Fat affects how brain cells talk

THE UNIVERSITY OF QUEENSLAND

“Changes in lipid composition have already been shown to be a factor contributing to the development of dementia in Alzheimer's disease." Image: Eraxion/iStockphoto Researchers at The University of Queensland's Queensland Brain Institute (QBI) have taken a significant step towards unravelling the mechanism by which communication between brain cells occurs. Findings from a study just published in Nature Communications reveals that the lipid (fat) from the membranes of brain cells controls the movement of vesicles containing chemical messengers called neurotransmitters. QBI's Associate Professor Frederic Meunier, who led the study, says these findings were made possible through experimentation with very selective compounds affecting the membrane. “Our findings explain how minute changes in the lipid composition of our neurons can have a dramatic effect on the way these cells communicate with each other in the brain,” he says. “We found that the lipid phosphatidylinositol(4,5)bisphosphate orchestrates the mobilization and movement of secretory vesicles towards the plasma membrane of neurosecretory cells.” According to Associate Professor Meunier, a better understanding of the mechanism underpinning neurotransmitter release will aid scientists' ongoing fight against the plethora of diseases affecting neuronal communication in the brain. “Changes in lipid composition have already been shown to be a factor contributing to the development of dementia in Alzheimer's disease,” he says. “We hope that developing novel compounds targetting the fat lipid composition of biological membranes could ultimately help in the treatment of such brain disorders.” Editor's Note: Original news release can be found here.