year civil war.
She "mobilized and organized women across ethnic and religious dividing lines to bring an end to the long war in Liberia," the Nobel committee said, adding she also encouraged women's participation in elections.
"She has since worked to enhance the influence of women in West Africa during and after war," it said.
Jan Egeland of Human Rights Watch told CNN the Nobel committee had come up with a great prize that merged the efforts of Liberian women in achieving "momentous change" in their country with the vital role of women in the ongoing Arab Spring movement.
Rights group Amnesty International said the award would encourage women everywhere to continue fighting for their rights.
Past Nobel Peace Prize winners
Two Nobel recipients from Liberia
In Yemen, Karman has played a leading role in the struggle for women's rights for democracy and peace, the committee said.
Karman is the president of Women Journalists Without Chains, a group campaigning for press freedom.
Abdu Ganadi, spokesman for Yemen's President Ali Abdullah Saleh, congratulated Karman but struck a warning note.
"We are happy that she won, but in the same time she needs to live up to the award and not take youths to protests in areas where it leads to bloodshed," he told CNN. "She has to be a caller for peace, not violence."
Mohammed al-Sabri, a spokesman for Yemen's opposition dialogue committee, highlighted her role in an ongoing protest involving more than 3 million young Yemenis, many of them women.
"Because of Karman, the world will have a different impression on Yemeni women," he said. "This prize is not only for her, but for all Yemeni women."
Mohammed Albasha, a spokesman for Yemen's embassy in Washington, D.C., told CNN: "To have the first Arab woman to win a Nobel Peace Prize be from Yemen is definitely an honor to all Yemeni women."
Prominent Yemeni human rights activist Khaled Al-Anesi, who is also heavily involved in anti-government demonstrations, said he was very happy Karman had won the award.
"I feel this is a reward for every Yemeni looking for peace, for freedom, for democracy," he said. "The Nobel Peace Prize will bring attention to our revolution, which doesn't have enough international attention and attention from the foreign media."
Yemeni online activist Atiaf Alwazir said it was "great news for Yemen."
"Tawakkol has become such a figure in the revolution. It's a prize for Yemen -- it's a prize for all Arab women and it's a show of international support and solidarity for the peaceful movement here," she said.
"I'm very happy she received this award, as a woman and as an activist. It shows that if you work hard enough, maybe the world will listen. I think the best thing about this is that it's for everybody.
"An award like this is really a way to restore faith in the peaceful movement and to give people moral support. After nine months, people here are tired, and this gives people hope."
A profile of Karman by Time magazine describes the mother of three as "Yemen's most active activist."
As well as leading demonstrations demanding freedom of speech, she can often be seen trying to get other protesters out of jail. "It's a place she is familiar with as well, having been there several times herself," the profile says.
The Norwegian Nobel Committee said it hopes that the prize will help end suppression of women in many countries and to "realize the great potential for democracy and peace that women can represent."
The award, which includes a cash prize (10 million Swedish kronor, or about U.S. $1.4 million) will be shared in three equal parts among the winners, the committee said.
"This Nobel Peace Prize recognizes what human rights activists have known for decades: that the promotion of equality is essential to building just and peaceful societies worldwide," said Amnesty International Secretary General Salil Shetty in a statement.
"The tireless work of these and countless other activists brings us closer to a world where women will see their rights protected and enjoy growing influence at all levels of government."
European Council President Herman Van Rompuy and European Union President Jose Manuel Barroso congratulated the winners.
They issued a statement saying the prize is "recognition of the pivotal role that women play in the peaceful settlement of conflicts and democratic transformation throughout the world. This is a victory for a new democratic Africa and for a new democratic Arab world that live in peace and respect for human rights."
Last year, Chinese dissident Liu Xiaobo won the prize but could not attend the award ceremony. The political activist and longtime critic of communist rule in China is serving an 11-year prison term for what the Chinese government calls "inciting subversion of state power."
U.S. President Barack Obama won for what the committee called "his extraordinary efforts to strengthen international diplomacy and cooperation between peoples" in 2009.
Nobel prizes in literature, chemistry, physics and physiology or medicine were awarded this week.
The Nobel Peace Prize is awarded by a committee of five people chosen by Norway's parliament and is named for Alfred Nobel, a Swedish scientist and inventor of dynamite.
Nominations come from lawmakers around the world, university professors, previous Nobel laureates and members of the Nobel committee.
CNN's Mohammed Jamjoom, Hakim Almasmari, David McKenzie, Faith Karimi, Lateef Mungin and Laura Smith-Spark contributed to this report.

10 Golden Lessons from Steven Jobs



I think we’re having fun. I think our customers really like our products. And we’re always trying to do better.” - Steve Jobs
His accomplishments and character helped define a generation and change the world. He is co-founder of the fairytale company we now know as Apple Computers. And he is the visionary of the personal computers world that led the entire computer hardware and software industry to restructure itself.
This man with boundless energy and charisma is also a master of hype, hyperbole and the catchy phrase. And even when he’s trying to talk normally, brilliant verbiage comes tumbling out.
Here’s a selection of some of the most insanely great things he said, golden lessons to help you succeed in life, Jobs-style:
1. Steve Jobs said: “Innovation distinguishes between a leader and a follower.”
Innovation has no limits. The only limit is your imagination. It’s time for you to begin thinking out of the box. If you are involved in a growing industry, think of ways to become more efficient; more customer friendly; and easier to do business with. If you are involved in a shrinking industry – get out of it quick and change before you become obsolete; out of work; or out of business. And remember that procrastination is not an option here. Start innovating now!
2. Steve Jobs said: “Be a yardstick of quality. Some people aren’t used to an environment where excellence is expected.”
There is no shortcut to excellence. You will have to make the commitment to make excellence your priority. Use your talents, abilities, and skills in the best way possible and get ahead of others by giving that little extra. Live by a higher standard and pay attention to the details that really do make the difference. Excellence is not difficult – simply decide right now to give it your best shot – and you will be amazed with what life gives you back.
3. Steve Jobs said: “The only way to do great work is to love what you do. If you haven’t found it yet, keep looking. Don’t settle. As with all matters of the heart, you’ll know when you find it.”
I’ve got it down to four words: “Do what you love.” Seek out an occupation that gives you a sense of meaning, direction and satisfaction in life. Having a sense of purpose and striving towards goals gives life meaning, direction and satisfaction. It not only contributes to health and longevity, but also makes you feel better in difficult times. Do you jump out of bed on Monday mornings and look forward to the work week? If the answer is ‘no’ keep looking, you’ll know when you find it.
4. Steve Jobs said: “You know, we don’t grow most of the food we eat. We wear clothes other people make. We speak a language that other people developed. We use a mathematics that other people evolved… I mean, we’re constantly taking things. It’s a wonderful, ecstatic feeling to create something that puts it back in the pool of human experience and knowledge.”
Live in a way that is ethically responsible. Try to make a difference in this world and contribute to the higher good. You’ll find it gives more meaning to your life and it’s a great antidote to boredom. There is always so much to be done. And talk to others about what you are doing. Don’t preach or be self-righteous, or fanatical about it, that just puts people off, but at the same time, don’t be shy about setting an example, and use opportunities that arise to let others know what you are doing.
5. Steve Jobs said: “There’s a phrase in Buddhism, ‘Beginner’s mind.’ It’s wonderful to have a beginner’s mind.”
It is the kind of mind that can see things as they are, which step by step and in a flash can realize the original nature of everything. Beginner’s mind is Zen practice in action. It is the mind that is innocent of preconceptions and expectations, judgements and prejudices. Think of beginner’s mind as the mind that faces life like a small child, full of curiosity and wonder and amazement.
6. Steve Jobs said: “We think basically you watch television to turn your brain off, and you work on your computer when you want to turn your brain on.”
Reams of academic studies over the decades have amply confirmed television’s pernicious mental and moral influences. And most TV watchers know that their habit is mind-numbing and wasteful, but still spend most of their time in front of that box. So turn your TV off and save some brain cells. But be cautious, you can turn your brain off by using a computer also. Try and have an intelligent conversation with someone who plays first person shooters for 8 hours a day. Or auto race games, or role-playing games.
7. Steve Jobs said: “I’m the only person I know that’s lost a quarter of a billion dollars in one year…. It’s very character-building.”
Don’t equate making mistakes with being a mistake. There is no such thing as a successful person who has not failed or made mistakes, there are successful people who made mistakes and changed their lives or performance in response to them, and so got it right the next time. They viewed mistakes as warnings rather than signs of hopeless inadequacy. Never making a mistake means never living life to the full.

8. Steve Jobs said: “I would trade all of my technology for an afternoon with Socrates.”
Over the last decade, numerous books featuring lessons from historical figures have appeared on the shelves of bookstores around the world. And Socrates stands with Leonardo da Vinci, Nicholas Copernicus, Charles Darwin and Albert Einstein as a beacon of inspiration for independent thinkers. But he came first. Cicero said of Socrates that, “He called philosophy down from the skies and into the lives of men.” So use Socrates’ principles in your life, your work, your learning, and your relationships. It’s not about Socrates, it’s really about you, and how you can bring more truth, beauty and goodness into your life everyday.
9. Steve Jobs said: “We’re here to put a dent in the universe. Otherwise why else even be here?”
Did you know that you have big things to accomplish in life? And did you know that those big things are getting rather dusty while you pour yourself another cup of coffee, and decide to mull things over rather than do them? We were all born with a gift to give in life, one which informs all of our desires, interests, passions and curiosities. This gift is, in fact, our purpose. And you don’t need permission to decide your own purpose. No boss, teacher, parent, priest or other authority can decide this for you. Just find that unique purpose.
10. Steve Jobs said: “Your time is limited, so don’t waste it living someone else’s life. Don’t be trapped by dogma – which is living with the results of other people’s thinking. Don’t let the noise of other’s opinions drown out your own inner voice. And most important, have the courage to follow your heart and intuition. They somehow already know what you truly want to become. Everything else is secondary.”
Are you tired of living someone else’s dream? No doubt, its your life and you have every right to spend it in your own individual way without any hurdles or barriers from others. Give yourself a chance to nurture your creative qualities in a fear-free and pressure-free climate. Live a life that YOU choose and be your own boss.
Each lesson might be difficult to integrate into your life at first, but if you ease your way into each lesson, one at a time, you’ll notice an immediate improvement in your overall performance. So go ahead, give them a try.

Imaging agents offer new view of inflammation, cancer





“Study describes first COX-2-targeted PET imaging agent”
A series of novel imaging agents could make it possible to “see” tumors in their earliest stages, before they turn deadly.

The compounds, derived from inhibitors of the enzyme cyclooxygenase-2 (COX-2) and detectable by positron emission tomography (PET) imaging, may have broad applications for cancer detection, diagnosis and treatment.
Positron emission tomography (PET) is a test that uses a special type of camera and a tracer (radioactive chemical) to look at organs in the body, and is often used to find cancer, to check blood flow, or to see how organs are working.
Vanderbilt University investigators describe the new imaging agents in a paper featured on the cover of the October issue of Cancer Prevention Research.
“This is the first COX-2-targeted PET imaging agent validated for use in animal models of inflammation and cancer,” said Lawrence Marnett, Ph.D., director of the Vanderbilt Institute of Chemical Biology and leader of the team that developed the compounds.
COX-2 is an attractive target for molecular imaging. It’s not found in most normal tissues, and then it is “turned on” in inflammatory lesions and tumors, Marnett explained.
“As a tumor grows and becomes increasingly malignant, COX-2 levels go up,” Marnett said.
To develop compounds that target COX-2 and can be detected by PET imaging, Jashim Uddin, Ph.D., research assistant professor of Biochemistry, started with the “core” chemical structures of the anti-inflammatory medicines indomethacin and celecoxib and modified them to add the element fluorine in various chemical configurations.
After demonstrating that the fluorinated compounds were selective inhibitors of COX-2, the investigators incorporated radioactive fluorine (18-F) into the most promising compound. Intravenous injection of this 18-F compound into animal models provided sufficient signal for PET imaging.
The researchers demonstrated the potential of this 18-F compound for in vivo PET imaging in two animal models: irritant-induced inflammation in the rat footpad and human tumors grafted into mice.
They showed that the 18-F compound accumulated in the inflamed foot, but not the non-inflamed foot, and that pre-treatment of the animals with celecoxib blocked the signal. In mice bearing both COX-2-positive and COX-2-negative human tumors, the 18-F compound accumulated only in the COX-2-positive tumor.
The studies support further development of these agents as probes for early detection of cancer and for evaluation of the COX-2 status of pre-malignant and malignant tumors.
“Because COX-2 levels increase during cancer progression in virtually all solid tumors, we think these imaging tools will have many, many different applications,” Marnett said.

Bone marrow cells migrate to tumors and can slow their growth




Bone marrow cancer is called multiple myeloma. Frequently the first sign of multiple myeloma is bone pain due to the presence of many malignant cells in the bone marrow.
Bone marrow-derived cells (BMDCs) participate in the growth and spread of tumors of the breast, brain, lung, and stomach. To examine the role of BMDCs, researchers developed a mouse model that could be used to track the migration of these cells while tumors formed and expanded. Their results, published in the November issue of The American Journal of Pathology, strongly suggest that more effective cancer treatments may be developed by exploiting the mechanism by which bone marrow cells migrate to tumors and retard their proliferation.

“Our results provide an excellent in vivo experimental model where the temporal dynamics of tumor-infiltrating BMDCs may be monitored in an immunocompetent host and novel therapies targeting BMDCs for the inhibition of tumor progression may be investigated,” commented lead investigator Wafik S. El-Deiry, MD, PhD, Professor and Chief, Hematology/Oncology Division at the Penn State Hershey Medical Center and Associate Director for Translational Research at the Penn State Hershey Cancer Institute. “In the future, it may be possible to use specific identified tumor-infiltrating BMDCs to deliver therapeutic cargo.”
A first group of mice expressing a fluorescence gene served as donors of the bone marrow cells. A second group of mice, whose marrow had been destroyed by radiation, were injected with the donated fluorescent bone marrow. The transplanted bone marrow cells were allowed to proliferate for 8 weeks. Then, colon cancer cells were injected into the same mice and tumors formed over the next 3 weeks.
Monitoring tumor growth by optical imaging, researchers found that the tumors contained numerous types of BMDCs. Notably they also found that tumor growth is reduced in animals that received the bone marrow transplants, compared with untransplanted host mice.
According to the authors, cancer has long been viewed as a disease in which transformed cells grow and invade tissues. However, they believe that it is becoming clear that cancer is a more complex disease in a heterogeneous microenvironment where many cellular interactions are occurring in the malignant tissue.
“This type of mouse model allows scientists to actually see in living color the complicated relationships and interplay between the…tumor’s own cells and the immune system cells within the host…” said El-Deiry, who is also an American Cancer Society Research Professor. He added: “this ongoing war on cancer within this tumor microenvironment has surprising twists and turns.” El-Deiry and his colleagues hope to steer patient outcomes “with additional treatments that can help [them] overcome the cancer.”
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The article is “High-Resolution Imaging and Antitumor Effects of GFP+ Bone Marrow-Derived Cells Homing to Syngeneic Mouse Colon Tumors” by Niklas K. Finnberg, Lori S. Hart, Nathan G. Dolloff, Zachary B. Rodgers, David T. Dicker and Wafik S. El-Deiry (doi: 10.1016/j.ajpath.2011.07.028). It will appear in The American Journal of Pathology, Volume 179, Issue 5 (November 2011) published b
y Elsevier.
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New study confirms genetic link to suicidal behavior



A new study from the Centre for Addiction and Mental Health has found evidence that a specific gene is linked to suicidal behaviour, adding to our knowledge of the many complex causes of suicide. This research may help doctors one day target the gene in prevention efforts.
In the past, studies have implicated the gene for brain-derived neurotrophic factor (BDNF) in suicidal behaviour. BDNF is involved in the development of the nervous system.
After pooling results from 11 previous studies and adding their own study data involving people with schizophrenia, CAMH scientists confirmed that among people with a psychiatric diagnosis, those with the methionine (“met”) variation of the gene had a higher risk of suicidal behaviour compared to those with the valine variation.
The review, published in the International Journal of Neuropsychopharmacology, included data from 3,352 people, of whom 1,202 had a history of suicidal behaviour.
The news coincides with Mental Illness Awareness Week, October 2-8, and World Mental Health Day, October 10.
“Our findings may lead to the testing and development of treatments that target this gene in order to help prevent suicide,” says Dr. James Kennedy, director of CAMH’s Neuroscience Research Department. “In the future, if other researchers can replicate and extend our findings, then genetic testing may be possible to help identify people at increased risk for suicide.”
As the low-functioning BDNF met variation is a risk factor for suicidal behaviour, it may also be possible to develop a compound to increase BDNF functioning, Dr. Kennedy says.
About 90 per cent of people who have died by suicide have at least one mental health disorder, the researchers note. Within the studies they reviewed, participants had schizophrenia, depression, bipolar disorder or general mood disorders. In each case, the researchers compared the genotypes of people who had attempted or completed suicide with those who were non-suicidal.
“Our findings provide a small piece of the puzzle on what causes suicidal behaviour,” says Dr. Kennedy.
“When assessing a person’s suicide risk, it’s also important to consider environmental risk factors, such as early childhood or recent trauma, the use of addictive drugs or medications and other factors.”