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Monday, August 29, 2011

The Mind's Eye


The Mind's Eye

Long preoccupied with technology, David Hockney is exploring a new artistic medium that uses high-definition cameras, screens, software, and moving images to capture the experience of seeing.
  • BY MARTIN GAYFORD
A still from the 18-screen video May 12th 2011 Rudston to Kilham Road 5 PM. Credit: ©David Hockney
One of your basic contentions, I say to the British artist David Hockney, is that there is always more to be seen, everywhere, all the time. "Yes," he replies emphatically. "There's a lot more to be seen." We are sitting in his spacious house in the quiet Yorkshire seaside town of Bridlington. In front of us is a novel medium, a fresh variety of moving image—a completely new way of looking at the world—that Hockney has been working on for the last couple of years.
We are watching 18 screens showing high-definition images captured by nine cameras. Each camera was set at a different angle, and many were set at different exposures. In some cases, the images were filmed a few seconds apart, so the viewer is looking, simultaneously, at two different points in time. The result is a moving collage, a sight that has never quite been seen before. But what the cameras are pointing at is so ordinary that most of us would drive past it with scarcely a glance.
At the moment, the 18 screens are showing a slow progression along a country road. We are looking at grasses, wildflowers, and plants at very close quarters and from slightly varying points of view. The nine screens on the right show, at a time delay, the images just seen on the left. The effect is a little like a medieval tapestry, or Jan van Eyck's 15th-century painting of Paradise, but also somehow new. "A lot of people who were standing in the middle of the Garden of Eden wouldn't know they were there," Hockney says.
The multiple moving images have some properties entirely different from those of a projected film. A single screen directs your attention; you look where the camera was pointed. With multiple screens, you choose where to look. And the closer you move to each high-definition image, the more you see.
Hockney “draws” with images from nine cameras. Credit: David Hockney
"Norman said this was a 21st-century version of ­Dürer's [Large] Piece of Turf," Hockney says. By "Norman" he means Norman ­Rosenthal, the former exhibitions secretary of the Royal Academy in London and one of the doyens of the international contemporary-­art world. The comparison is an intriguing one. Albrecht Dürer's 1503 drawing (Das große Rasenstück in German) was a work of great originality.
Dürer used the media of the time—watercolor, pen, ink—to do something unprecedented: depict with great precision a little slice of wild, chaotic nature. He revealed what was always there but had never before been seen with such clarity. Hockney, in 2011, is doing the same job, using the tools of the moment: high-definition cameras and screens, computer software. Of course Hockney, too, is a painter—indeed, his grid of 18 flat screens, run by seven Mac Pro computers, looks much like one of his multipanel oil paintings. Except, of course, that every panel moves.
Hockney's technology assistant, Jonathan Wilkinson, explains how this 21st-century medium works. "We use nine Canon 5D Mark II cameras on a rig we've made, mounted on a vehicle—either on the boot or on the side. Those are connected to nine monitors. I set it up initially, taking instructions from David, to block it in. At that point we decide the focal length and exposure of each camera. There are motorized heads with which we can pan and tilt, once we've got going, while we're moving along. There's a remote system he can operate from the car."
Hockney compares that process to drawing. For him, drawing is not merely a matter of making lines with a tool; it's fundamentally about constructing a two-dimensional image of three-dimensional space. He argues that the same is true of putting photographic images together in a collage, and also of altering a single photograph. Hockney complains that today's media are full of badly drawn (that is, Photoshopped) photographs.
Jonathan Wilkinson, Hockney, and Dominic Elliott rig up the cameras. Credit: Jean-Pierre Goncalves de Lima
The wild plants at the side of the road are only one subject. A number of other films chart the sequence of the seasons in the quiet corner of the English countryside where Hockney now spends much of his time. These too present a subject that is centuries old (the four seasons were a feature of medieval books of hours), but with a twist made possible by technology that became available only very recently.
They offer a lesson in the startling changes in vegetation, quality of light, and patterns of shadow that a few months will bring. The left-hand side will show, say, a progression down a country road in early spring, the right-hand side the same journey taken at exactly the same speed past the identical trees, fields, and bushes in high summer: the same, but utterly transformed. Because it is in practice impossible to drive at absolutely the same speed along a road in spring, summer, and winter, the precise synchronization of these sequences is achieved by editing. "Because we've done things at different times of the year," as Wilkinson puts it, "we remap time to get them in the same place simultaneously in each film."
The Camera's Eye
"A lot of people have told me," Hockney remarks, "that before they see these films they can't imagine what nine cameras could do that one can't. When they see them, they understand. It's showing a lot more; there's simply a lot more to see. It seems you can see almost more on these screens than if you were really there. Everything is in focus, so you're looking at something very complicated but with incredible clarity." In a way, this is a matter of multiplication: nine cameras see many times more than one.
Furthermore, Hockney believes that his multiscreen film collages are closer than conventional photography to the actual experience of human vision: "We're forcing you to look, because you have to scan, and in doing so you notice all the different textures in each screen. These films are making a critique of the one-camera view of the world. The point is that one camera can't show you that much."
Stills from Woldgate 7 November 2010 11:30 AM (left) and Woldgate 26 November 2010 11 AM (right). Credit: ©David Hockney
You could say Hockney is using cameras to reveal the limitations of the camera. The films are the result of decades' thought about the place of old art forms—painting and drawing—in a world dominated by rapidly evolving photographic and electronic media.
Now 74, Hockney was born in Bradford, on the other side of Yorkshire, in 1937. It was apparent from early on that he was an exceptionally brilliant draftsman. Indeed, he belongs to one of the last generations of artists to receive a rigorous training in draftsmanship before art education changed in the late 1960s.
Hockney started using photographs as a basis for paintings in the late 1960s. But he became dissatisfied with the direction his work was taking, which in some cases veered toward a form of photorealism. By the '80s he was conducting a personal research program into the nature of pictorial and photographic space. He began to entertain the idea that what the camera sees and what the eye sees are in some ways fundamentally different. "Most people feel that the world looks like the photograph," he says. "I've always assumed that the photograph is nearly right, but that little bit it misses by makes it miss by a mile. This is what I grope at."
A camera looks through one lens; we look—most of us, at least most of the time—through two eyes. Then we are not just looking at a scene from outside; we are always in it. People, you might say, are biological sensing devices, placed in an infinitely complex three-dimensional environment. What we see, subjectively, is always related to what we are interested in. Or, in Hockney's epigram, "The eye is attached to the mind."
Pearblossom Hwy. (1986) Credit: Collection: The J. Paul Getty Museum, Los Angeles. ©David Hockney
In the early 1980s, Hockney began a series of composite or collaged pictures made from a mosaic of Polaroid snaps, including Luncheon at the British Embassy, Tokyo, Feb. 16, 1983and the several versions of Pearblossom Hwy. (1986). These were images with not one viewpoint but dozens, presenting—Hockney would argue—a representation of the world truer to experience than a single photograph. (Just as today he likens his multiple-screen images to drawing, he classified these Polaroid collages as drawings rather than photographs.) At the time, he wanted to make moving multiple-viewpoint images—and produced one for a television documentary—but the process was prohibitively complex and costly. Only in the last few years has the technology become available that allows him to do so with his own studio team, and in richly detailed quality.
Another result of this preoccupation with the role of lenses in the making of art was his bookSecret Knowledge (2001). In it, Hockney argued that Western art had been affected by the lens-eye view for centuries before the official advent of photography in 1839. It had long been known that some artists had used the camera obscura—essentially, a filmless camera that came in portable or room-size versions (both Canaletto and Joshua Reynolds owned the former). But whereas conventional art history had tended to minimize this, Hockney maximized it.
An artist of the Renaissance or Baroque eras might have used a camera image in many ways. For Canaletto, tracing the image onto paper was evidently a handy way of noting architectural detail (such drawings by him, with a telltale traced line, exist). But other painters might have learned from observing how a camera obscura simplifies highlights and shadows onto a two-dimensional surface. There are compelling resemblances between such projections and 17th-­century painting. Once you've seen them it is hard to believe that Caravaggio, Van Dyck, and Dutch still-life painters hadn't looked through a camera obscura.
But there have always been ways to draw and paint that do not imitate cameras. Hockney reminds us that Far Eastern art, for example, has neither Renaissance-style single-­vanishing-point perspectives nor shadows. The former is an optical property of a single-lens view; the latter result from the strong illumination that cameras tend to require.
Luncheon at the British Embassy, Tokyo, Feb. 16, 1983. Credit: Photo: Richard Schmidt. ©David Hockney
The most recent of Hockney's nine-screen films were shot in his huge and light-filled Bridlington studio. They look like a cross between silent comedies and Chinese scrolls, filled with a characteristic range of astonishingly saturated color and—because of both the cameras and the light flooding through windows in the roof—without shadows.
Art as Technology
An exhilarating aspect of Hockney's approach is that it widens art history into a unified account of pictures, images, of all kinds—handmade, photographic, cinematic, televisual. They are all part of the same story. He is, for example, strongly interested in the movies (after all, before coming to work in Yorkshire in 2000, he lived for three decades in Los Angeles, which he still calls his base).
A basic point for Hockney is that all art is based on technology. The paintbrush, as he says, is a technological device. And paint, a discovery tens of thousands of years old, can still produce an intensity of color that no screen or printing machine can equal.
Though drawing itself is a very old human technique—going back at least to the prehistoric cave paintings of southwestern France—Hockney has been adept at using new technology to find new ways to draw. In the 1980s he used early color photocopiers and fax machines to make art. Using the fax, he distributed art by telephone; with the photocopier he made prints that, paradoxically, could not be photocopied (if you make an intense black by putting the paper through the machine four times, it cannot be replicated by a single copying process).
Untitled, 30 November 2010, No. 1, created on an iPad. Credit: ©David Hockney
During the last three years, he has been fascinated by the possibilities of drawing on, first, an iPhone and then—as soon as it appeared—an iPad. He had tried earlier forms of computer drawing but found them too slow for practical use. Now the iPad, plus an app called Brushes, is his medium of choice. He uses it as an electronic sketchbook; it is always by his side. A steady flow of iPhone and iPad drawings—loose, free, experimental, and intimate—pop, sometimes every day, into the mailboxes of his friends and acquaintances. More than 200 are currently in mine. They add up to a visual diary, recording sights that fall under Hockney's eyes as he moves through his day: the view from his bedroom window at dawn, the kitchen sink, a coffee cup, a candle burning in the evening. Looking at them gives clues to where Hockney is, how he's feeling, and what the current weather is like in east Yorkshire.
Recently he has begun printing Brushes drawings out at a large scale (this requires a program that prevents the images from pixelating, as they otherwise would). Early next year a sequence of these grand-scale iPad pictures will fill the largest gallery at the Royal Academy, where there is an exhibition of Hockney's new work depicting the very same Yorkshire landscapes that he films with his nine cameras and paints in oil. His work in all three media is interdependent. The paintings and drawings led on to the films, and the films in turn prompt new directions for the paintings and drawings.
All Hockney's work and thought is dedicated to the proposition that there is always more to see in the world around us. Art is a way—you might say a set of technologies—for making images, preserving them in time, and also for showing us things we aren't normally aware of. Those might include gods, dreams, and myths, but also hedgerows.
"Don't we need people who can see things from different points of view?" Hockney asks. "Lots of artists, and all kinds of artists. They look at life from another angle." Certainly, that is precisely what David Hockney is doing, and has always done. And yes, we do need it.
Martin Gayford is the chief art critic for Bloomberg News. His 2005 portrait by Lucian Freud, Man with a Blue Scarf, which has been exhibited at the Correr Museum in Venice and the Museum of Modern Art in New York, was the occasion of his most recent book, also titled Man with a Blue Scarf. His next book, A Bigger Message: Conversations with David Hockney, will be published in October.

Arabidopsis: Thanks to Its Flexible Genome, the Plant Can Adapt to Various Environmental Conditions



Different mutants of Arabidopsis thaliana. (Credit: Copyright Detlef Weigel/MPI f. Developmental Biology)
Science Daily — People can develop new technologies, and animals may migrate to other regions. However, plants are tied to their location. Nevertheless, they have found ways to ensure their survival. This is the case for the Arabidopsis thaliana, found throughout the entire northern hemisphere. But how does this small, inconspicuous plant deal with all these different extremes?


















Which genes and gene variants allow different individuals of one species to thrive under very different environmental conditions? The model plant for genetics, the thale cress, Arabidopsis thaliana, is especially well suited for investigating this question. It can deal with heat and drought in northern Africa and cold in the central Asian highlands and European temperate zones. Depending on the region it may display extensive foliage or appear small and fragile, yet it is always the same species. The answer lies without doubt in the diversity of its genetic material. Detlef Weigel and Karsten Borgwardt from the Max Planck Institute for Developmental Biology, Gunnar Rätsch from the Friedrich Miescher Laboratory in Tübingen, and Karl Schmid of the University of Hohenheim have, together with an international team, sequenced and analyzed the genome of different Arabidopsis strains from all over Europe and Asia. To reveal the effect of geographic distance on the genes they selected plants from strains growing locally -- in the Swabian Neckar Valley -- as well as plants growing at opposite ends of the plant's distribution area, such as North Africa or Central Asia.
The 1001 Genomes Project was launched in 2008 to discover the whole-genome sequence variation, with eleven research institutes participating worldwide. By investigating the genetic material of about one hundred strains of this plant from different geographical regions, researchers found a huge number of variations: in addition to millions of small differences that lead to a diversity of molecular gene products, they found hundreds of genes that are missing in some strains or have extra copies in others. This great flexibility within the genetic material makes this plant particularly adaptable. In the medium term, the complete catalogue of the genome and gene product variation of a species can be applied to modern plant breeding.
By sequencing nearly 100 genomes of different strains, the scientists hope to obtain a fundamental scientific understanding of evolution. The resulting information should pave the way for a new era of genetics in which alleles underpinning phenotypic diversity across the entire genome and the entire species can be identified. Scientists have found that thousands of proteins differ in their structure and function in the different Arabidopsis strains. In addition, they found several thousand cases of extra copies of genes, gene loss, and new genes previously only found in other plant species. "Our results show very impressively just how pronounced the genetic variability is," says Jun Cao from the Max Planck Institute for Developmental Biology and first author of one of the projects. Karl Schmid of the University of Hohenheim adds: "Adaptation through new mutations is very rare. More important is the recombination of already existing variants. With the information from more than a hundred genomes, not only can we make statements about these hundred individuals, but have thus laid the foundations to predict the genetic potential which could be realized by crossing particular individuals."
The geneticists working with Detlef Weigel, Karsten Borgwardt and Karl Schmid also found that the level of genetic variation differs widely between different regions. The researchers found the greatest genetic diversity in the Iberian Peninsula, where the plants have existed for a very long time. In Central Asia, which was only colonized after the last ice age, the Arabidopsis plants have relatively uniform genomes. Moreover, these populations have an above-average number of mutations that cause disadvantages for the plant, since protein functions are changed. Normally, natural selection removes these mutations over time, but in young emigrant populations they are enriched through cases of random evolution. "Figuring out how the plants and their genomes adapt to their environment is like a puzzle," says Jun Cao. "We need to collect all the pieces, before we can fit them together." The scientists have managed to create a nearly complete catalog of the genome variation of a species.
But how do these variations interact at the molecular level and what changes do they cause in the gene products? The computational biologist Gunnar Rätsch from the Friedrich Miescher Laboratory examined these questions in detail in a second study together with his international colleagues. They analyzed 19 strains of Arabidopsis with a particularly large genetic variability. These 19 individuals formed the basis of an artificial population of several hundred strains, created through multiple crosses such that different genome segments were shuffled systematically. The resulting individuals are ideally suited for examining gene interactions.
The scientists studied the genome segments using novel analysis methods of analysis and discovered in detail how DNA is read in detail and how the intermediate stage of protein production, the RNA, is produced. The researchers obtained detailed insight into the altered gene products arising from the various genomic variants. Depending on the genomic context some gene segments were either shut down or reactivated. "We can find a surprising number of changes affecting a single gene. However, they are often compensated for and therefore often have no significant effect on the gene products," says Gunnar Rätsch about the new results. The concepts, methods and platforms developed based on the genomic variation ofArabidopsis thaliana can also be used to study crop plants and for fast and accurate mapping of desirable characteristics. In addition, researchers can transfer this understanding about the influence of variation on gene products and their interactions to studies of the human genome.
These new projects should be viewed in the context of the 1001 Genomes Project, which was launched in 2008 at the Max Planck Institute for Developmental Biology and is being implemented through many individual projects in cooperation with ten other institutions worldwide. The aim is to analyze and compare the genes of 1001 different Arabidopsis strains. The goal of this large-scale project is to obtain fundamental insights into evolution, genetics and molecular mechanisms. Almost 500 different genomes have already been sequenced and analyzed at the different institutions. The data is being fed into a public database, which can be accessed not only by participants of the projects, but by all interested scientists.

Peculiar Pair of Galaxies Nicknamed 'The Eyes'


ESO's Very Large Telescope has taken a striking image of a beautiful yet peculiar pair of galaxies nicknamed The Eyes. The larger of these, NGC 4438, was once a spiral galaxy but has become badly deformed by collisions with other galaxies in the last few hundred million years. (Credit: Image courtesy of ESO)
Science Daily  — The European Southern Observatory's Very Large Telescope has taken a striking image of a beautiful yet peculiar pair of galaxies nicknamed The Eyes. The larger of these, NGC 4438, was once a spiral galaxy but has become badly deformed by collisions with other galaxies in the last few hundred million years. This picture is the first to come out of ESO's Cosmic Gems programme, an initiative in which ESO has granted dedicated observing time for outreach purposes.


























But although the centres of these two galaxies look similar, their outskirts could not be more different. The galaxy in the lower right, known as NGC 4435, is compact and seems to be almost devoid of gas and dust. In contrast, in the large galaxy in the upper left (NGC 4438) a lane of obscuring dust is visible just below its nucleus, young stars can be seen left of its centre, and gas extends at least up to the edges of the image.
The Eyes are about 50 million light-years away in the constellation of Virgo (The Virgin) and are some 100 000 light-years apart. The nickname comes from the apparent similarity between the cores of this pair of galaxies -- two white ovals that resemble a pair of eyes glowing in the dark when seen in a moderate-sized telescope.
The contents of NGC 4438 have been stripped out by a violent process: a collision with another galaxy. This clash has distorted the galaxy's spiral shape, much as could happen to the Milky Way when it collides with its neighbouring galaxy Andromeda in three or four billion years.
NGC 4435 could be the culprit. Some astronomers believe that the damage caused to NGC 4438 resulted from an approach between the two galaxies to within about 16 000 light-years that happened some 100 million years ago. But while the larger galaxy was damaged, the smaller one was significantly more affected by the collision. Gravitational tides from this clash are probably responsible for ripping away the contents of NGC 4438, and for reducing NGC 4435's mass and removing most of its gas and dust.
Another possibility is that the giant elliptical galaxy Messier 86, further away from The Eyes and not visible in this image, was responsible for the damage caused to NGC 4438. Recent observations have found filaments of ionised hydrogen gas connecting the two large galaxies, indicating that they may have collided in the past.
The elliptical galaxy Messier 86 and The Eyes belong to the Virgo Cluster, a very rich grouping of galaxies. In such close quarters, galaxy collisions are fairly frequent, so perhaps NGC 4438 suffered from encounters with both NGC 4435 and Messier 86.
This picture is the first to be produced as part of the ESO Cosmic Gems programme. This is a new initiative to produce astronomical images for educational and public outreach purposes. The programme mainly makes use of time when the sky conditions are not suitable for science observations to take pictures of interesting, intriguing or visually attractive objects. The data are also made available to professional astronomers through ESO's science archive.
In this case, although there were some clouds, the atmosphere was exceptionally stable, which allowed very sharp details to be revealed in this image taken using the VLT's FORS2 instrument. Light passing through two different filters was used: red (coloured red) and green-yellow (coloured blue), and the exposure times were 1800 seconds and 1980 seconds, respectively. FORS2 is the visual and near ultraviolet FOcal Reducer and low dispersion Spectrograph for the VLT. It is installed on the VLT's Unit Telescope 1.

Women, Education and Equality in Nepal


The Constitution of Nepal 2015 has been a huge improvement from the days of yore:  Article 43 deals with the rights of women that include rights to lineage, right to safe maternity and reproduction, right against all forms of exploitation, and equal rights in family matters and property. The Government of Nepal is also working to incorporate gender equality in all development policies and programs, including developing a gender responsive budget system. We also have excellent examples of women making great leaps in almost all fields – science, economics, banking and finance, media, environment, education, public health, social service and development. And in a heartening move, Chhaupadi, an inhuman practice that imposes upon women to stay outside their homes in unhygienic cow sheds during menstruation and childbirth, is set to be criminalized in the new legal code. However, progress made in specific fields has not yet contributed to the overall improvement in girls’ and women’s lives across the country. Similarly, plans and policies do not always spur positive changes in reality. In Nepal, the male and female literacy rates stand at 71.6% and 44.5% respectively, pointing to a huge disparity between the two genders. Credit: Bijay Gajmer/World Bank According to the Nepal Living Standards Survey (2010/11) Nepal has an adult literacy rate of 56.6%. However, the male and female literacy rates stand at 71.6% and 44.5% respectively, pointing to a huge disparity between the two genders. The National Census 2011 states that the literacy rates of men and women in Nepal differ by 17.7%. It is then no surprise that women have less education, information, and opportunities for self-enhancement at home, let alone in the professional world. More alarming, girls and young women, burdened by household chores and societal restrictions, are at a high risk of dropping out of school before even completing primary education. Similarly, a National Women’s Commission Report on the Socio-Economic Status of Women in Nepal presents evidence that women have lower access to education, health services, property, social security and freedom, as well as decision-making processes. This is a constant reminder that although Nepal has made progress, gender equality has not been achieved. Women in Nepal still face challenges in conferring citizenship rights to their offspring without the consent and support of the father, leaving single mothers at a huge disadvantage. Girls and young women face numerous challenges in their everyday life, ranging from the ill effects of early marriage to psychological and sexual violence, fewer opportunities in the workspace to superstitions and societal traditions that always seem to place women on a lower rung. International Women’s Day is a day which all conscientious and thoughtful individuals must carry in their hearts and minds. If we are to make our individual countries and the entire world a better –and more equal-- place for all men and women, every single day needs to be imbibed with the basic spirit of this day. In Nepal, the engine of change has been kicked into ignition. And each one of us is responsible to keep it running along the path to transformation.  

Irrigation and climate change





While attention has, appropriately, been focused on getting food and medicines to the victims of the famine in the Horn of Africa, many observers are asking about longer-term solutions, especially if droughts such as the current one become more frequent with climate change. One possibility is to expand irrigation. 

Currently, only about 4 percent of Sub-Saharan Africa’s arable land is irrigated; the rest is rain-fed, meaning it is susceptible to droughts and floods.  Yet, irrigated land can haveyields that are up to five times those of rain-fed areas.  It must be the case that the costs of irrigation—capital, recurrent, administrative, political—are sufficiently high to outweigh these benefits.  But if you take into account the possibility of more frequent floods and droughts, which would make irrigated land relatively more attractive, does the benefit-cost calculation change?

The short answer is yes.  In a calculation for the Zambezi basin, Aziz Bouzaher and Iestimate that the costs of tripling the irrigated area are about equal to the benefits—if you ignore the effects of climate change.  It is not surprising therefore that there has not been much investment in irrigation.  But when you include as benefits of irrigation the avoided damage from increasingly frequent droughts (using fairly conservative assumptions), the overall benefits are double the costs.  Recognizing that the effects of climate change will increasingly affect rain-fed agriculture may tip the scales in favor of more irrigation in Africa, and lead to higher yields for African farmers.

Possible Biological Control Discovered For Pathogen Devastating Amphibians



Zoologists at Oregon State University have discovered that a freshwater species of zooplankton will eat a fungal pathogen which is devastating amphibian populations around the world.
Researchers have confirmed that this zooplankton, Daphni magna, will eat a deadly fungus that is devastating amphibian populations around the world. It may provide a new biocontrol agent to help address this crisis. (Photo courtesy of Oregon State University)
This tiny zooplankton, called Daphnia magna, could provide a desperately needed tool for biological control of this deadly fungus, the scientists said, if field studies confirm its efficacy in a natural setting.
The fungus, B. dendrobatidis, is referred to as a “chytrid” fungus, and when it reaches high levels can disrupt electrolyte balance and lead to death from cardiac arrest in its amphibian hosts. One researcher has called its impact on amphibians “the most spectacular loss of vertebrate biodiversity due to disease in recorded history.”
The research, reported today in the journal Biodiversity and Conservation, was supported by the National Science Foundation.
“There was evidence that zooplankton would eat some other types of fungi, so we wanted to find out if Daphnia would consume the chytrid fungus,” said Julia Buck, an OSU doctoral student in zoology and lead author on the study. “Our laboratory experiments and DNA analysis confirmed that it would eat the zoospore, the free-swimming stage of the fungus.”
“We feel that biological control offers the best chance to control this fungal disease, and now we have a good candidate for that,” she said. “Efforts to eradicate this disease have been unsuccessful, but so far no one has attempted biocontrol of the chytrid fungus. That may be the way to go.”
The chytrid fungus, which was only identified in 1998, is not always deadly at low levels of infestation, Buck said. It may not be necessary to completely eliminate it, but rather just reduce its density in order to prevent mortality. Biological controls can work well in that type of situation.
Amphibians have been one of the great survival stories in Earth’s history, evolving about 400 million years ago and surviving to the present while many other life forms came and went, including the dinosaurs. But in recent decades the global decline of amphibians has reached crisis proportions, almost certainly from multiple causes that include habitat destruction, pollution, increases in ultraviolet light due to ozone depletion, invasive species and other issues.
High on the list, however, is the chytrid fungus that has been documented to be destroying amphibians around the world, through a disease called chytridiomycosis.
Its impact has been severe and defied various attempts to control it, even including use of fungicides on individual amphibians. Chytridiomycosis has been responsible for “unprecedented population declines and extinctions globally,” the researchers said in their report.
“About one third of the amphibians in the world are now threatened and many have gone extinct,” said Andrew Blaustein, a professor of zoology, co-author on this study and an international leader in the study of amphibian decline.
“It’s clear there are multiple threats to amphibians, but disease seems to be a dominant cause,” he said.
Although they have survived for hundreds of millions of years, amphibians may be especially vulnerable to rapid environmental changes and new challenges that are both natural and human-caused. They have a permeable skin, and exposure to both terrestrial and aquatic environments.
Because of this, OSU researchers said, other animals such as mammals, birds and fish have so far not experienced such dramatic population declines.

Protein in the urine spells kidney failure for African-Americans



African Americans are four times more likely to develop kidney failure than whites. A new study has found that a condition that occurs when the kidneys are damaged and spill protein into the urine contributes to this increased risk.
Proteinuria is another name for high protein in urine. Everyone has protein in their body and it is needed to help with bones, muscles, your hair and nails. They will help keep you healthy and help your blood clot when you are suffering from an injury. The kidneys play a very large role in filtering out the protein in your urine. If they are damaged and unable to complete this task, you may have high protein levels in your urine.
The study, conducted by William McClellan, MD of Emory University and his colleagues, appears in an upcoming issue of the Journal of the American Society Nephrology (JASN), a publication of the American Society of Nephrology.
The investigators analyzed information from 27,911 individuals (40.5% of whom were African Americans). Among the major findings:
  • After an average follow-up of 3.6 years, 133 individuals developed kidney failure.
  • There were 96 cases of kidney failure among African Americans and 37 among whites.
  • Kidney failure was most common in individuals who excreted large amounts of protein in their urine.
  • African Americans were more likely to excrete large amounts of protein in their urine than whites.

The investigators speculate that several factors may explain why African Americans tend to excrete more protein in their urine. These could include blood pressure and other heart-related factors, obesity, smoking, vitamin D levels, genetic differences, income, and birth weight. These factors may act at different times during an individual’s life to affect kidney health.
“Our large nationwide study brings attention to higher levels of urinary protein excretion as important contributors to the increased incidence of kidney failure experienced by blacks,” said Dr. McClellan. Treating urinary protein excretion may help reduce racial disparities related to kidney failure as well as reduce the rate of progression to kidney failure for all individuals.

Study co-authors include David Warnock, MD, Suzanne Judd, PhD, Paul Muntner, PhD, Leslie McClure, PhD, George Howard, DrPh (University of Alabama at Birmingham); Reshma Kewalramani, MD (Amgen Corporation); Mary Cushman, MD (University of Vermont); and Britt Newsome, MD (Denver Nephrologists, PC).
Disclosures: This research project is supported by a cooperative agreement U01 NS041588 from the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Department of Health and Human Services. Additional funding was provided by an investigator-initiated grant-in-aid from Amgen Corporation. Amgen did not have any role in the design and conduct of the study, the collection, management, analysis, and interpretation of the data, or the preparation or approval of the manuscript. The manuscript was sent to Amgen for review prior to submission for publication.
The article, entitled “Albuminuria and Racial Disparities in the Incidence of End-Stage Renal Disease,” will appear online at http://jasn.asnjournals.org/doi 10.1681/ASN.2010101085