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Thursday, March 29, 2012

சிந்தனை செய் மனமே



சிந்தனை ஒரு வரம். அடிக்க அடிக்க அம்மி நகரும், தட்டத் தட்டச் சிலை வடிவம் பெறும். அதே போல் சிந்தனையால் உங்கள் மூளையைக் குடையக் குடைய அறிவு வளரும், ஞானம் பிறக்கும். தினம் 15 முதல் 30 நிமிடம் நாம் சிந்திப்பதற்காக ஒதுக்கினால், நம் ஞானம் விருத்தியாகும். மூளையை உபயோகிக்காமல் விடும் பொழுதுதான், மறதி பெருகுகிறது. ஆய்வுகள் சொல்கின்றன, நாம் நம் மூளையின் திறனில் வெறும் 10 விழுக்காடு தான் பயன்படுத்துகிறோமாம். மிச்சம்.... சிந்தியுங்கள் மக்களே சிந்தியுங்கள்.

வேலைகளுக்கு நடுவே நாம் ஏதாவது எண்ணிக்கொண்டேதான் இருப்போம். அவை எண்ணங்கள். நான் சொல்வது, ஓய்வாக அமர்ந்து நமக்கு நாமே மனதுக்குள் விவாதம் நடத்துவது; 'சிந்தனை'. எதைப் பற்றியாவது கேள்வி கேட்டு, உங்கள் மூளையைக் குடையுங்கள்.  நீங்களே வியக்கும் வண்ணம், பல புதிய விஷயங்கள், சிந்தனைகள் உங்கள் கபாலத்தை நிரப்பும். ஏதோ ஓர் அலைவரிசை உங்களுக்குள் புதிதாய் பிறக்கும்.

சிந்தித்ததால் அசோகன் மனிதம் காத்தான், சித்தார்த்தன் புத்தன் ஆனான். சிந்தித்ததால் யானைமுகன் ஞானப் பழம் வென்றான். சிந்தனை ஞானம் கொடுக்கும் சரி... அதை வைத்துக்கொண்டு 'புளியங்காய்' கூட வாங்க இயலாது... ஆமாம்! ஆமாம்.... வாங்க முடியாது.... உற்பத்தி செய்யலாம்...! சிந்தனை வேறு என்ன தரும்? அது உங்களை வித்தியாசப்படுத்திக் காட்டும். வழக்கமான முறையில் அல்லாமல், புதிய வழியில் செயலாற்றி, மற்றவரை வியப்பில் ஆழ்த்துவீர்.

ஒரு துணுக்கு:

ஒரு அலுவலகத்தில் வேலைக்கான ஒரு நேர்காணலில், மேலாளர் கேட்கிறார் - "what is before you?"

ஒருவன் சொன்னான் - காபி

மற்றொருவன் சொன்னான் - காபி

மூன்றாமவன் சொன்னான் - டீ

எல்லோரும் சிரித்தார்கள். ஏனென்றால் காபி தானே பரிமாறப்பட்டது. வியப்பாக, 'டீ' என்று சொன்னவன் தேர்வு செய்யப்பட்டான். எப்படி?

ஆங்கில எழுத்து வரிசையான 'a,b,c,d' யில் 'U' விற்கு முன் 'T' தானே!!!!

இந்தச் சாதுர்யம், பக்குவம், யோசனையெல்லாம், நீங்கள் அன்றாடம் சிறந்த புத்தகங்களை, கருத்துகளை, நிகழ்வுகளை படித்துத் தெரிந்து, கேட்டு, பின்பு நன்கு ஆய்ந்து உங்கள் கபாலத்தில் போட்டு வைத்துக்கொள்ளுங்கள். தேவைப்படும் பொழுது தட்டித் திறந்துகொள்ளலாம்.

சிந்தனை நம்மை மனிதன் ஆக்குகிறது. செய்யும் பணியில் கவனம் செலுத்த உதவுகிறது, வெற்றிக்கு வழிவகுக்கிறது. நேரம் கிடைக்கும் போதெல்லாம் சிந்தித்துக்கொண்டே இருங்கள்.

Epigenetic changes in blood samples may point to schizophrenia




In a new study, researchers at the Swedish medical university Karolinska Institutet have identified epigenetic changes – known as DNA methylation – in the blood of patients with schizophrenia. The researchers were also able to detect differences depending on how old the patients were when they developed the disease and whether they had been treated with various drugs. In the future this new knowledge may be used to develop a simple test to diagnose patients with schizophrenia.
Schizophrenia is one of our most common chronic psychiatric diseases and affects 1% of the population. It is already known that the risk of developing schizophrenia increases if one has close family members who have had the disease. At the same time, studies on identical twins, who therefore have the same genetic make-up, show that 50% of the disease risk can be explained by genetic factors. This in turn suggests that environmental factors, which include epigenetic changes to the genome, account for the remaining 50% of the cause of the disease.
"Epigenetics involves small reversible chemical changes, for instance in the form of methyl groups that bind to certain DNA sequences in the genome, that can consequently modifythe function of the DNA. The research results we are now presenting suggest that epigenetic mechanisms are of great importance in mental illness. It is particularly interesting that these changes can also be linked to age at disease onset," says Professor Tomas Ekström, who has directed the study at the Center for Molecular Medicine (CMM).
The current study, which is published in the scientific journal FASEB Journal, shows that the methylation levels in DNA in the white blood cells from individuals who suffer from schizophrenia are substantially lower than normal and that the degree of methylation is related to age of disease onset and the severity of the disease. The researchers also compared the degree of methylation in samples from patients who had been treated with various types of drugs. It emerged that treatment with one type of antipsychotic drug could influence the levels of DNA methylation in the blood cells towards more normal levels. In their article in FASEB Journal, the researchers at CMM note that at present there is no 'biomarker' for schizophrenia that is suitable for clinical sampling. An interesting area of application for the new knowledge may therefore be to develop a simple test of this kind to diagnose schizophrenia, and to monitor how patients respond to the treatment they receive.
"The fact that DNA methylation in an ordinary blood sample can be used as a marker of the severity of schizophrenia opens up completely new opportunities. But follow-up studies are needed to clarify, for example, whether choice of treatment can be linked to this type of test," says Professor Martin Schalling, one of the researchers behind the study.
More information: "Epigenetic aberrations in leukocytes of patients with schizophrenia: association of global DNA methylation with antipsychotic drug treatment and disease onset ", Philippe A. Melas, Maria Rogdaki, Urban Ösby, Martin Schalling, Catharina Lavebratt & Tomas J. Ekström, FASEB Journal, published ahead of print 16 March 2012, doi:10.1096/fj.11-202069
Provided by Karolinska Institutet
"Epigenetic changes in blood samples may point to schizophrenia." March 27th, 2012. http://medicalxpress.com/news/2012-03-epigenetic-blood-samples-schizophrenia.html
Posted by
Robert Karl Stonjek

In immersion foreign language learning, adults attain, retain native speaker brain pattern




A first-of-its kind series of brain studies shows how an adult learning a foreign language can come to use the same brain mechanisms as a native speaker. The research also demonstrates that the kind of exposure you have to the language can determine whether you achieve native-language brain processing, and that learning under immersion conditions may be more effective in reaching this goal than typical classroom training. The research also suggests that the brain consolidates knowledge of the foreign language as time goes on, much like it does when a person learns to ride a bike or play a musical instrument.
The latest in this series of studies was published online in today's PLoS ONE by researchers from Georgetown University Medical Center (GUMC) and the University of Illinois at Chicago.
"In the last few years, research has begun to suggest that adults learning a foreign language can come to rely on the same brain mechanisms as native speakers of a language, and that this might be true even for those parts of a foreign language that are particularly difficult to learn, such as its grammar," explains Michael Ullman, Ph.D., a professor of neuroscience at GUMC and senior investigator of the studies. "We confirmed this in our studies."
However, even if it's true that foreign language learners might be able to achieve native-like processing of grammar, Ullman says it has not at all been clear just how they can get there that is, what exactly allows a learner to attain native-like processing.
Ullman and lead author Kara Morgan-Short, Ph.D., from the University of Illinois at Chicago, first tested whether the conditions under which a person learns a foreign language matter. Specifically, is the type of foreign language exposure typically found in classrooms, with a lot of explanations about the grammar, more or less beneficial than the type of exposure in an immersion situation, in which there are no such explanations, but simply many language examples?
"Surprisingly, previous studies have found that the type of exposure typically found in classrooms leads to better learning than that typically found in immersion. However, no studies have looked at the actual brain mechanisms after different types of exposure," Morgan-Short says. Also, because a foreign language is so slow to learn, previous studies have not examined the outcomes of different types of exposure beyond the early stages of learning, since it would take far too long to wait until participants reached high proficiency, she says.
To get around this problem, the scientists came up with a clever solution. Rather than teach people a full foreign language, they taught them a very small one, with only 13 words, which referred to the pieces and moves of a computer game. The language itself was made-up, and its grammar was constructed so that it was like that of other natural languages, but differed from the participants' native language English in important respects, such as its grammatical structure.
The scientists found that after a few days, adults had indeed reached high proficiency in the language, whether they had undergone classroom- or immersion-like training. However, measures of brain processing showed that different types of training led to different brain mechanisms.
"Only the immersion training led to full native-like brain processing of grammar," Ullman says. "So if you learn a language you can come to use native language brain processes, but you may need immersion rather than classroom exposure." (These results were published online Aug. 23, 2011 in theJournal of Cognitive Neuroscience.)
For the study published in PLoS ONE, the researchers asked another very interesting question: What happens after you've reached high proficiency in a foreign language, if you're not regularly exposed to it? Do you lose the use of any native-language brain mechanisms that you've attained? Many learners do not always have ongoing exposure, which makes this is a critical question, Ullman says.
So, without having warned their research participants beforehand, the researchers called them an average of five months later, and asked them to come back for another round of brain scanning. Because the language was made-up, the scientists were sure that the participants hadn't had any exposure to it during this entire time.
The researchers weren't sure what they would find, since this was the first study examining the brain after such a period of no exposure. However, previous studies testing only proficiency changes found, not surprisingly, that foreign language learners generally did worse after such periods, so the scientists assumed that the brain would also become less native-like.
"To our surprise, the participants actually became more native like in their brain processing of grammar," Ullman says. "And this was true for both the classroom and immersion training groups, though it was still the case that only the immersion group showed full native-like processing."
Ullman believes that, over time, memory of the language was "consolidated" in the brain, probably by the same mechanisms that also underlie native language. He says this process is probably similar to the consolidation of many other skills that a person might learn, such as learning to ride a bike or play a musical instrument.
Interestingly, the participants showed neither improvements nor loss of proficiency during the same five month period, even as their brains became more native like, Ullman says. The scientists are uncertain why this might be, though it is possible that proficiency changes might in fact have been observed with more precise measures, or that improvements had occurred some time after training but then were gradually lost in the absence of practice during the five months.
Ullman says that even without any observed changes in proficiency, the brain changes are important. "Native language brain mechanisms are clearly well suited to language, so attaining their use is a critical achievement for foreign language learners. We suspect that this should lead to improved retention of the language as well as higher proficiency over time."
Provided by Georgetown University Medical Center
"In immersion foreign language learning, adults attain, retain native speaker brain pattern." March 28th, 2012.http://medicalxpress.com/news/2012-03-immersion-foreign-language-adults-retain.html
Posted by
Robert Karl Stonjek