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Friday, October 21, 2011

A tale of three islands



The world’s population will reach 7 billion at the end of October. Don’t panic



IN 1950 the whole population of the earth—2.5 billion—could have squeezed, shoulder to shoulder, onto the Isle of Wight, a 381-square-kilometre rock off southern England. By 1968 John Brunner, a British novelist, observed that the earth’s people—by then 3.5 billion—would have required the Isle of Man, 572 square kilometres in the Irish Sea, for its standing room. Brunner forecast that by 2010 the world’s population would have reached 7 billion, and would need a bigger island. Hence the title of his 1968 novel about over-population, “Stand on Zanzibar” (1,554 square kilometres off east Africa).
Brunner’s prediction was only a year out. The United Nations’ population division now says the world will reach 7 billion on October 31st 2011 (America’s Census Bureau delays the date until March 2012). The UN will even identify someone born that day as the world’s 7 billionth living person. The 6 billionth, Adnan Nevic, was born on October 12th 1999 in Sarajevo, in Bosnia. He will be just past his 12th birthday when the next billion clicks over.


That makes the world’s population look as if it is rising as fast as ever. It took 250,000 years to reach 1 billion, around 1800; over a century more to reach 2 billion (in 1927); and 32 years more to reach 3 billion. But to rise from 5 billion (in 1987) to 6 billion took only 12 years; and now, another 12 years later, it is at 7 billion (see chart 1). By 2050, the UN thinks, there will be 9.3 billion people, requiring an island the size of Tenerife or Maui to stand on.
Odd though it seems, however, the growth in the world’s population is actually slowing. The peak of population growth was in the late 1960s, when the total was rising by almost 2% a year. Now the rate is half that. The last time it was so low was in 1950, when the death rate was much higher. The result is that the next billion people, according to the UN, will take 14 years to arrive, the first time that a billion milestone has taken longer to reach than the one before. The billion after that will take 18 years.
Once upon a time, the passing of population milestones might have been cause for celebration. Now it gives rise to jeremiads. As Hillary Clinton’s science adviser, Nina Fedoroff, told the BBC in 2009, “There are probably already too many people on the planet.” But the notion of “too many” is more flexible than it seems. The earth could certainly not support 10 billion hunter-gatherers, who used much more land per head than modern farm-fed people do. But it does not have to. The earth might well not be able to support 10 billion people if they had exactly the same impact per person as 7 billion do today. But that does not necessarily spell Malthusian doom, because the impact humans have on the earth and on each other can change.
For most people, the big questions about population are: can the world feed 9 billion mouths by 2050? Are so many people ruining the environment? And will those billions, living cheek-by-jowl, go to war more often? On all three counts, surprising as it seems, reducing population growth any more quickly than it is falling anyway may not make much difference.
Start with the link between population and violence. It seems plausible that the more young men there are, the more likely they will be to fight. This is especially true when groups are competing for scarce resources. Some argue that the genocidal conflict in Darfur, western Sudan, was caused partly by high population growth, which led to unsustainable farming and conflicts over land and water. Land pressure also influenced the Rwandan genocide of 1994, as migrants in search of a livelihood in one of the world’s most densely populated countries moved into already settled areas, with catastrophic results.
But there is a difference between local conflicts and what is happening on a global scale. Although the number of sovereign states has increased almost as dramatically as the world’s population over the past half-century, the number of wars between states fell fairly continuously during the period. The number of civil wars rose, then fell. The number of deaths in battle fell by roughly three-quarters. These patterns do not seem to be influenced either by the relentless upward pressure of population, or by the slackening of that pressure as growth decelerates. The difference seems to have been caused by fewer post-colonial wars, the ending of cold-war alliances (and proxy wars) and, possibly, the increase in international peacekeepers.
More people, more damage?
Human activity has caused profound changes to the climate, biodiversity, oceanic acidity and greenhouse-gas levels in the atmosphere. But it does not automatically follow that the more people there are, the worse the damage. In 2007 Americans and Australians emitted almost 20 tonnes of carbon dioxide each. In contrast, more than 60 countries—including the vast majority of African ones—emitted less than 1 tonne per person.
This implies that population growth in poorer countries (where it is concentrated) has had a smaller impact on the climate in recent years than the rise in the population of the United States (up by over 50% in 1970-2010). Most of the world’s population growth in the next 20 years will occur in countries that make the smallest contribution to greenhouse gases. Global pollution will be more affected by the pattern of economic growth—and especially whether emerging nations become as energy-intensive as America, Australia and China.
Population growth does make a bigger difference to food. All things being equal, it is harder to feed 7 billion people than 6 billion. According to the World Bank, between 2005 and 2055 agricultural productivity will have to increase by two-thirds to keep pace with rising population and changing diets. Moreover, according to the bank, if the population stayed at 2005 levels, farm productivity would have to rise by only a quarter, so more future demand comes from a growing population than from consumption per person.
Increasing farm productivity by a quarter would obviously be easier than boosting it by two-thirds. But even a rise of two-thirds is not as much as it sounds. From 1970-2010 farm productivity rose far more than this, by over three-and-a-half times. The big problem for agriculture is not the number of people, but signs that farm productivity may be levelling out. The growth in agricultural yields seems to be slowing down. There is little new farmland available. Water shortages are chronic and fertilisers are over-used. All these—plus the yield-reductions that may come from climate change, and wastefulness in getting food to markets—mean that the big problems are to do with supply, not demand.
None of this means that population does not matter. But the main impact comes from relative changes—the growth of one part of the population compared with another, for example, or shifts in the average age of the population—rather than the absolute number of people. Of these relative changes, falling fertility is most important. The fertility rate is the number of children a woman can expect to have. At the moment, almost half the world’s population—3.2 billion—lives in countries with a fertility rate of 2.1 or less. That number, the so-called replacement rate, is usually taken to be the level at which the population eventually stops growing.

The world’s decline in fertility has been staggering (see chart 2). In 1970 the total fertility rate was 4.45 and the typical family in the world had four or five children. It is now 2.45 worldwide, and lower in some surprising places. Bangladesh’s rate is 2.16, having halved in 20 years. Iran’s fertility fell from 7 in 1984 to just 1.9 in 2006. Countries with below-replacement fertility include supposedly teeming Brazil, Tunisia and Thailand. Much of Europe and East Asia have fertility rates far below replacement levels.
The fertility fall is releasing wave upon wave of demographic change. It is the main influence behind the decline of population growth and, perhaps even more important, is shifting the balance of age groups within a population.
When gold turns to silver
A fall in fertility sends a sort of generational bulge surging through a society. The generation in question is the one before the fertility fall really begins to bite, which in Europe and America was the baby-boom generation that is just retiring, and in China and East Asia the generation now reaching adulthood. To begin with, the favoured generation is in its childhood; countries have lots of children and fewer surviving grandparents (who were born at a time when life expectancy was lower). That was the situation in Europe in the 1950s and in East Asia in the 1970s.
But as the select generation enters the labour force, a country starts to benefit from a so-called “demographic dividend”. This happens when there are relatively few children (because of the fall in fertility), relatively few older people (because of higher mortality previously), and lots of economically active adults, including, often, many women, who enter the labour force in large numbers for the first time. It is a period of smaller families, rising income, rising life expectancy and big social change, including divorce, postponed marriage and single-person households. This was the situation in Europe between 1945 and 1975 (“les trente glorieuses”) and in much of East Asia in 1980-2010.
But there is a third stage. At some point, the gilded generation turns silver and retires. Now the dividend becomes a liability. There are disproportionately more old people depending upon a smaller generation behind them. Population growth stops or goes into reverse, parts of a country are abandoned by the young and the social concerns of the aged grow in significance. This situation already exists in Japan. It is arriving fast in Europe and America, and soon after that will reach East Asia.
A demographic dividend tends to boost economic growth because a large number of working-age adults increases the labour force, keeps wages relatively low, boosts savings and increases demand for goods and services. Part of China’s phenomenal growth has come from its unprecedentedly low dependency ratio—just 38 (this is the number of dependents, children and people over 65, per 100 working adults; it implies the working-age group is almost twice as large as the rest of the population put together). One study by Australia’s central bank calculated that a third of East Asia’s GDP growth in 1965-90 came from its favourable demography. About a third of America’s GDP growth in 2000-10 also came from its increasing population.
The world as a whole reaped a demographic dividend in the 40 years to 2010. In 1970 there were 75 dependents for every 100 adults of working age. In 2010 the number of dependents dropped to just 52. Huge improvements were registered not only in China but also in South-East Asia and north Africa, where dependency ratios fell by 40 points. Even “ageing” Europe and America ended the period with fewer dependents than at the beginning.
A demographic dividend does not automatically generate growth. It depends on whether the country can put its growing labour force to productive use. In the 1980s Latin America and East Asia had similar demographic patterns. But while East Asia experienced a long boom, Latin America endured its “lost decade”. One of the biggest questions for Arab countries, which are beginning to reap their own demographic dividends, is whether they will follow East Asia or Latin America.
But even if demography guarantees nothing, it can make growth harder or easier. National demographic inheritances therefore matter. And they differ a lot.
Where China loses
Hania Zlotnik, the head of the UN’s Population Division, divides the world into three categories, according to levels of fertility (see map). About a fifth of the world lives in countries with high fertility—3 or more. Most are Africans. Sub-Saharan Africa, for example, is one of the fastest-growing parts of the world. In 1975 it had half the population of Europe. It overtook Europe in 2004, and by 2050 there will be just under 2 billion people there compared with 720m Europeans. About half of the 2.3 billion increase in the world’s population over the next 40 years will be in Africa.

The rest of the world is more or less equally divided between countries with below-replacement fertility (less than 2.1) and those with intermediate fertility (between 2.1 and 3). The first group consists of Europe, China and the rest of East Asia. The second comprises South and South-East Asia, the Middle East and the Americas (including the United States).
The low-fertility countries face the biggest demographic problems. The elderly share of Japan’s population is already the highest in the world. By 2050 the country will have almost as many dependents as working-age adults, and half the population will be over 52. This will make Japan the oldest society the world has ever known. Europe faces similar trends, less acutely. It has roughly half as many dependent children and retired people as working-age adults now. By 2050 it will have three dependents for every four adults, so will shoulder a large burden of ageing, which even sustained increases in fertility would fail to reverse for decades. This will cause disturbing policy implications in the provision of pensions and health care, which rely on continuing healthy tax revenues from the working population.
At least these countries are rich enough to make such provision. Not so China. With its fertility artificially suppressed by the one-child policy, it is ageing at an unprecedented rate. In 1980 China’s median age (the point where half the population is older and half younger) was 22 years, a developing-country figure. China will be older than America as early as 2020 and older than Europe by 2030. This will bring an abrupt end to its cheap-labour manufacturing. Its dependency ratio will rise from 38 to 64 by 2050, the sharpest rise in the world. Add in the country’s sexual imbalances—after a decade of sex-selective abortions, China will have 96.5m men in their 20s in 2025 but only 80.3m young women—and demography may become the gravest problem the Communist Party has to face.
Many countries with intermediate fertility—South-East Asia, Latin America, the United States—are better off. Their dependency ratios are not deteriorating so fast and their societies are ageing more slowly. America’s demographic profile is slowly tugging it away from Europe. Though its fertility rate may have fallen recently, it is still slightly higher than Europe’s. In 2010 the two sides of the Atlantic had similar dependency rates. By 2050 America’s could be nearly ten points lower.
But the biggest potential beneficiaries are the two other areas with intermediate fertility—India and the Middle East—and the high-fertility continent of Africa. These places have long been regarded as demographic time-bombs, with youth bulges, poverty and low levels of education and health. But that is because they are moving only slowly out of the early stage of high fertility into the one in which lower fertility begins to make an impact.
At the moment, Africa has larger families and more dependent children than India or Arab countries and is a few years younger (its median age is 20 compared with their 25). But all three areas will see their dependency ratios fall in the next 40 years, the only parts of the world to do so. And they will keep their median ages low—below 38 in 2050. If they can make their public institutions less corrupt, keep their economic policies outward-looking and invest more in education, as East Asia did, then Africa, the Middle East and India could become the fastest-growing parts of the world economy within a decade or so.

Demography, though, is not only about economics. Most emerging countries have benefited from the sort of dividend that changed Europe and America in the 1960s. They are catching up with the West in terms of income, family size and middle-class formation. Most say they want to keep their cultures unsullied by the social trends—divorce, illegitimacy and so on—that also affected the West. But the growing number of never-married women in urban Asia suggests that this will be hard.
If you look at the overall size of the world’s population, then, the picture is one of falling fertility, decelerating growth and a gradual return to the flat population level of the 18th century. But below the surface societies are being churned up in ways not seen in the much more static pre-industrial world. The earth’s population may never need a larger island than Maui to stand on. But the way it arranges itself will go on shifting for centuries to come.

Sai sannidhe devotional song

Thursday, October 20, 2011

Ambition vs Abortion (100% recommend to watch)

Amazing Video


Libya officials: Gadhafi captured, possibly killed






(AP)  SIRTE, Libya — Libya's information minister said Moammar Gadhafi was killed Thursday when revolutionary forces overwhelmed his hometown, Sirte, the last major bastion of resistance two months after the regime fell. Amid the fighting, a NATO airstrike blasted a fleeing convoy that fighters said was carrying Gadhafi.

The head of Libya's interim government did not immediately confirm Gadhafi's capture or death, and many officials said they were still trying to verify what happened.

Information Minister Mahmoud Shammam said he was told that Gadhafi was dead from fighters who said they saw the body.

"Our people in Sirte saw the body," Shammam told The Associated Press. "Revolutionaries say Gadhafi was in a convoy and that they attacked the convoy." He said the government head, Mustafa Abdul-Jalil, would officially confirm the death, but it was not clear when. Prime Minister Mahmoud Jibril, the number two in the administration, called a press conference for 4 p.m. local time (10 a.m EDT)

Al-Jazeera TV showed photos of a man resembling Gadhafi lying dead or severely wounded. Other military officials in the government also said Gadhafi was dead and several revolutionary groups fighting in Sirte also said he was either killed or captured.

Celebratory gunfire and cries of "Allahu Akbar" or "God is Great" rang out across Tripoli as the reports spread. Cars honked their horns and people hugged each other. In Sirte, the ecstatic former rebels celebrated the city's fall after weeks of bloody siege by firing endless rounds into the sky, pumping their guns, knives and even a meat cleaver in the air and singing the national anthem.

Despite the fall of Tripoli on Aug. 21, Gadhafi loyalists mounted fierce resistance in several areas, including Sirte, preventing Libya's new leaders from declaring full victory in the eight-month civil war. Earlier this week, revolutionary fighters gained control of one stronghold, Bani Walid, and by Tuesday said they had squeezed Gadhafi's forces in Sirte into a residential area of about 700 square yards but were still coming under heavy fire from surrounding buildings.

Reporters at the scene watched as the final assault began around 8 a.m. and ended about 90 minutes later. Just before the battle, about five carloads of Gadhafi loyalists tried to flee the enclave down the coastal highway that leads out of the city. But they were met by gunfire from the revolutionaries, who killed at least 20 of them.

Col. Roland Lavoie, spokesman for NATO's operational headquarters in Naples, Italy, said the alliance's aircraft Thursday morning struck two vehicles of pro-Gadhafi forces "which were part of a larger group maneuvering in the vicinity of Sirte."

But NATO officials, speaking on condition of anonymity in accordance to alliance rules, said the alliance also could not independently confirm whether Gadhafi was killed or captured.

After the battle, revolutionaries began searching homes and buildings looking for any hiding Gadhafi fighters. At least 16 were captured, along with cases of ammunition and trucks loaded with weapons. Reporters saw revolutionaries beating captured Gadhafi men in the back of trucks and officers intervening to stop them.

In an illustration of how difficult and slow the fighting for Sirte was, it took the anti-Gadhafi fighters two days to capture a single residential building.

In the central quarter where Thursday's final battle took place, the fighters looking like the same ragtag force that started the uprising eight months ago jumped up and down with joy and flashed V-for-victory signs. Some burned the green Gadhafi flag, then stepped on it with their boots.

They chanted "Allah akbar," or "God is great" in Arabic, while one fighter climbed a traffic light pole to unfurl the revolution's flag, which he first kissed. Discarded military uniforms of Gadhafi's fighters littered the streets. One revolutionary fighter waved a silver trophy in the air while another held up a box of firecrackers, then set them off.

"Our forces control the last neighborhood in Sirte," Hassan Draoua, a member of Libya's interim National Transitional Council, told The Associated Press in Tripoli. "The city has been liberated."

The Misrata Military Council, one of the command groups, said its fighters captured Gadhafi. Another commander, Abdel-Basit Haroun, says Gadhafi was killed when the airstrike hit the fleeing convoy.

In a sign of the conflicting versions, military spokesman Col. Ahmed Bani in Tripoli told Al-Jazeera TV, "I can assure everyone in Libya that Gadhafi has been killed for sure and I'm definitely sure and I reassure everyone that this story has ended and this book has closed."

But rather than a strike on the convoy, he said a wounded Gadhafi "tried to resist (revolutionary forces) so they took him down."

The spokesman for Libya's transitional government, Jalal al-Gallal, and another military spokesman Abdul-Rahman Busin said the reports have not been confirmed.

The caution in making a definitive announcement came because past reports of Gadhafi family deaths or captures have later proven incorrect, even after they were announced by officials, because of the confusion among the revolutionary forces' ranks and the multiple bodies involved in commanding their fighters.

Gadhafi loyalists who have escaped could still continue the fight and attempt to organize an insurgency using the vast amount of weapons Gadhafi was believed to have stored in hideouts in the remote southern desert.

Unlike Iraq's Saddam Hussein, Gadhafi had no well-organized political party that could form the basis of an insurgent leadership. However, regional and ethnic differences have already appeared among the ranks of the revolutionaries, possibly laying the foundation for civil strife.

Gadhafi has issued several audio recordings trying to rally supporters. Libyan officials have said they believe he's hiding somewhere in the vast southwestern desert near the borders with Niger and Algeria.

___

Associated Press Writer Kim Gamel in Tripoli contributed to this report.

Scientists Reveal Surprising Picture of How Powerful Antibody Neutralizes HIV



This is the PGT 128 antibody in action. (Credit: Image courtesy of the Wilson lab, The Scripps Research Institute)
Science Daily  — Researchers at The Scripps Research Institute have uncovered the surprising details of how a powerful anti-HIV antibody grabs hold of the virus. The findings, published inScience Express on October 13, 2011, highlight a major vulnerability of HIV and suggest a new target for vaccine development.














"We can now start to think about constructing mimics of these viral structures to use in candidate vaccines," said co-senior author Ian Wilson, who is Hansen Professor of Structural Biology and member of the Skaggs Institute for Chemical Biology at Scripps Research.
"What's unexpected and unique about this antibody is that it not only attaches to the sugar coating of the virus but also reaches through to grab part of the virus's envelope protein," said the report's co-senior author Dennis Burton, a professor at The Scripps Research Institute and scientific director of the International AIDS Vaccine Initiative's (IAVI) Neutralizing Antibody Center, based on the Scripps Research La Jolla campus.
Other institutions in the United States, United Kingdom, Japan, and the Netherlands contributed to the research as part of an ongoing global HIV vaccine development effort.
Getting a Better Grip on HIV
Researchers from the current team recently isolated the new antibody and 16 others from the blood of HIV-infected volunteers, in work they reported online in the journal Nature on August 17, 2011. Since the 1990s, Burton, Wilson, and other researchers have been searching for such "broadly neutralizing" antibodies against HIV -- antibodies that work against many of the various strains of the fast-mutating virus -- and by now have found more than a dozen. PGT 128, the antibody described in the new report, can neutralize about 70 percent of globally circulating HIV strains by blocking their ability to infect cells. It also can do so much more potently -- in other words, in smaller concentrations of antibody molecules -- than any previously reported broadly neutralizing anti-HIV antibody.
The new report illuminates why PGT 128 is so effective at neutralizing HIV. Using the Wilson lab's expertise in X-ray crystallography, Robert Pejchal, a research associate in the Wilson lab, determined the structure of PGT 128 joined to its binding site on molecular mockups of the virus, designed in part by Robyn Stanfield and Pejchal in the Wilson group and Bill Schief, now an IAVI principal scientist and associate professor at Scripps Research, and his group. With these structural data, and by experimentally mutating and altering the viral target site, they could see that PGT 128 works in part by binding to glycans on the viral surface.
Thickets of these sugars normally surround HIV's envelope protein, gp120, largely shielding it from attack by the immune system. Nevertheless, PGT 128 manages to bind to two closely spaced glycans, and at the same time reaches through the rest of the "glycan shield" to take hold of a small part of structure on gp120 known as the V3 loop. This penetration of the glycan shield by PGT 128 was also visualized by electron microscopy with a trimeric form of the gp120/gp41 envelope protein of HIV-1 by Reza Kayat and Andrew Ward of Scripps Research; this revealed that the PGT 128 epitope appears to be readily accessible on the virus.
"Both of these glycans appear in most HIV strains, which helps explain why PGT 128 is so broadly neutralizing," said Katie J. Doores, a research associate in the Burton lab who was one of the report's lead authors. PGT 128 also engages V3 by its backbone structure, which doesn't vary as much as other parts of the virus because it is required for infection.
PGT 128's extreme potency is harder to explain. The antibody binds to gp120 in a way that presumably disrupts its ability to lock onto human cells and infect them. Yet it doesn't bind to gp120 many times more tightly than other anti-HIV antibodies. The team's analysis hints that PGT 128 may be extraordinarily potent because it also binds two separate gp120 molecules, thus tying up not one but two cell-infecting structures. Other mechanisms may also be at work.
Toward an AIDS Vaccine
Researchers hope to use the knowledge of these antibodies' binding sites on HIV to develop vaccines that stimulate a long-term -- perhaps lifetime -- protective antibody response against those same vulnerable sites.
"We'll probably need multiple targets on the virus for a successful vaccine, but certainly PGT 128 shows us a very good target," said Burton.
Intriguingly, the basic motif of PGT 128's target may mark a general vulnerability for HIV. "Other research is also starting to suggest that you can grab onto two glycans and a beta strand and get very potent and broad neutralizing antibodies against HIV," Wilson said.
In addition to Pejchal, Doores, and Khayat, Laura M. Walker of Scripps Research and Po-Ssu Huang of University of Washington at Seattle were co-first authors of the study, "A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield." Along with Wilson, Burton, and Ward, additional contributors were Sheng-Kai Wang, Chi-Huey Wong, Robyn L. Stanfield, Jean-Philippe Julien, Alejandra Ramos, Ryan McBride, and James C. Paulson of Scripps Research, and Pascal Poignard, and William R. Schief of Scripps Research, IAVI and University of Washington at Seattle; Max Crispin and Christopher N. Scanlan of the University of Oxford; Rafael Depetris and John P. Moore of Weill Medical College of Cornell University; Umesh Katpally, Andre Marozsan, Albert Cupo, and William C. Olson of Progenics Pharmaceuticals; Sebastien Maloveste of the National Institute of Allergy and Infectious Diseases at the National Institutes of Health; Yan Liu and Ten Feizi of Imperial College, London; Yukishige Ito of the RIKEN Advanced Science Institute in Japan; and Cassandra Ogohara of University of Washington at Seattle.
The research was supported by the International AIDS Vaccine Initiative, National Institutes of Health, the U.S. Department of Energy, the Canadian Institutes of Health Research, the UK Research Councils, the Ragon Institute, and other organizations.

How the Milky Way Killed Off Nearby Galaxies

Science Daily  — Two researchers from Observatoire Astronomique de Strasbourg have revealed for the first time the existence of a new signature of the birth of the first stars in our galaxy, the Milky Way. More than 12 billion years ago, the intense ultraviolet light from these stars dispersed the gas of our Galaxy's nearest companions, virtually halting their ability to form stars and consigning them to a dim future. Now Pierre Ocvirk and Dominique Aubert, members of the Light in the Dark Ages of the Universe (LIDAU) collaboration, have explained why some galaxies were killed off, while stars continued to form in more distant objects.




The first stars of the Universe appeared about 150 million years after the Big Bang. Back then, the hydrogen and helium gas filling the universe was cold enough for its atoms to be electrically neutral. As the ultraviolet (UV) light of the first stars propagated through this gas, it broke apart the proton-electron pairs that makeup hydrogen atoms, returning them to the so-called plasma state they experienced in the first moments of the Universe. This process, known as reionisation, also resulted in significant heating, which had dramatic consequences: the gas became so hot that it escaped the weak gravity of the lowest mass galaxies, thereby depriving them of the material needed to form stars.The two scientists publish their results in the October issue of the letters of the journal Monthly Notices of the Royal Astronomical Society.
It is now widely accepted that this process can explain the small number and large ages of the stars seen in the faintest dwarf galaxy satellites of the Milky Way. It also helps scientists understand why galaxies like the Milky Way have so few satellites around them -- the 'missing satellites' problem. The stripping out of gas from these galaxies makes them sensitive probes of the UV radiation in the reionisation epoch.
The satellite galaxies are also relatively close, from 30000 to 900000 light-years away, which allows us to study them in great detail, something that will be enhanced by the coming generation of larger telescopes. Comparing the population of their stars in each galaxy with its position could give us a unique insight into the structure of the UV radiation emitted from the earliest stars in the Milky Way.
Until now, models for this process assumed that the radiation leading to the removal of gas from galaxy satellites was produced collectively by all the large galaxies nearby, resulting in a uniform background of UV light. The new model put together by the two French researchers proves this assumption wrong.
Ocvirk and Aubert looked at the way the invisible 'dark matter' that makes up about 23% of the Universe structured itself with the stars in our Galaxy and its environs from shortly after the Big Bang to the present day. They used the high resolution numerical simulation Via Lactea II to model the formation of stars in gas trapped in the dark matter haloes that envelop galaxies, and then to describe how this gas reacted to UV radiation.
Pierre Ocvirk comments, "This is the first time that a model accounts for the effect of the radiation emitted by the first stars formed at the centre of the Milky Way on its satellite galaxies.
'In contrast to previous models, the radiation field produced is not uniform, but decreases in intensity as one moves away from the centre of the Milky Way.
'The satellite galaxies close to the galactic centre see their gas evaporate very quickly. They form so few stars that they can be undetectable with current telescopes. At the same time, the more remote satellite galaxies experience on average a weaker irradiation. Therefore they manage to keep their gas longer, and form more stars. As a consequence they are easier to detect and appear more numerous."
The new model appears to be a close match to observations of our Galaxy and its neighbourhood and suggests that the first stars of our galaxy played a major role in the photo-evaporation of the satellite galaxies' gas, adds Dr Ocvirk. "It is not large nearby galaxies but our own that caused the demise of its tiny neighbours, asphyxiating them through its intense radiation."

Computing Building Blocks Created from Bacteria and DNA



Scientists have successfully demonstrated that they can build some of the basic components for digital devices out of bacteria and DNA, which could pave the way for a new generation of biological computing devices. (Credit: Janice Haney Carr)
Science Daily  — Scientists have successfully demonstrated that they can build some of the basic components for digital devices out of bacteria and DNA, which could pave the way for a new generation of biological computing devices, in research published October 18 in the journal Nature Communications.














Professor Richard Kitney, co-author of the paper from the Centre for Synthetic Biology and Innovation and the Department of Bioengineering at Imperial College London, says: "Logic gates are the fundamental building blocks in silicon circuitry that our entire digital age is based on. Without them, we could not process digital information. Now that we have demonstrated that we can replicate these parts using bacteria and DNA, we hope that our work could lead to a new generation of biological processors, whose applications in information processing could be as important as their electronic equivalents."The researchers, from Imperial College London, have demonstrated that they can build logic gates, which are used for processing information in devices such as computers and microprocessors, out of harmless gut bacteria and DNA. These are the most advanced biological logic gates ever created by scientists.Although still a long way off, the team suggest that these biological logic gates could one day form the building blocks in microscopic biological computers. Devices may include sensors that swim inside arteries, detecting the build up of harmful plaque and rapidly delivering medications to the affected zone. Other applications may include sensors that detect and destroy cancer cells inside the body and pollution monitors that can be deployed in the environment, detecting and neutralising dangerous toxins such as arsenic.Previous research only proved that biological logic gates could be made. The team say that the advantage of their biological logic gates over previous attempts is that they behave more like their electronic counterparts. The new biological gates are also modular, which means that they can be fitted together to make different types of logic gates, paving the way for more complex biological processors to be built in the future.
In the new study, the researchers demonstrated how these biological logic gates worked. In one experiment, they showed how biological logic gates can replicate the way that electronic logic gates process information by either switching "on" or "off."
The scientists constructed a type of logic gate called an "AND Gate" from bacteria called Escherichia coli (E.Coli), which is normally found in the lower intestine. The team altered theE.Coli with modified DNA, which reprogrammed it to perform the same switching on and off process as its electronic equivalent when stimulated by chemicals.
The researchers were also able to demonstrate that the biological logic gates could be connected together to form more complex components in a similar way that electronic components are made. In another experiment, the researchers created a "NOT gate" and combined it with the AND gate to produce the more complex "NAND gate."
The next stage of the research will see the team trying to develop more complex circuitry that comprises multiple logic gates. One of challenges faced by the team is finding a way to link multiple biological logic gates together, similar to the way in which electronic logic gates are linked together, to enable complex processing to be carried out.

U.S. Rivers and Streams Saturated With Carbon




Science Daily  — Rivers and streams in the United States are releasing substantially more carbon dioxide into the atmosphere than previously thought, according to researchers publishing their results in the current issue of the journal Nature Geoscience.

Their findings could change the way scientists model the movement of carbon among land, water and the atmosphere.
"Direct measurements of carbon dioxide concentrations and fluxes in streams and rivers are still extremely rare," said Henry Gholz, program director in the National Science Foundation's (NSF) Division of Environmental Biology, which funded the research.
"This study demonstrates that both are much higher than assumed. The research should enable more predictive and precise models of carbon cycling at regional to global scales."
The researchers found that a significant amount of carbon contained in land, which first is absorbed by plants and forests through the air, is leaking into streams and rivers and then released into the atmosphere before reaching coastal waterways.
"What we are able to show is that there is a source of atmospheric carbon dioxide from streams and rivers, and that it is significant enough for terrestrial modelers to take note of it," said David Butman, a co-author of the paper and scientist at the Yale University School of Forestry & Environmental Studies.
He and his co-author, ecologist Peter Raymond also of Yale, analyzed data from samples of more than 4,000 rivers and streams throughout the United States, and incorporated detailed geospatial data to model the flux of carbon dioxide from water.
This release is equal to a car burning 40 billion gallons of gasoline, enough to drive back and forth to the moon 3.4 million times.
"These rivers breathe a lot of carbon," said Butman. "They are a source of carbon dioxide, just like we breathe out carbon dioxide and like smokestacks emit carbon dioxide.
"This has never been systematically estimated from a region as large as the United States."
The paper, titled "Significant Efflux of Carbon Dioxide from Streams and Rivers in the United States," also indicates that as the climate heats up there will be more rain and snow, and that an increase in precipitation will result in even more terrestrial carbon flowing into rivers and streams and being released into the atmosphere.
Any accurate estimate of carbon uptake vs. carbon released must include the carbon in streams and rivers, Butman said.
The researchers note that currently it's difficult to determine how to include this flux in regional carbon budgets, because the influence of human activity on the release of carbon dioxide into streams and rivers is still unknown.
The research was also funded by a NASA Earth and Space Science Fellowship, a NASA Carbon & Ecosystems Program grant, and the Yale School of Forestry & Environmental Studies.

Bioluminescence: Explanation for Glowing Seas Suggested




Science Daily  — It has long been known that distinctive blue flashes- a type of bioluminescence- visible at night in some marine environments are caused by tiny, unicellular plankton known as dinoflagellates. However, a new study has, for the first time, detailed the potential mechanism for this bioluminesence.














A key aspect of the potential mechanism for bioluminescence in dinoflagellates proposed in the PNAS study involves voltage-gated proton channels--channels in membranes that can be opened or closed by chemical or electrical events.The study, which was partially funded by the National Science Foundation, is reported by Susan Smith of Emory School of Medicine, Thomas DeCoursey of Rush University Medical Center and colleagues in the Oct. 17, 2011 issue of the Proceedings of the National Academy of Sciences(PNAS).
J. Woodland Hastings, a Smith and DeCoursey research team member and an author of the PNAS article, suggested the presence of voltage-gated proton channels in dinoflagellates almost forty years ago. But the Smith and Decoursey team only recently confirmed them by the identification and subsequent testing of dinoflagellate genes that are similar to genes for voltage-gated proton channels that had previously been identified in humans, mice and sea squirts.
According to the study, here is how the light-generating process in dinoflagellates may work: As dinoflagellates float, mechanical stimulation generated by the movement of surrounding water sends electrical impulses around an internal compartment within the organism, called a vacuole--which holds an abundance of protons. These electrical impulses open so-called voltage-sensitive proton channels that connect the vacuole to tiny pockets dotting the vacuole membrane, known as scintillons.
Once opened, the voltage-sensitive proton channels may funnel protons from the vacuole into the scintillons. Protons entering the scintillons then activate luciferase--a protein, which produces flashes of light, that is stored in scintillons. Flashes of light produced by resulting luciferase activation would be most visible during blooms of dinoflagellates.
This research illuminates the novel mechanisms underlying a beautiful natural phenomenon in our oceans, and enhances our understanding of dinoflagellates--some of which can produce toxins that are harmful to the environment.

First-Ever Pics of a Star Cluster on the Far Side of the Galactic Center

By Clay Dillow
ESO's New VISTA Shots Looking Through the Galactic Center ESO/D. Minniti/VVV Team
The European Southern Observatory’s VISTA survey telescope has turned its eyes inward to the center of our galaxy, and for the first time has looked straight through it. VISTA’s latest batch of infrared images have discovered two new globular clusters here in the Milky Way that had never been seen before, but more importantly they are the first star clusters that we’ve been able to image beyond the dusty and gaseous core of our galaxy.
That’s because the galactic center is extremely difficult for us to see through. Anything beyond the dense and swirling clouds of interstellar dust and other gases is impossible to see in the invisible spectrum, but VISTA’s infrared eyes can peer deep into areas impermeable with visible range telescopes.
The two new clusters--titled VVV CL001 and VVV CL002 (catchy, no?)--appear faint but visible in the new VISTA images. The beautiful panorama above is dominated by the bright globular cluster UKS 1 on the right hand side of the image, but if you look toward the upper left quadrant of the image you can see VVV CL001 as the faint bright spot that looks like a concentration of stars and gas. VVV CL002 is more visible in the detail below, where it rests squarely in the center of the image.
Closeup of VVV CL002:  ESO/D. Minniti/VVV Team
Download the ginormized, wallpaper-quality pic via ESO.
[ESO]

A Mashup of 3-D Printing and Augmented Reality Helps Find New Drug Targets


Today in things that are just plain neat: a mashup of 3-D printing and augmented reality that is helping molecular researchers test potential drug molecules in the lab. At the Scripps Research Institute in La Jolla, Calif., teams are making physical models of biological viruses and then testing them using an added layer of AR wizardry.
Arthur Olsen, researcher at the Molecular Graphics Lab at Scripps, gives a great hands-on explanation of how all this works in the video above. But in a few words, researchers there are basically modeling viruses like HIV on 3-D printers, which allow them to actually hold in their hands the real biological structures of the pathogens. They can then model various ligand molecules or proteins or enzymes, etc., in 3-D as well and see which would be best able to latch onto the virus.
But beyond that, they can use a simple web cam AR program that can model the energy needed for certain molecular bonds as well. So the researchers can basically hold a virus and various potential treatments in their hands, look at the computer screen, and play with different geometries and energetic attractions to see what might work best. Check out the short video, this is really cool.