In the Battle to Relieve Back Aches, Researchers Create Bioengineered Spinal Disc Implants

From left, a natural rat IVD was compared with a tissue-engineered IVD. (Credit: Bonassar lab)

Science Daily — Millions contend with lower back and neck discomfort every year. To ease their pain, Cornell University engineers in Ithaca and doctors at Weill Cornell Medical College in New York City have created a biologically based spinal implant that could someday relieve these countless sufferers.

The other scientists on the paper are Robby Bowles, Cornell Ph.D. '11, and Harry Gebhard, M.D., of Weill Cornell Medical College.Lawrence Bonassar, Ph.D., associate professor of biomedical engineering and mechanical engineering, and Roger Härtl, M.D., associate professor of neurosurgery at Weill Cornell Medical College and chief of spinal surgery at NewYork-Presbyterian Hospital/Weill Cornell Medical Center, have created bioengineered spinal discs that have been successfully implanted and tested in animals.

Their research will be published online Aug. 1, 2011 in theProceedings of the National Academy of Sciences.

"We've engineered discs that have the same structural components and behave just like real discs," says Bonassar. "The hope is that this promising research will lead to engineered discs that we can implant into patients with damaged discs."

Each year, 40 percent to 60 percent of American adults suffer from chronic back or neck pain. For patients diagnosed with severe degenerative disc disease, or herniated discs, neurosurgeons perform surgery called discectomy -- removing the spinal disc -- followed by a fusion of the vertebrate bones to stabilize the spine. In spite of the surgery, the patient's back will likely not feel the same as before their injury.

"The surgery prevents pain, but often limits mobility, which may hinder someone who has an active lifestyle or even end the career of a professional athlete," says Härtl, who is also the team neurosurgeon for the New York Giants.

Human discs look something like a tire, with the outer part, called the annulus, made of a stiff material, and the inner circle, the nucleus, made of a gel-like substance that gets pressurized and bears weight.

Bonassar's lab, which focuses on the regeneration and analysis of musculoskeletal tissue, engineered artificial discs out of two polymers -- collagen, which wraps around the outside, and a hydrogel called alginate in the middle. They seeded the implants with cells that repopulated the structures with new tissue. Remarkably, as opposed to artificial implants today that degrade over time, scientists are seeing that the implants get better as they mature in the body due to the growth of the cells.

"Our implants have maintained 70 to 80 percent of initial disc height. In fact, the mechanical properties get better with time," says Bonassar.

The implants would treat a broad category of illness called degenerative disc disease -- a leading cause of disability worldwide. According to Härtl, more patients need treatment or surgery for intervertebral disc degeneration. A surgical procedure approved by the FDA in 2005 involves obliterating the disc and replacing it with an implant made of metal and plastic, intending to mimic the normal movement of the lumbar and spine.

"Bone or metal or plastic implants are