Wednesday, August 5, 2015
Tuesday, August 4, 2015
WHAT A SUPERB AND BEAUTIFUL ARCHEOLOGY OF AMRUTESHWAR TEMPLE BHADADRA MAHARASTRA .
Amruteshwar Temple is located at the start of the Ratanwadi village in the Igatpuri region. It is considered to be over 1,200 year old temple which features Lord Shiva as the main deity. This temple comes under Ahmednagar District and is surrounded by varied mountain ranges. Ratangad Fort is also located at a close distance from this old Lord Shiva Temple.
The Amruteshwar Temple has been constructed in Hemadpanthi architectural style with beautiful rock carvings on the main shrine. Travelling by road to this temple is very difficult due to rough roads on the hills. Tourists can avail boats from Arthur Lake to visit this temple, which is situated approximately 8 km away from this lake.
L-Dopa treatment depresses serotonin synaptic transmission
Imbalance between the dopamine and serotonin (5-HT) neurotransmitter systems has been implicated in the comorbidity of Parkinson’s disease (PD) and psychiatric disorders.
L-DOPA, the leading treatment of PD, facilitates the production and release of dopamine. This study assessed the action of L-DOPA on monoamine synaptic transmission in mouse brain slices.
Application of L-DOPA augmented the D2-receptor-mediated inhibitory postsynaptic current (IPSC) in dopamine neurons of the substantia nigra. This augmentation was largely due to dopamine release from 5-HT terminals.
Selective optogenetic stimulation of 5-HT terminals evoked dopamine release, producing D2-receptor-mediated IPSCs following treatment with L-DOPA. In the dorsal raphe, L-DOPA produced a long-lasting depression of the 5-HT1A-receptor-mediated IPSC in 5-HT neurons.
When D2 receptors were expressed in the dorsal raphe, application of L-DOPA resulted in a D2-receptor-mediated IPSC.
Thus, treatment with L-DOPA caused ectopic dopamine release from 5-HT terminals and a loss of 5-HT-mediated synaptic transmission leading to synaptic imbalance in neurotransmitter release and might cause implusive behavior in patients..
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