Type 3 Diabetes

Diabetes refers to a health condition where your body has difficulty converting sugar to energy

Type 3 diabetes is a term used when Alzheimer’s disease is triggered by insulin resistance in the brain. This condition is most often used to describe people who have type 2 diabetes and are also diagnosed with Alzheimer’s or dementia.

Studies carried out by the research team at Warren Alpert Medical School at Brown University identified the possibility of a new form of diabetes after finding that insulin resistance can occur in the brain

Lead researcher, Dr Suzanne de la Monte, carried out a further study in 2012 to further investigate the link.

The researchers pinpoint resistance to insulin and insulin-like growth factor as being a key part of the progression of Alzheimer’s disease.

Whereas type 1 and type 2 diabetes are characterised by hyperglycemia (increased blood sugar), a separate study, carried out by the University of Pennsylvania and published in 2012, excluded people with a history of diabetes, indicating that Alzheimer’s can develop without the presence of significant hyperglycemia in the brain. 

Increased risk of Alzheimer's

People that have insulin resistance, in particular those with type 2 diabetes have an increased risk of suffering from Alzheimer's disease estimated to be between 50% and 65% higher.
Researchers have discovered that many type 2 diabetics have deposits of a protein called amyloid beta in their pancreas which is similar to the protein deposits found in the brain tissue of Alzheimer's sufferers.


Thankshttps://www.diabetes.co.uk

How the brain links the effects of insulin to light

By understanding how the brain links the effects of insulin to light, researchers are deciphering how insulin sensitivity fluctuates according to circadian cycles, but also according to the organs involved. At the heart of their discovery are neurons of the ventromedial hypothalamic nucleus, a part of the brain that masters this delicate balance. These results, to be discovered in the journal Cell Reports, should also encourage diabetic patients and their doctors to consider the best time to take insulin to properly control its effect and limit the risk of hyperglycemia.

 The disruption of our internal clocks seems to play a significant role in the explosion of metabolic diseases observed in recent decades, and particularly of diabetes. Indeed, if the importance of day-night alternation on the effect of insulin and on the body's glycaemic management is beginning to be known, what about the mechanisms involved? How does the organism synchronize its clocks? By understanding how the brain links the effects of insulin to light, researchers at the University of Geneva (UNIGE) are deciphering how insulin sensitivity fluctuates according to circadian cycles, but also according to the organs involved. At the heart of their discovery are neurons of the ventromedial hypothalamic nucleus, a part of the brain that masters this delicate balance. These results, to be discovered in the journal Cell Reports, should also encourage diabetic patients and their doctors to consider the best time to take insulin to properly control its effect and limit the risk of hypoglycaemia.

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