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Thursday, September 1, 2011

The space-age sickbay that diagnoses disease without need for tests from sight, smell and 'feel' of disease



A sickbay that uses space-age technology to diagnose diseases ranging from stomach bugs to cancer has been unveiled at a  British hospital.
The first of its kind, it contains a bewildering array of equipment, including probes designed for  missions to Mars.
The gadgets in the million-pound unit can detect illness without the need for painful and invasive tests. They combine information about the sight, smell and ‘feel’ of a disease to produce a diagnosis.
High-tech hospital: It looks like something out of a sci-fi film, but this is the latest sick bay to be unveiled in Britain
High-tech hospital: It looks like something out of a sci-fi film, but this is the latest sick bay to be unveiled in Britain
The unit is described as the first step towards the tricorder scanners that Star Trek’s Dr McCoy waved in front of patients’ bodies to diagnose and treat illness in the crew of the Starship Enterprise.
Professor Mark Sims, the Leicester University space scientist who led the project alongside Tim Coats, a professor of emergency medicine, said: ‘In the old days, it used to be said that a consultant could walk down a hospital ward and smell various diseases, as well as telling a patient’s health by looking at them and feeling their pulse.
Medical student Tom Geliot trials a new 'sick bay', which uses space-age technology similar to that used in science fiction series Star Trek to detect illness at Leicester Royal Infirmary
Medical student Tom Geliot trials a new 'sick bay', which uses space-age technology similar to that used in science fiction series Star Trek to detect illness at Leicester Royal Infirmary
Professor Tim Coats (right) and medical student Tom Geliot test out the expensive gadgets
Professor Tim Coats (right) and medical student Tom Geliot test out the expensive gadgets
‘What we are doing is a high-tech version of that to help doctors diagnose the disease. We are replacing doctors’ eyes with state-of-the-art imaging systems, replacing the nose with breath analysis, and the “feel of the pulse” with monitoring of blood flow using ultrasound technology and measurement of blood oxygen levels.’
The diagnostics development unit is part of Leicester Royal Infirmary’s A&E department. One group of instruments, the ‘eyes’, uses thermal imaging technology developed by the university’s space scientists to search for life on Mars to hunt for signs of disease via the surface of the human body.
For instance, it should be possible to get information about blood chemistry that points to liver or kidney problems without even taking a blood sample.
While some of the equipment is routinely used in hospitals around the country, other pieces were custom-built for the sickbay, making  it the only one of its type in the world. The unit will initially be used to check out patients thought to be suffering from heart failure, pneumonia and serious, body-wide infections – but the instruments have dozens of possible uses.


Read more: http://www.dailymail.co.uk/news/article-2032378/Space-age-sickbay-diagnoses-disease-need-tests.html#ixzz1Wh9j9vSD

Roman prostitutes were forced to kill their own children and bury them in mass graves at English 'brothel'



The babies of Roman prostitutes were regularly murdered by their mothers, archaeologists have found.
A farmer's field in Hambleden, Buckinghamshire, yielded the grisly secret after a mass grave containing the remains of 97 babies - who all died around the same age - was uncovered. 
Following a close study of the plot, experts have decided it was the site of an ancient brothel and terrible infanticides took place there.
The Yewden Villa excavations at Hambleden in 1912. Archaeologists at the site have found the remains of 97 babies they believe were killed by their prostitute mothers
The Yewden Villa excavations at Hambleden in 1912. Archaeologists at the site have found the remains of 97 babies they believe were killed by their prostitute mothers
With little or no effective contraception available to the Romans, who also considered infanticide less shocking than it is today, they may have simply murdered the children as soon as they were born.
Archaeologists say locals may have systematically killed and buried the helpless youngsters on the site. 
Measurements of their bones at the site in Hambleden show all the babies died at around 40 weeks gestation, suggesting very soon after birth. If they had died from natural causes, they would have been different ages.
Archaeologist Dr Jill Eyers, who lives locally, has been interested in the site for many years. She put together a team to excavate the site and is writing a book about her findings.
She said: 'Re-finding the remains gave me nightmares for three nights.
'It made me feel dreadful. I kept thinking about how the poor little things died. The human part of the tale is awful.
‘There were equal numbers of girls and boys. Some of the babies were related as they showed a congenital bone defect on their knee bones, which is a very rare gene.
'It would account for the same woman or sisters giving birth to the children as a result of the brothel.'
One of the infant skeletons found during the dig. Scientists believe the site was used to dump the bodies of prostitutes' babies because of a lack of contraception
One of the infant skeletons found during the dig. Scientists believe the site was used to dump the bodies of prostitutes' babies because of a lack of contraception
The Yewden villa at Hambleden was excavated 100 years ago and identified as a high status Roman settlement.
It is now covered by a wheat field, but meticulous records were left by Alfred Heneage Cocks, a naturalist and archaeologist, who reported his findings in 1921.
He gave precise locations for the infant bodies, which were hidden under walls or buried under courtyards close to each other. 
However, the matter was not investigated further until now. Cocks' original report was recently rediscovered, along with 300 boxes of photographs, artefacts, pottery and bones, at Buckinghamshire County Museum. 
Dr Eyers was suspicious that the infants were systematically killed because they were unwanted births  - a suspicion which has been confirmed by Simon Mays, a palaeontologist who has spent the past year measuring the bones.
Distressing: Part of one of the baby's skulls which was found at the site
Distressing: Part of one of the baby's skulls which was found at the site
Dr Eyers said 'He proved without doubt that all the infants were new-born. They were all killed at birth and all at the gestation period of between 38 and 40 weeks.
‘There are still little bits of the jigsaw to be pieced together. We want to see final figures of boys and girls and the relations to ascertain what sort of group we have here.
‘We also found a family of five buried in a well. Did they die in a fire or were they murdered?
‘There is another site about a mile down the river which we know nothing about but I think there must be a connection.' 

The find has been compared to the discovery of the skeletons of 100 Roman- era babies in a sewer beneath a bath house in Ashkelon, southern Israel, in 1988.

Invaders' hidden culture of death and debauchery

Ruling with an iron fist: A typical Roman soldier
Ruling with an iron fist: A typical Roman soldier
Nearly 2,000 years ago it was the Romans who were enjoying the pleasant climate and farming bountiful crops in this corner of south-east England.
The nearest Roman town was St Albans - or Verulamium - a busy market on Watling Street with its own gladiator theatre.
Life was tough, disease rife and hygiene for the poor dreadful, but the climate is thought to have been warmer than now, making farming easier.
The Roman name for Hambleden is lost to antiquity but the people would have been a mixture of native Celts and Roman settlers, most of them farmers growing wheat and barley and a mixture of other crops.
Living in houses made mostly of wood, some would have travelled the length of the empire in the army and settled in the fertile Thames Valley, but most would never have travelled any distance from home.
Despite the bloody image of the Roman Empire, Britain was - especially in the south - a peaceful and prosperous place for most of the period of the occupation.
Pottery found in Hambleden comes from modern-day Italy, France, Belgium and Germany, showing the trade which the Empire brought.
But it also brought a culture of debauchery and death - even to a tiny village near the Thames, or 'Tamesis' to the Romans - with gladiators a day's boat trip away in London ( Londinium), brothels, and unwanted babies left to die in the open.
The famously well-preserved remains at Pompeii revealed a city rife with brothels signposted with erotic frescoes tempting passers-by with phrases such as 'Hic habitat felicitas' (Here happiness resides) or 'Sum tua aere' (I am yours for money).
Unlikely as it seems, it is entirely possible that Hambleden could have supported a brothel, as it is so close to the Thames, a busy waterway bringing trade to and from London.
The two-storey building was a few hundred yards from the river, with plenty of signs of wealth in the coins and pottery found in the grounds.
The remains of writing tablets and stylae, used to write, were also found, telling of a place with extensive contact with the wider world.
Dr Simon Mays, a skeletal biologist at English Heritage, has examined the Hambleden Roman infant bones
Dr Simon Mays, a skeletal biologist at English Heritage, has examined the Hambleden Roman infant bones
Literacy was a sign of affluence, and rich men and women were in frequent correspondence with each other.
Correspondence found at Hadrian's Wall shows how they bickered over dinner parties, gossiped about friends and discussed fashion in notes to each other.
What went on inside the Hambleden villa is, of course, a matter of conjecture. But there is little doubt that the find of so many babies' skeletons proves that Roman Britain shared another part of the empire's culture - infanticide.
Illegal today, it was the opposite for the Romans, with the law making a child under two entirely the property of its father, to be disposed of as he saw fit - and if it was deformed, it was compulsory to put it to death. A letter from a Roman citizen to his wife, dating from 1BC, demonstrates the casual nature with which infanticide was often viewed:
'I am still in Alexandria. ... I beg and plead with you to take care of our little child, and as soon as we receive wages, I will send them to you. In the meantime, if (good fortune to you!) you give birth, if it is a boy, let it live; if it is a girl, expose it.'
In 374 - after Constantine made Christianity the official religion of the empire - the practice was banned. The Romans may have done much for us - but they left a very dark secret in the Home Counties.


Read more: http://www.dailymail.co.uk/sciencetech/article-2031727/Roman-prostitutes-forced-kill-children-bury-mass-graves-English-brothel.html#ixzz1Wh9Lu8U7

Potato diet for lower blood pressure... and no weight gain




Spuds - the new superfood: The potato can help lower blood pressure without piling on the pounds
Spuds - the new superfood: The potato can help lower blood pressure without piling on the pounds
They have long been maligned as fattening and shunned by those  following the Dukan and other low-carb diets.
But potatoes could be the latest superfood. For eating a portion twice a day can lower blood pressure, researchers say. What is more, it seems there is no weight gain involved.
However, before you get out the roasting tin or rush to the chip shop, read on.
Microwaved spuds, free of butter, oil or ketchup, are best for health, scientists say. Baked potatoes and boiled spuds, including mash, are also acceptable.
In the study, 18 men and women were asked to eat six to eight golf ball-sized potatoes with their lunch and dinner, as part of their normal diet.
Most of those taking part were overweight or obese and on pills to lower blood pressure.
After a month of the ‘tattie treatment’, their blood pressure readings dropped significantly – suggesting the potatoes were powerful enough to take over when the tablets could not do any more.
 


In addition, none of the volunteers put on any weight.
Potatoes are thought to have a satiating effect but it is also likely that those taking part in the study cut back on other foods, the American Chemical Society’s annual conference reported.
Those used in the U.S. agriculture department-funded study were purple and so small that they contained as few as 12 calories each, but the researchers believe that ordinary potatoes should also benefit health.
They should be cooked – ideally in the microwave – with their skins on.
This is because many of the health-boosting, blood pressure-lowering chemicals are in the skin.
The super spud
Microwaving is preferred because, unlike the high temperatures used to fry and roast, it preserves most of the goodness. Researcher Joe Vinson, from Scranton University in Pennsylvania, said: ‘Mention “potato” and people think “fattening, high carbs, empty calories”. 
‘We hope our research helps to remake the potato’s popular nutritional image.’  
Dr Vinson, who likes his potatoes baked and topped with salad cream, added that lowering blood pressure cuts the risk of heart attacks and strokes.
Previous research has shown potatoes contain phyto, or plant, chemicals similar to those found in blood pressure drugs.


Read more: http://www.dailymail.co.uk/health/article-2032413/Potato-diet-lower-blood-pressure--weight-gain.html#ixzz1Wh4AsuzL

Cancer-stricken grandfather given just 12 months to live sees tumours killed in TWO DAYS after breakthrough treatment



A cancer-stricken grandfather given just 12 months to live has undergone a breakthrough treatment which killed his tumours - in just two days.
Brian Brooks, 72, received a devastating death sentence after a random bowel screening test showed his colon and liver was riddled with cancer.
With nothing to lose, the father-of-two put himself forward for a trial therapy for liver cancer called Foxfire, spearheaded by Cancer Research UK's Bobby Moore Fund.
Breakthrough treatment: Brian Brooks (pictured with his wife Nicky) had his tumours killed by radioembolisation in just two days
Breakthrough treatment: Brian Brooks (pictured with his wife Nicky) had his tumours killed by radioembolisation in just two days at Addenbrooke's Hospital in Cambridge
The radical treatment, called radioembolisation, places radioactive material inside blood vessels which deliver a dose of radiation directly into the liver.
Remarkably, his tumours were killed off after only two days of treatment - which meant doctors were then able to treat the cancer in his colon.
Experts now believe the breakthrough treatment could now help treat thousands of cancer sufferers across Britain.
Mr Brooks, of Ely, Cambridgeshire, is one of only 40 Britons to receive the treatment and one of the first to be given the all-clear.
Delighted Brian is now in remission - and describes his treatment as a ‘miracle’.


He said: ‘I was given a death sentence, it's a very difficult thing to get your head around.
'My family were devastated and one of the worst things for me was thinking I may not see my three year-old granddaughter grow up.
'But they never gave up hope and were tremendously supportive, that helped me through the treatment.
'To be told you have 12 months to live and then to have completely healed 12 months down the line, we believe is a miracle.
'Obviously there is always the risk that the cancer can come back but I am now in remission and that is something that the doctors did not believe was possible.'
New lease on life: Brian taking his dog for a walk after recovering from cancer which was previously diagnosed as terminal
New lease on life: Brian taking his dog for a walk in Cambridgeshire after recovering from cancer which was previously diagnosed as terminal
His wife, Nicky, 67, said: 'It was completely random - Brian's name was picked and he underwent the trial alongside his chemotherapy.
'We've just had the results back and my doctors can't believe its success - they say they are astonished.
'If we hadn't been informed about this trial, Brian would not be here today.'
Brian, a retired boarding kennel owner from Ely, Cambridgeshire, went for a random bowel screening test at Addenbrooke's Hospital on September 6, 2010.
The scans showed a tumour in his colon and others in his liver - which doctors told him they were unable to operate on.
Brian and Nicky were forced to break the news to their son Iain, 45, daughter Joanne, 40, and grandson William, 3.
But they were given hope when Brian was accepted onto the Foxfire trial, to try radioembolisation therapy, which is not available on the NHS.
Brian was given the treatment at Addenbrooke's Hospital in Cambridge and went for the first stage, when doctors plotted the blood flow over his liver, on November 17.
The following day he was given the second part of the treatment which involved a blast of nuclear spores into the blood cells which were feeding the tumour.
Treatment: The grandfather-of-one and father-of-two had his treatment at Addenbrooke's Hospital in Cambridge
Treatment: The grandfather-of-one and father-of-two had his treatment at Addenbrooke's Hospital in Cambridge
Four months later Brian was told the tumours in his liver had completely disappeared and he could now undergo chemotherapy to shrink the tumour in his colon.
He began 11 sessions of traditional chemotherapy to shrink the tumour in his colon, which doctors removed seven weeks ago.
Brian added: 'I remember seeing the results of my scan and reading 'Complete resolution of all liver tumours' - it was incredible.
'My family and I are so grateful to the Bobby Moore Fund, Cancer UK and of cause the wonderful doctors at Addenbrookes.'
Radioembolisation is a combination of radiation therapy and a procedure called embolisation to treat cancer of the liver.
Unlike traditional radiotherapy, which is directed at the tumour from outside the body, this delivers a high dose of radiation from inside the diseased area of the body.
Tiny glass or resin beads called microspheres are placed inside the blood vessels that feed a tumour to block the supply of blood to the cancer cells.
Once these radioactive microspheres become lodged at the tumour site they deliver a high dose of radiation with minimal damage to healthy cells.
The trial co-ordinated by Oxford University was launched in February 2010 and 40 patients have so far enrolled.
Worldwide 800 patients have been treated, half receiving chemotherapy and radioembolisation and the other 400 given chemotherapy alone.
Kate Law, Cancer Research UK's director of clinical trials said: 'Without clinical trials like Foxfire, we wouldn't be able to improve techniques for cancer that are hard to treat.
'It's a promising trial and we look forward to following its progress and seeing the results.'


Read more: http://www.dailymail.co.uk/health/article-2032252/Cancer-stricken-grandfather-given-just-12-months-live-sees-tumours-killed-TWO-DAYS-breakthrough-treatment.html#ixzz1Wh3aoQHp


How Fraudsters Can Work out Your PIN from the Heat Traces your Fingers leave on an ATM

How Fraudsters Can Work out Your PIN from the Heat Traces your Fingers leave on an ATMBy DANIEL BATES


Fraudsters can work out your PIN by the heat traces your fingers leave on a cash machine, researchers have found.
Some 80 per cent of the time scientists were able to correctly identify the four-digit code using an infrared scanner on the ATM.
Even a full minute later the camera was able to show clearly which numbers had been pressed, giving a fraudster ample time to get what they needed.

Risk? Fraudsters using an infrared device can work out your PIN by the heat traces your fingers leave on a cash machine, researchers have found
Risk? Fraudsters using an infrared device can work out your PIN by the heat traces your fingers leave on a cash machine, researchers have found

All they would then need to do would be steal the person’s wallet and they could help themselves to their money.
The researchers said that using an infra red camera only told you the order 20 per cent of the time but that even then it was massively easier to work out because you knew the numbers.
The team from the University of California at San Diego built on previous research which used infrared cameras to work out safe combinations after workers had pressed the keys.

They found that even if the camera was used a minute later, it still showed the right digits on the ATM around half the time.
Pictures released by the researchers showed a plastic number pad on a cash machine with red spots where the PIN had been entered.
‘With plastic keypads, we can reliably detect which buttons were pressed, but it is really difficult to determine the order,’ said Keaton Mowery, a doctoral student in computer science at UCSD.
Using an infrared camera, however would not work with a metal keypad.

ATM blues: Fraudsters have over the years used a string of techniques to get the PIN numbers of people using cash machines
ATM blues: Fraudsters have over the years used a string of techniques to get the PIN numbers of people using cash machines

‘Essentially, if you pointed the camera directly at the metal keypad, it would show you the thermal fingerprint of you, the camera operator, rather than of the keypad itself,’ said Sarah Meiklejohn, another of the researchers.

‘However, we didn't push it, because the plastic keypad did work. It's possible that someone else could solve those issues.’
She added that another issue is the cost - a good quality infra red camera costs around £11,500 to buy new.

Fraudsters have over the years used a string of techniques to get the pin numbers of people using cash machines.

Among the most elaborate took place in Stroud, Gloucestershire, in which criminals put a fake ATM outside the front of a Tesco supermarket.

It included a ‘skimming’ device which allowed them to copy and read bank details and PINs while the machine paid out cash.

Other criminals have used tiny cameras in the ceiling to record people entering their pin numbers as they enter them in at the till.

The fraudsters then get the credit card details from the cashier and steal the person’s money.



Video Stroboscopy of the Vocal Cords


The Human Voice

vocal cords
If you touch the front of your neck while you say something, you will be able to feel your throat vibrating. This is because you have two flaps of skin inside your throat called vocal cords.

When you speak or sing, air from your lungs is forced over the vocal cords causing them to vibrate. In turn, this makes the air in your throat and mouth vibrate at the same rate. Muscles in the throat stretch the vocal cords tighter to make high sounds and relax them to make deeper tones. Women generally have higher voices than men because their vocal cords are shorter.

The basic sound from the vocal cords can be altered a great deal through movements of the mouth, tongue, and lips. In this way, we can produce all of the many variations of found in human languages.

Vocal Cords Singing

Many different parts of your body influence how you sing, but understanding how they all work together to produce the best sound is the key to great vocal cord singing. Of course it is important to know about breathing for singing and singing posture, but knowing where the vocal cords - your muscles for singing - are located and how they make tone is just as important. When developing good vocal technique, you need to understand how your breath, posture and tension affect how your vocal cords work.

Where are your vocal cords?

Your vocal cords are inside your larynx (pronounced lar-inks), which is the source of your singing voice. Your vocal cords are two small bands of tissue stretching across your larynx that vibrate to create pitch.

How do vocal cords create pitch?

vocal cords diagramYour vocal cords coordinate with your breath to release a pitch by opening and closing (vibrating) as your breath passes through. Each vibration of your vocal cords is called a "cycle of vibration" or "glottal cycle". If you're singing the same note that an orchestra plays to tune their instruments, your vocal cords are vibrating at 440 cycles per second - yes that's fast. So in order to make your vocal cords vibrate quickly, you need to keep your breath flowing otherwise you run out of air and can't sustain the tone.
In addition we have to make sure that our posture is correct. If we are not standing correctly, our breathing mechanism doesn't work well so we can't get the air moving for singing. Allowing ourselves to get too tense also prevents the body from working efficiently, which in turn can affect the vocal cords. Tense jaws, chests, and locked knees all make it impossible to breath and produce good tone.

Male Vocal Cords and Female Vocal Cords

Males and females have different vocal cord sizes. Adult male voices are usually lower pitched and have larger folds. The male vocal folds are between 17mm and 25mm in length. The female vocal cords are between 12.5 and 17.5 in length. The difference in vocal cord size between males and females means they have differently pitched voices. Additionally, genetics also causes variances amongst the same sex, with men's and women's voices being categorized into differentsinging voice types.
The home singing courses in the table below will provide you with all the information and vocal cord exercises you need to master your voice and sing like a star.



New UD tissue-engineering research focuses on vocal cords
UD scientists Xinqiao Jia and Randall Duncan are shown with the novel bioreactor that Jia designed. The device can simulate the demanding, high-frequency environment in which vocal cord cells live, vibrating back and forth at up to 100 hertz (100 times a second). Photo by Kathy F. Atkinson
1:54 p.m., July 31, 2007--Damaged or diseased vocal cords can forever change and even silence the voices we love, from a family member's to a famous personality's.
Julie Andrews, who starred in such classics as The Sound of Music, is among the professional singers who have undergone surgery to remove callus-like growths that can form from overuse of these two small, stretchy bands of tissue housed in the larynx, or voice box. Sadly, Andrews may never fully recover her singing voice after surgery on her vocal cords in 1997.
Engineering pliable, new vocal cord tissue to replace scarred, rigid tissue in these petite, yet powerful organs is the goal of a new University of Delaware research project. It is funded by a five-year, $1.8 million grant from the National Institutes of Health's National Institute on Deafness and Other Communication Disorders.
Xinqiao Jia, UD assistant professor of materials science and engineering, is leading the project. Jia's research focuses on developing intelligent biomaterials that closely mimic the molecular composition, mechanical responsiveness and nanoscale organization of natural extracellular matrices--the structural materials that serve as scaffolding for cells. These novel biomaterials, combined with defined biophysical cues and biological factors, are being used for functional tissue regeneration.
Randall Duncan, associate professor of biological sciences and mechanical engineering at UD and an expert in cellular biomechanics and signal transduction, is a co-investigator on the project. He will assist the interdisciplinary research team in determining how vocal cord cells respond to mechanical forces, which is the first step in engineering functional vocal cord tissue. Duncan is actively involved in Jia's career development as her senior mentor at UD.
Rodney Clifton, professor of engineering at Brown University and a member of the National Academy of Engineering, is providing the project with a unique testing capability, using a device he invented that can measure the mechanical properties, or elasticity, of tissue samples at human speech frequencies. Jia began working with Clifton a few years ago when she was a postdoctoral researcher and he was a visiting scientist at the Massachusetts Institute of Technology.
Also collaborating on the project is Dr. Robert Witt, a head and neck oncologist at Christiana Care Health System, in Newark, Del. Witt will provide clinical expertise in vocal cord pathology. The research partnership was established through the Center for Translational Cancer Research, which is directed by Mary C. Farach-Carson, professor of biological sciences and material sciences at UD.
Dr. Robert Witt, a head and neck oncologist at Christiana Care Health System, is collaborating on the UD research project. Photo courtesy of Robert Witt.
According to Jia, the vocal cords are more accurately defined as “vocal folds.” Each vocal fold is a laminated structure consisting of a pliable vibratory layer of connective tissue, known as the lamina propria, sandwiched between a membrane (epithelium) and a muscle. These flexible folds of tissue, coated in mucous to keep them moist, operate like an elevator door and must come together to produce a sound.
When you talk or sing, the folds may vibrate more than 100 times a second from the air that is forced up from the lungs through the trachea. However, excessive use or abuse of the voice can lead to scarring of the vocal fold lamina propria, which disrupts their natural pliability, resulting in hoarseness and other symptoms of vocal dysfunction.
“The reduction of vocal-fold scarring remains a significant therapeutic challenge,” Jia said.
Jia and her colleagues want to explore two parallel tissue-engineering approaches to regenerate the lamina propria. One method focuses on injecting gelatin-like materials, composed of soft, strong and long-lasting hydrogels, into damaged tissue to improve its pliability and prevent scar formation.
In the second approach, the scientists want to form functional tissue from a combination of vocal fold connective tissue cells (fibroblasts), artificial extracellular matrix, and biological cues and mechanical stimuli that capture the mechanical and biological characteristics of the natural organs.
“In order to grow a functional tissue in vitro, you need to provide the cells with a biological and physical environment that is as close to that of the natural tissue as possible,” Jia said.
To mimic the complex and rigorous movement experienced by vocal fold tissue, the researchers have constructed a bioreactor capable of delivering well-defined vibrational and tensile stresses.
The device, which Jia designed, simulates the demanding, high-frequency environment in which vocal fold cells live, vibrating back and forth at up to 100 hertz (100 times a second). Not only do the vocal folds collide as they open and close, driven by air from the lungs, they also must be able to elongate as the pitch of the voice changes, a movement that occurs at a much slower frequency of 1-2 hertz (1-2 times a second), according to Jia.
Image of normal vocal cords, courtesy of the Milton J. Dance Jr. Head and Neck Center at the Greater Baltimore Medical Center, Baltimore. For video of the vocal cords in action and vocal cord disorders,click here.
“The combination of vocal fold fibroblasts, elastic and bioactive artificial extracellular matrices, and a dynamic bioreactor offers an exciting opportunity for in vitro tissue engineering of vocal fold lamina propria,” Jia noted.
Earlier this year, Jia received the National Science Foundation's Faculty Early Career Development Award. The highly competitive award is bestowed on those scientists deemed most likely to become the academic leaders of the 21st century.
Jia received her bachelor's degree in applied chemistry and master's degree in polymer chemistry and physics from Fudan University in Shanghai, China, and a doctoral degree in polymer science and engineering from the University of Massachusetts at Amherst.
Before joining the UD faculty in 2005, Jia worked as a postdoctoral researcher with Robert Langer, a pioneer in tissue engineering at the Massachusetts Institute of Technology. Langer recently was awarded the National Medal of Science, the nation's highest honor for science and technology.
Article by Tracey Bryant

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