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Monday, March 19, 2012

The First Living Animal Ever Imaged With a Scanning Electron Microscope



Bombarded with electrons and sealed in a vacuum, the noble tick survived the ordeal
Up Close With the First Living Animal Captured via Scanning Electron Microscopy via Not Exactly Rocket Science
You didn’t wake up this morning thinking that a tick under a scanning electron microscope was going to be the coolest thing you saw all day, and yet here you are. After discovering some ticks alive inside a vacuum drying chamber, Yasuhito Ishigaki of Kanazawa Medical University decided to see if the hardy little bloodsuckers could stand up to the electron bombardment and vacuum conditions inside a scanning electron microscope (SEM). They could, and he’s got the video to prove it.
SEM rigs are great for capturing very fine detail of very small things, but they aren’t easy on their subjects. They work by bombarding a sample with electrons and recording how they scatter to create an image. Air interferes with this electron beam, so all this takes place inside a vacuum. And samples are often stained or even coated with metal beforehand to enhance the resolution of the microscopy.
All said, life is not good for a SEM sample. In fact, putting anything living into an SEM sample chamber pretty much ensures that it won’t be living when you take it out. But this clearly isn’t true for ticks. In the video below, you can clearly see the tick moving its legs. Ishigaki did this with 20 different ticks, and all of them survived, making them the first animals to ever be scanned with SEM.

For the First Time, a Message Sent With Neutrinos



Straight through 780 feet of rock
Neutrino Message University of Rochester
In a major step for truly wireless communications, scientists have figured out how to send a message with neutrinos, transmitting a single word through 780 feet of bedrock and translating it at the other end. It’s just a first step, but the message suggests that someday, submarine crews and maybe average civilians will communicate by sending chargeless, ghostly particles through any obstacle. The message? “Neutrino.”

Maybe researchers from the University of Rochester and North Carolina State University could have come up with a more interesting or ominous word, but their breakthrough is pretty impressive. Using neutrinos, you could theoretically communicate between any two points without any cables or wires — through water, which is what makes them an attractive option for marine applications, or even through the entire planet. Chargeless and tiny, neutrinos are unperturbed by obstacles the way radio waves are.
The neutrino message was produced at Fermilab, using one of the institution's particle accelerators to produce a high-energy neutrino beam and then using the MINERvA detector, located in a subterranean cave, to read them. The research team translated the word “neutrino” into binary code, and fired large groups of neutrinos to ensure the detector would pick them up.
Neutrinos are incredibly hard to detect, so finding them requires enormous networks of equipment. Even with a multi-ton detector like MINERvA, only about one in 10 billion neutrinos is spotted. After MINERvA detected them, the binary signal was translated back into English, and the word “neutrino” was received loud and clear.
Using a particle accelerator and massive detector to send a single word is not exactly a practical communication system, but the fact that it worked suggests there’s ample room for further study. The researchers submitted their work to the journal Modern Physics Letters A.

During Two-Year Personal Study, Doctor Watches Himself Get Diabetes In Close Detail



A milestone in personalized medicine

Personal Omics The integrative personal omics profile took several tissue samples and required various types of analysis. Cell
For more than two years, Stanford University geneticist Michael Snyder donated his living body to science. He and fellow researchers examined his DNA, RNA, proteins and metabolites, creating an incredibly detailed profile of his personal “omics.” They watched in real-time and at the molecular level as viruses attacked his cells, and they figured out, to their shock, that he was prone to developing type 2 diabetes. And then they watched him develop it.
It’s the first study to follow the molecular processes of sickness and health in one individual, and as such, it’s a significant breakthrough for personalized medicine. It’s also the first real-time view of the birth of a disease that afflicts millions of people, according to Stanford University Medical Center.

Since the earliest days of human genome sequencing, personalized medicine has promised to predict a person’s propensity for disease, helping individuals and their doctors better monitor their health. But this is the first time anyone has done it to such a comprehensive degree. The study goes far beyond the “ome” we know best, the genome, to include nearly every trackable large-scale structure in the body. Stanford researchers studied Snyder’s DNA (genome), RNA (transcriptome), metabolites (metabolome), and proteins (the proteome), as well as antibodies in his cells. They called it an integrative Personal “Omics” Profile, or iPOP. The goal was to study his disease risks and the various physiological states associated with health and illness.
Snyder, who led the study, donated blood samples every two months when he was healthy, upping the samples when he fell ill, for 20 blood draws. The team performed scores of tests and came up with thousands of data points, which required using complex algorithms and other processing techniques.
To start, the team sequenced Snyder’s genome and found that he has a genetic predisposition to type 2 diabetes, despite having no family history or significant risk factors (he’s thin, doesn’t smoke, etc.). They sequenced his mother’s genome, too. When Snyder came down with a nasty viral infection, the researchers watched his blood sugar levels rise, and he immediately changed his diet and exercise regimen. Ultimately, the researchers say he could lower his glucose levels. It’s a compelling example of how genetic information can be used to improve a person’s health.
The researchers also uncovered changes in RNA transcription and gene expression between healthy and diseased states, watching the body’s changes in response to various phenomena.
“Detailed omics profiling coupled with genome sequencing can provide molecular and physiological information of medical significance,” the researchers write. “This approach can be generalized for personalized health monitoring and medicine.”
The study appears in the journal Cell.

The Electric-Car Movement Enters A Quiet, Crucial Phase



The transition from novelty to normality
Electric-Car Alison Seiffer
Early this year, when it became clear that the Chevrolet Volt and Nissan Leaf had missed their 2011 sales targets, critics declared the electric-car revolution over. Yet at Detroit’s annual North American International Auto Show in January, plug-in cars abounded. BMW displayed its forthcoming i3 electric city car, along with its i8 plug-in hybrid sports car. Acura unwrapped a hybrid concept version of the NSX supercar. Tesla Motors brought its all-electric Model S sedan. But the most important car on the show floor might have been one that, on the surface, seemed much less exciting: the new Ford Fusion, which will be available in gasoline, hybrid and plug-in hybrid versions.
Carmakers long refused to build plug-in cars because they said they had no idea how many people would buy them. Then, rising oil prices and environmental concerns led governments to enact stricter emissions standards and push carmakers to build cars that could meet those standards. In the U.S., the federal government lent several carmakers (not just GM and Chrysler) money to develop electric vehicles and retool factories.
Ford used part of its $5.9-billion loan to develop a system for building gas cars, hybrids, plug-ins and electric cars all on the same line. In a renovated Detroit-area factory, it will build gas and electric versions of the Focus compact car, along with hybrid and plug-in hybrid C-Max minivans. The company will use the same strategy for the Fusion.
Compared with the ambitious e-car launches of recent years—particularly those of the Chevy Volt and the Nissan Leaf—Ford’s approach might appear noncommittal. But it could turn out to be transformative. It’s evidence that once the investments have been made, manufacturing electric cars isn’t all that hard. It’s a matter of adding a few assembly-line stations where plug-in cars get their batteries, electric motors and electronic controls. And when Ford and other automakers use the same lithium-ion batteries across a range of electrified vehicles, it will help reduce the cost of those batteries, pushing electric-vehicle sticker prices down and ultimately in line with conventional gas cars.
Drivers won’t just benefit from lower prices; they will finally get some choice. Picking a power train could eventually become as simple as opting for the premium sound-system package. And making that choice won’t have to be a lifestyle statement. Outwardly, the plug-in hybrid version of the Ford Fusion will be almost indistinguishable from the hybrid or conventional versions, with the exception of a charge-port door and a little badge that says “Energi.” Habituating Americans to the concept of plugging in should make it more likely that all manner of electrified cars receive a warm reception.
The debut of the Volt and the Leaf was just one phase of a long process. First came the high-profile launches and the saturation media coverage. Now it’s time for plug-in cars to slowly become normal, even boring—or, to put it another way, accepted.

Top 10 Inventions That Changed the World


Inventions often extend the boundaries of human knowledge, experience or capability. An invention that is not derived from an existing model or idea, or that achieves a completely unique function, discovery, or result, may be a radical breakthrough. Here 10 such breathtaking inventions that changed the way in which we look at the future.




10. The Plow


Compared to some of the gleaming, electronic inventions that fill our lives today, the plow doesn't seem very exciting. It's a simple cutting tool used to carve a furrow into the soil, churning it up to expose nutrients and prepare it for planting. Yet the plow is probably the one invention that made all others possible. No one knows who invented the plow, or exactly when it came to be. It probably developed independently in a number of regions, and there is evidence of its use in prehistoric eras. Prior to the plow, humans were subsistence farmers or hunter/gatherers. Their lives were devoted solely to finding enough food to survive from one season to the next. Growing food added some stability to life, but doing it by hand was labor intensive and took a long time. The plow changed all that.

Plows made the work easier and faster. Improvements in the plow's design made farming so efficient that people could harvest far more food than they neededto survive. They could trade the surplus for goods or services. And if you could get food by trading, then you could devote your day-to-day existence to something other than growing food, such as producing the goods and services that were suddenly in demand. The ability to trade and store materials drove the invention of written language, number systems, fortifications and militaries. As populations gathered to engage in these activities, cities grew. It's not a stretch to say that the plow is responsible for the creation of human civilization.
  
9. Wheel



The wheel is another invention so ancient that we have no way of knowing who first developed it. The oldest wheel and axle mechanism we've found was near Ljubljana, Slovenia, and dates to roughly 3100 B.C.
The wheel made the transportation of goods much faster and more efficient, especially when affixed to horse-drawn chariots and carts. However, if it had been used only for transportation, the wheel wouldn't have been as much of a world-changer as it was. In fact, a lack of quality roads limited its usefulness in this regard for thousands of years.

A wheel can be used for a lot of things other than sticking them on a cart to carry grain, though. Tens of thousands of other inventions require wheels to function, from water wheels that power mills to gears and cogs that allowed even ancient cultures to create complex machines. Cranks and pulleys need wheels to work. A huge amount of modern technology still depends on the wheel, like centrifuges used in chemistry and medical research, electric motors and combustion engines,jet engines,power plants and countless others.

8. Printing Press



Like many of the inventions on this list, the man we believe invented the printing press (Johann Gutenberg in the 1430s) actually improved on per-existingtechnologies and made them useful and efficient enough to become popular. The world already had paper and block printing -- the Chinese had them as early as the 11th century -- but the complexity of their language limited popularity. Marco Polo brought the idea to Europe in 1295.

Gutenberg combined the idea of block printing with a screw press (used for olive oil and wine production). He also developed metal printing blocks that were far more durable and easier to make than the hand-carved wooden letters in use previously. Finally, his advances in ink and paper production helped revolutionize the whole process of mass printing.

The printing press allowed enormous quantities of information to be recorded and spread throughout the world. Books had previously been items only the extremely rich could afford, but mass production brought the price down tremendously. The printing press is probably responsible for many other inventions, but in a more subtle way than the wheel. The diffusion of knowledge it created gave billions of humans the education they needed to create their own inventions in the centuries since.

7. Refrigeration



Refrigerators cool things down by taking advantage of the way substances absorb and unload heat as their pressure points and phases of matter change (usually from gas to liquid and back). It's difficult to pinpoint a single inventor of the refrigerator, because the concept was widely known and gradually improved over the course of about 200 years. Some credit Oliver Evans' 1805 unproduced design of a vapor-compression unit, while others point to Carl von Linde's 1876 design as the actual precursor of the modern refrigerator in your kitchen. Dozens of inventors, including Albert Einstein, would refine or improve refrigerator designs over the decades.

In the early 20th century, harvested natural ice was still common, but large industries such as breweries were beginning to use ice-making machines. Harvested ice for industrial use was rare by World War I. However, it wasn't until the development of safer refrigerant chemicals in the 1920s that home refrigerators became the norm.

The ability to keep food cold for prolonged periods (and even during shipping, once refrigerated trucks were developed) drastically changed the food production industry and the eating habits of people around the world. Now, we have easy access to fresh meats and dairy products even in the hottest summer months, and we're no longer tied to the expense of harvesting and shipping natural ice -- which never could have kept pace with the world's growing population in any case.

6. Communications



Maybe it's cheating to lump the telegraph,telephone,radio and television in to one "invention," but the development of communication technology has been a continuum of increased utility and flexibility since Samuel Morse invented the electric telegraph in 1836 (building on the prior work of others, of course). The telephone simply refined the idea by allowing actual voice communications to be sent over copper wires, instead of just beeps that spelled out the plain text in Morse code. These communication methods were point-to-point, and required an extensive infrastructure of wires to function.

Transmitting signals wirelessly using electromagnetic waves was a concept worked on by many inventors around the world, but Guglielmo Marconi and Nikola Tesla popularized it in the early 20th century. Eventually, sound could be transmitted wirelessly, while engineers gradually perfected the transmission of images. Radio and television were new landmarks in communications because they allowed a single broadcaster to send messages to thousands or even millions of recipients as long as they were equipped with receivers.

These developments in communications technology effectively shrank the world. In the span of about 120 years, we went from a world where it might take weeks to hear news from across the country to one where we can watch events occurring on the other side of the globe as they happen. The advent of mass communications put more information within our grasp and altered how we interact with each other.

5. Steam Engine



Prior to the invention of the steam engine, most products were made by hand.Waterwheels and draft animals provided the only "industrial" power available, which clearly had its limits. The Industrial Revolution, which is perhaps the greatest change over the shortest period of time in the history of civilization, was carried forward by the steam engine.

The concept of using steam to power machines had been around for thousands of years, but Thomas Newcomen's creation in 1712 was the first to harness that power for useful work (pumping water out of mines, for the most part). In 1769, James Watt modified a Newcomen engine by adding a separate condenser, which vastly increased the steam engine's power and made it a far more practical way to do work. He also developed a way for the engine to produce rotary motion, which may be just as important as the efficiency gains. Thus, Watt is often considered the inventor of the steam engine.

Newcomen's and Watt's engines actually used the vacuum of condensing steam to drive the pistons, not the pressure of steam expansion. This made the engines bulky. It was the high-pressure steam engine developed by Richard Trevithick and others that allowed for steam engines small enough to power a train. Not only did steam engines power factories that made the rapid production of goods possible, they powered the trains and steamships that carried those goods across the globe.

While the steam engine has been eclipsed by electric and internal combustion engines in the areas of transport and factory power, they're still incredibly important. Most power plants in the world actually generate electricity using steam turbines, whether the steam is heated by burning coal, natural gas or a nuclear reactor.

4. Automobile



If the steam engine mobilized industry, the automobile mobilized people. While ideas for personal vehicles had been around for years, Karl Benz's 1885 Motorwagen, powered by an internal combustion engine of his own design, is widely considered the first automobile. Henry Ford's improvements in the production process -- and effective marketing -- brought the price and the desire for owning an auto into the reach of most Americans. Europe soon followed.

The automobile's effect on commerce, society and culture is hard to overestimate. Most of us can jump in our car and go wherever we want whenever we want, effectively expanding the size of any community to the distance we're willing to drive to shop or visit friends. Our cities are largely designed and built around automobile access, with paved roads and parking lots taking up huge amounts of space and a big chunk of our governments' budgets. The auto industry has fueled enormous economic growth worldwide, but it's also generated a lot of pollution.

3. Light Bulb



If there's a common theme to this list, it's that no major invention came from a single stroke of genius from a single inventor. Every invention is built by incrementally improving earlier designs, and the person usually associated with an invention is the first person to make it commercially viable. Such is the case with the light bulb. We immediately think of Thomas Edison as the electric light bulb's inventor, but dozens of people were working on similar ideas in the 1870s, when Edison developed his incandescent bulb. Joseph Swan did similar work in Britain at the time, and eventually the two merged their ideas into a single company, Ediswan.
The bulb itself works by transmitting electricity through a wire with high resistance known as a filament. The waste energy created by the resistance is expelled as heat and light. The glass bulb encases the filament in a vacuum or in inert gas, preventing combustion.

You might think the light bulb changed the world by allowing people to work at night or in dark places (it did, to some extent), but we already had relatively cheap and efficient gas lamps and other light sources at the time. It was actually the infrastructure that was built to provide electricity to every home and business that changed the world. Today, our world is filled with powered devices than we can plug in pretty much anywhere. We have the light bulb to thank for it.

2. Computer



A computer is a machine that takes information in, is able to manipulate it in some way, and outputs new information. There is no single inventor of the modern computer, although the ideas of British mathematician Alan Turing are considered eminently influential in the field of computing. Mechanical computing devices were in existence in the 1800s (there were even rare devices that could be considered computers in ancient eras), but electronic computers were invented in the 20th century.

Computers are able to make complicated mathematical calculations at an incredible rate of speed. When they operate under the instructions of skilled programmers, computers can accomplish amazing feats. Some high-performance military aircraft wouldn't be able to fly without constant computerized adjustments to flight control surfaces. Computers performed the sequencing of the human genome, let us put spacecraft into orbit, control medical testing equipment, and create the complex visual imagery used in films and video games.
If we only examine these grandiose uses of computers, we overlook how much we rely on them from day to day. Computers let us store vast amounts of information and retrieve a given piece of it almost instantly. Many of the things we take for granted in the world wouldn't function without computers, from cars to power plants to phones.

1. Internet



The Internet, a network of computers covering the entire planet, allows people to access almost any information located anywhere in the world at any time. Its effects on business, communication, economy, entertainment and even politics are profound. The Internet may not have changed the world as much as the plow, but it's probably on par with the steam engine or automobile.

DARPA (Defense Advanced Research Projects Agency), the research and development arm of the U.S. military, created ARPANET in the late 1960s. This network of computer-to-computer connections was intended for military and academic research. Other computer networks began to cross the globe in the next few years, and by the late 1970s computer scientists had created a single protocol, TCP/IP, that would allow computers on any network to communicate with computers on other networks. This was, essentially, the birth of the Internet, but it took 10 or so years for various other networks in the world to adopt the new protocol, making the Internet truly global.

The Internet is such a powerful invention that we've probably only begun to see the effects it will have on the world. The ability to diffuse and recombine information with such efficiency could accelerate the rate at which further world-changing inventions are created. At the same time, some fear that our ability to communicate, work, play and do business via the Internet breaks down our ties to local communities and causes us to become socially isolated. Like any invention, the good or ill it accomplishes will come from how we choose to use it.

Eyes & PC


Step I:- 
 

After every 20 minutes of looking at the computer screen, turn your head and try to look at any object placed at least 20 feet away. This changes the focal length of your eyes, a must-do for tired eyes.
 

Step II :-
 


Try and blink your eyes 20 times in succession to moisten them..
 

Step III:-
 


Time permitting, one should walk 20 paces after every 20 minutes of sitting in one particular posture. Helps blood circulation for the entire body.
 
Circulate among your friends if you care for them and their eyes. They say that your eyes mirror your soul, so do take care of them; they are priceless... ...
 


Frustration


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There is nothing that makes you frustrated. 
Any frustration you experience is the result of 
your own choice to react with frustration. 

There is nothing that makes you annoyed. 
Any annoyance you experience comes about because 
you have decided to be annoyed. 

You can choose to be annoyed, 
frustrated, angry, and spiteful. 
You can also choose not to be. 

Imagine how effective you could be if there was nothing that annoyed you. 
That level of effectiveness is yours to choose, right here, right now. 

All sorts of things will happen in your world today. 
You can let them get to you, and annoy and frustrate you, 
or you can choose to follow your own path. 

You have the power to be free of frustration, free of annoyance, 
free to accomplish and enjoy life. Choose that freedom today.
~Ralph Marston~