| THE UNIVERSITY OF OTAGO |
While genetic variants linked to heart disease can cause the disease to develop at a younger age, it doesn't appear to reduce an individual's life expectancy after a heart attack.
Image: Dkart/iStockphoto
Inheriting gene variants that increase the risk of developing coronary heart disease does not necessarily mean an individual is going to have reduced life expectancy if he or she suffers a heart attack.
Two research papers revealing these findings by Dr Katrina Ellis and colleagues at the University of Otago, Christchurch have been highlighted in the leading international cardiology journal Circulation, along with 42 other papers from cardiac researchers around the world. “These results have attracted considerable international attention as we found for the first time that the most likely gene variants for risk of developing coronary heart disease didn’t have a major negative effect on survival after heart attack, as might have been expected by the medical and scientific community,” explains Dr Ellis. “When we examined the progress of patients with four key gene variants, who were admitted to Christchurch Hospital with either angina or heart attack, we found little or no effect on their subsequent survival eight to 15 years after a heart attack compared with those carrying the more common form of the gene sequence. “However we noted those who carried these gene variants tended to develop heart disease at a younger age or have more risk factors, like high cholesterol.” As the head of the research group Professor Vicky Cameron says: “This is good news for those patients, and of high interest to medical science as it would be expected that gene variants associated with a greater risk for having a heart attack would also indicate a negative rather than positive prognosis.” Research into gene variants and their relationship to heart attacks has rapidly progressed since 2007 when it became possible to examine all 23,000 genes in humans relatively quickly using new computerised technology. This lead to ‘genome-wide association studies’ which identify those gene variants most strongly linked to the development of coronary heart disease, and subsequent survival after treatment. Coronary heart disease is the leading cause of death world-wide and in New Zealand, with sixteen people dying each day from this condition. Risks include environmental or lifestyle factors such as smoking and obesity, but about 50% of heart disease is actually inherited through our genetic make-up and gene variants.
“For many this means our genes make us more susceptible to lifestyle risk factors, such as bad diet or lack of exercise,” says Professor Cameron.
Dr Ellis is now moving to the prestigious Mt Sinai School of Medicine in New York. However her research is continuing at the University of Otago, Christchurch under Professor Cameron. A new research project, ‘The Family Heart Study’, is looking at the specific genetic risk factors that contribute to early coronary heart disease in New Zealanders. This will enable identification of genetic factors, such as gene variants, which put people at risk of heart attack and will enable even earlier intervention and better chances of survival.
Editor's Note: Original news release can be found here.
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Tuesday, May 1, 2012
Heart disease genes no death sentence
Neutrinos best studied in space
| Neutrinos best studied in space |
| THE UNIVERSITY OF QUEENSLAND |
Neutrinos are flowing through the Earth all the time, and many of them come from the Sun. In this computer simulation, the Sudbury Neutrino Observatory in Canada has detected a solar neutrino, which then produces a small burst of light, depicted by the colourful lines. The new research suggests the mass of neutrinos is better measured in the galaxy than in experiments such as this one.
Image: Lawrence Berkeley National Laboratory
The lightest known subatomic particles in the Universe are now able to be more accurately scrutinised, in light of new astronomic research two years in the making.
After more than 200 nights of galaxy-gazing and thousands of calculations, an international team of astronomers, including researchers from The University of Queensland, has published a new study that has made a remarkable headway in the way the mass of neutrinos are measured. The study, published in the May edition of Physical Review D Rapid Communication concludes that cosmological galaxy measurements are more effective than laboratory experiments on Earth when it comes to constraining neutrino mass for measurement. Neutrinos are the subatomic-sized fundamental particles floating in the Universe and the lightest massive known particles, yet they are traditionally treated as not having any mass. Lead author of the study, Dr Signe Riemer-Sørensen of the UQ School of Mathematics and Physics, said this new study would allow researchers to gain a more accurate and highly sensitive picture of neutrino mass, and this could ultimately lead to new understandings of the Universe. “This research paves the way for more sensitive future galaxy surveys to understand the mysterious workings of the Universe, and will help in new advancements such as improved models of supernova explosions and in designing neutrino telescopes that can probe much more distant objects than classical telescopes,” said Dr Riemer-Sørensen. Although laboratory experiments on Earth so far have been able to measure the differences in the masses between the various species of neutrinos, they have been unsuccessful in measuring the absolute neutrino mass with sufficient sensitivity. Using the Universe as a large particle physics experiment, the team in this study attempted to limit the range of possible neutrino masses by understanding how galaxies form. “One of the major challenges is that galaxy formation is not well-described theoretically,” said Dr Riemer-Sørensen. “We have tested a range of previously used theories and demonstrated that most of them are not precise enough to use with present and upcoming galaxy surveys with the much-desired higher level of sensitivity to the neutrino mass.” Using high-quality data from the team's WiggleZ Dark Energy Survey - a massive three-dimensional galaxy map of 240,000 galaxies - the researchers in this study applied a mixture of analytical modelling and simulation to achieve their results. “Despite the modelling challenges, cosmology does a much better job than laboratory experiments when it comes to constraining the neutrino mass,” said Dr Riemer-Sørensen. The team is currently working on refining the neutrino mass measurement by combining their results with other independent data sets, such as measurements from other astronomical observations. Other researchers in the study are Professor Michael Drinkwater, Dr Tamara Davis and Dr David Parkinson, all from the UQ School of Mathematics and Physics, as well as researchers from Australia, USA, South Africa, and Canada.
Editor's Note: Original news release can be found here.
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Looking Out For You
 “The Vedic literatures composed by the omniscient Mahamuni Vyasadeva are evidence of all spiritual existence. Only through these revealed scriptures can all conditioned souls attain knowledge.” (Lord Chaitanya, Chaitanya Charitamrita, Madhya 20.353)
“Did I make the most out of my life? What did my actions really amount to in the end? What was the purpose to my living? Where will I go from here?” These are the most important questions in life which the fortunate person will one day look to answer. The true saints of the earth, who were brave enough to share their sentiments with others regardless of the reception they received, thankfully have addressed these issues for us. In this sense they have looked out for everyone, including yourself, even if they have not met you personally.
How can someone answer an intimate question relating to my life if I have never met them? Ah, there are patterns to the human life cycle. Every person goes through birth, old age, disease and death. The living person hearing these facts obviously has not undergone death yet, but this doesn’t mean that it won’t happen eventually for them. The force of all-devouring time, known as kala in Sanskrit, has yet to lose. When it arrives, nothing can be done to send it away. No amount of begging or pleading can extend the predestined lifespan for the individual.
Since every living entity must die, we know that all the people of the past suffered death. They also went through the full cycle of birth to death, wherein if they had the fortune of maturing into adulthood they likely reached a position where they eventually pondered over the meaning of life and why they were put on the earth. These are valuable pieces of information to know because if someone else has already studied an issue that perplexes us today, we can consult their findings to see if anything tangible can be made of them. We can perhaps get an answer before we run any tests ourselves.
But which people should we consult? There are the mental speculators who have devised the scheme to enjoy life as much as possible. If you are destined to die, why worry at all about sin and good behavior? If the pious person meets the same fate as the miscreant, why the attention to following law codes? Shouldn’t every person just be out for themselves? Compete for resources and may the strongest person survive, no?
 The best combination is when you have an inquisitive person of a saintly character who meets the right set of information. That information must date back to the beginning of time and be presented through the mouth of a flawless person. The only being that cannot fall down is the Supreme Lord, who is thus known as Achyuta in the Vedic tradition. He has thousands of names which try to address His specific features, though there are too many glorious attributes to describe.
The Vedas are His talking points, His vital pieces of information passed on to the bewildered spirit souls unaware of their true position in the larger scheme. If you don’t know your defining position, which also represents your identity, how will you know how to act? A student acts by following the guidelines of the teacher, the worker the boss, and the citizen the government. In each case there is a specific identification leading the way.
But at the time of birth, these designations don’t exist; thus we know that they are temporary. They change throughout the course of one’s lifetime, and at death’s calling, the body itself is renounced. Therefore there must be more to life. There must be more to having an existence than struggling through temporary ups and downs that the animals experience as well.
The information originally passed on by God at the beginning of time has taken on a variety of forms with the passing of ages. In some forms brevity is the distinguishing factor, while in other forms there is more comprehensiveness attached. Thankfully for the world, the same speaker periodically comes to earth and repeats the information He originally presented at the beginning of time. Considering time and circumstance, He tailors His message accordingly.
 Arjuna’s chariot lay stationary on the battlefield. The war was about to begin, but the leading fighter for the Pandava side was hesitant. If you’re not ready to go full speed ahead, you won’t stand a chance in a violent conflict. Desire is as contributing a factor to victory as ability in the game itself. Arjuna had the ability. He could shoot arrows with the best of them. His marksmanship was so perfect that he once pierced the eye of a fish just by seeing its reflection in water. That feat earned him the hand of the beautiful queen Draupadi, but now the stakes were a little higher. A fight to the death would determine the control over a kingdom, one which rightfully belonged to Arjuna and his brothers.
To settle the doubts in His cousin and dear friend, Krishna stepped in and offered some sound words of advice. Ironically enough, the same lessons were imparted at the beginning of the creation. Krishna Himself revealed this cogent fact during the talk with Arjuna. He previously spoke these words to the sun-god, Vivasvan, who in turn passed it on to his son Manu, who then gave it to his son Ikshvaku. The saintly kings thus held on to the tradition of the essence of Vedic wisdom, but since the chain of disciplic succession had broken, Krishna was there to reinstate the tradition, to pass it on to another saintly fighter.
But the fighters weren’t the only ones familiar with this information. In fact, it was the saintly class of renounced mendicants who best understood this information and remained firmly convinced of its validity. You see, through sitting in their hermitages and steering clear of material attachment, the saints of the past had plenty of time to contemplate on both the meaning of life and the essence of the Vedas. They did all the heavy lifting for us, and the conclusions they produced were flawless.
They didn’t keep these secrets to themselves, though they didn’t openly proclaim them to every single person either. If I have a specific piece of information relevant to the field of computer science, I’m not going to walk into a doctor’s office and start sharing that with the doctor. They may or may not be interested in hearing what I have to say, but the office is not the proper venue. The constitutional position of the doctor’s office or the hospital is to heal sick patients.
 If the patients aren’t willing to take the medicine, then no amount of treatment can save them. In a similar manner, if the hearts and minds of the listeners are not attuned to learning about the meaning of life and the way to properly act, no amount of instruction will do them good. Ah, though qualified recipients are rare to find, the saints couldn’t keep all of this information bottled up. They documented their sense perceptions, their mental conclusions based on the original fact of God and His divine presence, into written form to be passed on to future generations.
So what was the conclusion they reached? The same one that Arjuna did, of course. The hesitant warrior, through heeding Krishna’s advice, threw away his doubts and decided to fight ahead. He was no longer concerned with victory or defeat or whether the friends and family fighting for the opposing side would continue to live. He followed through because Krishna asked him to. The relational link to the Supreme Lord is what serves as our guiding force. Knowledge of the link is the first step, and following through on the steps necessary to revive that link represent the next leap forward.
A life lived in devotional service, or bhakti-yoga, dispels all doubts as to the reason for existence. There is no regret at the time of death if much time was spent chanting, “Hare Krishna Hare Krishna, Krishna Krishna, Hare Hare, Hare Rama Hare Rama, Rama Rama, Hare Hare”, during one’s days on earth. The purpose to the existence is solved through devotional practices, as one tastes the sweet fruit of Krishna’s association. His name is as good as His personal self, and His activities are equally as representative of Him.
These names, forms, activities and attributes are passed on in the Vedic literature, and simply hearing about them from someone who follows the same mood of devotion as Arjuna can eliminate all doubts. The saints look out for us, often before we are even born. The spiritual masters of the Vaishnava tradition, who devote their thoughts, words and deeds to Vishnu, or Krishna, know what is best for every single person. They know the answers to problems before they are encountered, and because of this prescience their association is always the most wonderful boon in life.
In Closing:
At death’s call, your body about to quit,
Ponder your time on earth, was it worth it?
What did it all mean, what did I really do?
Life after death, is it real, can it be true?
Saints of the past on this did all the heavy lifting,
Their conclusions profound wisdom to mankind gifting.
Ultimate truth of devotion to Krishna they did reach,
How to find that same path to others they do teach.
Arjuna followed devotion and saints do the same,
Live a life devoted to God, chant always His name.
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Scientists identify brain circuitry associated with addictive, depressive behaviors
(Medical Xpress) -- Scientists at the UCSF-affiliated Gladstone Institutes have determined how specific circuitry in the brain controls not only body movement, but also motivation and learning, providing new insight into neurodegenerative disorders such as Parkinson’s disease — and psychiatric disorders such as addiction and depression.
Previously, researchers in the laboratory of Gladstone Investigator Anatol Kreitzer, PhD, discovered how an imbalance in the activity of a specific category of brain cells is linked to Parkinson’s.
Now, in a paper published online today in Nature Neuroscience, Kreitzer, who is also an assistant professor of physiology at UCSF, and his team used animal models to demonstrate that this imbalance may also contribute to psychiatric disorders. These findings also help explain the wide range of Parkinson’s symptoms — and mark an important step in finding new treatments for those who suffer from addiction or depression.
“The physical symptoms that affect people with Parkinson’s — including tremors and rigidity of movement — are caused by an imbalance between two types of medium spiny neurons in the brain,” said Kreitzer, whose lab studies how Parkinson’s disease affects brain functions. “In this paper we showed that psychiatric disorders — specifically addiction and depression —might be caused by this same neural imbalance.”
Normally, two types of medium spiny neurons, or MSNs, coordinate body movements. One type, called direct pathway MSNs (dMSNs), acts like a gas pedal. The other type, known as indirect pathway MSNs (iMSNs), acts as a brake. And while researchers have long known about the link between a chemical in the brain called dopamine and Parkinson’s, Gladstone researchers recently clarified that dopamine maintains the balance between these two MSN types.
But abnormal dopamine levels are implicated not only in Parkinson’s, but also in addiction and depression. Kreitzer and his team hypothesized that the same circuitry that controlled movement might also control the process of learning to repeat pleasurable experiences and avoid unpleasant ones—and that an imbalance in this process could lead to addictive or depressive behaviors.
Kreitzer and his team genetically modified two sets of mice so that they could control which specific type of MSN was activated. They placed mice one at a time in a box with two triggers — one that delivered a laser pulse to stimulate the neurons and one that did nothing. They then monitored which trigger each mouse preferred.
“The mice that had only dMSNs activated gravitated toward the laser trigger, pushing it again and again to get the stimulation — reminiscent of addictive behavior,” said Alexxai Kravitz, PhD, Gladstone postdoctoral fellow and a lead author of the paper. “But the mice that had only iMSNs activated did the opposite. Unlike their dMSN counterparts, the iMSN mice avoided the laser stimulation, which suggests that they found it unpleasant.” These findings reveal a precise relationship between the two MSN types and how behaviors are learned. They also show how an MSN imbalance can throw normal learning processes out of whack, potentially leading to addictive or depressive behavior.
“People with Parkinson’s disease often show signs of depression before the onset of significant movement problems, so it’s likely that the neural imbalance in Parkinson’s is also responsible for some behavioral changes associated with the disease,” said Kreitzer, who is also an assistant professor of physiology at UCSF.. “Future research could discover how MSNs are activated in those suffering from addiction or depression—and whether tweaking them could reduce their symptoms and improve their quality of life.
Graduate student Lynne Tye was also a lead author on this paper. Funding came from a variety of sources, including the W.M. Keck Foundation, the Pew Biomedical Scholars Program, the McKnight Foundation and the National Institutes of Health.
Gladstone is an independent and nonprofit biomedical-research organization dedicated to accelerating the pace of scientific discovery and innovation to prevent, treat and cure cardiovascular, viral and neurological diseases.
UCSF is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care.
Provided by University of California, San Francisco
"Scientists identify brain circuitry associated with addictive, depressive behaviors." April 30th, 2012. http://medicalxpress.com/news/2012-04-scientists-brain-circuitry-addictive-depressive.html
Posted by
Robert Karl Stonjek
Robert Karl Stonjek
Sunday, April 29, 2012
Friday, April 27, 2012
Paper Sculptures
Nature
Harpy
Bridge
Obi Wan Kenobi
Writer
Paper Skull
Reflection Sagrada Familia
Chinese Warriors
Buffalo Spirit Dancer
Over time, populace has been using normal things to generate something strange out of it and for case a very essential material such as paper. You might suppose that papers in connection with arts is only controlled to drawings, sketch and something imaginative like origami, but those are irony because there are plenty more that paper master can create by just using papers. Paper sculptor is an artwork shaped by determining or combining dissimilar types of papers that wants a huge accuracy. In this post, you will find extra and attractive examples of paper sculptures and the artist behind it. As you will see from these images, paper sculptures can be enthused by anything, starting from trash papers. We hope this post will give you a superior sympathetic of this type of art .-
Post-cancer fatigue “overestimated"
| THE UNIVERSITY OF NEW SOUTH WALES |
Previous studies had stated that up to 50% of breast cancer survivors suffered fatigued for many months after treatment ends, but the new research suggests the number is as small as 6%.
Image: MorePixels/iStockphoto
Despite widespread belief to the contrary, as few as 6% of women experience cancer-related persistent fatigue a year after undergoing treatment for breast cancer, a new study has found.
Prolonged and disabling fatigue is a common side-effect of many cancer treatments, with large numbers of women reporting that cancer-related fatigue persists for many months after treatment ends. Some studies put the figure as high as 50%.
But a study of breast cancer survivors from a group of collaborating hospitals in Sydney together with staff of the UNSW’s newly established Cancer Survivors’ Centre has found that figure is overstated, with the previously reported high rates of fatigue most likely attributable to factors unrelated to the cancer or its treatment.
And while the study, published this month in Journal of Clinical Oncology, looked at breast cancer, the researchers believe the same results would apply to survivors of other cancers.
“The good news is that the vast majority of women who have undergone cancer treatment either never experience ongoing debilitating fatigue in the weeks and months after treatment ends or if they do, it passes relatively quickly,” said study author, Professor David Goldstein, from UNSW’s Prince of Wales Clinical School.
“This is not to say that cancer-related fatigue is not a problem. It is still one of the main symptoms of cancer and a major side effect of treatment, but people can be reassured that for the vast majority receiving adjuvant treatment, it is not an ongoing or long term debilitating experience,” Professor Goldstein said.
The 5-year prospective study followed 218 women with early-stage breast cancer. The women were observed and questioned at three-monthly intervals for a year after treatment and again at five years. A rigorous definition of fatigue was used to rule out any “background” fatigue.
The study found the case rate for cancer-related fatigue fell from 31% at the end of treatment to 11% at six months and 6% at 12 months.
The findings suggest that previous studies have overestimated the prevalence of cancer-related fatigue and included transient fatigue states associated with unrelated infections, surgery and minor psychiatric disorders and chronic fatigue states attributable to other conditions.
The researchers say for the significant minority of people (6%) who do experience ongoing fatigue, attention can now be focussed on early identification and directing resources where they are most needed.
The success of cancer treatments and the increasing number of cancer survivors makes finding find better ways to manage survivorship essential. Researchers believe exercise may be one key element.
To that end, the UNSW Cancer Survivors’ Centre, in conjunction with one of its partners the UNSW Lifestyle Clinic, has begun trials of a twelve-week intensive program of exercise and cognitive behaviour therapy to help people with established cancer-related fatigue.
“Exercise is increasingly being identified as a medicine, potentially even with a dose response, and it may have a very important role as a therapy not only in cancer recovery but also in the treatment process itself,” Professor Goldstein said.
UNSW’s Cancer Survivor Centre is the first comprehensive centre in Australia and is also one of very few worldwide to focus on survivors of both childhood and adult cancers.
Editor's Note: Original news release can be found here.
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Billa 2 Teaser
Staring: Ajith Kumar
Directed By: Chakri Toleti
Music: Yuvan Shankar Raja
Produced By: Sunir Kheterpal, Suresh Balaje, George Pius
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