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புகைப்படங்களை இணைத்து அழகான வீடியோவாக உருவாக்க

பிரபல சமூக இணையத்தளமான பேஸ்புக்கில் உங்களது குடும்ப நிகழ்வுகள், சுற்றுலா சென்ற போது எடுத்த புகைப்படங்கள் என அனைத்தையும் பகிர்வீர்கள். இந்த புகைப்படங்கள் அனைத்தையும் இணைந்து, ஒரு வீடியோவாக உருவாக்கலாம். இதற்கு முதலில் http://www.timelinemoviemaker.com/ என்ற தளத்திற்கு செல்லவும். அதன் பின் தோன்றும் விண்டோவில் Make your Movie என்ற பட்டனை அழுத்தவும். இந்த பட்டனை அழுத்தியவுடன் பேஸ்புக் permission கேட்கும் Allow கொடுக்கவும். பிறகு உங்களுடைய Timeline movie தயாராகும். உங்களுடைய கணக்கில் உள்ள புகைப்படங்களை ஒட்டுமொத்தமாக சேர்த்து வீடியோ தயாரிக்கும். உங்கள் கணக்கில் குறிப்பிட்ட அளவு புகைப்படங்கள் இல்லை என்றால் புகைப்படத்தை சேருங்கள் என்ற அறிவிப்பை வெளியிடும். முடிவில் உங்களுடைய வீடியோ தயாராகிவிடும். இந்த வீடியோவில் உள்ள பின்னணி இசையை உங்கள் விருப்பத்திற்கு மாற்றி கொள்ளலாம். இப்பொழுது உங்களுக்கு பிடித்த மாதிரி வீடியோவாக உருவாக்கியதும் Share என்ற பட்டனை அழுத்தி அந்த வீடியோவை உங்கள் கணக்கில் பகிருங்கள்.

New stable antibodies created

GARVAN INSTITUTE OF MEDICAL RESEARCH

Share on emailShare on print Scientists have developed specific mutations that increase the stability of antibody molecules. Image: z80/iStockphoto Australian scientists have overcome one of the most pressing problems facing the pharmaceutical industry – how to create antibodies that are stable enough to meet stringent requirements necessary for production in large quantities, injection into patients and long-term storage. Members of the Antibody Engineering Laboratory at Sydney’s Garvan Institute of Medical Research – Dr Daniel Christ* and PhD students Kip Dudgeon and Romain Rouet – have developed specific mutations that universally increase the stability of antibody molecules. The breakthrough finding is published in the early online edition of theProceedings of the Academy of Science (PNAS), the journal of the United States National Academy of Sciences. “When we talk to collaborators in industry, we find that 30-50% of the antibody-based drugs they develop have to be put on hold because they don’t meet quality tests that the companies or regulatory agencies such as the US Food and Drug Administration, require before marketing or approving these molecules,” said Dr Christ. “Until now, the issue of antibody instability has been tackled on a case-by-case basis, which is only tinkering with the problem. When you’re dealing with such a diverse population of molecules, you have to make sure that the method you develop is generally applicable – and that’s what we’ve done.” Produced by the immune system in response to infection there can be as many as 100 million different kinds of antibodies in the circulation of a single human being. Antibodies have ‘constant regions’ and ‘variable regions’, the latter determining the binding specificity of the molecule. The shape of the variable region will exactly match the ‘antigen’, or invader, in the same way as a lock matches a key. With infinite variability of antibody structure comes varying levels of stability. It is fairly common, therefore, to have an antibody that is very good at binding to a specific antigen, but which is also very unstable. The mutations created by the Garvan team fix the stability problem without compromising the antigen binding properties of an antibody. Antibodies consist of two chains – a heavy and a light chain – and Dr Christ emphasises that mutations have to work with each chain individually and both chains in combination. “Typically you’d have both chains present in a therapeutic molecule, as well as additional biological activity, such as the ability to bind to a cancer target,” he said. “Our challenge was to maintain biological activity under very unnatural conditions, for which antibodies were not optimised by evolution. It is really when you take these molecules out of their natural environment, purify and concentrate them, that stresses become apparent. When used as a drug, antibodies are formulated at very high concentrations, for instance for delivery in a small syringe. You end up with an almost honey-like, highly viscous preparation. Under these conditions, antibodies can stick to surfaces like tubing and become entangled with one another. Our mutations make them much less sticky, much less entangled. They also make the antibodies more robust against common storage methods such as freeze drying.” The next step for the Garvan team will be to work with colleagues in the pharmaceutical industry to improve the stability of antibody therapeutics for the treatment of cancer and inflammatory conditions. Editor's Note: Original news release can be found here.

மூட்டு வலிக்கு மருந்தாகும் ஆமணக்கு

ஆமணக்கு செடியில் மருத்துவ குணங்கள் மிகவும் நிறைந்து காணப்படுகின்றன. ஆமணக்கு மிகச்சிறந்த எண்ணெய் வித்தாகும். இதிலிருந்து எடுக்கப்படுகின்ற விளக்கு எண்ணெயை யுனானி மருத்துவர்கள் மிகச்சிறந்த மருந்துப் பொருளாகப் பயன்படுத்துகின்றார்கள். ஆமணக்கு செடியின் விதைகள் கொட்டை முத்து எனப்படுகிறது. இதன் இலைகள், எண்ணெய், வேர் ஆகியவை மருத்துவப் பொருளாகப் பயன்படுகின்றன. குடிநீரில் ஆமணக்குச் செடியின் வேரைச் சேர்ப்பது வழக்கமாகும். அது போலவே, பல்வேறு விதமான தைலங்களிலும் இந்த வேரைச் சேர்ப்பார்கள். சளித் தொல்லை, ஜலதோஷம் நீங்கவும், காலை, மாலை இரு வேளைகளிலும் சிறிது அளவில் தொடர்ந்து ஐந்து நாட்களுக்குக் கொடுத்து வர, சளித்தொல்லை குணமாகும். இதன் இலைகளை கீழாநெல்லி இலைகளுடன் சேர்த்து அரைத்து சிறு எலுமிச்சம்பழ அளவில் எடுத்து மூன்று நாட்களுக்கு காலை நேரத்தில் தொடர்ந்து கொடுத்து வருவதுடன், நான்காவது நாள் மூன்று முறை சிறிதளவு சிவதைப் பொடி கொடுத்து வந்தால் காமாலை நோய் தீர்ந்துவிடும். சிற்றாமணக்கு எண்ணெய் அடி வயிற்றின் மீது பூசி, அதன் மேல் இந்த இலைகளை வதக்கிப் போட்டால் மலச்சிக்கல், வயிற்றுவலி குணம் பெறும். இதன் இலைகளைப் பொடியாய் அரைத்து, அதில் ஆமணக்கு நெய்விட்டு வதக்கி ஒத்தடம் கொடுப்பதால் மூலக்கடுப்பு, கீழ்வாதம், வாத வீக்கம் குணம்பெறும். ஆமணக்கு விதைகளைப் பாலில் அல்லது தண்ணீரில் கொதிக்க வைத்து மூட்டுவலி, பின்தொடை, நரம்பு வலிகளுக்கு மருந்தாகத் தரலாம். இதன் விதைகள் கல்லீரல் நோய்கள், மண்ணீரல் நோய்களையும் குணப்படுத்துகின்றது.

LG Cloud: இலவசமான ஒன்லைன் சேமிப்பு வசதி

தற்போது காணப்படும் விண்டோஸ், கூகுள் என்பவற்றின் ஒன்லைன் சேமிப்பு வசதிகளைப் போன்று LG நிறுவனமும் ஒன்லைன் சேமிப்பு வசதியை அதன் வாடிக்கையாளர்களுக்கு ஏற்படுத்தியுள்ளது. அதாவது LG Smartphone, LG Smart TV பயனர்களுக்கு 5 GB வரையிலான சேமிப்பு கொள்ளளவு கொண்ட இடத்தினை இலவசமாக வழங்க முன்வந்துள்ளது. இவ்வசதியின் மூலம் புகைப்படங்கள், வீடியோக்கள், பாடல்கள் போன்றவற்றின் குறிப்பிட்ட சில வகை கோப்புக்களை தரவேற்றம் செய்ய முடியும். மேலும் தனது பிரீமியம் பயனர்களுக்கான முதல் ஆறு மாதங்களும் 50 GB இலவச ஒன்லைன் சேமிப்பகத்தை வழங்கும் திட்டத்தினையும் GB நிறுவனம் கொண்டுள்ளமை குறிப்பிடத்தக்கது. தரவிறக்க சுட்டி

Sai Nath-Hindi Devotional Video Saibaba Bhajan Song Of 2012-Sai Ram Sai ...

A Step Toward Minute Factories That Produce Medicine Inside the Body

Scientists are reporting an advance toward treating disease with minute capsules containing not drugs -- but the DNA and other biological machinery for making the drug. (Credit: © Benicce / Fotolia)                                                                               Science Daily — Scientists are reporting an advance toward treating disease with minute capsules containing not drugs -- but the DNA and other biological machinery for making the drug. In an article in ACS' journal Nano Letters, they describe engineering micro- and nano-sized capsules that contain the genetically coded instructions, plus the read-out gear and assembly line for protein synthesis that can be switched on with an external signal.

They describe the nanoscale production units, which are tiny spheres encapsulating protein-making machinery like that found in living cells. The resulting nanoparticles produced active proteins on demand when the researchers shined a laser light on them. The nanoparticles even worked when they were injected into mice, which are stand-ins for humans in the laboratory, producing proteins when a laser was shone onto the animals. This innovation "may find utility in the localized delivery of therapeutics," say the researchers.Daniel Anderson and colleagues explain that development of nanoscale production units for protein-based drugs in the human body may provide a new approach for treating disease. These production units could be turned on when needed, producing medicines that cannot be taken orally or are toxic and would harm other parts of the body. Until now, researchers have only done this with live bacteria that were designed to make proteins at disease sites. But unlike bacterial systems, artificial ones are modular, and it is easier to modify them. That's why Anderson's group developed an artificial, remotely activated nanoparticle system containing DNA and the other "parts" necessary to make proteins, which are the workhorses of the human cell and are often used as drugs.

The authors acknowledge funding from the Misrock Foundation, the Life Sciences Research Foundation, the National Cancer Institute, the National Institutes of Health and the Marie D. & Pierre Casimir-Lambert Fund.

Nerve pathway for combating axon injury and stress may hold benefits for individuals with neurodegenerative disorders

Neurons expressing a toxic form of spinocerebellar ataxia type 3 (SCA3) with protective pathway enabled (left) and blocked (right). Credit: Melissa Rolls.

(Medical Xpress) -- Researchers from the Huck Institutes' Center for Cellular Dynamics — led by Center director Melissa Rolls — have found that a neuroprotective pathway initiated in response to injured or stressed neural axons serves to stabilize and protect the nerve cell against further degeneration.

Neurons, or nerve cells, typically have a single axon that transmits signals to other neurons or to output cells such as muscle tissue, and as these axons extend for long distances within the cell, they are thus at risk for injury.

Furthermore — if an axon is damaged, its parent neuron can no longer function; and since many animals develop only one set of neurons, those neurons will mount major responses to axon injury.

"Neurons are quite remarkable cells," says Dr. Rolls. "Most of them need to survive and function for your entire lifetime. Maybe then it shouldn’t be a surprise that they do not give up easily when damaged or stressed, but it is amazing to be able to watch them fight back and stabilize themselves."

Dissecting Drosophila

Dr. Rolls and her team set out to understand these cellular responses to axon injury by observing the effects of severing fruit fly axons with a laser.

What they found was that the neurons responded to the injury by increasing production of microtubules — cytoskeletal components responsible for maintaining cell structure and providing platforms for intracellular transport — in order to stabilize the neural dendrites, which are the branched structures responsible for transmitting signals to the nerve cell body.

In addition to acute injury response, the team also investigated neurons' response to long-term axon stress — and found similar results.

This video is not supported by your browser at this time.

This video shows the difference in microtubule dynamics between cells expressing a non-toxic form of the huntingtin protein (left) and cells expressing a disease-causing form (right).

Accumulation of misfolded proteins or protein aggregates — responsible for neurodegenerative diseases such as Huntington's disease and spinocerebellar ataxia — induced the same type of cytoskeletal changes as acute axon injury.

Dr. Rolls elaborates: "The assays that we use are all in vivo, so we can literally watch what the neurons do in different scenarios, including cutting of their axon. Being able to observe the cellular responses gave us some ideas we would not have come up with otherwise. For example, it is not intuitive that expressing a protein that causes degeneration would trigger the cell to turn on a pathway that delays degeneration."

Conclusions and implications

Based on their observations, the authors suggest that this pathway represents an endogenous neuroprotective response to axon stress — and could potentially be developed into a diagnostic tool for the detection of early stages of neurodegenerative disease, or even utilized in novel therapies for such illnesses.

"We don't yet know if all types of neurodegenerative disease trigger this type of stabilization pathway; but if there are some diseases in which it is off, then it may be beneficial to try to turn it on to help the neurons resist degeneration," says Dr. Rolls.

The results of the study have been published in Proceedings of the National Academy of Sciences.

Provided by Pennsylvania State University

"Nerve pathway for combating axon injury and stress may hold benefits for individuals with neurodegenerative disorders." June 27th, 2012.http://medicalxpress.com/news/2012-06-nerve-pathway-combating-axon-injury.html

Posted by
Robert Karl Stonjek

Beautiful Plains

SEVEN TIPS TO IMPRESS THE CEO

7 Rules for Meetings With Top Execs

Executives are busy people. So once you’ve gotten onto the calendar, make the most of the opportunity.

Congratulations! You’ve finally landed a one-on-one meeting with a top exec, a powerful player inside your customer’s firm.  It’s a great opportunity, but you’ve got to be certain to take advantage of it.

Make sure you follow these simple steps.

1. Do your research.

Before the meeting, research and review the exec’s “business agenda”–what he or she needs to accomplish organizationally.  Then use your contacts in the firm and your own business acumen to understand the exec’s “personal agenda”–likely career goals, the job that he or she is angling for, and so forth.

2. Don’t assume the exec knows who you are.

Busy execs are often unaware (or can’t remember) why a particular meeting is on their agenda. Introduce yourself and explain why you’re there, tying the subject matter to both the business agenda and, more subtly, the personal agenda of the executive in question.  For example: “I’m John Doe from Acme and I’m here to discuss how to increase profitability through improvements in quality control.”

3. Establish credibility immediately.

Within the first few minutes, demonstrate that you’ve done your homework and understand the company, its challenges and its place in its industry.  Focus on business issues that the executive faces–never the specific bells and whistles on your product.  Execs don’t care about features and functions; they want to know how you’re going to change the bottom line.

4. Ask intelligent questions.

Frame everything according to the drivers that affect the business and the metrics that this exec uses to evaluate activities.  For example, if you're talking to a CFO, you might ask questions about the ROI expectations that the firm uses to make purchasing decisions. If you're talking to a chief technology officer, you might ask questions about the how the rest of the company measures IT performance.

5. Listen more than you talk.

Once you've asked a question, hear what the exec has to say. A productive conversation with a customer is one in which the customer does most of the talking.  Your job is to guide the conversation so that you discover what you need to know in order to be of service to that customer. You need to fully understand a company's problem before proposing a solution.

6. Add value to the conversation.

Resist the temptation to present your solution right then and there.  Anything resembling a sales pitch will make it seem as if your haven't been listening or (worse) don't care about what the exec just told you.  Instead, bring additional value to the conversation by introducing a different business perspective and your experience dealing with similar problems.

7. Close on a next step.

Involve the exec directly in planning any subsequent actions concerning your offering. In most cases, this will involve an opportunity for you to present some kind of customized solution to the problems you've been discussing. However, take the exec's lead on how to go about this.  Ideally, you want the executive to make some kind of public commitment to the project, even if it's just to schedule a group meeting to discuss the idea further.

The above is based on several sources, but draws heavily on a conversation with Dr. Steve Bistritz and Nicholas A.C. Read, authors of the bestselling book Selling to the C-Suite.