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Tuesday, October 18, 2011

A Social-Media Decoder



New technology deciphers— and empowers—the millions who talk back to their televisions through the Web.

  • BY DAVID TALBOT
Power shift: Deb Roy, CEO of Bluefin Labs, says social media have changed the relationship between media consumers and producers. Credit: Ian Allen
From his 24th-floor corner office in midtown Manhattan, the veteran CBS research chief David Poltrack can gaze southward down the Avenue of the Americas, its sidewalks teeming. For more than four decades, it has been his job to measure people's television habits, preferences, and reactions. In large part, this has meant following the viewing habits of Nielsen panels of TV viewers and parsing the results of network surveys on their opinions. On a late September afternoon, with fall premieres under way, his desk was strewn with color-coded opinions from 3,000 Americans who had wandered into CBS's Las Vegas research outpost, Television City, at the MGM Grand Hotel and Casino, and agreed to fill out TV surveys for the chance to win a 3-D home entertainment system.
But now he's also dealing with a growing force: the masses talking back through social media. Of the approximately 300 million public comments made online worldwide every day—about two-thirds of them on Twitter—some 10 million, on average, are related to television (though daily numbers vary quite widely). "¿Que sera two and a half men si[n] Charlie?" one viewer recently tweeted, alluding to the replacement of Charlie Sheen by Ashton Kutcher on the CBS sitcom. "The beginning of Person Of Interest is like Jack&Ben all over again," remarked another. (A couple of weeks later, another added: "I assume CBS will keep going with what's been working for them, and replace Andy Rooney with Ashton Kutcher.") TV executives like Poltrack must now grapple with these spontaneous, messy, irreverent remarks.
How to make sense of it all? Poltrack walked into the office of a staff member, John Butler, clutching a report from a startup called Bluefin Labs, a social-media analytics firm that attempts to track comments on shows and ads and discern the commenters' interests and demographics. Some of what it had found seemed surprising. For example, the season premiere of Two and a Half Men had attracted 78,347 comments compared with 82,980 forDancing with the Stars, on ABC, even though the latter show has lower Nielsen ratings and an older audience that's less likely to participate in social media. (It turns out that reality competition shows, by their nature, attract more active audience response.) Poltrack wondered how a little-watched show called Bad Girls Club—on the Oxygen network—had garnered 32,665 comments. "Get Bad Girls Club up there," he said to Butler, motioning to Butler's computer screen. "What are they saying?" Butler scrolled through the raw comment string. "This bitch angie on #Badgirlsclub wear the same damn socks in every episode,"remarked one viewer; "BGC, shower & bed," announced another. It was hard to know what any of it meant.
Overall, the data was raw and, in many cases, ambiguous. But Poltrack came away with some respect for what he was seeing. "As a one-time measurement, we have better ones," he said, referring to CBS's precisely constructed surveys. But whereas the surveys are intermittent, social-media analytics can provide "a continuous monitor of conversation about a program, episode by episode," he said. "And that is something we can't replicate." What's more, the quantity of commentary is increasing all the time, making it more important as an object of study and as a force network executives would like to harness. As Poltrack explained, real-world and online chatter—the "exponential movement of a conversation through the population"—drives the success or failure of TV shows and, in turn, the allocation of $72 billion in U.S. television ad spending.
Six hundred miles to the west, a similar assessment was under way at the Cincinnati headquarters of Procter & Gamble, the world's largest advertiser (its brands include Tide, Gillette, Bounty, Pringles, and Duracell). Each year the company spends $5 billion on media ads—the bulk of them on TV—and another $5 billion on in-store advertising worldwide. While Procter & Gamble carefully vets ads with consumers before airing them, it has never known whether the same viewers would respond differently to an ad depending on what show surrounded it.
Craig Wynett, the company's chief learning officer, says Bluefin Labs is teasing out nuances in the way context affects the extent to which an ad generates buzz. One specific product ad (he wouldn't say which) was placed on two shows with similar demographics and ratings. One show produced eight times more social-media response than the other. Nobody knows why, but that's what happened. "Historically, we have held context as a constant. Well, surprise! In the real world, context plays a fundamental role," he says.
Bluefin Labs is one of a growing number of analytics companies parsing the meaning of comments in social media. And its CEO, Deb Roy, believes they are capturing a fundamental change in the relationship between creators and consumers of mass media. "What I have learned by hanging out with TV executives, talent agencies, and creative types is that the assumption is built into their organizations' DNA that this is a one-way dialogue," he says. "Audience members speaking through social media is effectively a shift in power."
In some ways, a two-way conversation has begun. And in future years a TV network could, in theory, continue the conversation by revising its promotions to emphasize characters that have caught on with audiences—or even by revising plot lines midway through a season. Advertisers, meanwhile, could swap out ads—or place them differently—on the basis of the social-media response they get. (Something like this already happens with online ads; increasingly, algorithms use real-time metrics like page views and content changes to guide placement decisions.) In the political realm, campaigns could rapidly determine, among other things, which messages animate people. And early feedback from the first adopters of analytics—network executives and advertisers—could provide clues to wider potential impacts. Wynett says he doesn't know if the people who commented on his advertisement bought the product or "if the message spread until every man, woman, and child heard it." Still, he says, "It's early days, but it shows promise."
MINING SOCIAL SENTIMENT
Analyses of online comments are already influencing corporate, financial, and governmental behavior. Certain companies, Comcast among them, keep an ear open for outbursts of anger to help them detect and respond to service outages and product problems. A London hedge fund, Derwent Capital, makes trades based on the financial calm or anxiety it gleans, in part, from social-media data. And while recent events have suggested that revolutionaries can use social media to help them overthrow some authoritarian regimes (see "Streetbook," September/October 2011), China has learned to manage citizen outrage through measured responses to specific online complaints about matters such as police corruption (see "China's Internet Paradox," May/June 2010)
Playing ball: As a doctoral candidate, Michael Fleischman used televised Red Sox games to teach computers to recognize home runs and other plays. Now the company he cofounded, Bluefin Labs, analyzes social media to decipher mass reactions to TV shows and ads viewed in the United States. In its offices, a screen (top) displays the number of comments searched, minutes of TV ingested, and connections found. Credit: Ian Allen
For marketing purposes, it has become de rigueur for companies to set up Facebook pages and send out tweets, and to keep a watchful eye on the bubbling up of blogged anger. This is true of television networks as well as other companies. For example, Discovery Communications, which runs channels including the Discovery Channel, TLC, and Animal Planet, maintains 75 Facebook pages with 45 million fans, and keeps 23 Twitter accounts crackling with reminders like "Mythbusters starts in 5 minutes!" "It's all that beautiful viral effect of social media to get people to watch our shows," says Gayle Weiswasser, Discovery's vice president of social-media communications, "and we aren't the only ones who do it."
To tap the other side of the conversation—the unscripted response of consumers with social-media accounts—companies like Radian6 (now owned by Salesforce), General Sentiment, Sysomos, Converseon, and Trendrr track social-media sentiment and volume on a range of topics. Of course, even the best filtering efforts don't eliminate all spam. And it's not always clear what prompted a post, how a slang-filled tweet should be interpreted, or how to identify the author's demographics. Yet it is "critically important" for businesses to make sense of all this, says Radha Subramanyam, senior vice president of media and advertising insights and analytics at Nielsen: "This is the world's largest focus group, the world's largest town hall. Companies that figure this out will thrive in the next 10 to 15 years. Companies that don't will fail."
It's especially important for TV networks and advertisers. Nielsen says that Americans, on average, spend 20 percent of their day watching TV, and many simultaneously peck away at laptops or mobile devices. Sites like Miso and GetGlue encourage people to discuss favorite shows with friends and other fans. Evidence is emerging that social-media buzz has some relationship to ratings: NM Incite, a Nielsen-McKinsey joint venture, found that among people aged 18 to 34, a 9 percent increase in such chatter in the weeks before a show's premiere correlated to a 1 percent ratings increase.
Recognizing these kinds of connections, sentiment-analysis firms including Trendrr.tv (part of Trendrr) and Socialguide specifically track social response to television content. But Bluefin is unique in also tracking most of what is on TV—including the ads—to draw specific relationships between televised stimulus and social-media response. "What Bluefin is doing is technically impressive," says Duane Varan, chief research officer at the Disney Media and Advertising Lab in Austin, Texas. Already, it's becoming possible to measure TV viewership directly through cable boxes rather than through samples such as Nielsen panels, he says, and "Bluefin is doing a similar thing with this universe of public social-media discourse." 
THE NFL AND SOCIAL TV
Bluefin Labs' headquarters occupy a one-story 19th-century factory that once made hoses, next to a boutique movie theater in the Kendall Square area of Cambridge, Massachusetts. Lego blocks strewn on café tables busy the fingers of visitors or employees at informal meetings. Roy, the cofounder and CEO, sits at one of an open cluster of desks in close quarters with nearly 40 employees, most of them engineers with experience in fields like artificial intelligence, search, and video analysis. A poster showing the "bloodline" of the advertising industry is pinned on a worn wooden post to his right.
Roy, who is 42, is a Winnipeg-born computer and cognitive scientist who until 2008 had spent his entire career in academia, first at the University of Waterloo and then at MIT and its Media Lab, where he became head of a research group called Cognitive Machines. Among other things, his group concerned itself with problems such as how to teach English to robots. In 2005 he launched the ambitiously named "Human Speechome Project" to document how children learn language. Before his son was born, he equipped his home with 11 video cameras and 14 microphones. Then the proud papa recorded (almost) everything that happened in the house to figure out how different adult interactions—as well as activities and objects in different locations of the house—affected the boy's speech development. In 2008, after collecting 300 gigabytes of data every day, Roy stopped. Then he and his graduate students performed feats like charting his son's gradual mastery of the word "water." (A presentation of this process was the hit of the 2011 TED conference and has spread virally throughout the Internet.)
Conversation starter: The total number of social-media comments is rising sharply, providing more fodder for analysis. Most of these are public.
Source: Gnip. Figures reflect both public and private instances of active participation in online conversations: tweets, comments, and other posts.
The project married linguistic analysis with video analysis, but it was Roy's PhD student Michael Fleischman, now 34, who made the conceptual leap to TV. For his dissertation, Fleischman initially planned to use lessons from the speechome project to teach computers language. But there was a problem: "It became clear to me that I'd have to wait until Deb's son grew up," Fleischman says. "I needed to find a new data set." The answer came, appropriately, in front of the television. One night, while watching a Red Sox game with his girlfriend (now his wife), Fleischman realized that televised sports had what he needed: visual action, play-by-play dialogue, and sufficient repetition and structure. So he started creating software that would turn baseball games into a language-teaching tool. The spoken words "home run," for example—when accompanied by a camera angle arcing across a stadium—might lead the computer to learn how to distinguish an actual home run. AfterTechnology Review wrote about the baseball-interpreting technology, he and Roy were invited to apply for a $100,000 National Science Foundation Small Business Innovation Research grant.
In 2008, Fleischman and Roy got the grant and named the company after a sushi restaurant where they'd discussed their plans. The initial focus on sports led to angel investments from sports magnates including Jonathan Kraft, president of the New England Patriots; Jim Pallotta, an owner of the Boston Celtics; and Dan ­Gilbert, majority owner of the Cleveland Cavaliers. (As of October 2011, the company had received $8.5 million in funding, mostly from Redpoint Ventures but also from angel investors.) Bluefin's first customer was the National Football League, which already had a new online feature called "Game Rewind" that let fans review already-played games. Fleischman and Roy expanded the concept by tying the video stream to social-media comments. They tuned search algorithms to look for football-related keywords; the result was an on-screen interface that let fans read, play by play, what others had written. (This turned out to be an early instance of the now-popular trend in social TV applications.)
During this process, Roy and Fleischman had another "Aha!" moment. The comment stream that turned up for televised games had blank patches at regular intervals. "We looked and said, 'What's that?'" says Roy. "Well, those were the ads." It hadn't occurred to them that people would talk about ads. But they do. They write—as one recently did, in a tweet picked up by Bluefin—things like "The dude rappin in the mcdonalds commercial about the smoothies will forever be clowned where ever he goes."
Roy and Fleischman realized that the advertising industry might be interested in understanding more about such comments, and advertisers had large research budgets. "We took the principles of big data, data mining, and visualization," Roy says, "and turned that microscope [in my house] into a telescope to look at the world of social media as it relates to television." They called their work the "TV genome." Today Bluefin has 15 clients, including Pepsi, Mars, and Comcast; the TV networks CBS, Fox Sports, A+E Networks, AMC Networks, and Turner Broadcasting; and the ad agencies McGarryBowen and Hill Holliday. The company business is selling subscriptions to its interface and custom analytics. While making these conquests, Roy encountered a language learning issue of his own. "When I started talking to people in TV, I'd hear the word 'programming.' Turns out they weren't talking about programming software," he recalls. "It took me a while to figure this out."
INSIDE THE TELESCOPE
In order to capture almost everything happening on television, Bluefin uses a data center studded with satellite dishes in Medford, Massachusetts (see "Heeding the Tweets" chart, below). Through the first week of October, they'd pulled in every minute of more than 210,000 episodes of 7,100 television shows, plus advertisements. The company now monitors 200 networks.
After uploading the raw feed to Amazon's cloud computing service, Bluefin gathers programming-guide information—the names of the shows, their broadcast channels and times, and also the names of characters and actors—along with closed-­captioning text extracted from the video signal itself. This provides a list of keywords that can help identify relevant social-media comments. Since advertising schedules are not published ahead of time, Bluefin creates one. The algorithm detects when a "pod" of ads has started. Then a system of digital fingerprinting identifies repeat airings; human staffers are notified of first-time airings to make the initial identification. 
Among the more than 10 million comments made daily about TV content, Bluefin's algorithms identify about 1.4 million that are made in the three hours before or after a show or advertisement aired on one of the networks it tracks. (About 90 percent of these comments are tweets; the bulk of the remainder are public Facebook posts.) Although on-demand services, recording technologies, and new Internet models of TV delivery are changing viewing habits (see "Searching for the Future of Television," January/February 2011), most people still watch television the old-fashioned way, and Roy says they seem more likely to make real-time comments when they know they are watching the first airing. Bluefin also keeps close tabs on the 9.8 million people who have commented about television at least once in the past 90 days, to build up knowledge about their demographics and interests.
Text analysis underpins all these efforts: whereas "delicious" or "tasty" might indicate a positive response to a restaurant, terms like "can't wait" or "fascinating" or "drivel" might show up in comments related to TV shows. Bluefin is working on identifying not only positive or negative reactions but ones that are vulgar or polite, serious or amused, calm or excited. "At the highest level, what we are trying to do is language understanding," Fleischman says. It also tries to glean demographic information about who is commenting. Women, for example, are more likely to refer to family members, while men are more likely to mention friends or electronic devices. Emoticons hint at age: someone who uses :-) is probably 10 years older than someone who uses :). People using 8-) are even older.
Bluefin ultimately turns all this data into two main measurements. "Response level" reports the number of people commenting on any given ad or episode of a show, measured on a logarithmic 10-point scale. "Response share" measures what percentage of all social-media response to television programming at a given airtime focused on a particular show or ad. The company's first interface—Bluefin Signals, which provides analytics on comments about TV shows—went live in June. A second, which is due for release in December, will track response to individual ad campaigns. Next year Bluefin plans to include Spanish-language comments in its analysis. Roy says there is no reason why the company couldn't track television signals and analyze the sentiments expressed through social media in other countries, too. So far, though, there are no immediate plans to expand beyond the United States.
HOW PEPSI RESONATES
Bluefin can tell you certain things very clearly, and one of them is the degree to which audiences are moved to talk about Diet Pepsi when a swimsuit-clad Sofia Vergara is involved. Vergara, who plays the Colombian trophy wife on the comedy Modern Family, appeared this past summer in a widely aired commercial in which she met soccer heartthrob David Beckham on a beach. Traditional social-media analysis showed a 7 percent increase in chatter about the drink during the time the campaign aired. But Bluefin knew the ad had run exactly 746 times, on 260 different shows, and it knew who had commented on those 260 shows during the commercial's run. Among those 1.8 million people, mentions of Diet Pepsi were up by 19 percent. Bluefin was also able to determine that in June, a spike in negative sentiment about the Hyundai brand throughout social media coincided with the premiere of a TNT science fiction drama, Falling Skies, during which commenters complained that a promise of "limited commercials" had been broken.
Such insights could be a boon to television advertisers wondering what ads to place and where to place them. "If I'm moved by comedy, drama, or sheer creativity in an ad, then I have a propensity to talk about it," says Mike Proulx, senior vice president for social media at the ad agency Hill Holliday. "There is a theory—and it's unproven—that the greater the social-media mentions, the higher the content's resonance."
Network effect: David Poltrack, chief research officer for CBS, has long recognized the value of viewer conversations about shows. Now he’s evaluating tools that scrutinize millions of comments made about TV online. Credit: Ian Allen
The new tools could also complement analytics like those provided by Simulmedia, a New York City company that licenses anonymized viewing data from 18 million set-top boxes. "Bluefin is able to associate specific delivery of an ad to positive sentiment in some target audience," says Dave Morgan, Simulmedia's CEO. "That alone is becoming a key marketing objective. It's no longer just 'Spend a certain amount of money on sex, age, income'; it's 'Spend money that causes positive sentiment from a target audience.'"
Of course, the applicability of Bluefin's data goes only so far. For one thing, most conversations still happen in the real world, not online; according to one market research firm, KelleyFey, 90 percent of the conversations people have about brands in the United States happen offline. Further confusing matters, "people who use social media are not representative of the general population, it's very difficult to understand the differences, and it's a dynamic, variable thing," says Varan, the Disney research executive. "There is so much we don't know about how the social-media universe differs from the real universe. So the danger is looking at the kinds of results that Bluefin would produce and drawing conclusions that it's a reflection of what the overall population is doing."
MAKING OF THE PRESIDENT, 2012
Fleischman and Roy predict, however, that applications will ultimately go well beyond TV, helping to reveal the events and media sources that inspire people in radio, newspapers, and magazines, as well as online. "You can look at the affinity from any one thing to any set of things," Fleischman says. "Pop culture expands fairly widely—politics, media, actors, books, plays, religion. The tail gets longer and longer, to anything you can imagine people talking about. If you are looking for a set of people with a particular interest, we can tell you how this relates to another set of interests."
The next obvious area for Bluefin is politics. Early next year, in time for the presidential primary season, the company expects to analyze social-media reaction to speeches, televised debates, and political advertisements. "What's potentially more interesting is understanding who, positively and negatively, is making connections between audience members," Roy says. Already, social media have become a key political organizing tool (see "How Obama Really Did It," September/October 2008). But political operatives are tough customers: they care mainly about two things. First, in presidential races, they care what undecided voters in swing states think. And second, they want to know who, among their reliable base of supporters, is willing to take some action, such as donating or spreading a message. Comments in social media are of limited value.
Still, political operatives might be just as interested as Procter & Gamble in learning which messages are resonating. Andrew ­Heyward, former president of CBS News and a Bluefin advisor, thinks such analyses could be vital for political commentators and anchors, too. "Getting almost real-time feedback on scale and sentiment is very valuable for a political organization or a candidate—or a news organization trying to cover the race," he says.
The value of social-media analytics will only rise. The number of comments is growing every month, and Roy predicts that analytical technology will improve as algorithms are refined and as more participants crunch the data and pursue yet-unimagined applications. Today, conversations in social media are still hard to overhear and decipher. But what might someday emerge from Bluefin, or one of its competitors, are technologies that make those conversations easy to capture and understand—and produce a metric akin to a Nielsen rating. (The Nielsen and McKinsey findings about the correlation between buzz and ratings are a step in that direction.)
In the future, then, marketing officers and network executives such as David Poltrack may be able to leave the survey takers back at the Vegas slot machines and tune in to a continuous social-media conversation that is now either inaudible or incomprehensible. They may see ways to create television programming, advertising, political communications, and ultimately other media that are smarter—or at least more responsive to what audiences find appealing.
David Talbot is Technology Review's chief correspondent.

Monitoring HIV on a Cheap Chip


Slip and slide: The microfluidic device shown here, called a SlipChip, contains two slides imprinted with wells of varying volumes, making it possible to measure molecules at a wide range of concentrations. Here, one chip is used to analyze five different samples, represented by different colors.
Rustem Ismagilov

COMPUTING

Monitoring HIV on a Cheap Chip

A microfluidic chip could measure effectiveness of patient treatments in resource-poor countries.

  • BY COURTNEY HUMPHRIES
Measuring viral load, or the concentration of HIV in the bloodstream, is one of the techniques that physicians use to monitor the effectiveness of HIV treatments. A spike in viral load can be a warning of drug failure or drug resistance, possibly indicating that the patient should be switched to a different drug. But in resource-poor settings, such monitoring is prohibitively expensive and equipment-heavy. A new microfluidic chip designed by the lab of Rustem Ismagilov at Caltech may make it possible to monitor viral load in HIV and other viral infections more cheaply and easily, and the technique could also be useful for other kinds of genetic tests.
Viral load is often measured with PCR, a standard laboratory tool that copies the DNA or RNA in a sample many times. A newer approach, called digital PCR, makes it possible to get much more precise counts. Using microfluidics, the sample is first divided among a multitude of tiny wells, so that each well is likely to have no more than one molecule. When the molecules are then amplified, the result is a simple yes-or-no signal for each well.
"The bottleneck of those methods comes when you need a measurement with a large dynamic range," Ismagilov says. HIV viral load, for example, can range from 50 to a million molecules per milliliter. A test to measure it must be able to handle large numbers of molecules, yet be sensitive enough count rare molecules. Normally, achieving such sensitivity requires diluting a sample and spreading it out over more and more wells in order to ensure that no more than one molecule is in each well. Ismagilov says that such large numbers of wells can be cumbersome to analyze. At the same time, the sample can't be spread so thin that scarce molecules will be missed.
Ismagilov and his lab members came up with a trick to handle this dilemma: divide the sample into a series of different-sized wells calibrated to detect molecules at different concentrations, which can be calculated together. "Each volume is sensitive to a particular concentration range," he says. "Together these volumes provide more information than any one volume individually."
The technique relies on the SlipChip, a simple microfluidic device developed by Ismagilov. Two overlapping glass or plastic slides can be injected with a fluid sample and then rotated slightly to separate the fluid into the wells. The rotation can also bring certain wells into contact so that chemical reactions can be performed.
In two recent papers in Analytical Chemistry and the Journal of the American Chemical Society, Ismagilov and his colleagues describe the mathematics of the design and its application in testing viral load in both HIV and hepatitis C. The chips can be designed to perform multiple tests or measure multiple samples, which Ismagilov says adds to their flexibility. Currently, other devices are needed for other stages of PCR preparation and analysis, but the researchers' ultimate goal is for one chip to handle all these steps.

மஞ்சள்காமாலை நோயை தடுப்பதற்கான வழிமுறைகள்


மஞ்சள்காமாலை நோயை தடுப்பதற்கான வழிமுறைகள்

சரியான நேரத்தில் கண்டுபிடித்து முறையான சிகிச்சை செய்து எடுக்காவிட்டால் உயிருக்கே ஆபத்தை விளைவிக்கும் நோய் மஞ்சள் காமாலை.
கல்லீரலில் ஏற்படும் வைரஸ் தொற்று தான் இந்த நோய் ஏற்பட காரணம். கல்லீரல் அழற்சி வைரஸ் ஏ என்ற வைரசின் தாக்குவதினால் மட்டுமே இந்நோய் ஏற்படுகிறது. இந்த வைரஸ் கல்லீரலை தாக்கி மஞ்சள்காமாலையை உருவாக்குகிறது. இது குழந்தைகள் மற்றும் சிறுவர்களை எளிதில் தாக்கும்.
சுகாதாரமற்ற குடிநீர், உணவின் வழியாக இந்த வைரஸ் ஒருவரது உடலுக்குள் நுழைந்து விடுகிறது. ரத்தம் செலுத்தும் போது அல்லது உடலுறவின் போதுகூட இது பரவ வாய்ப்பு இருப்பதாக மருத்துவர்கள் தெரிவிக்கிறார்கள். இந்த வைரஸ் உடலுக்குள் நுழைந்த ஒன்று அல்லது இரண்டாவது வாரத்தில் மஞ்சள் காமாலை தோன்றுகிறது.
நோய்த் தொற்று ஏற்பட்டவர்களுக்கு காய்ச்சல், உடல் அசதி, பசியின்மை, உடல் வலி, சோர்வு, மூட்டுவலி போன்ற அறிகுறிகள் தென்படும்.
கண்களின் வெள்ளைப் பகுதி மஞ்சளாக காட்சியளிக்கும். சிறுநீரும் மஞ்சள் நிறத்தில் வெளியாகும். மேலும் சிறுநீர் வெளியேற்றுவதிலும் சிரமங்கள் தோன்றும். கல்லீரல் அழற்சியின் அடுத்தகட்டமாக கல்லீரல் மற்றும் மண்ணீரல் வீங்கி பெரிதாகும். இத்துடன் நிணநீர்க் கட்டிகளிலும் வீக்கம் ஏற்பட வாய்ப்பு உள்ளது.
ரத்தப் பரிசோதனையின் மூலமே மஞ்சள் காமாலை நோயை உண்டாக்கும் வைரஸ் பற்றி கண்டறிய முடியும். இந்த வைரசுக்கு எதிரான எதிர்ப்பாற்றல், புரதத்தின் அளவு ரத்தத்தில் அதிகரித்திருப்பதை வைத்து மஞ்சள் காமாலை நோயின் தாக்கத்தை அறியலாம். மேலும் கல்லீரலில் முக்கிய என்சைமின் அளவும் அதிகரித்து காணப்படும்.
ரத்தம், சிறுநீர் பரிசோதனைக்கு அடுத்தபடியாக வயிற்றுப் பகுதியில் ஸ்கேன் செய்து பார்ப்பார்கள். அப்போது இந்த நோய் பாதிப்பினால் ஏற்பட்ட கல்லீரல் வீக்கம் மற்றும் மண்ணீரல் பாதிப்புகளை அறிந்து கொள்ளலாம்.
சிகிச்சை: உடனடியாக முறையான சிகிச்சை எடுப்பதோடு பத்தியமும் இருக்க வேண்டும். உணவுக் கட்டுப்பாட்டை நோய் முழுமையாக குணமடையும் வரை கடைபிடிக்க வேண்டும். கல்லீரல் அழற்சி நீண்ட காலம் இருந்தால் அது கல்லீரல் புற்றுநோயாக மாறவும் வாய்ப்பு உள்ளது. மேலும் கல்லீரல் செயல் இழப்பும் ஏற்படலாம்.
கர்ப்பிணிகளுக்கு மஞ்சள் காமாலை பாதிப்பு ஏற்படும் போது கூடுதல் பாதுகாப்பு நடவடிக்கைகளை மேற்கொள்வது அவசியமாகிறது. கர்ப்பிணிகளுக்கு கல்லீரல் அழற்சி பி வைரசால் பாதிப்பு இருக்கும் பட்சத்தில் பிறக்கும் குழந்தைக்கும் தடுப்பூசி போட வேண்டியது முக்கியம்.
இதற்காக வைரசுக்கு எதிரான தடுப்பாற்றல் புரதமும் குழந்தைக்கு கொடுக்கப்பட வேண்டும். இதன் மூலம் மட்டுமே பிறக்கும் குழந்தைக்கு மஞ்சள் காமாலை நோய் ஏற்படுவதைத் தடுக்க முடியும் என்கிறார்கள் மருத்துவர்கள்.

மாதுளம் பழத்தின் மருத்துவ குணங்கள்




ரத்தத்தில் சிவப்பு அணுக்கள் குறைவாக இருப்பவர்களுக்கு மருத்துவர்கள் சொல்லும் அறிவுரையே மாதுளம் பழத்தை அல்லது சாறை அதிகம் உட்கொள்ளுங்கள் என்பதுதான்.
அந்த மாதுளம் பழம் பல்வேறு நோய்களைத் தீர்க்கும் அரிய மருத்துவக் குணத்தைத் தன்னுள்ளே கொண்டிருக்கிறது என்று இப்போதுதான் ஆராய்ச்சியில் கண்டுபிடித்திருக்கிறார்கள்.
வில்லோ மரத்திலிருந்து ஆஸ்பிரின் என்ற மருந்து கண்டுபிடிக்கப்பட்டதற்குச் சமமானது இந்தக் கண்டுபிடிப்பு என்று கூத்தாடுகிறது லண்டனிலிருந்து வெளியாகும் சண்டே எக்ஸ்பிரஸ் நாளிதழ்.
மாதுளம் பழத்தைச் சாப்பிடுகிறவர்கள்கூட அதன் கதுப்புகளை உட்கொண்டு கொட்டையைத் துப்பிவிடுகின்றனர். அதன் ரசத்தை மட்டுமே குடிக்கின்றனர்.
ஆனால் அதன் தோல்,விதை, மஞ்சள் நிறத்தில் உள்ளே காணப்படும் மெல்லிய சவ்வுப்படலம், அதன் பட்டை, செடியின் தண்டுக்குள்ளே இருக்கும் சோறு என்று அனைத்துமே அரிய மருத்துவ குணங்களைக் கொண்டிருக்கிறது.
அவற்றிலிருந்து எடுக்கப்படும் சாறு இதயத் துடிப்பைச் சீராக்கும், இதய ரத்தக் குழாய்களில் ஏற்படும் அடைப்பை நீக்கும், ரத்தக் கொதிப்பைக் குறைக்கும், உள் உறுப்புகளின் வீக்கத்தைக் கட்டுப்படுத்தி போக்கும், புற்றுநோய் வரும் ஆபத்தைக் குறைக்கும்.
மாதுளம் பழத்தின் அரிய மருத்துவத் தன்மைகள் அலோபதி என்கிற ஆங்கில மருத்துவர்களுக்கு வேண்டுமானால் இப்போது தான் தெரிந்திருக்கலாம். ஆனால் ஆயுர்வேதமும் சித்த வைத்தியமும் அதன் பலனை ஏற்கெனவே உணர்ந்தவைதான்.

பழைய டயர்களை கொண்டு ரோடு போடலாம்: ஆராய்ச்சியாளர்கள் தகவல்




பழைய டயர்கள் இனி வீணாகாது. அதை மறுசுழற்சி செய்து ரப்பர், புதிய டயர்கள் தயாரிக்கலாம். ரோடு போட பயன்படுத்தலாம் என்கின்றனர் அவுஸ்திரேலிய ஆராய்ச்சியாளர்கள்.
இரண்டு, நான்கு சக்கர வாகனங்கள் அத்தியாவசிய தேவைகளாகி விட்டன. வாகனங்கள், உதிரிபாக விற்பனைக்கு ஏற்ப கழிவுகளும் அதிகரிக்கின்றன. அந்த வகையில் உலகம் முழுவதும் ஒவ்வொரு ஆண்டும் 100 கோடி டயர்கள் வீணாக குப்பையில் வீசப்படுகிறது என்கிறது ஒரு ஆய்வு.
பழைய டயரை குப்பையோடு குப்பையாக வீசுவதால் நிலத்தடி நீர், சுற்றுச்சூழல் மாசுபடுகிறது. இதை தவிர்ப்பது தொடர்பாக அவுஸ்திரேலியாவில் உள்ள டீகின் தொழில்நுட்ப பல்கலைக்கழகத்தில் ஆராய்ச்சி மேற்கொள்ளப்பட்டது.
இதுதொடர்பாக ஆய்வுக்குழு தலைவர் கிறிஸ் ஸ்கோரிட்ஸ் கூறியதாவது: குப்பையாக வீசப்படும் டயர்களில் உள்ள ரசாயன கலப்புகள் நிலத்தடிநீரை பாதிக்கிறது. சுற்றுச்சூழலை மாசுபடுத்துகிறது. இவற்றை எரிப்பதால் வெளியாகும் ரசாயன புகை, வளிமண்டலத்தில் கலந்து காற்றை மாசுபடுத்துகிறது.
இந்த விஷப் புகையை சுவாசித்தால் ஆஸ்துமா உள்ளிட்ட சுவாச கோளாறுகள் உண்டாகிறது. இது மட்டுமின்றி மலேரியா, டெங்கு உள்ளிட்ட பல்வேறு நோய் தாக்குதல்களுக்கு காரணமான கொசுக்களில் பெரும்பாலானவை வீணான டயர்களில் தேங்கும் நீரிலேயே உற்பத்தி ஆகின்றன.
ரசாயன பொருட்கள் பயன்படுத்தாமல் குறைந்த அளவு மின்சாரத்தை கொண்டு டயர்களை மறுசுழற்சி செய்யும் முறையை கண்டறிந்துள்ளோம். இதை பயன்படுத்தி புதிய டயர்கள், ரப்பர், கார் பாகங்கள், கன்வேயர் பெல்ட்கள் தயாரிக்கலாம்.
ரோடு போடுவதற்கு தார் உள்ளிட்ட பொருட்களை கலப்பதற்கு அஸ்பால்ட் என்ற பொருள் தற்போது பயன்படுத்தப்படுகிறது. இது பெட்ரோலிய சுத்திகரிப்பின் போது கிடைக்கும் பொருளாகும்.
இதற்கு பதிலாகவும் டயரை மறுசுழற்சி செய்து பயன்படுத்தலாம். இது சுற்றுச்சூழல் பாதுகாப்பில் கணிசமான மாற்றத்தை ஏற்படுத்தும்.

உன் மைவிழி ஆனந்தபைரவி பாடும்...உன் தேகத்தில் மோகன ராகத்தின் பாவம்


கர்னாடக இசையுடன்  SPBயின் இனிமையான் குரலில் நல்லதொரு பாடல்



படம்:   பெண் ஒன்று கண்டேன்   (1974)
இசை: M S விஸ்வனாதன்
நடிப்பு: முத்துராமன், பிரமிளா
இயக்கம்: கோபு


உன் மைவிழி ஆனந்தபைரவி பாடும்...

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நீ ஒரு ராக மாளிகை...
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நீ ஒரு ராக மாளிகை...உன் நெஞ்சம் என் காதல் மாளிகை...

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இந்த நாயகன் தேடிடும் நாயகியே.....


Ridding dust mites from toys



UNIVERSITY OF OTAGO   

sajoiner_-_teddy_bear
“Children frequently sleep with their favourite toys close to their airways and this may be important for HDM-sensitised asthmatic children.”
Image: sajoiner/iStockphoto
Infestations of house dust mites on children’s soft toys can be eradicated by freezing, hot tumble drying or washing with eucalyptus oil and detergent according to new research by the University of Otago, Wellington.

The study has just been published in Paediatric Allergy and Immunology and has been carried out in association with colleagues at the Changhua Christian Hospital, Taiwan.

House dust mites (HDM) and their allergens are a serious issue for asthmatics and are strongly associated with the development of asthma in children. The severity of asthma shows a dose-response relationship according to the number of house dust mites a child is exposed to when sleeping with soft toys.

“Children frequently sleep with their favourite toys close to their airways and this may be important for HDM-sensitised asthmatic children,” says Associate Professor Rob Siebers.

The aim of the study was to determine whether freezing of soft toys overnight, or hot tumble drying for one hour, or adding eucalyptus oil when washing actually kills house dust mites. The study looked at 36 toys in three groups of 12.

“The results are very positive, and we found the vast majority of house dust mites on the soft toys used were killed by either one of these three methods,” says Associate Professor Siebers.

Freezing of toys for at least 16 hours at -15˚C resulted in a 95 per cent reduction of HDM, hot tumble drying for one hour reduced mites by 89 per cent, and soaking in an emulsion of eucalyptus oil and liquid detergent for one hour, then rinsing and drying, also resulted in a HDM reduction of 95 per cent.

“Washing and soaking with eucalyptus oil and detergent is very effective in not only reducing live mites, but also reducing house dust mite allergens, compared to freezing and tumble drying,” he says. “Of the 12 toys studied, 10 showed no live mites at all after washing with eucalyptus oil and liquid detergent.”

Associate Professor Siebers says all three methods are more effective than just washing toys, because water needs to be above 55˚C to kill HDMs, and this is usually too hot and damages the toys.

“My advice for parents is to either tumble dry for one hour, or freeze the soft toy overnight, and then wash it in a cold wash to remove any allergens.”

However, Associate Professor Siebers says that the effectiveness of these three methods can vary according to the thickness of the material with which the toys are made.

Another issue not covered in the study, is how quickly soft toys are re-colonised by house dust mites, and further research would be useful to determine how often a toy should be treated to control infestation.
Editor's Note: Original news release can be found here.

Breastmilk to provide stem cells



THE UNIVERSITY OF WESTERN AUSTRALIA   

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"The benefit of obtaining stem cells from breastmilk is that they can be accessed non-invasively."
Image: ChepeNicoli/iStockphoto
Human breastmilk has the potential to help people suffering from diseases including Parkinson's disease and diabetes, according to a researcher at The University of Western Australia.

Dr Foteini Hassiotou presented her findings at the National finals at the 2011 AusBiotech Conference in Adelaide and was the national winner of the AusBiotech-GSK Student Excellence Awards.

Dr Hassiotou, a member of the UWA Hartmann Human Lactation Research Group, has discovered that human breastmilk contains stem cells which are able to turn into not only breast cells, but also cells of the bone, cartilage, fat, brain, liver and pancreas, depending on the medium in which they are grown.

"The benefit of obtaining stem cells from breastmilk is that they can be accessed non-invasively, unlike getting them from the bone marrow, umbilical cord blood or peripheral blood," she said.

"If we can understand the properties of these cells and their role in the breast and in the breast-fed baby, we can use them as models for breast cancer research and in innovative stem cell therapies.

"Stem cell therapy is a very promising technology.  Every year there are more than 1,000 stem cell transplants in Australia and over 60,000 around the world.  The limitations of the current therapies are that the transplanted stem cells are accessed using invasive methods and have limited differentiation potential.  Breastmilk offers a new exciting opportunity for stem cell therapies, with the potential to benefit not only the mother and child, but also other people."

Dr Hassiotou said that she is currently examining the in vivo transplantation potential of milk stem cells into animals.

Her supervisors are Winthrop Professor Peter Hartmann, head of the 30-year old Human Lactation Research Group of UWA, and Professor Luis Filgueira, an expert in cell development and function.
Editor's Note: Original news release can be found here.

Cervical cancer rates higher in Aboriginals



MARY-ANNE ROMANO, SCIENCENETWORK WA   

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To date, cervical cancer is the 18th most common cause of death from cancer for women in Australia.
Image: janulla/iStockphoto
A new international study has found that Aboriginal women have a significantly higher rate of cervical cancer and dying from it than non-indigenous women in Australia.

The study, ‘Cervical cancer in Indigenous women: The case of Australia,’ published earlier this month in Maturitas, has found that Indigenous women have 2 to 5 times higher age standardised incidences and have a 3 to 18 times higher death rate from cervical cancer.

According to the WA Cancer Registry, there have been 19 incidences of cervical cancer and 15 deaths in WA from 2005 to 2009.

Head researcher on the study, Dr Geordan Shannon of Cambridge University, says the research highlights the massive health inequities between Indigenous and non-Indigenous women.

“These health inequalities lead to higher mortality among Indigenous people at a younger age and subsequently lead to a gap in life expectancy of about 12 years,” she says.

According to Dr Shannon, cervical cancer is an example of an inequity in Australia’s health outcomes.

“Such high incidences and subsequent mortality from cervical cancer is a shocking outcome for Indigenous women who live in such a well resourced country with a great health system.”

One of the main reasons for these high figures is attributed to poor screening amongst Indigenous women, with about half to two-thirds the cervical screening participation of non-Indigenous Australian women.

This is echoed by the WA Cervical Cancer Prevention Program (WACCPP) who, through their own ongoing research, says Indigenous women are less likely to have regular pap smears.

In addition, WACCPP Program Manager Nerida Steel, says there are other factors that may limit indigenous women from engaging in regular cervical screening practices.

“There is a sensitivity in discussing the topic in Aboriginal communities, embarrassment, anxiety or fear about the procedure,” she says.

“A difficulty in accessing services, for example, transport, a lack of a female GP, trained pap smear provider or trained female Aboriginal Health Workers are also issues.”

For Ms Steel, gaining an insight into why indigenous women do not take preventative steps is an ongoing commitment.

“WACCPP is committed to developing culturally safe and appropriate strategies to increase participation of cervical screenings among Aboriginal women in Western Australian communities,” she says.

These approaches include employing full-time Aboriginal Health Promotion Officers to liaise with both metropolitan and rural indigenous women and holding culturally appropriate education sessions for indigenous women and health professionals.

To date, cervical cancer is the 18th most common cause of death from cancer for women in Australia.
Editor's Note: Original news release can be found here.

Study finds ‘dengue genes’



AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH   
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"2.5 billion people worldwide are at risk from dengue infection, yet we still do not have any specific treatments or licensed vaccines."
Image: Henrik_L/iStockphoto
Researchers in South East Asia have identified two genetic variants associated with increased susceptibility to severe dengue. The study, funded by the Wellcome Trust and the Agency for Science, Technology, and Research (A*STAR), Singapore, offers clues to how the body responds to dengue infection.
 
Dengue is globally the most common mosquito-borne infection after malaria, with an estimated 100 million infections occurring annually. Symptoms range from mild to incapacitating high fever, with potentially life-threatening complications. No clinically-approved vaccine or specific treatments exist for the disease.
 
In children, severe dengue is characterised by increased vascular permeability, a state in which blood plasma is able to ‘leak’ from blood vessels to surrounding tissues. This is a potentially deadly complication that can lead to dengue shock syndrome – a life-threatening form of hypovolemic shock caused by a decrease in the volume of blood plasma. Epidemiological studies have suggested that certain populations are more susceptible to severe dengue, implying that some people’s genetic make-up makes them more susceptible to the disease.
 
To test this hypothesis, researchers at the Wellcome Trust Vietnam Research Programme and Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam, together with researchers from the Genome Institute of Singapore (GIS), a research institute under A*STAR, conducted the first ever genome-wide association study to compare the genomes of children with severe dengue against population controls. Initially, they compared 2,008 patients against 2,018 controls. They then replicated their findings in an independent follow-up sample of 1,737 cases and 2,934 controls.
 
The findings are published in the journal Nature Genetics. The researchers identified changes in the DNA code located within two genes – MICB on chromosome 6 and PLCE1 on chromosome 10 – that appeared to increase a child’s susceptibility to dengue shock syndrome.
 
MICB is known to play a role the body’s immune system and the researchers believe that a variant of this gene may affect the activation of natural killer cells or CD8 T-cells, two types of cells that play a key role in combating viral infection. If these cells are not properly functioning, their ability to rid the body of the dengue virus becomes impaired. This hypothesis is consistent with evidence that increased viral loads occur in the tissues of patients with severe dengue.
 
Mutations in PLCE1 have previously been linked to nephrotic syndrome, a childhood disease characterised by impairment of the normal barrier and blood filtering functions of cells in the kidney. The researchers believe that PLCE1 may also contribute to the normal functioning of the vascular endothelium, the thin layer of cells that lines the interior surface of blood vessels, with some variants of PLCE1 predisposing an individual to leakage from the blood vessels, the hallmark clinical feature of dengue shock syndrome.
 
Professor Cameron Simmons, senior author of the study from the Oxford University Clinical Research Unit, Vietnam, said: “Dengue is a potentially life-threatening disease. Our study confirms epidemiological evidence that some people are naturally more susceptible to severe forms of the disease than others. Our findings offer tantalising clues as to why this should be the case and open up new avenues for us to explore to help us understand the disease.”
 
Dr Khor Chiea Chuen, first author of the study, added: “This study implicates genetic variation within our natural killer cells as a highly suspicious culprit for increased susceptibility to severe Dengue. This is extremely surprising as prior to this it was thought that defects in other components of the immune response, such as. T-cells, B-cells or dendritic cells, were responsible. However, they did not show up in our large, well-powered genome scan.”
 
Combating infectious diseases is one the strategic priorities of the Wellcome Trust. Much of this work is carried out at a local level in regions where disease is endemic. This includes several major overseas programmes, including the Wellcome Trust’s Vietnam Research Programme.
 
Joint senior author Dr Martin Hibberd, Senior Group Leader at the GIS, said: “This study has shown the value of international collaboration, with team leaders from the Genome Institute of Singapore and the Oxford University Clinical Reseach Unit in Vietnam, working together to understand the mechanisms leading to severe dengue disease.”
 
Commenting on the research, Professor Danny Altmann, Head of Pathogens, Immunology and Population Health at the Wellcome Trust, said: “The World Health Organization estimates that two-fifths of the world’s population – 2.5 billion people – are at risk from dengue infection, yet we still do not have any specific treatments or licensed vaccines. This study, the first of its kind for dengue, is a step along the road towards understanding and eventually combating this deadly disease.”
Editor's Note: Original news release can be found here.

Researchers Unveil Method for Detecting Lung Cancer



 
"Nanotechnology sensor could lead to earlier diagnosis for world's deadliest form of cancer" 

When lung cancer strikes, it often spreads silently into more advanced stages before being detected. In a new article published in Nature Nanotechnology, biological engineers and medical scientists at the University of Missouri reveal how their discovery could provide a much earlier warning signal. 

"Early detection can save lives, but there is currently no proven screening test available for lung cancer," said Michael Wang, MD, PhD, assistant professor of pathology and anatomical sciences at MU and a corresponding author for the article. "We've developed highly sensitive technology that can detect a specific molecule type in the bloodstream when lung cancer is present." 

Worldwide and in the United States, lung cancer is the most common cause of cancer-related death. In the U.S., more than 221,000 people will be newly diagnosed with lung cancer in 2011, and more than 155,000 people will die from the disease this year. 

MU researchers used blood plasma samples to detect a change in a specific small ribonucleic acid (microRNA) molecule that is often elevated in lung cancer patients. The scientists put an extract of blood plasma through a protein-based nanopore, which is a tiny hole in a thin membrane that is just big enough for a single molecule to pass through. By applying an ionic current to the nanopore, the scientists measured changes in the current that occur when the microRNA molecule associated with lung cancer is present. 

"That altered current acts as a signal or bio-signature that is related to lung cancer," said Li-Qun Gu, PhD, an associate professor of biological engineering at MU and a corresponding author for the article. "Our new nanopore sensor is selective and sensitive enough to detect microRNAs at the single molecular level in plasma samples from lung cancer patients. 

"While there are many research labs that focus on nanopore applications, this is the first time that nanopore technology has been used to detect lung cancer," Gu added. "This technology could possibly be used in the future to detect other cancer types as well as other types of diseases with specific DNA or RNA in the blood." 
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