Watch the real story about Christopher Columbus (what your teachers never told you).

Tips for Writing Your Research Proposal

1. Know yourself: Know your area of expertise, what are your strengths and what are your weaknesses. Play to your strengths, not to your weaknesses. If you want to get into a new area of research, learn something about the area before you write a proposal. Research previous work. Be a scholar.
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2. Know the program from which you seek support: You are responsible for finding the appropriate program for support of your research.
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3. Read the program announcement: Programs and special activities have specific goals and specific requirements. If you don’t meet those goals and requirements, you have thrown out your chance of success. Read the announcement for what it says, not for what you want it to say. If your research does not fit easily within the scope of the topic areas outlined, your chance of success is nil.
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4. Formulate an appropriate research objective: A research proposal is a proposal to conduct research, not to conduct development or design or some other activity. Research is a methodical process of building upon previous knowledge to derive or discover new knowledge, that is, something that isn’t known before the research is conducted.
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5. Develop a viable research plan: A viable research plan is a plan to accomplish your research objective that has a non-zero probability of success. The focus of the plan must be to accomplish the research objective.
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6. State your research objective clearly in your proposal: A good research proposal includes a clear statement of the research objective. Early in the proposal is better than later in the proposal. The first sentence of the proposal is a good place. A good first sentence might be, “The research objective of this proposal is...” Do not use the word “develop” in the statement of your research objective.
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7. Frame your project around the work of others: Remember that research builds on the extant knowledge base, that is, upon the work of others. Be sure to frame your project appropriately, acknowledging the current limits of knowledge and making clear your contribution to the extension of these limits. Be sure that you include references to the extant work of others.
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8. Grammar and spelling count: Proposals are not graded on grammar. But if the grammar is not perfect, the result is ambiguities left to the reviewer to resolve. Ambiguities make the proposal difficult to read and often impossible to understand, and often result in low ratings. Be sure your grammar is perfect.
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9. Format and brevity are important: Do not feel that your proposal is rated based on its weight. Use 12-point fonts, use easily legible fonts, and use generous margins. Take pity on the reviewers. Make your proposal a pleasant reading experience that puts important concepts up front and makes them clear. Use figures appropriately to make and clarify points, but not as filler.
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10. Know the review process: Know how your proposal will be reviewed before you write it. Proposals that are reviewed by panels must be written to a broader audience than proposals that will be reviewed by mail. Mail review can seek out reviewers with very specific expertise in very narrow disciplines.
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11. Proof read your proposal before it is sent: Many proposals are sent out with idiotic mistakes, omissions, and errors of all sorts. Proposals have been submitted with the list of references omitted and with the references not referred to. Proposals have been submitted to the wrong program. Proposals have been submitted with misspellings in the title. These proposals were not successful. Stupid things like this kill a proposal. It is easy to catch them with a simple, but careful, proof reading. Don’t spend six or eight weeks writing a proposal just to kill it with stupid mistakes that are easily prevented.
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12. Submit your proposal on time: Duh? Why work for two months on a proposal just to have it disqualified for being late? Remember, fairness dictates that proposal submission rules must apply to everyone. It is not up to the discretion of the program officer to grant you dispensation on deadlines. Get your proposal in two or three days before the deadline.

Microbes can play games with the mind

The bacteria in our guts may help decide who gets anxiety and depression

The 22 men took the same pill for four weeks. When interviewed, they said they felt less daily stress and their memories were sharper. The brain benefits were subtle, but the results, reported at last year’s annual meeting of the Society for Neuroscience, got attention. That’s because the pills were not a precise chemical formula synthesized by the pharmaceutical industry.

The capsules were brimming with bacteria.

In the ultimate PR turnaround, once-dreaded bacteria are being welcomed as health heroes. People gobble them up in probiotic yogurts, swallow pills packed with billions of bugs and recoil from hand sanitizers. Helping us nurture the microbial gardens in and on our bodies has become big business, judging by grocery store shelves.

These bacteria are possibly working at more than just keeping our bodies healthy: They may be changing our minds. Recent studies have begun turning up tantalizing hints about how the bacteria living in the gut can alter the way the brain works. These findings raise a question with profound implications for mental health: Can we soothe our brains by cultivating our bacteria?

By tinkering with the gut’s bacterial residents, scientists have changed the behavior of lab animals and small numbers of people. Microbial meddling has turned anxious mice bold and shy mice social. Rats inoculated with bacteria from depressed people develop signs of depression themselves. And small studies of people suggest that eating specific kinds of bacteria may change brain activity and ease anxiety. Because gut bacteria can make the very chemicals that brain cells use to communicate, the idea makes a certain amount of sense.

Though preliminary, such results suggest that the right bacteria in your gut could brighten mood and perhaps even combat pernicious mental disorders including anxiety and depression. The wrong microbes, however, might lead in a darker direction.

Open channels

Although the communication lines aren’t fully understood, bacteria in the gut and cells in the brain may stay in touch in several ways. Signals can move along the vagus nerve or be carried by chemical messengers, such as serotonin, and by molecules that travel via the immune system. 

Studying germ-free mice
Bacteria in the gut may help brains develop, based on studies from mice born and raised without bacteria. These mice are different from normal mice in several key brain areas.

Striatum: In mice without bacteria, the flux of the neural messengers dopamine and serotonin is altered in the striatum, a brain area involved in movement and emotional responses. New connections may form more readily in the striatum too. These changes may cause bacteria-free animals to move and explore abnormally.

Hippocampus: Involved in memory and navigation, the hippocampi of germ-free mice have reduced levels of molecules that sense serotonin and the growth factor BDNF. These mice display memory problems.

Amygdala: Germ-free mice have changes in the levels of serotonin, BDNF and other signaling molecules in the amygdala, a brain structure involved in emotions. These alterations might contribute to an increase in risk-taking behavior.

Hypothalamus: The brain’s stress responder, the hypothalamus, shows boosts in corticotropin-releasing factor and adrenocorticotropic hormone in germ-free mice. The changes might be related to the animals’ heightened stress responses.

SOURCE: S.M. COLLINS, M. SURETTE AND P. BERCIK/NAT. REV. MICROBIOL. 2012

Cecile G. Tamura