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Friday, June 20, 2014

Boost for dopamine packaging protects brain in Parkinson's model

Boost for dopamine packaging protects brain in Parkinson's model
Dopamine and related neurotransmitters are stored in small storage packages called vesicles by the vesicular monoamine transporter (VMAT2). When released from these packages dopamine can help regulate movement, pleasure, and emotional response. Low dopamine levels are associated with neurodegenerative diseases such as Parkinson's disease and recent research has shown that VMAT2 function is impaired in people with the disease.
Scientists generated transgenic mice with increased levels of VMAT2 and found it led to an increase in dopamine release. In addition, the group found improved outcomes on anxiety and depressive behaviors, increased movement, and protection from MPTP, the chemical that can cause Parkinson's disease-related damage in the brain.
The complete study is available in the journal Proceedings of the National Academy of Sciences (PNAS).