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Tuesday, November 3, 2015

Brain Inflammation Linked to Schizophrenia Risk

Immune cells in the brain (microglia) are more active in individuals with schizophrenia and those at very high risk for the disorder, according to new study.
Interestingly bipolar disorder, which is in some mysterious way related to schizophrenia, is often treated with lithium. Lithium is neuroprotective in part by boosting BCL 2, a mitochondrial anti-apoptotic protein that helps reduce inflammation. Yesterday I noted some abstracts regarding a news release Frank posted on the protective effects of N acetyl cysteine + minocycline post traumatic rain injury. Minocycline also boosts BCL-2. Frank, I was hoping to find data indicating minocycline increased nitric oxide expression and so compensated for the vasospasm that occurs in TBI. Data is confusing, may be that in non-pathological states it increases nitric oxide but in pathological states decreases it. It definitely impacts on nitrogenic pathways.
Much more importantly we need to recognise that microglia in particular play a fundamental role in emotional regulation. We haven't crossed that bridge yet but the foundations are currently being prepared.