Search This Blog

Friday, November 18, 2022

Preventing Wood Decay


With the warm days of summer coming to an end and autumn beautifying our surroundings with oranges and yellows, now is an excellent time to start thinking of how to protect your deck/veranda from decay next year caused by rot and insect infestation. Understanding what causes wood to decay will help you choose the method of protection that is right for your home.

 

 


 

Natural Processes

 

 

Wood is a natural, organic substance with a distinct life cycle involving seeding, growth, death and decomposition. We have discovered that wood is an economical material to build with. We have developed methods to keep wood from decomposing once a tree has been felled and sectioned for log homes, decks, porches, or verandas.

 

Weathering, insect infestation and fungal attacks are all natural processes that significantly affect wood's life. However, fungal attack, or rot, leads to more rapid decomposition of the wood and causes more significant structural problems in North America than weathering or insect infestation.

 

 

 

Weathering

 

The effects of the sun's ultraviolet rays, rain, wind and freeze/thaw lead to a decomposition of the wood structure on the surface called weathering. This often leads to a greying or browning of the surface of the wood to a depth of about 1/100" deep.

 

 

Insect Infestation

 

Insects use the wood in the logs for food, lodging and breeding. This may lead to decomposition of the wood or decomposition of your level of satisfaction with the home.

 

 

Fungus

 

Fungus attack can lead to the structural decomposition of your wood elements of your home. Where does fungus come from? Fungus is in the particular plant family which does not produce their own food by photosynthesis as green plants containing chlorophyll do.

 

Fungi comes in various rot-producing forms, none of which any of us want in our wood. These fungi are all around us – in the forest before the tree is felled and at the sawmills where the trees are made into logs or boards. Understanding how fungi attach to the wood is half the battle in protecting our homes.

 

 

Elements Necessary for Fungal Growth

 

Four basic elements must be present for the fungus spores (seed for fungus plants) to grow and reproduce. These are food sources (wood), water, oxygen and proper temperature.

 

 

 

Wood

 

Some species contain natural chemicals (extractives, tannins or resins), that act to resist fungal attack. However, over time and given satisfactory conditions, even the more resistant species of wood will succumb to fungal attack. The natural chemicals disperse and fungus attacks the wood structure feeding on the cellulose and lignin fibers that make up the structure of the wood.

 

 

 

Water

Fungus require moisture (water) in close proximity to the wood fiber to grow. The moisture content by weight in wood at which fungus begins to thrive is 20-22% and ideal conditions exist at 26-32%.

 

 

 

Oxygen

In addition to water, oxygen must be present to provide for fungal growth. Generally, it is agreed that 20% air volume in the wood is required to provide enough oxygen for the fungus to process the wood into food.

 

 

 

Temperature

 

The ideal temperature for fungus to thrive is 75-90˚ F. A more comprehensive range of 40-105˚ F will sustain fungal growth.

 

If you remove one or more of these necessary elements, the fungus cannot develop, and rot is prevented. For example, wood has not decomposed after centuries locked up in an Egyptian tomb where water is not in proper amounts. Furthermore, logs remain solid and intact underwater, where oxygen does not exist in necessary quantities.

 

Therefore, it is essential to minimize the opportunities for our log home to be exposed to these four elements. Of these, water is perhaps the easiest element to control. There are many ways we deal with water content in our logs.

 

 

 

Moisture Content Control

If you are in the planning stages of your log home, there are things to be done to reduce the potential of increasing moisture content in the wood of your home. Following are some home design provisions you may want to incorporate.

 

Eave overhang minimum 24" at the base to 36" at the peak (ideally 48" at the peak)

Flashings over windows and doors and projections from walls

Properly installed eavestroughing

Adequate attic ventilation to prevent moisture buildup in the wall/attic interfaces

Adequate grade clearance or splash height (19" min), ideally with a first course flashing (see Figure 2), keeping ground moisture away from the log.

Also, there are some points to consider in terms of where you choose to build your home. The location should be on dry ground, have access to air movement, and be orientated to allow sun exposure.

 

The design of log joinery in your home is also essential. Try to include the following items in your home:

 

Logs incorporating a drip edge to provide for shelf water runoff

Boxed in heart logs that dry in an oval shape providing a slope for continual runoff of shelf water that moves into the space between logs and comes to rest on flat spots of logs like at corners

Fill all countersunk spike head holes with caulking as construction takes place.

NOTE:  Heartwood generally contains the largest concentration of extractives which aid in preventing the attack from fungus. Thus, removing sapwood from logs or wood can improve decay resistance.

 

Some species, such as northern white cedar, contain inherent heart rot (found in naturally growing trees), which can counteract the positive feature of the extractive. It is necessary to screen out all logs containing this fungus.

 

Further, logs cut in the winter or fall are less likely to have fungus spores attached because the low temperatures prevent spore development, movement and deposit on the records. Logs at the mill and on your property should be stacked apart and stored in well-ventilated, covered sites off the ground.

 

Wood which is placed in open areas free from direct contact with moisture (resting off the ground and protected at least partially from rain) will dry out to an equilibrium moisture content of 15-19%. This moisture content is lower than the wood moisture content of 20% or greater. This depends somewhat upon the location. For example, wood would be drier stored in a desert than by the ocean.

 

Thus, wood will not decay from fungus attack unless extra moisture is in contact with the logs for more extended periods, causing a higher moisture content in the wood. An example of this situation would be a window header improperly flashing, allowing rainwater to collect and lay for long periods.

 

If your log home is already constructed and you are trying to decide what finishes you might apply, consider the following. Paints, stains and varnishes do not prevent rot if the elements necessary to sustain fungal growth are present.

 

Paints and coatings were first used to prevent weathering, not rotting. They acted as UV blockers preventing the decomposition of lignin by the ultraviolet rays from the sun. Additives that resisted fungal attacks were introduced, such as copper naphthenate and additives like paraffin wax, which prevents or retards moisture migration.

 

 

 

Use of Coatings

A log home, deck, veranda, or porch should never be painted since paint places a coating on the log, preventing the log from absorbing and releasing moisture. Moisture will become trapped, leading to contents higher than 20% in the wood. This will result in decay.

 

A coating is defined as any material with a percentage of solids higher than 36-38%. Stains usually have 25-30% solids. A stain contains water or petroleum-based product known as the carrier, which moves the pigments (solids) into the cellular structure on the surface of the wood and deposits the pigment against the cell wall. These pigments are usually darker and absorb the ultraviolet rays before they get to the wood structure, thereby protecting the wood from weathering.

 

 

Use of Stains

 

Stains allow the wood's pores to remain open, providing free travel of moisture, which is desired. Thus, stains are preferable for log homes.

 

Additives which resist insect attack can be added to the stain for extra protection. Additives can also be used to retard (not stop) moisture flow allowing logs to dry more evenly and reduce checking and surface cracks.

 

This still allows the wood to transfer moisture in and out through the surface and is acceptable. Repellents that totally block moisture flow are not advisable to put on a log home.

 

When staining a log home or other wooden structures, it is also important to note that if the structure(s) that have just been constructed with green logs needs 2-4 months, the surface can dry to a depth of about 1/4". This will prevent water, migrating from the inside of the log, from mixing with the stain causing drip marks, flaking, peeling blotches and white powder (standard in pine).

 

Commercial methods impregnate the log under vacuum pressure with chemicals like chromated copper arsenate. These processes generally only impregnate the sapwood and are incapable of fair heartwood treatment. Since they can only be impregnated this way at the plant, re-machining the log on the site will expose untreated wood.

 

Recently a method of dipping the green logs (logs that have a moisture content over 26-30%) at the plant in a liquid containing a borate has been becoming popular. This is commonly called a diffuse wood treatment. The borate in the liquid diffuses into the log and onto the cell wall. This then acts as a repellent to insects and fungus. Since sapwood exhibits less favourable shrinkage characteristics and the chemical toxicity is questionable, some people find this technique unacceptable.

 

However, care should be exercised in generalizing the effectiveness of this technique. Little independent research has been carried out, and neither information nor regulatory standards for control of key variables during the processing have been established, variables such as the temperature of wood, species of wood and the time of immersion.

 

However, if performed correctly, the process has a promising future for log home protection and maintenance.

 

 

 

Conclusion

In summary, the best approach to preventing decay in your home or outdoor area is to remove the opportunities for moisture buildup at various points in the wood.

 

Stains are used to prevent weathering and, with additives, can repel insects and fungus, but they won't prevent rot if suitable conditions exist. Measures must be taken to ensure that you know how to deal with the sources of food (wood, water, oxygen and temperature) on which fungus thrives on.

 

A proper balance of design, manufacture and log surface protection will protect your log home and provide low maintenance for years to come.

 

 Thanks https://woodrandd.com/


Wednesday, November 16, 2022

The law of reversed effort

The Law of Reversed Effort was first coined by the author Aldous Huxley, who wrote:

 


"The harder we try with the conscious will to do something, the less we shall succeed.

 

"Proficiency and the results of proficiency come only to those who have learned the paradoxical art of doing and not doing, or combining relaxation with activity, of letting go as a person so that the immanent and transcendent unknown quantity may take hold."

 

Aldous Huxley coined the term 'The Law of Reversed Effort' to explain that the harder we try with the conscious will to do something, the less we shall succeed.  

Imagine your work, family, health and play as your four wheels - how much traction is each wheel getting? Are your tyres wearing evenly, are you holding the race line, is your car in good shape to last the distance, or are you just flat out focusing on being first into the next corner, as though your happiness depended on it?

That’s nice, you might think, but how does that translate to real life? How can Huxley’s law of reversed effort be seen not as an ideology but as a practical guide? The fact is that “not doing” is fundamental to the nature of many tasks. The problem with a lot of philosophy of this kind is that it leaves us no better off than before. Here are just a few examples.

 

 A common example is falling asleep: Sometimes when you can’t fall asleep it helps to stop trying: count sheep, read a book, focus on your breath, etc. Likewise, golf pros instruct their pupils that they must relax to hit the ball well — too much effort ruins the swing. Playing piano requires relaxed effort, as does shooting free throws.

Leo Tolstoy described this concept perfectly in Anna Karenina where he describes a day of labor undertaken by Konstantin Levin, a member of the upper crust of Russian society, as he mows hay with a scythe alongside his peasants:

“A change began to come over his work, which gave him immense satisfaction. In the midst of his toil there were moments during which he forgot what he was doing, and it came all easy to him, and at those same moments his row was almost as smooth and well cut as Tit’s. But so soon as he recollected what he was doing, and began trying to do better, he was at once conscious of all the difficulty of his task, and the row was badly mown.”

– Leo Tolstoy, Anna Karenina

people who are desperate to get married, but they don’t get any candidate for that purpose. On the other side, I see people who have absolutely no urge or plan to marry, yet these people have plenty of suggestions in their circle. I see people who desperately tried to pass the CSS exam with various attempts, yet they failed. And then I came across people who were not much obsessive and cracked the exam on their first attempt easily. Weird!

Universe has a weird algorithm. We often get things when we stop looking for them or when we let go. Our subconscious part of the mind takes anything we feed it. So focusing on what we want or desire will only reinforce to our subconscious mind that we currently lack that thing. So if we focus on wanting more money, this tells our subconscious mind that we are broke. Such a mindset will keep us broke.

Technical skills: When learning a new sport or skill, you must understand the technique. You go through the motions, ticking off steps in your head and eventually succeeding. But there comes the point when overthinking is detrimental. It’s probably why your favourite team are rubbish at penalty shoot-outs.

 

Stress and anxiety: We all get stressed about things. All jobs involve bottlenecks and crunch points. Life has good days and bad days. But when we obsessively run things over in our heads, we make anxiety worse. There is a reason “mindfulness” is such a breakaway phenomenon, and Headspace is a $250-million business. Stepping away, taking a breath, and doing nothing is good for you.

 

Conversations: When it comes to how we talk to people, less really is more. A lousy conversation involves you talking too much, and your “listening” consists of simply waiting to speak again. Yet research shows that active listening gives more “conversational satisfaction” and leaves the partner feeling more understood.

Thanks https://www.theifod.com/the-law-of-reversed-effort/,

https://minutemirror.com.pk/law-of-reversed-effort-61291/

https://www.linkedin.com/pulse/law-reversed-effort-how-youre-quicker-slowing-down-andrew-hurrell/,

https://bigthink.com/neuropsych/law-reversed-effort/

Wednesday, August 17, 2022

சித்தர்கள் வகுத்த கலைகளுள் ஒன்றான வர்மக்கலை..!

 

வாசி தட்டும் இடமெல்லாம் -வர்மம் அதாவது வர்மம் என்றால் உயிர் நிலைகளின் ஓட்டம் என்று பொருள். இதை சித்த மருத்துவத்திற்கும், வர்மக்கலைக்கும் பயன்படுத்தலாம். இடகலை, பிங்கலை, சுழு முனை நாடிகள், தச வாயுக்கள், சரங்களின் ஓட்டமே -வர்மம்
அகத்தியர் வர்ம சூட்சமத்தை அளவு நூல் மூலம் அளந்து தெரியப்படுத்தியதுடன் வர்மப் புள்ளிகள் தான் மனித உடலை இயக்குகின்றன. இவைதான் மனித உடலுக்கு ஆதாரமாக இருப்பவை. இவை பாதிக்கப்பட்டால் மனித உடலின் இயங்கும் தன்மை முற்றிலும் பாதிக்கப்படும் என்பதை ஆணித்தரமாக கூறினார். காரணம் வர்மப் புள்ளிகள் அனைத்தும் ஒடுங்கியிருக்கும் இடங்களில்தான் உயிர்நிலை சுவாசமும் ஒடுங்கியுள்ளது.
மனித உடலில் 108 வர்மப் புள்ளிகளாக அதாவது உயிர்நிலை சுவாசமாக ஒடுங்கியுள்ளது. இந்த வர்மப் புள்ளிகளின் ஏதாவது ஒன்று பாதிக்கப் படுமானால் உடலில் நோய் உண்டாகும். இவற்றை சீர் செய்வதன் மூலம் தான் நோயைத் தீர்க்க முடியும். உதாரணமாக உடம்பில் ஏதாவது ஒரு இடத்தில் பாதிப்பு ஏற்பட்டாலோ அல்லது நோயின் தாக்குதல் இருந்தாலோ அது வர்மப் புள்ளிகளை சார்ந்துதான் இருக்கும்.
வர்ம கலையை அகத்தியர் நான்கு பிரிவுகளாக பிரிக்கிறார் அவை:
தொடு வர்மம்:
இது பலமாக தாக்க படுவதன் மூலம் ஏற்படுகிறது. இதை எளிதில் குனபடுத்த முடியும்
தட்டு வர்மம்:
இது ஒரே ஒரு விரலை மட்டும் பயன்படுத்தி தாக்கபடுபவரின் உடலில் வலி ஏற்படாமல் மிக லேசாக தட்டுவதன் மூலம் பாதிப்புகளை ஏற்படுத்துவதாகும், நான் ஏற்கனவே கூறியவாறு இம்முறையில் தக்கபடுபவரை இதற்க்கு உரிய தனியான சிகிச்சை முறையில் மட்டுமே குனபடுத்த முடியும்
நோக்கு வர்மம்:
பார்வை ஒரே இடத்தில செலுத்தி விளைவுகளை ஏற்படுத்துவதே நோக்கு வர்மம் ஆகும். இந்த முறை ஆபத்தானது என்று அகத்தியர் குறிப்பிடுகிறார். நோக்கு வர்மம் முறையில் தேர்ச்சி அடைந்தவர்களுக்கு நிகர் உலகில் எவரும் இல்லை என குறிப்பிடுகிறார்
படு வர்மம் :
நான்கு வகை வர்மங்களில் அபாயகரமானது இதுவே, உடலில் உள்ள வர்ம பகுதிகளில் அடியோ தாக்குதலோ ஏற்படுத்தினால் அதுவே படு வர்ம ஆகும். இத்தாக்குதலுக்கு ஆளானவர்கள் உயிரிழக்கும் அபாயம் உள்ளதால் இது மிகவும் ஆபத்தானது என்று அகத்தியர் குறிப்பிடுகிறார்
ஒரு மனிதன் படுவர்மா புள்ளிகளில் அடிபட்டால் உடனே மயங்கி விழுவான் என்று, வாயில் நுரை தள்ளி நாக்கு வெளியே தள்ளும் என்றும், அடிபட்ட இடம் குளிர்ச்சியாக என்றும் குறிப்பிடுகிறார் எல்லோராலையும் இதை செய்து விடமுடியாது. மிகுந்த பயிற்சி உள்ளவரால் மட்டுமே இது இயலும்.
உடலில் உள்ள முக்கியமான வர்ம புள்ளிகளை பட்டியலிடுகிறார் அவை:
* தலைப்பகுதி வர்மங்கள் = 37
* நெஞ்சுப் பகுதி வர்மங்கள் = 13
* உடலின் முன் பகுதி வர்மங்கள் = 15
* முதுகுப் பகுதி வர்மங்கள் = 18
* கைப்பகுதி வர்மங்கள் = 17
* கால் பகுதி வர்மங்கள் = 32
தலைப்பகுதி வர்மங்கள் (37)
திலர்த வர்மம்
கண்ணாடி கால வர்மம்
மூர்த்தி கால வர்மம்
அந்தம் வர்மம்
தும்மிக் கால வர்மம்
பின் சுவாதி வர்மம்
கும்பிடு கால வர்மம்
நட்சத்திர வர்மம்
பால வர்மம்
மேல் கரடி வர்மம்
முன் சுவாதி வர்மம்
நெம வர்மம்
மந்திர கால வர்மம்
பின் வட்டிக் கால வர்மம்
காம்பூதி கால வர்மம்
உள்நாக்கு கால வர்மம்
ஓட்டு வர்மம்
சென்னி வர்மம்
பொய்கைக் கால வர்மம்
அலவாடி வர்மம்
மூக்கடைக்கி கால வர்மம்
கும்பேரிக் கால வர்மம்
நாசிக் கால வர்மம்
வெட்டு வர்மம்
அண்ணாங்கு கால வர்மம்
உறக்க கால வர்மம்
கொக்கி வர்மம்
சங்குதிரி கால வர்மம்
செவிக்குத்தி கால வர்மம்
கொம்பு வர்மம்
சுமைக்கால வர்மம்
தலைப்பாகை வர்மம்
பூட்டெல்லு வர்மம்
மூர்த்தி அடக்க வர்மம்
பிடரி கால வர்மம்
பொச்சை வர்மம்
சரிதி வர்மம்
நெஞ்சுப் பகுதி வர்மங்கள் (13)
தள்ளல் நடுக்குழி வர்மம்
திவளைக் கால வர்மம்
கைபுஜ மூன்றாவது வரி வர்மம்
சுழி ஆடி வர்மம்
அடப்பக்கால வர்மம்
முண்டெல்லு வர்மம்
பெரிய அஸ்தி சுருக்கி வர்மம்
சிறிய அஸ்தி சுருக்கி வர்மம்
ஆனந்த வாசு கால வர்மம்
கதிர் வர்மம்
கதிர் காம வர்மம்
கூம்பு வர்மம்
ஹனுமார் வர்மம்
உடலின் முன் பகுதி வர்மங்கள் (15)
உதிர்க் கால வர்மம்
பள்ளை வர்மம்
மூத்திர கால வர்மம்
குத்து வர்மம்
நேர் வர்மம்
உறுமி கால வர்மம்
ஆமென்ற வர்மம்
தண்டு வர்மம்
லிங்க வர்மம்
ஆண்ட கால வர்மம்
தாலிக வர்மம்
கல்லடைக் கால வர்மம்
காக்கடை கால வர்மம்
புஜ வர்மம்
விதனு மான் வர்மம்
முதுகுப் பகுதி வர்மங்கள் (18)
மேல் சுருக்கி வர்மம்
கைக்குழி காந்தாரி வர்மம்
மேல்க்கைப் பூட்டு வர்மம்
கைச் சிப்பு எலும்பு வர்மம்
பூணூல் கால வர்மம்
வெல்லுறுமி தல்லறுமி வர்மம்
கச்சை வர்மம்
கூச்ச பிரம்ம வர்மம்
சங்கு திரி கால வர்மம்
வலம்புரி இடம்புரி வர்மம்
மேல் சுருக்கு வர்மம்
மேலாக கால வர்மம்
கீழாக கால வர்மம்
தட்டேல்லு வர்மம்
மேலஅண்ட வர்மம்
நாயிருப்பு வர்மம்
கீழ் அண்ட வர்மம்
குத்திக் கால வர்மம்
கைப்பகுதி வர்மங்கள் (17)
வலம்புரி இடம்புரி வர்மம்
தல்லை அடக்க வர்மம்
துதிக்கை வர்மம்
தட்சணக் கால வர்மம்
சுழுக்கு வர்மம்
மூட்டு வர்மம்
மொளியின் வர்மம்
கைக்குசத்திட வர்மம்
உள்ளங்கை வெள்ளை வர்மம்
தொங்கு சதை வர்மம்
மணி பந்த வர்மம்
திண்டோதரி வர்மம்
நடுக்கவளி வர்மம்
சுண்டு விரல் கவளி வர்மம்
மேல் மணிக்கட்டு வர்மம்
விஷ மணி பந்த வர்மம்
கவளி வர்மம்
கால் பகுதி வர்மங்கள் (32)
முதிர கால வர்மம்
பத்தக்களை வர்மம்
ஆமைக்கால வர்மம்
பக்க வர்மம்
குழச்சி முடிச்சி வர்மம்
சிறுவிரல் கவளி வர்மம்
சிரட்டை வர்மம்
கால் மூட்டு வர்மம்
காலக் கண்ணு வர்மம்
நாய்த் தலை வர்மம்
குதிரை முக வர்மம்
கும்பேறி வர்மம்
கண்ணு வர்மம்
கோணச்சன்னி வர்மம்
கால வர்மம்
தட வர்மம்
கண் புகழ் வர்மம்
அனகால வர்மம்
பூமிக் கால வர்மம்
இடுப்பு வர்மம்
கிழிமேக வர்மம்
இழிப் பிழை வர்மம்
அணி வர்மம்
கோச்சு வர்மம்
முடக்கு வர்மம்
குளிர்ச்சை வர்மம்
குசத்திட வர்மம்
உப்புக் குத்தி வர்மம்
பாதச் சக்கர வர்மம்
கீழ் சுழி வர்மம்
பதக்கல வர்மம்
முண்டக வர்மம்
இவையே உடலின் முக்கிய வர்மப் புள்ளிகள் என்று குறிப்பிடுகிறார்

Patients reportedly beating cancer with just one tablet a day

 


An experimental cancer drug appears to have cured every single patient in a small clinical trial conducted in the US.

All 12 patients, who had been diagnosed with rectal cancer, entered into remission after taking dostarlimab for over six months, according to a study published in the New England Journal of Medicine.

Dosage Forms & Strengths

injectable solution

  • 50mg/mL (10 mL, single-dose vials)

Mismatch Repair–Deficient (dMMR) Tumors

Indicated for adults with mismatch repair–deficient (dMMR) recurrent or advanced endometrial cancer that has progressed on or following a prior platinum-containing regimen

Also indicated for adults with dMMR recurrent or advanced solid tumours who have progressed on or following previous treatment and have no satisfactory therapeutic options.

Doses 1-4: 500 mg IV q3Weeks, THEN

Dose 5 and thereafter (start 3 weeks after Dose 4): 1,000 mg IV q6Weeks until disease progression or unacceptable toxicity

Dosage Modifications

No dose reductions are recommended

Pneumonitis

  • Grade 2: Withhold therapy; resume when complete or partial resolution occurs (Grade <1) after corticosteroid taper
  • Permanently discontinue if there is no complete or partial resolution within 12 weeks of initiating steroids or inability to reduce prednisone ≤10 mg/day (or equivalent) within 12 weeks of starting steroids.
  • Grade 3 or 4 or recurrent Grade 2: Permanently discontinue

Colitis

  • Grade 2 or 3: Withhold therapy; resume when complete or partial resolution occurs (Grade <1) after corticosteroid taper
  • Permanently discontinue if no complete or partial resolution within 12 weeks of initiating steroids or inability to reduce prednisone ≤10 mg/day (or equivalent) within 12 weeks of initiating steroids.
  • Grade 4: Permanently discontinue

Hepatitis with no tumor involvement of the liver

  • AST or ALT increases to >3 and ≤8x ULN or total bilirubin [TB] increases to >1.5 and <3x ULN: Withhold therapy; resume when complete or partial resolution (Grade <1) occurs after corticosteroid taper
  • Permanently discontinue if no complete or partial resolution within 12 weeks of initiating steroids or inability to reduce prednisone ≤10 mg/day (or equivalent) within 12 weeks of initiating steroids.
  • AST or ALT increases to >8x ULN or TB increases to >3x ULN: Permanently discontinue

Hepatitis with tumour involvement of the liver

  • Withhold therapy
    • Baseline AST or ALT >1 and ≤3x ULN and increases to >5 and ≤10x ULN
    • Baseline AST or ALT >3 and ≤5x ULN and increases to >8 and ≤10x ULN
    • Resume when complete or partial resolution occurs (Grade <1) after corticosteroid taper
    • Permanently discontinue if no complete or partial resolution within 12 weeks of initiating steroids or inability to reduce prednisone ≤10 mg/day (or equivalent) within 12 weeks of initiating steroids
  • Permanently discontinue
    • AST or ALT increases >10x ULN or TB increases to >3x ULN

Endocrinopathies

  • Grade 2, 3, or 4: Withhold until clinically stable or permanently discontinue depending on the severity
  • Permanently discontinue if no complete or partial resolution (Grade <1) within 12 weeks of initiating steroids or inability to reduce prednisone ≤10 mg/day (or equivalent) within 12 weeks of starting steroids.

Nephritis with renal dysfunction

  • Grade 2 or 3 increased blood creatinine: Withhold therapy; resume when complete or partial resolution occurs (Grade <1) after corticosteroid taper
  • Permanently discontinue if no complete or partial resolution within 12 weeks of initiating steroids or inability to reduce prednisone ≤10 mg/day (or equivalent) within 12 weeks of starting steroids.
  • Grade 4 increased blood creatinine: Permanently discontinue

Exfoliative dermatologic conditions

  • Suspected Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), or drug rash with eosinophilia and systemic symptoms (DRESS) syndrome: Withhold therapy

  • Permanently discontinue if no complete or partial resolution within 12 weeks of initiating steroids or inability to reduce prednisone ≤10 mg/day (or equivalent) within 12 weeks of initiating steroids.

  • Confirmed SJS, TEN, or DRESS syndrome: Permanently discontinue

Myocarditis

  • Grade 2, 3, or 4: Permanently discontinue

Neurologic toxicities

  • Grade 2: Withhold therapy; resume when complete or partial resolution occurs (Grade <1) after corticosteroid taper
  • Permanently discontinue if there is no complete or partial resolution within 12 weeks of initiating steroids or inability to reduce prednisone ≤10 mg/day (or equivalent) within 12 weeks of initiating steroids.
  • Grade 3 or 4: Permanently discontinue

Infusion-related reactions

  • Grade 1 or 2: Interrupt or slow infusion rate
  • Grade 3 or 4: Permanently discontinue

Renal or hepatic impairment

  • Mild-severe and end-stage renal disease: No dosage adjustment necessary

Hepatic impairment

  • Mild-to-moderate (TB ≤3x ULN and any AST): No dose adjustment is recommended
  • Severe: Not studied

Dosing Considerations

Females of reproductive potential: Verify pregnancy status before initiation

Recurrent or advanced dMMR endometrial cancer or solid tumours

“This is the first time this has happened in the history of cancer”, Dr Luis Diaz, one of the lead authors of the paper, told The New York Times.

The patients also experienced no significant side effects during the course of their treatment.

 https://www.independent.co.uk/topic/us -

Wednesday, May 11, 2022

Anti-Aging and food

 Ageing is inevitable, but that does not mean you can’t slow down the process. Premature ageing can be effectively controlled with a proper diet. Dull and lifeless looking skin can be rejuvenated by consuming the correct supplements and following a healthy, nutritious diet. A good diet will boost cell growth and give you glowing skin. While it is essential to turn back the clock once the damage has been done, nonetheless, it is crucial to follow good eating habits from a young age. No matter what drinking ample water throughout the day can help you attain flawless skin!

Similarly, a good sleep cycle plays a crucial role in skin-related issues and maintaining a healthy weight. You don’t have to search far and wide to incorporate anti-ageing foods in your meal; they are present in your kitchen! Make sure to get eight hours of undisturbed sleep every single night.



We've all grown up listening to the following phrases almost every day of our lives - “age is just a number”, “age doesn't determine your capabilities”, etc. While it is true that age is limited to being just a number, age does not conceal its arrival when it dawns upon someone. It is easily visible unless the person might have resorted to alternatives such as plastic surgery to conceal signs of ageing of skin and hair. Growing old is often accompanied by wrinkles, dry skin, blemishes or darkened skin. However, these issues are not restricted to old age; younger people are also susceptible to these problems if a proper lifestyle is not followed and the body is subjected to harsh chemical products. While ageing may be inevitable, one can definitely slow down the process, especially with premature ageing. Dull and lifeless looking skin can be rejuvenated by feeding your body with correct supplements and following a healthy, nutritious diet which can boost cell growth and provide you glowing skin. While it may be difficult to turn back the clock once the damage has been done, it becomes crucial to inculcate good eating habits from a young age. Drinking efficiently large quantities of water has the potential to help you attain flawless skin, which remains a dream for most of us. Consciously making an effort to drink water irrespective of thirst is deemed to have a positive influence on the skin.



















While we don't prioritize a good sleep cycle, it plays a crucial role in skin-related issues and weight management. Getting eight hours of undisturbed sleep is an antecedent for 
radiant skin. Why we lay emphasis on the skin is because it is the skin that most certainly reflects the age of a person. If one has a reputation for good and flawless skin, it can deceive the others around you. While age should not be given much importance, we have a solution to your dull and lifeless skin. Try anti-ageing food! According to Dr Sheela Krishnaswamy, anti-ageing food does not constitute a single category of food that must be consumed. It comprises a series of fruits and vegetables that must be consumed on a daily basis in order to witness good results. Thus, in order to bring about a stop to signs of premature ageing, a combination of the following food must be consumed:1. Antioxidant-Rich FoodThis includes food that is rich in antioxidant content. As a large category, it includes all organic fruits and vegetables. These antioxidants prevent the process of oxidation and remove harmful free radicals from the blood which could lead to major diseases like cancer and heart ailments.
2. SpicesIncrease the intake of spices in your diet. Indian food is naturally spicy and therefore proves to be effective for anti-ageing. Spices like basilfennel seeds, cuminturmeric, etc prevent oxidative damage to the cells.
https://food.ndtv.com/

Electrochemistry Mcq 1979 to 2020

 


Electrochemistry is the study of chemical processes that cause electrons to move. This movement of electrons is called electricity, which can be generated by movements of electrons from one element to another in a reaction known as an oxidation-reduction ("redox") reaction.

Tuesday, January 11, 2022

Amrutesvara Temple


Location: In the town of Amruthapura, 67 km north of Chikmagalur district
Built-in: 1196 C.E.
Built By: Amrutheshwara Dandanayaka ,under Hoysala King Veera Ballala II

Dedicated to:
Lord Shiva
Entry: Free
Photography: Allow
Significance:  One of the most temple
Temple Timing:9:30 Am to 1:30 Am,4:00 Pm to 6:00 Pm
Visiting Timing: 1 Hour
Best time to Visit: Oct to Feb
Nearest Railway Station: Tarikere  station 
Nearest Airport: Bangalore Airport

More Information about  Amrutesvara Temple 

The Amrutesvara Temple is located at the town of Amruthapura, 67 km north of Chikmagalur district Karnataka. Amruteshwara Temple was built in 1196 by Amrutheshwara Dandanayaka under Hoysala King Veera Ballala II. It is sictuated  in the close vicinity of the Bhadra River reservoir, a short distance from Tarikere town. The temple is dedicated to Lord Shiva and it has a Shiva Ling made of saligram, a black kind of stone that was brought from River Kandikevale in Nepal. The temple is maintained by ASI (Archeological Survey of India) and is open to tourists till 6PM only. The temple is surrounded by coconut and palm plantations. The temple is a fine example of 12th century Hoysala architecture with a wide-open mandapa (hall). The temple is a fine example of 12th century Hoysala architecture with a wide-open mandapa (hall). There are many devotees and tourists visit Amrutesvara Temple. The Amrutesvara temple is still presented and all the beautiful stone arts of this temple attract people towards it. Every year thousands of people come to visit this temple which proves that this is a very popular temple among visitors.

History of Amrutesvara Temple

The Amrutesvara Temple was built in 1196 during the Hoysala period in 1196. It was built by, Amrutesvara Dandanayaka, a commander of the Hoysala Army of King Veera Ballala II. The famous Hoysala sculptor, Ruvari Mallitamma began his career with this temple. Within the temple complex, there is a large stone inscription that represents a fine example of medieval Kannada poetry.