Central serotonin (5-HT) is an anorexigenic neurotransmitter in the brain. However, accumulating evidence suggests peripheral 5-HT may affect organismal energy homeostasis.
Authors in Nature Communications show 5-HT regulates white and brown adipose tissue function.
Under high-fat diet (HFD) condition, the inhibition of 5-HT synthesis by various means reduced body weight gain, improved glucose tolerance, increased thermogenic activity in brown adipose tissue (BAT) and decreased lipogenesis in white adipose tissue (WAT).
Authors also show that 5-HT inhibited thermogenesis through (serotonin receptor) Htr3 in BAT and increased lipogenesis through Htr2a in WAT.
These data suggest important roles for adipocyte-derived 5-HT in controlling energy homeostasis.
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