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Friday, July 22, 2011

Why Location Matter in Manufacturing


BUSINESS

Location Matters in Manufacturing

Research shows that regional and national differences in manufacturing practices help determine whether emerging technologies are economically viable.
  • BY DAVID ROTMAN
The migration of manufacturing from the United States to Asia could have a significant impact on which advanced technologies are commercialised. Specifically, there is evidence that the shift in manufacturing is curtailing the development of emerging technologies in areas such as optoelectronics and advanced materials for the automotive industry.
In studies with colleagues at MIT, Erica Fuchs, an assistant professor of engineering and public policy at Carnegie Mellon University in Pittsburgh, shows that the relocation of component manufacturing from the United States to East Asia in optoelectronics and to China in composite body parts for automobiles changed the economics of producing the technologies. The result in both cases is that emerging technologies developed in the United States were not economically viable to produce in the Asian countries because of differences in manufacturing practices. And Fuchs suspects similar effects are happening more generally as production shifts to the developing world. Location matters for "which products will be economically viable, which products countries will be most competitive in producing, and which products countries and companies globally are most likely to develop," she says.
The findings add to a growing awareness that manufacturing is critical in driving innovation. Harvard Business School professors David Pisano and Willy Shih argue, for example, that innovation capacity often disappears if a country loses its manufacturing sector, because the knowledge and abilities needed to develop new technologies are often closely linked to the skills and expertise associated with manufacturing (see "Innovation Depends on a Robust Manufacturing Sector"). Fuchs builds on this idea by showing that regional manufacturing differences can cause the most advanced technologies to fall by the wayside. "Manufacturing locations can affect the evolution of technology globally," she says.
At the core of Fuchs' argument is the recognition that there are significant differences in manufacturing practices in different countries and regions, and that those differences drive which technologies are economically viable to produce. While labor cost is the most obvious difference between countries, Fuchs says, it is not necessarily the most important one. Manufacturing downtime, yields, and material costs and quality are among the factors influenced by location. Engineers are routinely taught in introductory design classes to "take all these different variables into account when considering the most competitive technology," she says. Yet businesses and policy makers often neglect the potential impact of manufacturing location on technology competitiveness when picking manufacturing locations.

In the case of optoelectronics, Fuchs and her colleagues examined how manufacturing economics affected the commercialization of new integrated circuits in which various photonic components, such as lasers and modulators, are squeezed together on a single chip.  Fuchs found that in the United States, the newer technology would be cheaper to produce than older optoelectronic designs, in which the laser and other photonic devices are built as discrete components. But in East Asia, the reverse is true; her analysis showed that because of local manufacturing practices, the older design was cheaper to make. As a result, says Fuchs, working on developing the new technology "was largely abandoned" by the companies that shifted their manufacturing away from the United States. 
Fuchs drew similar lessons from a case study on the automotive industry, where cars made with polymer composite bodies are far lighter and thus consume less gasoline than cars with conventional steel bodies. Producing the new composite bodies could be competitive with the prevailing technology when the manufacturing was done in the United States. But in China, the newer technology is more expensive to make than the prevailing one. Her analysis shows, for example, that assembly accounts for more of the cost in steel bodies than composite bodies, and assembly is cheaper in China than in the United States. In composite automotive parts, material costs dominate, and there China lost its advantages.
Of course, consumers in different countries tend to prefer different types of cars, and those preferences can also help determine which technology is most economically attractive for local manufacturers. But surprisingly, says Fuchs, she found that manufacturing variables were far more significant than consumer preferences in determining the economic viability of the automotive technologies.
What happens to emerging technologies when manufacturers abandon them? Where do the engineers who worked on the newer technologies go? Can new companies sprout up in developed countries to exploit the newer technologies? Fuchs is beginning to look at those questions. Much of the responsibility for commercializing the emerging technologies will fall to small firms, supported by venture capital and government funding. But it's unclear whether those companies can compete in the short term with larger, multinational firms pursuing older technologies that are currently more cost-effective. "Does our innovation ecosystem have a way to push the new technology forward anyway—to have inventors move to new places and pick up the technologies, or to have other firms pick up the new technologies?" she asks.
But Fuchs also says her research suggests there are plenty of opportunities for businesses that learn how to take advantage of regional and national differences to match technologies with manufacturing locations. In this globalized world, "we have to understand national differences and what they mean for the economic viabilities of emerging technologies," she says. "And we have to learn to integrate [these national differences] into new technology development, not just from the market side but also from the production side."

RNA-Based Cholesterol Drug Is Readied for Human Tests

New methods for delivering the therapies to the target tissue could boost a wavering field.
  • BY LAUREN GRAVITZ
A number of drugs can help lower dangerously high cholesterol, but as many as half a million people worldwide are resistant to existing therapies. Alnylam Pharmaceuticals, a leader in the development of therapies using RNA, aims to begin human tests of a treatment that could make a drastic dent in drug-resistant high cholesterol. The company recently filed a clinical trial application to test a new formulation of the drug in 32 U.K. volunteers. It will be the fourth therapy from Alnylam to be tested in humans.
The technology targets an enzyme involved in clearing cholesterol from the blood. A single dose has already been shown to reduce LDL, or "bad," cholesterol, in nonhuman primates by as much as 50 percent.
Alnylam's technique coöpts a method of gene silencing employed by our own cells. It uses short lengths of small interfering RNA (siRNA) to interrupt gene transcription and prevent the production of proteins produced by the gene. The process was first discovered in animals fewer than 15 years ago, and was heralded as a way for drug manufacturers to regulate troublesome, disease-causing genes. Over two dozen such therapies have advanced to early-stage clinical trials.
But progress hasn't been as fast as pharmaceutical companies had hoped. Last year alone, Roche terminated its program after only three years, and Novartis decided not to spend $100 million to renew its partnership with Alnylam.

One big problem is getting the molecules delivered to the right tissues. Many RNA interference approaches use "naked" siRNA delivered as directly as possible to the relevant tissue, such as the eyes or lungs. But this only works for easy-to-access tissues. In Alnylam's cholesterol therapy, siRNA is encapsulated into a lipid-based nanoparticle designed to be taken up by liver cells. The siRNA blocks transcription of the gene that produces an enzyme called PCSK9, which binds to LDL receptors on liver cells and prevents them from clearing LDL from the blood.
A new version, developed in collaboration with AlCana Technologies and MIT researchers, uses the same siRNA encapsulated in a nanoparticle that is more effectively taken up by the liver. In animal testing, the second-generation drug was just as effective as the first at a substantially lower dose.
"A few years ago, achieving human systemic delivery was something that was still on the horizon for us," says Akshay Vaishnaw, Alnylam's chief medical officer. "But our second-generation nanoparticles have now shown very effective systemic delivery in nonhuman primates in very low doses."
Alnylam and its collaborators have developed an extensive library of lipids, each with specific properties that can help get their payload to the right tissue. "They have this nice grocery store of [lipid-like molecules] that they can pull off the shelf and test for various indications," says John Rossi, a researcher at City of Hope in Duarte, California. Rossi was not involved with the research but is working with a competing company on an siRNA treatment for HIV. "I think it's a great technical improvement in the field," he says.

Yes, South Sudan Can


At the recent launch of the book, Yes Africa Can: Success Stories from a Dynamic Continent, someone asked whether there are any lessons for Africa’s newest country, South Sudan.  I can think of at least three.

1.It can be done.  Yes Africa Can documents a number of countries, such as Mozambiqueand Uganda, which emerged from civil conflict and sustained above-7-percent GDP growth for over a decade.  It also describes the well-known case of a mineral exporter, Botswana, that had the world’s fastest per-capita growth rate (7 percent) from 1966-99.   These case studies show that South Sudan, which is both a post-conflict country and an oil exporter, can also succeed.

2.Home-grown solutions.  Whether it’s Mali’s mangoesRwanda’s gorilla tourism orKenya’s kickstart irrigation pumps, most of the case studies in the book describe interventions that were inspired, designed and promoted by the citizens of the country.  Perhaps the most extreme case is Somaliland where, in the absence of other aspects of a state, people have organized themselves to provide security to traders.  And the case ofNew Rice for Africa (NERICA) shows how, by having African farmers test and give feedback on new seed varieties as they were being developed, they were able to increase adoption rates and productivity from this agricultural innovation.  While welcoming the advice and support from the international community, South Sudan stands a greater chance of success if they can adapt this assistance to local conditions, listening to their people.

3.Technology.  Unlike other African countries, South Sudan is gaining independence in the digital technology era.  Meanwhile, the growth and spread of information and communications technology (ICT) in Africa has been a real success story.  And M-PESA, Kenya’s mobile payments system, is used by about half the adult population.  South Sudan, which is sparsely populated with poor transport infrastructure, has an opportunity to harness this technology to overcome some of the traditional barriers to development.  They have already started by collecting survey data with cell phones; they could go further with the use of mobile phones for health care and laptops for education.
 

Only the sky is the limit!


Hello everybody!

My name is Beatriz, I am a social change-maker from Peru. In 2003, thanks to the Development Marketplace, a group of enthusiastic, passionate young people in Lima received funds to start the first Cybercafé for the blind in Peru. During the first year, more than 250 visually impaired were trained in word processing and E-Mail.

 In 2004, the World Bank invited us to Washington, to exchange lessons and experiences among other Latin American projects. Certainly, this opportunity was extremely beneficial to our project. Now, thanks to private sponsorship, our Cybercafé has become ATECNODIS, an NGO that promotes access to information and technology for the visually impaired.

Why our project? Every day, disabled people face great difficulties to access digital information and entertainment. Things that are common in your life, such as chat in Messenger or sharing photos on Facebook, are unachievable for thousands of blind people in Peru. Thanks to our pioneering Cybercafé, these dreams came true in Lima, and now, people in the capital have some the opportunity to participate as well.

But what about people in outlying provinces or rural areas? This is the gap I want to bridge by launching the first mobile training center called "Edubus: Education on Wheels." The project seeks to empower those who cannot travel to a special training center.

Since I lost my sight when I was a child, Braille was the main tool to use for my education. In 2001, I received a scholarship from Japan International Cooperation Agency (JICA) to pursue studies in computer programs for the blind, and since then, my life was completely changed.

My passion is to travel, to explore different worlds, countries, situations. I love challenges, and I know how important is to be trained in mobility and the use of technology to go steps beyond what could have ever been imagined. At present, I am one of the 17 participants at the International Institute for Social Entrepreneurs (IISE), in Kerala, India. IISE is a factory of dreams that promotes social change through innovation. I am experiencing a unique opportunity to interact with people from different countries, share inspiring stories and help underprivileged children.

Here in India I go frequently through rural areas, walk along narrow roads and interact with local citizens in Malayalam, the second most difficult language in India. And in April, I traveled alone three days to Delhi by train, with the purpose of visiting the Taj Mahal as well as other centers for the blind. Visiting world famous monuments, touching camels and snakes was amazing!

Now, I am ready to start my adventures in the Andes. Can you imagine how exciting it will be to travel in my Edubus, crossing rivers, and climbing hills to reach my beneficiaries? There, in the middle of the nature, I can download my favorite songs or read an audio book. Looking back through my life, I can say from experience that nothing is impossible, only the sky is the limit!

Fountains of Knowledge: Interactions with Rural Residents Living in Pakistan's Northwestern Border Areas

Fountains of Knowledge: Interactions with Rural Residents Living in Pakistan's Northwestern Border Areas

The best part about working in a country office is the wide array of stakeholders one gets to work with. Development is never a solitary, insular process; indeed, it combines the expertise and inputs of a variety of people from diverse backgrounds: the government, civil society, the private sector, multilateral and bilateral financing institutions – the list is long! So you can imagine my excitement when my colleague, Tahira Syed, called me a few days ago to ask me to participate in a series of consultations with government and civil society representatives from the Federally Administered Tribal Areas (FATA) of Pakistan. Tahira is the TTL for a Multi-Donor Trust Fund-financed project which will focus on providing sustainable livelihood opportunities and improvement in local-level infrastructure for FATA residents.

As the project is moving forward in the design and preparation phase, it was an opportune time to hold consultations with the two most important stakeholders of the project: local government and community organizations and representatives. Both groups have very different mandates and roles to play in the development of their areas, but hearing their perspective is crucial and informs the overall outcome of the project.

The morning of the consultations, Tahira provided some overall context about the MDTF, the rationale behind the project and introduced the broad themes of the project. After that, there was no going back. On day one, the political administration officials had so much to say that we found the three hours scheduled for the consultation to be barely sufficient for their tremendous amount of insight and knowledge of their areas. They told us about how tribes operate in FATA, leadership norms, concepts of justice and equity.

Day two’s discussions with FATA civil society organizations and community representatives were equally enlightening. And to see the passion with which they participated was also refreshing. One tribal leader (called a “Mallack”) travelled 700 kilometres to attend the meeting! (He and I later had a detailed discussion on his turban, which is an honorary headdress given to only a select few in an entire region). He, and other participants, were unwavering in their criticism of projects which were not adequately monitored. Most of the feedback we received revolved around the need to strengthen civil society organizations, but moreover, to improve agriculture and livestock production. FATA’s economy is largely agrarian, so to ignore agriculture and livestock would be a big mistake.

On a personal level, two inter-related points will continue to be at the forefront of my thoughts as this project – and the MDTF’s work – progresses. One is that I am constantly humbled by my ignorance. The FATA residents we met and interacted with taught us so much about their customs, traditions and lifestyle that I was left speechless at how mis-informed and ill-informed I was. And this relates to my second point, which is that we need to visit these people in their communities to see how they lead their lives. It is my sincere hope that one day, the security situation improves to the extent that I can sit with them and deliberate on a village dispute, or that I can help them rebuild a small business that was destroyed in the militancy crisis.

Many of my colleagues and friends share these hopes and desires. Indeed, the MDTF was established for just these reasons. And today, Tahira and her team are doing their small part in helping improve lives for the people of FATA. If a tribal leader can travel 700 kilometers to assist us in our project preparation, the least we can do is heed their advice and benefit from their immense knowledge. We’ve taken the first steps and are quite excited about the journey which will follow.  

Aananda Raagam - Panneer Pushpangal (HQ)

Poonthalir aada..

Naan Oru Ponnoviyam

Naan Partha Rathidevi Yengae

Vacha Parvai

Bhuvana oru kelvikuri - Vizhiyile malarnthathu - Ilaiyaraaja

anbu megame Vijayabhaskar SPB Vani Jeyaram அன்பு மேகமே Sivakumar

Devathai Oru Devathai from Pattakathi Bairavan

Tamil Movie Song - Pattakathi Bairavan - Engengo Sellum En Ennangal

A Semiconductor DNA Sequencer


BIOMEDICINE


Unlike other systems, Ion Torrent's technology promises to improve with advances in electronics—and it's already proving beneficial for public health.
  • BY EMILY SINGER
Last December, Ion Torrent, something of an upstart in the sequencing industry, launched its new semiconductor-based sequencing machine. At $50,000, it was a comparatively inexpensive device designed to move DNA sequencing from large, specialised centres to the standard lab bench. The company says its machine is en route to becoming the most popular in a competitive market.
Life Technologies, which bought Ion Torrent for $375 million in cash and stock last August, is feeling good about its bet. The technology has already proved its worth as a valuable public health tool. In June, two groups used the Ion Torrent machine to rapidly sequence the genome of a new strain of E. coli that killed more than 20 people in Europe. The effort helped identify the microbe's drug-resistance genes. And researchers across the globe are using it to sequence genes involved in cancer and other diseases, intending to create rapid tests to determine the best medicine for a patient. 
Ion Torrent is competing with several sequencing technologies, all racing to become the fastest and cheapest. A landmark goal in the field is to sequence an entire human genome for $1,000, putting it on par with many other routine medical tests. But Jonathan Rothberg, Ion Torrent's founder, says his technology, based on semiconductors, is getting better faster than anyone else's. 
Most advanced sequencing technologies rely on fluorescently tagged molecules and a microscope to sequence DNA. At the heart of Ion Torrent's machine are sequencing chips that detect DNA sequences electronically. This approach removes the need for expensive lasers and cameras. The chips are made in the same semiconductor fabs as computer microprocessors. And just as with computer chips, production costs per chip drop as larger numbers are produced. As sales of the Ion Torrent machine have risen, the cost of the sequencing chips has dropped from $250 to $99.

Researchers have also improved the chip's sequencing capacity by tenfold; each chip can generate 100 million base pairs, up from 10 million base pairs when the technology first launched. Rothberg says a third-generation chip capable of sequencing a billion bases will be available next year.
As a tip of the hat to the power of superconductors, Ion Torrent has now sequenced the full genome of Intel cofounderGordon E. Moore, now 82. Moore is best known as the creator of Moore's law, which posits that the processing power of new chips would double approximately every two years. Ion Torrent's chip has improved tenfold over six months, a rapid advance that Rothberg attributes to "accumulated Moore's law," or the decades of research and billions of dollars that have gone into making faster microprocessors
At this point, Ion Torrent's technology isn't well-suited to sequencing entire human genomes. Moore's sequence required about 1,000 chips and a total cost of about $200,000. Other technologies, in contrast, have brought the cost of a whole genome down to $5,000 to $20,000, depending on how the cost is calculated.
Ion Torrent's technology is most adept at sequencing small genomes, like those of microbes, or a selection of genes, such as those that have been linked to cancer. "We are not the cheapest machine for a human genome, but we are the cheapest if you want to look at 200 genes or a pathogen behind an outbreak," says Rothberg. He predicts that by 2013, Ion Torrent will have developed a chip capable of sequencing an entire human genome. 
However, many of the most medically relevant tests physicians want to run today encompass only tens or hundreds of genes. In these cases, the most significant advantage of the new technology is its speed; it can sequence a sample of DNA in a couple of hours, rather than the week or more required by most of the machines now on the market. For genetic diagnostics, physicians want results fast. The Ion Torrent machine, however, is still considered a research device; it has yet to be approved by the U.S. Food and Drug Administration for clinical use.
Yemi Adesokan, cofounder of the genomics startup Pathogenica, uses Ion Torrent's technology to develop a test for human papillomavirus in pap smear samples. Unlike existing tests, the Ion Torrent one will be able to detect infection with multiple strains of the virus, which can be linked to an increased risk of cancer. "It works really well, particularly in terms of turnaround time," says Adesokan.

It's Coming: A True Replacement for Paper



Whether or not NoteSlate ever produces a real product, no barriers remain to a competitor building a tablet purpose-built for sketching and note-taking.
CHRISTOPHER MIMS 07/20/2011
  • 1 COMMENT
The NoteSlate sketching tablet is coming, even if it won't be built by NoteSlate.
The notoriously secretive, English language-challenged, and so far entirely vaporware companyNoteSlate just rumbled to life on its Twitter account, announcing that the company had finally discovered the technology required to realize its vision, but unfortunately it would mean exceeding the device's original price of $99.
The fact that this makes the company, which is apparently nothing more than a website set up by 29-year-old Czech product and furniture designer Martin Hasek, no more likely to ever release a working version of its inexpensive note-taking tablet is irrelevant. Hasek has already completed all the market research any competitor would ever need to justify coming out with a working clone of his vision, and they will.
The Long Nose of Innovation: Bill Buxton
To understand the forces at work here, it helps to understand Bill Buxton's concept of the "long nose" of innovation. The metaphor here is that the "next big thing" is already with us, and it's just slowly poking its nose out before it comes fully into view. Technologies that will be disruptive in the next 10 years are all around us at the research and development stage, because that's how long it takes to perfect a technology and get it to market.
And the already visible "nose" of a viable, inexpensive technology required to realize a tablet that could fully replace paper was just highlighted by Hasek.
Most e-paper has abysmally low refresh rates, far too slow to trace the movement of a stylus on a tablet. But as Hasek pointed out in response to questions from eager fans, the Bridgestone QR-LPD e-paper technology is more than fast enough to do the trick.
So far, Bridgestone's e-paper efforts have gotten a bum rap on account of the company's attempts to sell their screens as an admittedly washed-out alternative to other color e-paper technology. But in grayscale mode, it appears that QR-LPD might be more than adequate for a device like the NoteSlate. What's more, its refresh rate, in evidence at 0:19 in the following video, is more than fast enough to accommodate note-taking and sketching.
Many other e-paper displays with similar refresh rates are already on their way. What's significant about e-paper that refreshes fast enough to play video is that it could also be fast enough to respond in a realistic manner, which is exactly what tablets already accomplish, albeit at a much coarser resolution.
Other examples of this technology have already materialized in the form of the countless stylusesand note-taking apps for the iPad, the LiveScribe pen computer, and even a ginned-up Magna Doodle for gadget-obsessed adults calling itself the e-note.
What all of these efforts suggest is that there is a very real market desire to digitize absolutely everything, even that last bastion of analog functionality, the blank sheet of paper and the writing device of your choice. Nothing quite satisfies, yet the technology to accomplish the recording and transmission of our every doodle more or less exists already. All that's left is for an OEM to distill those parts into just the device for which consumers have already demonstrated a desire.