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Tuesday, November 1, 2011

The Virtual Nurse Will See You Now



A few pointers: A patient interacts with a virtual nurse.
Glenn Kulbako

BIOMEDICINE

The Virtual Nurse Will See You Now

In the hectic world of a hospital, a computer-simulated nurse can be surprisingly comforting.

  • BY EMILY SINGER
Researchers at Northeastern University have developed a virtual nurse and exercise coach that are surprisingly likable and effective—even if they're not quite as affable as the medical hologram on Star Trek. In fact, patients who interacted with a virtual nurse named Elizabeth said they preferred the computer simulation to an actual doctor or nurse because they didn't feel rushed or talked down to.
A recent clinical trial of the technology found that Elizabeth also appears to have a beneficial effect on care. A month after discharge, people who interacted with the virtual nurse were more likely to know their diagnosis and to make a follow-up appointment with their primary-care doctor. The results of the study are currently under review for publication.
"We try to present something that is not just an information exchange but is a social exchange," says Timothy Bickmore, associate professor in Northeastern's College of Computer and Information Science. Bickmore led the research. "It expresses empathy if the patient is having problems, and patients seem to resonate with that."
Bickmore first became interested in working on "virtual agents" after seeing demonstrations of very early interactive animated characters. "I was amazed at how people were instantly mesmerized by them, and how quickly this effect vanished when the characters did something stupid," he says. "I was interested in seeing how they could be engineered to maintain the enchantment over long periods of time and be used for practical purposes beyond entertainment."
He adds that patients with little or no computer experience seem to prefer the virtual person to more standard computer interactions, because it feels more natural.
"Most people get frightened when they hear they are going to get care from a computer, so to hear so clearly that we are not short-changing patients is gratifying," says Joseph Kvedar, a physician and founder and director of the Center for Connected Health at Partners Healthcare. Kvedar has collaborated with Bickmore in the past.
To develop the computer-controlled avatars, researchers first recorded interactions between patients and nurses. They then tried to emulate the nurses' nonverbal communication by endowing the virtual character with hand gestures and facial expressions. (The resulting animation is, however, much simpler than today's sophisticated video games.)
Researchers also add small talk, asking users about local sports teams and the weather, which real nurses and coaches often do to put patients at ease. The verbal interactions are fairly basic; the nurse or trainer has a set repertoire of questions, and users choose from a selection of possible answers. For anything beyond that repertoire, the virtual agent will refer the patient to a human health-care provider.
Adding these apparently simple touches of humanity does appear to influence how people interact with the program. Patients more accurately reported their health information when interacting with the virtual character than they were when filling out a standard electronic questionnaire.
"This was designed from the ground up to be patient-friendly, warm and engaging; it's not necessarily the most lifelike and real-human-looking representation, but through trial and error, they have found the characteristics that resonate with patients," says Steven Simon, chief of general internal medicine at the VA Boston Healthcare System. "I think they are just scratching the surface in terms of how it can best be used, such as in patients with chronic conditions, such as asthma and diabetes." 
Such technologies will become increasingly important with rising health-care costs and an aging population. "We already know we don't have enough health-care providers to go around, and it's only getting worse," says Kvedar. "About 60 percent of the cost of delivering health care comes from human resources, so even if you can train more people, it's not an ideal way to improve costs."
Kvedar worked with Bickmore on a second, home-based trial, in which a virtual coach called Karen encouraged overweight sedentary adults to exercise. Users checked in with Karen three times a week, and she gave them recommendations and listened to their problems. Over 12 weeks, those who talked to the coach were significantly more active than those who simply had an accelerometer to record how much they walked.
"Older adults seem to be really accepting. They like the social aspect of it," says Bickmore. "With the home-based agent, I think they would like to chat with them longer than we let them."
Some users wanted to know more about their virtual coaches, so Bickmore's team experimented with giving the characters a backstory. They found that participants whose virtual coach told them stories in the first person were more likely to log into the system than those who heard the same stories in the third person.
"They had more frequent conversations with the coach when it was being more human, and they did not report feeling more deceived," says Bickmore. He adds that when asked, participants do understand the character is virtual, but they say they sometimes forget. "They say they will feel guilty about not logging in, which means they have formed some kind of emotional bond."
But not everyone responded well to Karen. One of the challenges in broadening the use of this technology will be creating virtual characters that can learn from users and adapt to their preferences.
Bickmore's team is now working on a virtual nurse that would reside in the hospital room. Patients can talk to it about their hospital experience, report pain levels, and ask questions. The researchers are also integrating sensors into the system, to record when the patient is sleeping, for example, or to track when different doctors enter the room.
In a pilot study, patients had an average of 17 conversations with the nurse per day. "When we interviewed them afterward, we found that the agent seemed to be effective at addressing the loneliness you often feel if you're at the hospital by yourself," says Bickmore. 

Test Could Show Which Cancers Will Respond to Chemotherapy



Tumors closer to committing "cellular suicide" are more sensitive to conventional anticancer drugs.

  • BY ERIKA JONIETZ
A laboratory test that evaluates how close cancer cells are to a specific form of cell death could help oncologists predict which patients will benefit from chemotherapy drugs. Researchers tested samples from patients at several hospitals and showed that those whose cancer cells were on the edge of self-destructing responded better to various kinds of chemotherapy.
The test helps explain a long-standing puzzle in oncology. Cancer biology dogma holds that chemotherapy drugs target all rapidly dividing cells, leading to both tumor death and side effects such as hair loss and gastrointestinal distress. But some rapidly dividing tumors, such as pancreatic cancers, tend to be highly resistant to chemotherapy, while some slow-growing cancers, such as chronic myelogenous leukemia, respond well to the drugs.
The new research, led by Anthony Letai, an associate professor at Harvard Medical School and the Dana-Farber Cancer Institute, suggests that regardless of how fast the tumor cells divide, the cancer's likelihood of responding to chemotherapy is correlated with, and perhaps determined by, whether they are approaching a type of cellular suicide known as apoptosis. Apoptosis is a natural process in multicellular organisms, but it is often disrupted in cancerous cells. The study was published online last week in Sciencexpress.
"This is a very important paper," says Peter Sorger, a professor of systems biology at Harvard Medical School, who was not involved in the research. He says identifying patients who might be responsive to chemotherapy is "the key issue in contemporary cancer pharmacology—individualizing treatments so specific drugs are given to patients likely to respond."

Letai and his colleagues tested samples from patients with four kinds of cancer: multiple myeloma, acute myelogenous leukemia, acute lymphocytic leukemia, and ovarian cancer. The process involves taking live tumor cells and exposing them to proteins that promote apoptosis. In cells already on the edge of committing apoptosis, the membranes of energy-producing organelles called mitochondria break down and take up more of a fluorescent dye that the scientists used to monitor the process. This mitochondrial disintegration is one of the first steps in apoptosis. The researchers then followed the patients' response to chemotherapy and found that those whose cells took up the most dye had the best outcomes.
Though the test is more complicated than most cancer diagnostics because it involves handling live cells, Letai believes it could be a practical way to predict which cancer patients will respond to chemotherapy. "In the cancer biology world today, people are looking at genetic biomarkers almost exclusively for trying to understand the response to chemotherapy," he says. "Something like this, a more functional assay, comes out of left field."
Letai's lab is already testing whether the assay could be used in clinical cancer therapy, andEutropics Pharmaceuticals of Cambridge, Massachusetts, which Letai cofounded, has licensed the technology. If clinical trials go well, Letai says, the test might be used for acute myelogenous leukemia in about five years. He hopes that ultimately it will be applicable to most kinds of cancer. Sorger calls the possibility "highly likely."
The researchers also investigated whether treating tumors to move their mitochondria closer to the threshold of apoptosis could boost the efficacy of conventional chemotherapy. They treated a myeloid leukemia cell line with an experimental drug, made by Abbott Labs, that mimics the apoptosis-promoting proteins used in their cell assay. The treated cells became more sensitive to three different chemotherapeutic agents. Abbott and Genentech are collaborating on clinical trials of a related drug, which can be taken orally, to see if it increases the effectiveness of various chemotherapy medicines used for both chronic lymphocytic leukemia and various solid tumors.

Highly Efficient Oxygen Catalyst Found: Rechargeable Batteries and Hydrogen-Fuel Production Could Benefit


Materials Science and Engineering Graduate Student Jin Suntivich (left) and Mechanical Engineering Graduate Student Kevin J. May (right) inspecting the electrochemical cell for oxygen evolution reaction experiment. (Credit: Photo by Jonathon R. Harding)
Science Daily  — A team of researchers at MIT has found one of the most effective catalysts ever discovered for splitting oxygen atoms from water molecules -- a key reaction for advanced energy-storage systems, including electrolyzers, to produce hydrogen fuel and rechargeable batteries. This new catalyst liberates oxygen at more than 10 times the rate of the best previously known catalyst of its type.

The team, which includes materials science and engineering graduate student Jin Suntivich, mechanical engineering graduate student Kevin J. May and professor Yang Shao-Horn, published their results in Science on Oct. 28.The new compound, composed of cobalt, iron and oxygen with other metals, splits oxygen from water (called the Oxygen Evolution Reaction, or OER) at a rate at least an order of magnitude higher than the compound currently considered the gold standard for such reactions, the team says. The compound's high level of activity was predicted from a systematic experimental study that looked at the catalytic activity of 10 known compounds.
The scientists found that reactivity depended on a specific characteristic: the configuration of the outermost electron of transition metal ions. They were able to use this information to predict the high reactivity of the new compound -- which they then confirmed in lab tests.
"We not only identified a fundamental principle" that governs the OER activity of different compounds, "but also we actually found this new compound" based on that principle, says Shao-Horn, the Gail E. Kendall (1978) Associate Professor of Mechanical Engineering and Materials Science and Engineering.
Many other groups have been searching for more efficient catalysts to speed the splitting of water into hydrogen and oxygen. This reaction is key to the production of hydrogen as a fuel to be used in cars; the operation of some rechargeable batteries, including zinc-air batteries; and to generate electricity in devices called fuel cells. Two catalysts are needed for such a reaction -- one that liberates the hydrogen atoms, and another for the oxygen atoms -- but the oxygen reaction has been the limiting factor in such systems.
Other groups, including one led by MIT's Daniel Nocera, have focused on similar catalysts that can operate -- in a so-called "artificial leaf" -- at low cost in ordinary water. But such reactions can occur with higher efficiency in alkaline solutions, which are required for the best previously known catalyst, iridium oxide, as well as for this new compound.
Shao-Horn and her collaborators are now working with Nocera, integrating their catalyst with his artificial leaf to produce a self-contained system to generate hydrogen and oxygen when placed in an alkaline solution. They will also be exploring different configurations of the catalyst material to better understand the mechanisms involved. Their initial tests used a powder form of the catalyst; now they plan to try thin films to better understand the reactions.
In addition, even though they have already found the highest rate of activity yet seen, they plan to continue searching for even more efficient catalyst materials. "It's our belief that there may be others with even higher activity," Shao-Horn says.
Jens Norskov, a professor of chemical engineering at Stanford University and director of the Suncat Center for Interface Science and Catalysis there, who was not involved in this work, says, "I find this an extremely interesting 'rational design' approach to finding new catalysts for a very important and demanding problem."
The research, which was done in collaboration with visiting professor Hubert A. Gasteiger (currently a professor at the Technische Universität München in Germany) and professor John B. Goodenough from the University of Texas at Austin, was supported by the U.S. Department of Energy's Hydrogen Initiative, the National Science Foundation, the Toyota Motor Corporation and the Chesonis Foundation.

Savannas and Forests in a Battle of the Biomes


Princeton researchers report that savanna wildfires — such as this one in South Africa — maintain the balance between forest and savanna, but that these blazes may be susceptible to human activity. The border between the habitats could degenerate into patches of encroachment in some areas. The researchers suggest forests that experience less rainfall due to climate change could become more prone to land-clearing fires. At the same time, the breakup of the savanna through land use, fire-prevention measures and road construction could disrupt the natural path of fires, presenting an opportunity for forests to take root. (Credit: Carla Staver)
Science Daily — Climate change, land use and other human-driven factors could pit savannas and forests against each other by altering the elements found by Princeton University researchers to stabilize the two. Without this harmony, the habitats, or biomes, could increasingly encroach on one other to the detriment of the people and animals that rely on them.

The Princeton researchers reported this month in the journal Science that savanna wildfires, combined with climate conditions, maintain the distinct border between savannas and forests in many tropical and subtropical areas. Savanna fires keep tree cover low and prevent forests from encroaching on the grassland. When tree cover is high, as in a forest, fires cannot spread as easily, halting the savanna's advance into the forest.
But the Princeton team's findings suggest that savanna wildfires could be heavily influenced by factors such as climate change, road construction and fire-prevention measures. Less rainfall can result in an uptick in fires that can transform a forest into a savanna, just as breaking up the landscape through road construction and fire control disrupt natural blazes and allow a forest to sprout where there once was a savanna.
The researchers suggest that because of these factors, large stretches of South American and African forest and savanna could degenerate into chaotic mutual encroachment. The changeover from one biome to the other -- which can happen within several decades -- can be extremely difficult to reverse once it has happened, explained lead author Carla Staver, a doctoral student in the laboratory of co-author Simon Levin, the Moffett Professor of Biology in Princeton's Department of Ecology and Environmental Biology. She and Levin worked with co-author Sally Archibald, a senior research scientist at the Council for Scientific and Industrial Research in South Africa.
Plants and animals that thrive in a forest or savanna often cannot transition from one habitat to the other, Staver said. The Science paper illustrates that the loss of savanna to forest is just as ecologically traumatic -- though less well known -- as deforestation, she said.
"Savanna and forest are definitely not locally compatible," she said. "There is a risk of losing plants and animals endemic to one or the other, which would affect the people who depend on those species.
"Savannas, for instance, are useful to people as cattle rangeland," she said. "When forests encroach, the grass productivity decreases dramatically and the land becomes much less useful. In terms of livelihood, that would have a huge impact."
The team's work provides among the first experimental evidence that fire feedback -- the ecological effect of fires -- is the dominant force in maintaining the division between forests and savannas, and that it can determine where the habitats flourish. The researchers used satellite data of fire distributions -- combined with climate and soil data, as well as satellite data of tree cover -- to survey the tropical and subtropical regions of Africa, Australia and South America.
The researchers found that the frequency of fires determines whether forest or savanna will dominate an area more than other factors such as rainfall, seasons and soil texture, especially in areas with moderate precipitation. Regular fires prevent trees from establishing and savannas from turning into forest. A lack of fires allows a forest to develop, which in turn excludes future fires.
Human alterations to the climate and landscape, however, may disrupt the natural spread of fire in many areas and lead to very rapid changes in biome distribution, the Princeton researchers suggest. Direct actions such as building roads and deploying methods such as controlled burning that prevent the natural spread of wildfires could break up savannas, altering wildfires and allowing forests to take root. At the same time, drier conditions -- particularly in areas now experiencing diminished monsoons -- rob forests of their primary safeguard against fire, rain.
Under these circumstances, a forest can overtake a savanna, or vice versa, in a matter of decades, and a return to the original terrain would prove exceedingly difficult, even if the original climate conditions return, Staver said.
"If a savanna were to turn into a forest, for instance, that change would be quite sudden, much quicker than we might expect, and it would be hard to reverse," Staver said. "You'd cross a threshold where fire cannot spread anymore. Conversely, if a forest dried out and fire started to spread, it could turn into a savanna, maintained by fire. The magnitude of change needed to return a biome to its original state would be much more than it needed to change in the first place."
The Princeton research could be significant in determining the "future trajectory" of global forest cover, and also illustrates the natural obstacles to restoring cleared forests, said Brian Walker, who studies ecological sustainability and resilience as a research fellow at the Commonwealth Scientific and Industrial Research Organization in Australia.
"Savanna systems are very resilient across a range of climatic and herbivore variation, in regard to fire. Forest systems are less so, except under very high rainfall where fire cannot be regular," said Walker, who had no role in the Princeton research but is familiar with it.
"In the case of rainforests, once they are in a state where fire can play a role and therefore keep the system in a savanna state, it is extremely difficult to prevent fires from recurring, and so the chances of a savanna state getting back to rainforest are small. In the original forest state, the amount of dry fuel in the ground layer is insufficient for fire to take hold and 'run.'"
In a broader sense, the Princeton findings stress that encroachment is not a threat unique to forests, Staver said.
"There's a sense among savanna ecologists that the loss of savanna is considered secondary to deforestation as a conservation concern, but it really shouldn't be. The loss of functionality and diversity in the savanna is just as important as in forests.
"At the moment, we can't say that one is winning out over the other," Staver said. "We can come up with examples where savannas are encroaching into forests and forests are encroaching into savannas. Both are happening extensively, and both are really huge issues that are likely to become even more important."
This research, reported Oct. 13 in the journal Science, was supported with funds from the Andrew W. Mellon Foundation.

World's Most Efficient Flexible Organic Light-Emitting Diodes Created On Plastic


Wang and Helander were able to re-construct the high-refractive index property previously limited to heavy metal-doped glass by using a 50-100 nanometre thick layer of tantalum(V) oxide (Ta2O5), an advanced optical thin-film coating material. This advanced coating technique, when applied on flexible plastic, allowed the team to build the highest-efficiency OLED device ever reported with a glass-free design. (Credit: © University of Toronto)
Science Daily — Researchers in the University of Toronto's Department of Materials Science & Engineering have developed the world's most efficient organic light-emitting diodes (OLEDs) on plastic. This result enables a flexible form factor, not to mention a less costly, alternative to traditional OLED manufacturing, which currently relies on rigid glass.

The results are reported online in the latest issue of Nature Photonics.
OLEDs provide high-contrast and low-energy displays that are rapidly becoming the dominant technology for advanced electronic screens. They are already used in some cell phone and other smaller-scale applications.
Current state-of-the-art OLEDs are produced using heavy-metal doped glass in order to achieve high efficiency and brightness, which makes them expensive to manufacture, heavy, rigid and fragile.
"For years, the biggest excitement behind OLED technologies has been the potential to effectively produce them on flexible plastic," says Materials Science & Engineering Professor Zheng-Hong Lu, the Canada Research Chair (Tier I) in Organic Optoelectronics.
Using plastic can substantially reduce the cost of production, while providing designers with a more durable and flexible material to use in their products.
The research, which was supervised by Professor Lu and led by PhD Candidates Zhibin Wang and Michael G. Helander, demonstrated the first high-efficiency OLED on plastic. The performance of their device is comparable with the best glass-based OLEDs, while providing the benefits offered by using plastic.
"This discovery, unlocks the full potential of OLEDs, leading the way to energy-efficient, flexible and impact-resistant displays," says Professor Lu.

Live Longer With Fewer Calories? Key Enzyme Involved in Aging Process Found


Yeast. (Credit: Mikael Molin)
Science Daily  — By consuming fewer calories, aging can be slowed down and the development of age-related diseases such as cancer and type 2 diabetes can be delayed. The earlier calorie intake is reduced, the greater the effect. Researchers at the University of Gothenburg have now identified one of the enzymes that hold the key to the aging process.

By gradually reducing the intake of sugar and proteins, without reducing vitamins and minerals, researchers have previously shown that monkeys can live several years longer than expected. The method has also been tested on everything from fishes and rats to fungi, flies and yeasts with favourable results. Caloric restriction also has favourable effects on our health and delays the development of age-related diseases. Despite this, researchers in the field have found it difficult to explain exactly how caloric restriction produces these favourable effects."We are able to show that caloric restriction slows down aging by preventing an enzyme, peroxiredoxin, from being inactivated. This enzyme is also extremely important in counteracting damage to our genetic material," says Mikael Molin of the Department of Cell and Molecular Biology.
Using yeast cells as a model, the research team at the University of Gothenburg has successfully identified one of the enzymes required. They are able to show that active peroxiredoxin 1, Prx1, an enzyme that breaks down harmful hydrogen peroxide in the cells, is required for caloric restriction to work effectively.
The results, which have been published in the journal Molecular Cell, show that Prx1 is damaged during aging and loses its activity. Caloric restriction counteracts this by increasing the production of another enzyme, Srx1, which repairs Prx1. Interestingly, the study also shows that aging can be delayed without caloric restriction by only increasing the quantity of Srx1 in the cell. Repair of the peroxiredoxin Prx1 consequently emerges as a key process in aging.
"Impaired Prx1 function leads to various types of genetic defects and cancer. Conversely, we can now speculate whether increased repair of Prx1 during aging can counteract, or at least delay, the development of cancer."
Peroxiredoxins have also been shown to be capable of preventing proteins from being damaged and aggregating, a process that has been linked to several age-related disorders affecting the nervous system, such as Alzheimer's and Parkinson's. The researchers are accordingly also considering whether stimulation of Prx1 can reduce and delay such disease processes.

A Short Neurological Test



Find the C below.. Please do not use any cursor help.

OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO
OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO
OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO
OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO
OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO
OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO
OOOOOOOOOOOOOOOOOOOCOOOOOOOOOOO
OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO
OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO
OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO
OOOOOOOOOOOOOOOOOOOOOOOOOOOOOOO


2- If you already found the C, now find the 6 below.

99999999999999999999999999999999999999999999999
99999999999999999999999999999999999999999999999
99999999999999999999999999999999999999999999999
69999999999999999999999999999999999999999999999
99999999999999999999999999999999999999999999999
99999999999999999999999999999999999999999999999


3 - Now find the N below. It's a little more difficult.

MMMMMMMMMMMMMMMMMMMMMMMMMMMMNMM
MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM
MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM
MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM
MMMMMMMMMMMMMMMMMMMMMMMMMMMMMMM


This is NOT a joke. If you were able to pass these 3 tests, you can cancel your annual visit to your neurologist. Your brain is great and you're far from having a close
 relationship with Alzheimer. 

At 7 billion, realizing the economic benefits of family planning




JE-GH060621_32957 World Bank

With the 7 billionth baby joining the planet, many of us are rightly concerned about the challenges posed by a growing population and its impact on health care, climate change, food security, jobs, and poverty.

Here at the World Bank, we’ve been talking recently about the critical link between population change and economic growth. In some countries, where falling fertility rates have led to expanding working-adult populations and a smaller proportion of dependent children, the economic and social impact has been transformative.

For example, Thailand’s Minister of Finance said at a Bank panel last month that after his country introduced a national family planning policy in the 1960s, more women had the time and opportunity to access education, and take jobs in manufacturing and services. This shift was matched by greater government investment in health, education, gender equality, and skills training for women and the growing young population, together with reforms improving the country investment climate, all resulting in a generation of healthier, more educated and more productive citizens.

As a result, people’s opportunities and quality of life improved. This way, Thailand put in place long-term policies to ensure economic benefit from its demographic transition—it harnessed the “demographic dividend.”

But Thailand isn’t alone. Other countries, such as Indonesia and South Korea, have followed similar paths.

Governments have found that, the more rapid the pace of fertility decline, the more favorable the ratio of young dependents to productive workers to potentially realize the dividend. But there is a short window of opportunity during which fertility and dependency ratios fall to invest in education and health care, and to create job opportunities to benefit from the demographic transition.

Failure to address high fertility with large and growing population cohorts results in unsustainable health care and schooling costs and lags in economic growth, and may increase the risk of social and political unrest. But, addressing high fertility is a necessary, but not sufficient, condition to harness the demographic dividend.

To do so, countries also need to invest in new generations and create an environment conducive to good jobs.

Greater investment and policy efforts to reduce the barriers to family planning and reproductive health services (including availability of contraceptives and services, as well as empowering women to access them) is essential if the demographic dividend is to materialize at all. This is a priority for the Bank in our Reproductive Health Action Plan.

So let’s treat this milestone as an opportunity.  In a world of 7 billion, if we empower women to plan for their families, if we invest wisely in women’s and children’s health and education, if we create the conditions for good jobs, the demographic dividend is there for the taking.

 

Fat cells in abdomen fuel spread of ovarian cancer






A large pad of fat cells that extends from the stomach and covers the intestines provides nutrients that promote the spread and growth of ovarian cancer, reports a research team based at the University of Chicago in the journal Nature Medicine, published online October 30th, 2011.
Ovarian cancer, the fifth leading cause of cancer deaths in women, tends to spread within the abdominal cavity as opposed to distant organs. In 80 percent of women, by the time ovarian cancer is diagnosed, it has spread to the pad of fat cells, called the omentum. Often, cancer growth in the omentum exceeds the growth of the original ovarian cancer.
“This fatty tissue, which is extraordinarily rich in energy-dense lipids, acts as a launching pad and energy source for the likely lethal spread of ovarian cancer,” said study author Ernst Lengyel, MD, PhD, professor of obstetrics and gynecology at the University of Chicago. “The cells that make up the omentum contain the biological equivalent of jet fuel. They feed the cancer cells, enabling them to multiply rapidly. Gaining a better understanding of this process could help us learn how to disrupt it.”
The researchers performed a series of experiments to identify the role of these fat cells as major mediators of ovarian cancer metastasis. The first step was to understand the biological signals that attract ovarian cancer cells to the omentum and use it for rapid growth.
The spread of ovarian cancer cells to the omentum can happen quickly. Ovarian cancer cells injected into the abdomen of healthy mice find their way to the omentum within 20 minutes. The researchers found that protein signals emitted by the omentum can attract the tumor cells. Inhibitors which disturbed these signals reduced this attraction by at least 50 percent.
Once ovarian cancer cells reach the omentum, they quickly develop the tools to devour the sustenance provided by this fatty tissue, reprogramming their metabolism to thrive on lipids acquired from fat cells. Ovarian cancer can rapidly convert the entire omentum, a soft fat pad, into a solid mass of cancer cells.

Caption: This is Ernst Lengyel, MD, PhD, professor of obstetrics & gynecology, the University of Chicago. Credit: David Christopher for the University of Chicago Medical Center
“This mechanism may not be limited to ovarian cancer cells,” the authors note. Fat metabolism may also contribute to cancer development in other environments where fat cells are abundant, such as breast cancer.
A protein known as fatty acid binding protein (FABP4), a fat carrier, may be crucial to this process and could be a target for treatment.
When the researchers compared primary ovarian cancer tissue with ovarian cancer tissue which had spread to the omentum, they found that tumor cells next to omental fat cells produced high levels of FABP4. Cancer cells distant from the fat cells did not produce FABP4.
When they inhibited FABP4, the transfer of nutrients from fat cells to cancer cells was drastically reduced. Inhibition of FABP4 also reduced tumor growth and the ability of tumors to generate new blood vessels.
“Therefore,” the authors wrote, “FABP4 emerges as an excellent target in the treatment of intra-abdominally disseminating tumors, which preferentially metastasize to adipose tissue such as ovarian, gastric, and colon cancers.”
________________
Additional authors in this study include Kristin Nieman, Hilary Kenny, Carla Penicka, Andras Ladanyi, Marion Zillhardt, Iris Romero, Diane Yamada, Rebecca Buell-Gutbrod and Katja Gwin of the University of Chicago; Mark Carey and Gordon Mills of M.D. Anderson Cancer Center; Gökhan Hotamisligil of the Harvard School of Public Health, and Marcus Peter of Northwestern University.

HISTORY


கி.மு 14 பில்லியன்

பெரும் வெடியில் உலகம் தோன்றியது.

கி.மு 6 - 4 பில்லியன்

பூமியின் தோற்றம்.

கி.மு. 2.5 பில்லியன்

நிலத்தில் பாறைகள் தோன்றிய காலம். முதன் முதலில் தமிழ் நாட்டில் மனித இனம் தோன்றியது. தென் குமரிக்குத் தெற்கே இலெமூரியா கண்டத்தில் முதலில் மனித இனம் தோன்றியது.

கி.மு. 470000

இக்கால இந்தியாவின் தமிழ் நாடு, பஞ்சாப் ஆகிய இடங்களில் மனித இனம் சுற்றித் திரிந்தது.

கி.மு. 360000

முதன் முதலாக சைனாவில் யோமோ எரக்டசு நெருப்பை கட்டுக்குள் கொண்டு வந்தனர்.

கி.மு. 300000

யோமோ மனிதர்கள் ஆசியாவிலும் ஆப்பிரிக்காவிலும் சுற்றித் திரிந்தனர்.

கி.மு. 100000


நியாண்டெர்தல் மனிதன்
கிழக்கு ஆப்பிரிக்காவில் தற்கால மனிதனின் மூளை அளவு உள்ள மனிதர்கள் வாழ்ந்தனர்.

கி.மு. 75000

கடைசி பனிக்காலம.். உலக மக்கட் தொகை 1.7 மில்லியன்.

கி.மு. 50000

தமிழ்மொழியின் தோற்றம்.

கி.மு. 50000 - 35000

தமிழிலிருந்து சீன மொழிக் குடும்பம் பிரிவு.

கி.மு. 35000 - 20000

ஆஸ்திரேலிய, ஆப்பிரிக்க சிந்திய மொழிகள் தமிழிலிருந்து பிரிந்ந காலம்.

கி-மு. 20000 - 10000

ஒளியர் கிளைமொழிகள் தமிழிலிருந்து பிரிந்தகாலம் ( இந்தோ ஐரோப்பிய மொழிகள் )

கி-மு. 10527

முதல் தமிழ்ச்சங்கத்தை பாண்டிய மன்னன் காய்கினவழுதி தோற்றுவித்த காலம். 4449 புலவர்கள் கூடினர். முதுநாரை, முதுகுருகு, களரியாவிரை முதலிய நூல்கள் இயற்றப்பட்டன.

கி.மு. 10527 - 6100

பாண்டிய மன்னர்கள் காய்கினவழுதி வடிவம்பலம்ப நின்ற நெடியோன், முந்நீர்ப் விழவின் நெடியோன், நிலந்தரு திருவிற் பாண்டியன் செங்கோன், பாண்டியன் கடுங்கோன்.

கி.மு. 10000

கடைகி பனிக்காலம் முற்றுப்பெற்றது. உலக மக்சுள் தொகை 4 மில்லியன். குமரிக்கணடம் தமிழர் 100000.

கி.மு. 6087

கடல் கொந்தளிப்பில் குமரிக் கண்டம் மூழ்கியது.

கி.மு 6000 - 3000

கபாடபுரத்தைத் தலைநகரமாகக் கொண்டவன் பாண்டிய மன்னன் வெண்தேர் செழியன். இரண்டாம் தமிழ்ச்சங்கத்தை நிறுவினான். 3700 புலவர்கள் இருந்தனர். அகத்தியம், தொல்காப்பியம் முதலிய இலக்கண நூல்கள் எழுந்தன. பாண்டிய மன்னர்கள் செம்பியன் மந்தாதன், மனுச்சோழன், தூங்கெயில் எறிந்த தொடிதோட் செம்பியன் அதியஞ்சேரல், சோழன் வளிதொழிலாண்ட உரவோன், தென்பாலி நாடன் ராகன், பாண்டியன் வாரணன், ஒடக்கோன், முட்டதுத் திருமாறன் ஆண்டகாலம்.

கி.மு. 5000

உலக மக்கள் தொகை 5 மில்லியன். சிந்து சமவெளி நாகரிகம் தொடக்கம். முகஞ்சதாரோ, ஹரப்பா.

கி.மு. 4000

சிந்து சமவெளி மக்கட் தொகை 1 மில்லியன்.

கி.மு - 4000

கிருத்துவ உலக நாட்குறிப்பு ஆரம்பம். சுமேரியாவில் புதை பொருளாராய்ச்சி சிந்து சமவெளி வணிகப் பொருள் கண்டது.

கி.மு - 3200

சிந்து சமவெளியினர் 27 விண்மீன்கள் இடைத்தொடர்பு நோக்கி சூரிய, சந்திரனின் முழு மறை வடிவங்கள் நிலைபபாடு கண்டனர்.

கி.மு - 3113

அமெரிக்க- தமிழினத்தவராகிய மாயர்கள் தொடங்கிய மாயன் ஆண்டுக் கணக்கு ஆரம்பம்.

கி.மு - 3102

சிந்து சமவெளிக் தமிழர்களின் "கலியாண்டு" ஆண்டு தொடக்கம், சிந்து சமவெளியில் தமிழர்களின் நாகரிகம் தழைத் தொடங்கியது.


மண்டையோட்டு வடிவங்களின் வகைகள்

இடமிருந்து வலம்: நெடுமண்டை நீள்வட்ட வடிவம்; இரண்டு குட்டைமண்டை வடிவங்கள்- நீளுருண்டை வடிவமும் ஆப்பு வடிவமும்; நடுமண்டை ஐங்கோண வடிவம்.



கி.மு - 3100 - 3000

ஆரியர்கள் சிந்து சமவெளி வழி நுழைந்தனர். துணி நெய்தல் ஐரோப்பா சிந்து சமவெளியில் ஆரம்பித்தது. தென்னிந்தியாவில் குதிரைகள் இருந்தது. சைவ ஆகமங்கள் முதல் தமிழ்ச் சங்க காலத்தில் பொறிக்கப்பட்டன.

கி.மு - 2600

எகிப்திய பிரமிடுகள் வேலை ஆரம்பம்.

கி.மு - 2387

இரண்டாம் கடல் கொந்தளிப்பால் கபாடபுரம் அழிந்தது. ஈழம் பெருநிலப் பகுதியிலிருந்து பிரிந்தது.

கி.மு - 2000 - 1000

காந்தாரத்தில் இருந்த ஆரியர்களுடன் வடபுலத் தமிழ் மன்னர்களும் சிந்து வெளி தமிழர்களும் போர் புரிந்த காலம். கடற்பயணங்களில் புதியன கண்டுபிடித்த சேர இளவரசர்கள் ஈழத்தில் ஆண்டகாலம். கங்கைவெளி - சிபி மரபினர் ஆட்சி. சிந்து வெளி - சம்பரன் ஆட்சி.

கி.மு - 1915

திருப்பரங்குன்றத்தில் மூன்றாம் தமிழ்ச் சங்கம் நடந்தது.

கி.மு. - 1900

வேத கால முடிவு. சரசுவதி ஆறு வற்றியதினால் மக்கள் தொகை கங்கை ஆறு நோக்கி நகர்ந்தது.

கி.மு. 1500

முக்காலத்து பிராமி மொழி வழக்கத்தில் இருந்த துவாரக நகர் வெள்ளத்தில் மூழ்கியது. இரும்பின் உபயோகம். கிராம்பு சேர நாட்டிலிருத்து மத்திய கிழக்கு நாடுகளுக்கு ஏற்றுமதி செய்யப்பட்டது.

கி.மு. - 1450

உபநிசத்துக்களும் வேதங்களும் உண்டாக்கப்பட்டன.

கி.மு. - 1316

மகாபாரத கதை வசிஸ்டரால் அமைக்கப் பட்டது.


கி. மு. 1250

மோசஸ் 600,000 யூதர்களை எகிப்திலிருந்து வெளியேற்றினார்.

கி. மு . 1200

ஓமரின் இல்லயாய்டு, ஓடசி பாடல்கள் மேற்கோற்படி கிரேக்க துரோசன் சண்டை.

கி. மு. 1000

உலக மக்கள் தொகை 50 மில்லியன்.

கி. மு. 1000-600

வடக்கில் சிபி மரபினர், தெற்கில் திங்கள் மரபினர் ஆட்சி நிலவியது.

கி. மு. 950

அரசன் சாலமன் வர்த்தகக் கப்பலில் யூதர்கள் இக்காலத்து கூறப்படும் இந்தியா வருகை.

கி. மு. 950

வடமொழி முழு வளர்ச்சியடையாது பேச்சு மொழி உருவெடுத்தக் காலம்.

கி. மு. 925

யூதர்களின் அரசன் தாவிது இப்போதைய இசுரேல், லெபனானை பேரரசாகக் கொண்டிருந்தான்.

கி. மு. 900

இப்போதைய இந்தியாவில் இரும்பின் உபயோகம்.

கி. மு. 850பின்

இபபோதைய இந்தியாவின் பொதுவான மொழி தமிழ், வடமொழி, (வடதமிழ், தென்தமிழ்) என மொழிகள் உருவாயின. வடபுலத்தில் பிராமி எனவும் தென்புலத்தில் தமிழி எனவும் பெயர்பெற்றன. பிராமிக்கும், தமிழுக்கும் எழுத்திலக்கண ஒற்றுமை உண்டு. வடமொழி பாகதமாகவும், தென்மொழி தமிழாகவும் பெயற்பெற்றன. (சமசுகிருதம் வடமொழி அல்ல. காரணம் அது போதுமான வளர்ச்சி அடைந்திருக்கவில்லை.) தொல்காப்பியம்- பிராகிருதப் பிரகாசா இலக்கண நூற்கள் எழுதப்பட்டன, கடைச் சங்க காலத்தில் நற்றினை, குறுந்தொகை, அகநானூறு, புறநானூறு, கலித்தொகை, பதிற்றுப்பத்து, பரிபாடல், பத்துபாட்டு, எட்டுத்தொகை, பதினெண்கீழ்க்கணக்கு நூல்கள், திருமுருகாற்றுப்படை, சிறுபாணாற்றுப்படை, பெரும்பாணாற்றுப்படை, பொருநராற்றுப்படை, கூத்தராற்றுப்படை, மருதக்காஞ்சி, முல்லைப்பட்டு, குறிஞ்சிப்பாட்டு, பட்டினப்பாலை, நெடுநல்வாடை, முதலிய நூல்கள் தோன்றின. திருக்குறள் தலையாய நூல், பின்னர் சங்க கால முடிவுக்குப் பின் சிலப்பதிகாரம், மணிமேகலை, சீவகசிந்தாமணி, வளையாபதி, குண்டலகேசி முதலிய ஐம்பெரும்காப்பியங்களும், முதுமொழிக்காஞ்சி, களவழி நாற்பது, கார்நாற்பது, நாலடியார் திரிகடுகம், நான்மணிக்கடிகை, சிறுபஞ்ச மூலம், ஏலாதி, ஆசாரக்கோவை, பழமொழி நானூறு, இன்னா நாற்பது, இனியவை நாற்பது, முத்தொள்ளாயிரம் முதலிய நூல்களும் தோன்றின.

கி. மு. 776

கிரேக்கத்தில் (கிரிஸ்) முதல் ஒலிம்பிக் விளையாட்டுப் போட்டி.


குழந்தைகள் குகையில் கண்டு எடுக்கப்பட்ட மண்டையோடு. மென்டோனா, இத்தாலி. பித்திக்காந்திரோப் பஸ் 1 யின் மண்டையோடு. (தூபுவா 1891ல் கண்டு எடுத்தது) சீனாந்திரோப்பஸின் மண்டையோடு (மீட்டமைப்பு: கெராஸிமவ்)


கி. மு. 750

பிராகிருத மொழி மக்கள் மொழியாக ஆரம்பித்தது.

கி. மு. 700

சொரோஸ்டிரேணியிசம் பெர்சியாவில் சொரோஸ்டரால் துவக்கப்பட்டது, இவருடைய மதப்புத்தகம் செண்டு அவெசுடா.

கி. மு. 623- 543

கெளதம புத்தர் காலம், தற்போதைய உத்திரப்பிரதேசத்தில் பிறந்தார்.

கி. மு. 600

லாவோ - துசு காலம். துவோசிசம் சைனாவில் புழக்கம், எளிமை, தன்னலமின்மை சீனர்கள் வாழ்வானது.

கி. மு. 600

கோதடிபுத்தர் அறிந்த மொழிகளில் தமிழும் ஒன்று, கி.மு. நான்கு, ஐந்து, ஆறாம், நூற்றாண்டுகளில் குறிப்பிடத்தக்க மன்னர்கள் இளைஞன் கரிகாற்சோழன், பெருஞ்சோற்று உதயஞ்சேரலாதன். பழந்தமிழ் இசைக்கருவிகள் வடநாடு முழுவதும் வழக்கில் இருந்தன. (தோற்கருவிகள்) தமிழிலக்கணத்தைப் பின்பற்றி சமஸ்கிருதத்திலும் எழுத முயற்சி மேற்கொள்ளபட்டது. புணர்ச்சி இலக்கணம் சமஸ்கிருதத்தில் திணிக்கப்பட்டுள்ளது.

கி. மு. 599 - 527

மகாவீரர் காலம். ஜெயின மதம் தோற்றம் உயிர்த்துண்பம் தவிர்த்தல் இவரின் பெருங்கருத்து.

கி. மு. 560

பித்தகோரசு கிரேகத்தில் (கீரிஸ்) கணிதம், இசைக் கற்றுக் கொடுத்தக் காலம். மரக்கறி உண்ணல், யோகாசனம், ஓவியம் தமிழ் நாட்டில் கற்பிக்கப்பட்டன.

கி. மு. 551-478

கன்பூசியஸ் காலம். சீனர்களின் கல்விக்கு அடிப்படையே இவருடைய சமுதாய கல்வி, மக்களின் வாழ்முறை, மதம் யாவும்.

கி. மு. 500

கரிகாற் சோழன் காலம். உலக மக்கள் தொகை 100 மில்லியன். இப்போதைய இந்திய மக்கள் தொகை 25 மில்லியன்.

கி. மு. 478

இளவரசன் விசயா 700 துணையாளர்களுடன் இலங்கையில் சிங்கள அரசு ஏற்படுத்தல்.

கி. மு. 450

ஏதேன்சில் சாக்கரடீஸ் புகழோடு இருந்த காலம்.

கி. மு. 428 - 348

சாக்கரடீஸ் மாணவர் புளுட்டோவின் காலம்.

கி. மு. 400

கிரேக்கத்தில் மருத்துவமேதை இப்போகிரட்டீசின் காலம். பனினி வடமொழி இலக்கணம் அமைத்தார்.

கி. மு. 350 - 328

உதயஞ் சேரலாதன் காலம் (செங்குட்டுவன் நெடுஞ்சேரலாதன்)

கி. மு. 328 - 270

மகன் இமயவரம்பன் - நெடுஞ்சேரலாதன் ( ஆரியரை வென்றவன் - கிரேக்க யவனரை அடக்கியவன்)

கி. மு. 326

அலெக்சாண்டர் சிந்துப் பிரதேசத்தின் மீது படையெடுப்பு. வெற்றி அமையவில்லை.

கி. மு. 305

சந்திரகுப்த மெளரியரின் அட்சிக்காலம். கிரேக்க பேரரசு அமைத்த செலுக்கசை தோற்க்கடித்தவர்.

கி. மு. 302

சந்திரகுப்தரின் அமைச்சர் கெளடில்யர் அர்த்தசாத்திரம் எழுதல்.

கி. மு. 300

சீனர்கள் வார்த்த இரும்பு கண்டுபிடித்தல்.

கி. மு. 300

கல்வெட்டுகளில் சோழ, பான்டிய, சத்தியபுத்திர, சேர அரசுகள் இருந்தன. கி.மு. இரண்டாம் நூற்றாண்டு வரை தமிழ், பிராகிருதம் இரண்டும் எழுத்து மொழியாகவும் பேச்சு மொழியாகவும் விளங்கின. பிராகிருதம் - மக்களின் மொழி. நாணயங்களின் ஒரு பக்கம் தமிழ், மறுபக்கம் பிராகிருதம் என அமைந்திருந்தன.

கி.மு. 273-232

மெளரிய பேரரசர் அசோகர் காலம். தமிழ்நாடு தவிர மற்றவை இவர் வசம் இருந்தது. கலிங்க போர் இவரை புத்த மதத்திற்கு மாற வைத்தது. இவரது அசோக சக்கரம் இன்று இந்தியக் கொடியில் உள்ளது.

கி.மு. 270-245

சேரன் பல்யானை செல்கெழு குட்டுவன், சோழன் பெரும்பூண் சென்னி, பாண்டியன் ஒல்லையூர் பூதப் பாண்டியன், ஆகியோரின் காலம்.

கி.மு. 251

புத்த மதம் பரப்ப அசோகர் தன் மகனை இலங்கைக்கு அனுப்பினார்

கி.மு. 245-220

சேரன் களங்காய்க்கண்ணி நார்முடிச்சேரல் காலம்.

கி.மு. 221

புகழ் வாய்ந்த சைனாவில் 2600 கல் நீளமுள்ள பெரும் சுவர் கட்டப்பட்டது.

கி.மு. 220 - 200

கரிகாற்சோழனுக்கும் பெருஞ் சேரலாதனுக்கும் போர்.

கி.மு. 220-180

குடக்கோ நெடுஞ்சேரலாதன் ஆட்சி. உறையூர்ச் சோழன் தித்தன், ஆட்டணத்தி, ஆதிமந்தி, ஆகியோர் வாழ்ந்த காலம்.

கி.மு. 200

முனிவர் திருமூலர் காலம். 3047 சைவ ஆகமங்களின் தொகுப்பான திருமந்திரம் எழுதினார்.

கி.மு. 200

தமிழ்நாட்டில் பதஞ்சலி முனிவர் யோக சூத்திரங்கள் எழுதினார். 18 சித்தர்களில் ஒருவரான போகர் முனிவர் பழனி முருகன் கோவிலை ஏற்படுத்தினார்.

கி.மு. 125-87

ஆடு கோட்பாட்டுச் சேரலாதன் காலம்.

கி.மு. 87-62

செல்வக் கடுங்கோ வாழியாதன் ஆட்சி. பாரி, ஒரி, காரி, கிள்ளி, நள்ளி முதலிய குறுநில மன்னர்கள் ஆட்சி

கி.மு. 62-42

யானைக்கட்சேய் மாந்தரஞ்சேரல் இரும்பொறை ஆட்சி, சேரமான் மாரி வெண்கோ தொண்டியில் ஆட்சி. இக்காலத்தில் வாழ்ந்தவர்களில் குறிப்பிடத்தக்கவர்கள் தலையாலங்கானத்துச் செருவென்ற நெடுஞ்செழியன், மாங்குடி மருதனார் கல்லாடனார்.(கல்லாடம்)

கி.மு. 42-25

பெருஞ்சேரலிரும்பொறை ஆட்சி, சேரமான் மாரிவென்கோ இராசசூயம் வேட்ட பெருநற்கிள்ளி, கானபெரெயில் கடந்த உக்கிரப்பெருவழுதி ஒற்றுமையாய் இருந்தார்கள். இவர்களை இன்றே போல்கநும்புணர்ச்சி என அவ்வை பாராட்டினார், மோசிக்கீரனார், பொன்முடியார் கொண்கானங்கிழான் நன்னன், கரும்பனூர்கிழன், நாஞ்சில் வள்ளுவன் குறிப்பிடத்தக்கவர்கள்.

கி.மு. 31

உலகப் பொது மறையாம் தமிழனின் நன்கொடையாம் திருக்குறளைத் தந்த திருவள்ளுவர் பிறந்த ஆண்டு.

கி.மு. 25-9

இளஞ்சேரல் இரும்பொறை ஆட்சி. பாண்டியன் பழையன் மாறன். கோப்பெருஞ்சோழன், பிசிராந்தையார், பொத்தியார், புல்வற்றூர் ஏயிற்றியனார் ஆகியோரின் காலம்.

கி.மு. 9-1

கருவூர் ஏறிய ஒள்வாட் கோப்பெருஞ்சேரல் இரும்பொறை, பாண்டியன் கீரன் சாத்தன் வாழ்ந்த காலம்.

கி.மு. 4

ஏசுநாதர் - கிருத்துவர் மதம் கண்டவர் பெத்தலயேமில் பிறந்தார்.

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